Navigation Links
Melanoma-initiating cell identified by Stanford scientists
Date:6/30/2010

eural crest stem cells. These cells are unique in that they are a multipotent, migratory cell population that becomes many cell types during development including melanocytes (cells responsible for skin pigmentation), bone, smooth muscle, neurons, and cartilage in the head and face.

When Boiko transplanted the melanoma cells from nine human samples into laboratory mice with severely compromised immune systems, he found that the cells expressing CD271 on their surface were much more likely to cause cancers in the recipients than those from the same tumor that didn't express the marker (70 percent versus 7 percent, respectively). And all but one of the newly induced tumors arising from the transplantation of the CD271-positive cells went on to develop a population of a mixture of CD271-expressing and non-expressing cells indicating that the cells with the marker were both self-renewing and differentiating into other types of tumor cells.

Boiko then collaborated with researchers in the medical school laboratories of professor of surgery Michael Longaker, MD, and assistant professor of surgery George Yang, MD, to further test the tumor initiating properties of the cells expressing CD271. They transplanted normal human skin on to the backs of the immunocompromised mice and injected the skin with the melanoma cells. Only cells expressing CD271 (isolated from melanomas from two patients) gave rise to tumors and lung metastasis in the mice.

Finally, the researchers looked to see whether the cancer-initiating cells also expressed common cellular antigens currently used for melanoma therapy. They found that melanoma cells expressing CD271 either completely or partially lacked expression of three common therapeutic targets TYR, MART and MAGE in 86 percent, 69 percent and 68 percent of melanoma patients, respectively.

"This could be the reason why we often see melanoma patients relapsing and coming back to the clinic," said Boiko. "Our
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Mechanism that may trigger degenerative disease identified
2. New Alzheimers Risk Genes Identified
3. Strange Artifact Identified as Ancient Anti-Snoring Device
4. New Alzheimers Gene Identified
5. Newly identified proteins critical to FA pathway DNA repair function
6. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
7. Salmonella Tennessee Identified in a Processed Food Ingredient
8. Predisposing factors for conversion of mild cognitive impairment to AD identified
9. Meat Might Be Behind Many Unidentified Allergic Reactions
10. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
11. Tumor mechanism identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... May 23, 2015 Javon Bea ... the Sports Medicine and Rehabilitation Center, 557 N. Washington ... Mondays, June 1-July 20, 5:30-6:30 pm. , The 8-week ... and Laurie Finke, RN, BSN, who will offer training ... on nutrition, running mechanics and show selection and weekly ...
(Date:5/22/2015)... Portland, OR (PRWEB) May 22, 2015 ... world, remains at the forefront of designing with reclaimed ... on Design in Los Angeles, California. Their newest offerings, ... will bring much-anticipated surface and color to America's largest ... pack our exhibit at each show, anxious to see ...
(Date:5/22/2015)... May 22, 2015 Hundreds of ... behalf of individuals who allegedly experienced serious internal ... continue to move forward in the U.S. District ... Pretrial Order dated May 4, 2015, the Court ... and electronically stored information. Among other things, the ...
(Date:5/22/2015)... 22, 2015 Hands On HealthCare Massage ... 2015, the Annual One Day Sale on Massage ... On HCMT offers drastically reduced certificates one day a year. ... enough sessions, through what used to be the slowest time ... the community as well. This once a year occurrence has ...
(Date:5/22/2015)... 2015 Coordinating care for people ... Historically providers have not been reimbursed or rewarded ... 2015, Medicare has paved the way by offering ... the launch of Oculus Health , an ... using the platform will now be able to ...
Breaking Medicine News(10 mins):Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Announces Their Eighth Annual One Day Sale on Gift Certificates Will Take Place on June 17, 2015 3Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4
... can be considered as an important breakthrough in our ... identified a new gene linked to major mental illness ... gene known to increase the risk of schizophrenia and ... and Glasgow, together with scientists from the pharmaceutical company ...
... HIV virus in the UK has come just in ... be celebrated on December 1st. This has created panic ... a second wave epidemic of resistant virus. ... AIDS victims. The currently available drugs are Zidovudine, Stavudine, ...
... There has been a mixed response from private professional ... examination for admission into medical and engineering colleges // ... the admission should be based on higher secondary marks ... that private colleges have the right to decide upon ...
... were reached after a comprehensive study conducted by the ... researchers entered data on climate-sensitive diseases // into mapping ... shows that the worst affected by the climate change ... the phenomenon in any way. The study's lead author, ...
... worrying anthrax outbreak in Makassar, Indonesia, has infected at least ... Jakarta Post // . ,The human infections came to ... buffaloes in Tamangapa subdistrict have died of anthrax recently. ... on the five persons after it was discovered that the ...
... could change the way we treat breast cancer. The new Halo ... identify breast disease // up to eight years earlier than a ... patient Amy Rhoades is taking a screening test that could potentially ... advance. ,Amy says this Pap test for the breast ...
Cached Medicine News:Health News:A Step Towards Unraveling The Schizophrenia And Depression Mystery 2Health News:Mixed Opinion Regarding Common Medical And Engineering Entrance Test 2Health News:Five People Treated For Anthrax In Indonesia 2
(Date:5/22/2015)... 22, 2015 Today, Rhodes Pharmaceuticals L.P. announced ... stimulant indicated for the treatment of Attention-Deficit/Hyperactivity Disorder ... 2015. The announcement comes just ... the U.S. Food and Drug Administration (FDA). ... of methylphenidate capsule with an onset of effect ...
(Date:5/21/2015)... , May 21, 2015 ... has announced the addition of the ... (Ankle Replacement, Digit Replacement, Elbow Replacement, Hip ... to 2019" report to their offering. ... knee replacement was valued at $4,470.9 million ...
(Date:5/21/2015)... -- CryoLife, Inc. (NYSE: CRY ), a leading medical ... vascular surgery, announced today that its Board of Directors ... quarter 2015 of $0.03 per share of common stock ... will be paid on June 19, 2015 to all ... The ex-dividend date for the quarterly dividend is June ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2
... 2012  BioParadox, Inc., a regenerative medicine company pioneering ... a strategic alliance with Fogarty Institute for Innovation.  ... working with the Fogarty Institute for Innovation known ... patients with challenging problems.  The Fogarty Institute,s unique ...
... 2, 2012 Synthetic Genomics, Inc. (SGI), a ... to solve a variety of global needs, and ... in production and supply of oligonucleotides, today jointly ... to manufacture, market, and commercialize small synthetic gene ...
Cached Medicine Technology:BioParadox Announces Partnership with Fogarty Institute for Innovation 2Synthetic Genomics, Inc. and Integrated DNA Technologies, Inc. Sign Agreement to Manufacture, Market, and Commercialize Small Synthetic Gene Products Using SGI Technology 2
One channel transcranial doppler with multigate, emboli detection, monitoring module and tests for hemodynamic evaluation. Looki 1TC is suitable as well for routine diagnosis as for monitoring in ope...
Locates flow easily, and identifies flow depth and direction for multiple vessels simultaneously....
Pakistani Watchmaker Forceps, 4" precision ground points....
Verte-Span is the latest advancement in vertebral body replacement technology. This device allows surgeons to reconstruct and stabilize certain types of anterior column defects in the spine....
Medicine Products: