Navigation Links
Melanoma-initiating cell identified by Stanford scientists
Date:6/30/2010

eural crest stem cells. These cells are unique in that they are a multipotent, migratory cell population that becomes many cell types during development including melanocytes (cells responsible for skin pigmentation), bone, smooth muscle, neurons, and cartilage in the head and face.

When Boiko transplanted the melanoma cells from nine human samples into laboratory mice with severely compromised immune systems, he found that the cells expressing CD271 on their surface were much more likely to cause cancers in the recipients than those from the same tumor that didn't express the marker (70 percent versus 7 percent, respectively). And all but one of the newly induced tumors arising from the transplantation of the CD271-positive cells went on to develop a population of a mixture of CD271-expressing and non-expressing cells indicating that the cells with the marker were both self-renewing and differentiating into other types of tumor cells.

Boiko then collaborated with researchers in the medical school laboratories of professor of surgery Michael Longaker, MD, and assistant professor of surgery George Yang, MD, to further test the tumor initiating properties of the cells expressing CD271. They transplanted normal human skin on to the backs of the immunocompromised mice and injected the skin with the melanoma cells. Only cells expressing CD271 (isolated from melanomas from two patients) gave rise to tumors and lung metastasis in the mice.

Finally, the researchers looked to see whether the cancer-initiating cells also expressed common cellular antigens currently used for melanoma therapy. They found that melanoma cells expressing CD271 either completely or partially lacked expression of three common therapeutic targets TYR, MART and MAGE in 86 percent, 69 percent and 68 percent of melanoma patients, respectively.

"This could be the reason why we often see melanoma patients relapsing and coming back to the clinic," said Boiko. "Our
'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Mechanism that may trigger degenerative disease identified
2. New Alzheimers Risk Genes Identified
3. Strange Artifact Identified as Ancient Anti-Snoring Device
4. New Alzheimers Gene Identified
5. Newly identified proteins critical to FA pathway DNA repair function
6. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
7. Salmonella Tennessee Identified in a Processed Food Ingredient
8. Predisposing factors for conversion of mild cognitive impairment to AD identified
9. Meat Might Be Behind Many Unidentified Allergic Reactions
10. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
11. Tumor mechanism identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... One of the most popular vaccine brands for ... doctors may be overlooking some cost factors when choosing ... more expensive option, according to a new study by ... to administer can be driven by numerous factors," says ... a professor of computer science and of mathematics at ...
(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... Jon McCullers, MD, was recently invited to submit ... Nature Reviews Microbiology , one of the world,s ... infectious disease specialist, and chair of the Department ... Science Center, analyzed the epidemiology and microbiology of ... as well as more recent 2009 novel H1N1 ...
(Date:4/17/2014)... 2014) Doctors who treat patients with a ... can face an agonizing treatment decision. , The ... and help relieve shortness of breath. But some ... can cause potentially fatal complications following transplantation. , ... Dilling, medical director of Loyola University Medical Center,s ...
(Date:4/17/2014)... CHICAGO, IL, April 17, 2014-- Colic affects about one ... accounts for numerous pediatric visits during the first several ... of colic symptoms was showing promise; however, the April ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics ... probiotic L reuteri for infant colic ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... involving the use of a mathematical model, suggest that ... best way to deal with an emerging pandemic. ... a worldwide human epidemic yet because it rarely passes ... would take 6-8 months to develop a vaccine effective ...
... drugs should not be recommended as a way to prevent ... during pregnancy. It is characterized by high blood pressure, swelling ... The high blood pressure can affect the brain, kidneys, liver, ... the 1960s to women in order to avoid dangerously high ...
... to think on their feet, but are they getting on ... overtaking us by the hour, are we fit// enough, is ... especially with a pedometer latched on! ,The government ... will be given pedometers; these instruments count the number of ...
... The Madhya Pradesh government has decided to implement a ... mothers// through several 'anganwadis' (mother and child care centres). ... 3-6 years are in full swing in the 59,324 ... said an official of the women and child welfare ...
... children suffering from asthma compared to other methods ... safety of different medicines. ,Although ... asthma, clinical trials directly comparing them have not ... ,For the first time, researchers in the ...
... the current issue of the Cochrane Library journal concludes //that ... Cialis, Levitra and Viagra appear to be safe and effective ... family of medications called phosphodiesterase type 5 (PDE-5) inhibitors. ... Experts have estimated that the diabetic men are about ...
Cached Medicine News:Health News:Avoid Diuretic Pills During Pregnancy 2Health News:ED Drugs - Safe and Effective for Diabetic Men 2
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... used on patients in order to treat dental impairments, ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... CVS ) is leading the private-sector effort ... several recently introduced initiatives now set to deliver long-term ... Operating Officer Larry Merlo and other senior executives will ... York City today. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) ...
... Oct. 7 A new women,s health, whole soy ... of moderate to severe hot flashes and reduced muscle ... kind among postmenopausal U.S. women, according to peer-reviewed data ... Menopause Society (NAMS) Annual Meeting.  Also, the first study ...
Cached Medicine Technology:CVS Caremark Ready to Support Patients and Payors Through Coming Era of Health Care Expansion 2CVS Caremark Ready to Support Patients and Payors Through Coming Era of Health Care Expansion 3New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 2New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 3New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 4New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 5New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 6New Soy-Based Natural S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in First Study Among U.S. Women 7
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
... has been selling replacement bulbs ... and we are extremely proud ... Check out our catalog of ... discount light bulbs specials. ...
... has been selling replacement bulbs ... and we are extremely proud ... Check out our catalog of ... discount light bulbs specials. ...
... Direct has been selling replacement ... 1996, and we are extremely ... guarantee. Check out our catalog ... our discount light bulbs specials. ...
Medicine Products: