Navigation Links
Medication does not lower risk of fungal infection, death among ELBW infants
Date:5/3/2014

Use of the antifungal medication fluconazole for six weeks for extremely low birth-weight infants did not significantly reduce the risk of death or invasive candidiasis, a serious infection that occurs when candida (a type of fungus) enters the bloodstream and spreads through the body, according to a study in the May 7 issue of JAMA, a theme issue on child health. This issue is being released early to coincide with the Pediatric Academic Societies Annual Meeting.

Invasive candidiasis is an important cause of infection in premature infants; despite treatment with antifungal therapy, invasive candidiasis has serious effects on premature infants, including severe neurodevelopmental impairment and death. Current recommendations include the use of fluconazole for prevention of this infection for infants with a birth weight of less than 1,000 grams (2.2 lbs.) who receive care in neonatal intensive care units (NICUs). However, most NICUs in the United States and the European Union have not uniformly adopted preventive use of fluconazole, based on controversies regarding high-risk patients, resistance, and safety, according to background information in the article.

Daniel K. Benjamin Jr., M.D., Ph.D., of Duke University, Durham, N.C., and colleagues evaluated the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low birth-weight infants (weighing less than 750 grams [1.7 lbs.] at birth). The study included 361 infants from 32 NICUs in the United States who were randomly assigned to receive either fluconazole (6mg/kg of body weight) or placebo twice weekly for 42 days.

The primary composite end point of death or invasive candidiasis by study day 49 was not statistically different between the 2 groups (fluconazole, 16 percent vs placebo, 21 percent). The percentage of infants who died prior to study day 49 was not different between the groups (14 percent vs 14 percent). Fewer infants developed
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
The JAMA Network Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nearly 50 percent of M.D.s believe diversion of ADHD stimulant medications among teens is a problem
2. UH Rainbow to study African-Americans response to asthma medications
3. HHS leaders call for expanded use of medications to combat opioid overdose epidemic
4. Medication does not help prevent ED following radiation therapy for prostate cancer
5. Medication does not reduce risk of recurrent CV events among patients with diabetes
6. Erectile dysfunction can be reversed without medication
7. Electronic medication alerts designed with provider in mind reduce prescribing errors
8. One in 5 older Americans take medications that work against each other
9. Anti-psychotic medications offer new hope in the battle against glioblastoma
10. Blood pressure medications given right after stroke not beneficial, study finds
11. MIT robot may accelerate trials for stroke medications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Randy Dotinga HealthDay Reporter ... cholesterol-lowering drugs while in the hospital for a hemorrhagic stroke ... than four times more likely to survive than people who ... People taking the commonly used drugs known as statins were ... to a rehabilitation facility, the study reports. When it ...
(Date:9/23/2014)... Investigators at Cincinnati Children,s Hospital Medical Center have ... gastritis (EG). The study, published in The ... that EG is a systemic disorder that has ... gastrointestinal tract, involves a series of allergy-associated-immune mechanisms ... is distinct from that of a related disorder, ...
(Date:9/23/2014)... Klose, professor of biology and a researcher in UTSA,s ... up with researchers at Ruhr University in Bochum, Germany ... findings were released this week in an article published ... Sciences . , Cholera is an acute infection caused ... with the bacterium Vibrio cholerae . An estimated ...
(Date:9/23/2014)... The community college system represents a potential source ... who will serve poor communities; however, there are ... colleges to four-year universities to medical schools. The ... recruitment, outreach and admissions practices be more inclusive ... Researchers from UCLA, UC San Francisco and San ...
(Date:9/23/2014)... "Obamacare" was signed into law in 2010 ... system since the 1960s. Designed to provide medical care ... an unwarranted intrusion into the affairs of private businesses ... healthcare systems in six Western countries, published last month ... move away from privatized medicine toward state-sponsored healthcare systems. ...
Breaking Medicine News(10 mins):Health News:Cholesterol-Lowering Drugs May Help After Certain Strokes 2Health News:Cholesterol-Lowering Drugs May Help After Certain Strokes 3Health News:Advancing the understanding of an understudied food allergy disorder 2Health News:Advancing the understanding of an understudied food allergy disorder 3Health News:UTSA microbiologists discover regulatory thermometer that controls cholera 2Health News:Medical students who attended community college likelier to serve poor communities 2Health News:Life, liberty, and the pursuit of healthcare? 2
... about glioblastoma multiforme: the malignant brain tumor is aggressive, ... In a novel effort to unravel the ... Cincinnati (UC) researchers has begun sequencing individual glioblastoma genomes ... by mapping the various DNA rearrangements of glioblastoma tumors ...
... the majority of people who binge drink. This may come ... episodes of heavy alcohol drinking within the previous two weeks ... of 10th graders, 28 percent of 12th grade seniors and ... 12 to 20 years of age, marks a critical period ...
... Disorder, or ADHD, is widely recognized by the medical community, ... as many as six percent of all children suffer from ... of refined motor skills, children with DCD tend to have ... school. They appear to be uncoordinated and many parents ...
... The Royal Marsden Hospital Manual of Clinical Nursing Procedures ... that organises 15 key chapters into four key stages ... areas such as risk management and preparing patients for ... the world-renowned UK centre of excellence, the Manual provides ...
... News) -- The brains of people with autism concentrate more ... activity in areas used to plan and control thoughts and ... why people with autism have exceptional visual abilities, said the ... from 26 brain imaging studies that were conducted over 15 ...
... can be assessed by examining the epithelial cells found ... at the AACR 102nd Annual Meeting 2011, held April ... to provide a personalized assessment of breast cancer risk, ... of veterinary and animal sciences at the University of ...
Cached Medicine News:Health News:University of Cincinnati team to track tumor DNA through bloodstream 2Health News:University of Cincinnati team to track tumor DNA through bloodstream 3Health News:Underage binge drinking can create lasting brain changes 2Health News:Clumsy kids who don't 'grow out of it' 2Health News:Patient's journey format drives new edition of vital student nurse manual 2Health News:Patient's journey format drives new edition of vital student nurse manual 3Health News:Brains of People with Autism Focus More on Visual Skills 2Health News:Breast milk may provide a personalized screen of breast cancer risk 2
(Date:9/23/2014)... Sept. 23, 2014  Decision Resources Group ... (P&R) decision criteria and payer requirements in ... into each country, allow pharma to leverage ... Global market access is extremely complex, with ... requirements and challenges—and a vast variety of ...
(Date:9/23/2014)... 23, 2014 Research and Markets  has announced ... report to their offering. Diabetes is ... globe. Over 382 million people are estimated to be currently ... to 592 million by 2035. With a very high ... and India , an increasing ...
(Date:9/23/2014)... DUBLIN , September 23, 2014 /PRNewswire/ ... ) has announced the addition of the  ...  report to their offering.  ... injectable drug delivery market holds significant potential ... with vials and painful needles to the ...
Breaking Medicine Technology:Similarities In Key Global Markets Allow Pharma To Leverage Payer Value Messaging In Multiple Countries Through "Country Archetypes" Approach 2Similarities In Key Global Markets Allow Pharma To Leverage Payer Value Messaging In Multiple Countries Through "Country Archetypes" Approach 3Similarities In Key Global Markets Allow Pharma To Leverage Payer Value Messaging In Multiple Countries Through "Country Archetypes" Approach 4Glycated Haemoglobin (HbA1c) Testing Market 2Glycated Haemoglobin (HbA1c) Testing Market 3Large Volume Wearable Injectors - 2nd Edition 2Large Volume Wearable Injectors - 2nd Edition 3Large Volume Wearable Injectors - 2nd Edition 4Large Volume Wearable Injectors - 2nd Edition 5
... February 23 BN,ImmunoTherapeutics, Inc. today provided updated ... vaccine, MVA-BN(R)-HER2, in development as,therapy of metastatic breast ... its primary endpoint with regards to safety and ... immune response was,detected in approximately 70% of evaluated ...
... An international team of,researchers has evaluated ... the knee, and the results have been ... journal "Osteoarthritis and Cartilage".,The researchers followed 376 ... treatments. After six months as well as ...
Cached Medicine Technology:BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine 2BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine 3New Treatment Against Osteoarthritis: Orthokine Therapy Highly Effective Against Knee Arthritis After Two Years 2
... is powerful, lightweight, easy ... soft, durable foam silicone ... covered by machine washable ... headband easily adjusts to ...
Xenon surgical headlight system is durable, comfortable, lightweight and deliver dependable bright light through a patented shielded fiber optic bundle. It is easy to wear....
Solarc surgical headlight is durable, comfortable, lightweight and delivers the bright, white light expected from a xenon system, but at a fraction of the cost....
View Mex-3 is designed for out-patient surgery, hospital rounds and house calls....
Medicine Products: