Navigation Links
Mechanism involved in addictions and some forms of obesity discovered in U of A lab
Date:10/4/2010

A researcher from the Faculty of Medicine & Dentistry at the University of Alberta has discovered a mechanism underlying some forms of obesity and addictions which could lead to a treatment for both diseases.

When a hungry animal finds food in the wild, it is a rewarding stimulus for the animal and is recognized by the brain by the release of the chemical messenger dopamine. Because narcotics such as cocaine, heroin and amphetamines, and even tasty and highly-caloric foods also cause the release of dopamine and therefore make people feel rewarded, it's clear that dopamine has a role in addiction and the development of obesity. When an animal knows it can expect rewarding stimuli, like a treat, in a certain location, either in the wild or captivity, this is called 'conditioned place preference' and is dependent on spatial memories being formed in a specific part of the brain called the dentate gyrus.

Professor Bill Colmers and his research group, in the department of pharmacology, set out to find if dopamine may have an effect on the memory-forming brain cells in the dentate gyrus. His group used living brain slices from laboratory models and were able to mimic activity in brain cells when an animal is exploring a novel environment. When dopamine was added, it increased the excitability in part of the brain cell called the dendrites. A chemical secreted by the brain, Neuropeptide Y, had the opposite effect making the cells less excitable.

They took this experiment further by looking at a model called long term potentiation, which is the name for a form of cellular learning. When the scientists stimulated dopamine receptors they found that cellular learning was strengthened. While doing the same experiment with neuropeptide Y, applied together with dopamine, it prevented long-term potentiation from happening

The group also did this in human brain slices taken from patients undergoing therapy for temporal lobe epilepsy. The human brain cells
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
2. Targeted therapy triggers complex mechanism of resistance
3. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
4. New dual recognition mechanism discovered in tuberculosis
5. Scientists discover the mechanisms and function of a type of mysterious immune cell
6. Study of cell division sheds light on special mechanism in egg cells
7. New radiation mechanism may ward off cancer, oil spills and terrorism
8. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
9. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
10. A key mechanism links virgin olive oil to protection against breast cancer
11. Mechanism that may trigger degenerative disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... In partnership with Raw Beauty NYC, OC healthcare ... project’s social media efforts. StudioPMG is honored to be a ... of beauty as it applies to disabled women. , ... Baer and Vanessa Silberman, who wanted to create a photo ... Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen later joined ...
(Date:9/19/2014)... September 19, 2014 -- Recent two-generation approaches to ... are receiving increasing attention from researchers, advocates, and ... to enable them to move to jobs that ... early care and education for children, these programs ... However, according to a new report from ...
(Date:9/19/2014)... 2014 As summer vacations end and everyone ... NY now reminds area patients about the reality and impact ... population affected by gum disease, there is simply not an ... 20 years Dr. Krishnan has treated patients with varying degrees ... patients that come in due to common symptoms such as ...
(Date:9/19/2014)... Recently, Top10BestSEOHosting.com has compared many professional ... Web Hosting and Bluehost are the best VPS ... to most people, VPS (Virtual Private Server) is ... into many servers, each of which has the ... dedicated computer,” the manager of Top10BestSEOHosting.com says. ...
(Date:9/19/2014)... and large protein complexes are notoriously difficult to study ... very difficult, if not impossible, to crystallize, but also ... The result is that when a structure can be ... reveals a mosaic-like spread of protein domains that sometimes ... Brunger. (2014), Acta Cryst . D70, 2241-2255; ...
Breaking Medicine News(10 mins):Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:A two generation lens: Current state policies fail to support families with young children 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:Top10BestSEOHosting.com: JustHost is One of the Best VPS Suppliers in 2014 2Health News:A refined approach to proteins at low resolution 2Health News:A refined approach to proteins at low resolution 3
... LA JOLLA, Calif., Jan. 29 There,s a rumble ... their feet and planting,their behinds on yoga mats and ... World Health Research shows that,74% of Americans have expressed ... A surge in popularity of Pilates, Yoga, Qigong, Meditation, ...
... recurrence and painful side effects, small trial finds , , ... to treating deep vein thrombosis, injecting the clot-busting drug ... the risk of complications and recurrence, a small U.S. ... of blood thinners appears to completely destroy the clots, ...
... Opportunities for the Company, -- Potentially Denotes a Positive Sign ... ... Process, NEW YORK and HAIKOU, China, ... Board: CPHI),which develops, manufactures, and markets generic and brand,bio-pharmaceutical products in ...
... Ind., Jan. 29 , ... Quarter Highlights, -- Net Sales of $1.07 billion represents an increase of 15% ... 15% reported (10% constant currency), -- Diluted EPS were ... period, and $1.18 adjusted, an increase of 16% over the prior year ...
... MS -- Cold and flu season is upon ... year, according to,the Centers for Disease Control. A cold ... in children and the elderly. Early detection,is key, especially ... days,of the infection,s onset., (Photo: http://www.newscom.com/cgi-bin/prnh/20080129/NYTUFNS1 ...
... for blood clots in the legs appears to be safe ... February issue of Radiology. The study found that injecting or ... deep vein thrombosis (DVT) and reduces the risk of subsequent ... clear blood clots rapidly and safely, restoring blood flow in ...
Cached Medicine News:Health News:Are People Asking Their Doctors?: Halo Rejuvenator a Holistic Remedy for Headache, Neck and Shoulder Pain 2Health News:Are People Asking Their Doctors?: Halo Rejuvenator a Holistic Remedy for Headache, Neck and Shoulder Pain 3Health News:Clot-Busting Drug Offers New Approach to DVT 2Health News:Clot-Busting Drug Offers New Approach to DVT 3Health News:China Pharma Holdings, Inc. Receives Chinese SFDA Approval for Generic Bumetanide Injection 2Health News:China Pharma Holdings, Inc. Receives Chinese SFDA Approval for Generic Bumetanide Injection 3Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 2Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 3Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 4Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 5Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 6Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 7Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 8Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 9Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 10Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 11Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 12Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 13Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 14Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 15Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 16Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 17Health News:Flu and Fever Detection Facts for Dr. Mom 2Health News:Flu and Fever Detection Facts for Dr. Mom 3Health News:New therapy effectively treats deep vein thrombosis 2
(Date:9/19/2014)... 19, 2014 Today, iHealth Lab Inc. announced it ... Ltd. for its first institutional round of funding. The ... global reach, accelerate growth and innovation, and invest in ... investment, Xiaomi Ventures will join iHealth,s board of directors, ... and ecommerce. "We are very pleased to ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
(Date:9/19/2014)... 2014 Research and Markets has announced ... Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023" ... of this report, the human microbiome market is segmented by ... market is expected to be valued as $294 million in ... 22.3% within the forecast period of 2019-2023. The market is ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3
... Va., Sept. 20, 2011 Rock Creek Pharmaceuticals, a ... ), announced that on September 19, 2011 a utility ... Office ("PTO"). This utility patent application is based on ... various products containing anatabine and the administration of anatabine ...
... Sept. 20, 2011 /PRNewswire-Asia/ -- Chindex International, Inc. (NASDAQ: ... providing health care services in China through the operations ... care hospitals and affiliated ambulatory clinics, today announced that ... to be held October 13-14, 2011 at Nomura,s Singapore ...
Cached Medicine Technology:Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 2Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 3Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 4
Provides the security of braided polyester suture and ease of an automated knot for vascular closure of 5-8Fr....
The ACE Alera clinical chemistry system serves a wide variety of chemistry diagnostic needs with the power of a large floor model analyzer in an easily integrated and economizing compact footprint of...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: