Navigation Links
Mechanism involved in addictions and some forms of obesity discovered in U of A lab
Date:10/4/2010

A researcher from the Faculty of Medicine & Dentistry at the University of Alberta has discovered a mechanism underlying some forms of obesity and addictions which could lead to a treatment for both diseases.

When a hungry animal finds food in the wild, it is a rewarding stimulus for the animal and is recognized by the brain by the release of the chemical messenger dopamine. Because narcotics such as cocaine, heroin and amphetamines, and even tasty and highly-caloric foods also cause the release of dopamine and therefore make people feel rewarded, it's clear that dopamine has a role in addiction and the development of obesity. When an animal knows it can expect rewarding stimuli, like a treat, in a certain location, either in the wild or captivity, this is called 'conditioned place preference' and is dependent on spatial memories being formed in a specific part of the brain called the dentate gyrus.

Professor Bill Colmers and his research group, in the department of pharmacology, set out to find if dopamine may have an effect on the memory-forming brain cells in the dentate gyrus. His group used living brain slices from laboratory models and were able to mimic activity in brain cells when an animal is exploring a novel environment. When dopamine was added, it increased the excitability in part of the brain cell called the dendrites. A chemical secreted by the brain, Neuropeptide Y, had the opposite effect making the cells less excitable.

They took this experiment further by looking at a model called long term potentiation, which is the name for a form of cellular learning. When the scientists stimulated dopamine receptors they found that cellular learning was strengthened. While doing the same experiment with neuropeptide Y, applied together with dopamine, it prevented long-term potentiation from happening

The group also did this in human brain slices taken from patients undergoing therapy for temporal lobe epilepsy. The human brain cells
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
2. Targeted therapy triggers complex mechanism of resistance
3. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
4. New dual recognition mechanism discovered in tuberculosis
5. Scientists discover the mechanisms and function of a type of mysterious immune cell
6. Study of cell division sheds light on special mechanism in egg cells
7. New radiation mechanism may ward off cancer, oil spills and terrorism
8. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
9. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
10. A key mechanism links virgin olive oil to protection against breast cancer
11. Mechanism that may trigger degenerative disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , ... July 02, 2015 , ... Global leader and ... in compression socks designed for men. , For style that’s quick on its ... daily routine. This is great news for men everywhere because a simple change in ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... 2015” provides comprehensive information on the pipeline products with comparative analysis of ... wound therapy (NPWT) with 22 market data tables and 4 figures, spread ...
(Date:7/2/2015)... , ... July 02, 2015 , ... ... Tunnel treatment and wrist pain treatment. Dr. Lev Kalika, founder of New ... a leading international authority on the conservative treatment of back, hip, knee and ...
(Date:7/2/2015)... ... ... Hand sanitizers have become extremely popular with an annual industry growth rate ... and radio host Sharon Kleyne, hand sanitizers can effectively decrease the presence of disease ... must be applied correctly and users must be aware of its limitations. , ...
(Date:7/2/2015)... ... July 02, 2015 , ... The report summarizes ... manufacturers. The report is a valuable source of guidance and direction for companies ... Chinese market for the Gelatin Capsule industry including capacity, production, production value, cost ...
Breaking Medicine News(10 mins):Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 2Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 3Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 4Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 2Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 3Health News:Breakthrough Technologies for Carpal Tunnel Treatment in New York City 4Health News:Summer flu season hand sanitizers are most effective when correctly applied reports fresh water advocate Sharon Kleyne 2Health News:Summer flu season hand sanitizers are most effective when correctly applied reports fresh water advocate Sharon Kleyne 3Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 2Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 3Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 4
... on Inc. 5000 list ... and new members, DOVER, N.H., Aug. 25 ... Free" atmosphere and friendly prices, earned,the top spot among ... 5,000 fastest-growing private businesses in the United States., ...
... consulting with school staff on avoidance strategies , , MONDAY, ... staff need to take measures to ensure the safety ... food allergies, says the American Academy of Allergy, Asthma ... and school staff is a key ingredient to keeping ...
... Aug. 25 Researchers at Scripps Translational,Science Institute (STSI) ... of a gene responsible for the majority of inherited ... online Aug. 24 in,Nature., Neuroblastoma -- a cancer ... childhood cancer deaths and has bleak survival probabilities of,less ...
... Integrated EHR Leader,s Growth Up 47 Percent from ... Greenway Medical Technologies,Inc., further establishing itself as ... practice management and interoperability,solutions, recently announced a 47 ... ending June 30, 2008, as compared to fiscal ...
... General Assembly for Allowing Dependents Ages,19-26 to Get Covered ... The face of a,broken health care system keeps ... are now the largest segment of the population without,health ... to change that by allowing more people in their ...
... N.Y., Aug. 25 Reflecting the expanding,scope of ... social, cultural,and environmental factors on health care systems ... Mary Ann Liebert Inc. have renamed,the peer-reviewed journal ... name of the journal (formerly Disease Management) begins ...
Cached Medicine News:Health News:N.H.-Based Health Club Operator Sets The Industry's Pace 2Health News:Food Allergy Action Plan Can Keep Kids From Harm 2Health News:Scripps Translational Science Institute Contributes to Discovery of Predisposition Gene for Childhood Cancer 2Health News:Greenway Medical Technologies' Growth Continues with Significant Fiscal Year 2008 Gains 2Health News:Greenway Medical Technologies' Growth Continues with Significant Fiscal Year 2008 Gains 3Health News:Younger Adults in Illinois Aided by Expansion of Health Care Coverage 2Health News:Disease Management Journal Changes Name and Expands Focus to Population Health Management 2
(Date:7/2/2015)... , July 2, 2015  The Green Exchange, Inc., ... world,s first HIPAA compliant mobile app that connects cannabis ... fresh medical marijuana, announced today that their service provides ... Eaze, Meadow and more than half a dozen other ... year, Loud Cannabis is unique in that it ...
(Date:7/2/2015)... 2, 2015 Pharma Major Lupin Limited ... "Biocom" in Russia subject to certain ... pharmaceutical market which recorded RUB 765 billion in sales, placing ... the world in 2014 (IMS Health). For over a decade, ... continue with this trend, projecting Russia ...
(Date:7/2/2015)... DURHAM, N.C. , July 2, 2015 /PRNewswire/ ... acquisition of assets related to the ion channel biology ... had previously been obtained as part of Pfizer,s 2011 ... of Pfizer,s rights to the "Icagen" name and trademark. ... provide comprehensive services for ion channel and transporter drug ...
Breaking Medicine Technology:New Cannabis Delivery App Gets Product to Patient in Under 7 Minutes 2Lupin Acquires Biocom in Russia 2Lupin Acquires Biocom in Russia 3Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 2Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 3Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 4
... Presented at Society for Investigative Dermatology, FREEPORT, ... Dermatics,recently announced new comparative clinical data that ... to recognize, transport and,utilize L-ergothioneine (EGT) as ... (EGT) acts as a more powerful and,efficient ...
... 2007 - Results,published this week in The Lancet ... Papillomavirus (Types 6, 11,16, 18) Recombinant Vaccine) was ... dysplasias caused by HPV,types 16 and 18, two ... protection was observed in women who were not,infected ...
Cached Medicine Technology:AGI Dermatics Presents Comparative Data That Indicates OCTN-1 Skin,Cells Have the Ability to Recognize, Transport and Utilize,L-ergothioneine (EGT) As A Protector Against Oxidative Damage 2Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 2Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 3Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 4Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 5Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 6Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 7Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 8Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 9Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 10Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 11Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 12Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 13Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 14Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 15Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 16Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 17Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 18Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 19Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 20Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 21Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 22Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 23Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 24Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 25Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 26Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 27Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 28Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 29Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 30Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 31Data Published in The Lancet Show Gardasil was 100 Percent,Effective in Preventing High-Grade Vulvar and Vaginal Lesions,Caused by HPV Types 16 and 18 32
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: