Navigation Links
Mechanism involved in addictions and some forms of obesity discovered in U of A lab
Date:10/4/2010

A researcher from the Faculty of Medicine & Dentistry at the University of Alberta has discovered a mechanism underlying some forms of obesity and addictions which could lead to a treatment for both diseases.

When a hungry animal finds food in the wild, it is a rewarding stimulus for the animal and is recognized by the brain by the release of the chemical messenger dopamine. Because narcotics such as cocaine, heroin and amphetamines, and even tasty and highly-caloric foods also cause the release of dopamine and therefore make people feel rewarded, it's clear that dopamine has a role in addiction and the development of obesity. When an animal knows it can expect rewarding stimuli, like a treat, in a certain location, either in the wild or captivity, this is called 'conditioned place preference' and is dependent on spatial memories being formed in a specific part of the brain called the dentate gyrus.

Professor Bill Colmers and his research group, in the department of pharmacology, set out to find if dopamine may have an effect on the memory-forming brain cells in the dentate gyrus. His group used living brain slices from laboratory models and were able to mimic activity in brain cells when an animal is exploring a novel environment. When dopamine was added, it increased the excitability in part of the brain cell called the dendrites. A chemical secreted by the brain, Neuropeptide Y, had the opposite effect making the cells less excitable.

They took this experiment further by looking at a model called long term potentiation, which is the name for a form of cellular learning. When the scientists stimulated dopamine receptors they found that cellular learning was strengthened. While doing the same experiment with neuropeptide Y, applied together with dopamine, it prevented long-term potentiation from happening

The group also did this in human brain slices taken from patients undergoing therapy for temporal lobe epilepsy. The human brain cells
'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
2. Targeted therapy triggers complex mechanism of resistance
3. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
4. New dual recognition mechanism discovered in tuberculosis
5. Scientists discover the mechanisms and function of a type of mysterious immune cell
6. Study of cell division sheds light on special mechanism in egg cells
7. New radiation mechanism may ward off cancer, oil spills and terrorism
8. Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
9. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
10. A key mechanism links virgin olive oil to protection against breast cancer
11. Mechanism that may trigger degenerative disease identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 21, 2014 (HealthDay News) -- Measures taken by Firestone ... Ebola-ravaged Liberia may have limited the spread of the ... The Firestone Natural Rubber Co. provides health services ... of nearby densely populated communities. Between Aug. 1 ... Ebola cases among those 80,000 people. That incidence rate ...
(Date:10/20/2014)... October 20, 2014 The newly updated ... source of thousands of facts, figures and forecasts on ... 68 medical sector forecast categories the Worldwide Medical ... regional and national views on the worldwide medical market ... The report gives you data for 2010-2019, covering each ...
(Date:10/20/2014)... The Advocator Group, LLC ... American Foundation for Suicide Prevention’s (AFSP) Out of the ... not-for-profit organization that hosts hundreds of community walks throughout ... are used to help understand and prevent suicide through ... as well. , The Advocator Group shares this ...
(Date:10/20/2014)... ATLANTA, Ga. (PRWEB) October 20, 2014 ... networking and relationship-marketing firm, announced today that William ... been named the 2014 ISE® Luminary Leadership Award ... celebrates the achievements of an outstanding leader and ... stewardship and contributions in advancing the information security ...
(Date:10/20/2014)... JZ Fitness, an independently operated wellness ... programming, authorship, international lecturing and community wellness, created by ... release of the JZ Fitness nutrition app, available on ... thousands of individuals on nutrition, Jenn Zerling (“JZ”) has ... require calorie counting or cumbersome food logging. ...
Breaking Medicine News(10 mins):Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3
... in Goa has supported HIV test before marriage saying ... ,'Respecting the conscience and the freedom that ... principle of informed consent and voluntary testing with counselling ... practices that offend the dignity of the concerned individuals,' ...
... found that exercise can benefit some cancer patients who ... cope with the side effects. ,An estimated ... year, according to the National Center for Chronic Disease ... treatment that produced side effects such as weight gain ...
... Drug company, PowerMed is seeking approval for conducting the first ... avian flu virus H5N1//. ,The World Health Organisation ... 2003, with at least 53 deaths. ,The company ... Medicines and Healthcare Products Regulatory Agency. The Agency is expected ...
... advertising campaign in an attempt to curtail the alarming rise ... have a graphic Ad campaign, 'The Don't Ignore Diabetes', features ... from a body. Members of the association have stated that ... disease or stroke. Explaining that each day an average of ...
... ugly head, many thousands of Fire Island residents have been ... has not been boiled. This is close on the heels ... ,Nearly 100,000 pounds of ice and 30,000 bottles of water ... to almost 10 badly troubled communities. ,County Executive ...
... of Calgary scientists have unearthed the secret to youthful looks ... not need to// count the wrinkles!!!. ,A study conducted ... were subjected to diet restrictions, which showed that there was ... loss of muscle function. Infact the older rats seemed to ...
Cached Medicine News:Health News:Drug Company Seeks Approval for Human Testing of Vaccine against H5N1 Virus 2
(Date:10/22/2014)... 2014  CryoLife, Inc. (NYSE: CRY ), ... on cardiac and vascular surgery, announced today that ... Officer, has been elected to the Company,s Board of ... G. Anderson , Executive Chairman of CryoLife, stated, "Since joining ... an excellent leader who is well positioned to maximize ...
(Date:10/22/2014)... October 22, 2014 Oramed ... a clinical-stage pharmaceutical company focused on the development ... top-line clinical results from its Phase IIa clinical ... capsules, to treat type 1 diabetes. The trial was ... under a U.S. Food and Drug Administration ...
(Date:10/22/2014)... Oct. 21, 2014  Early symptoms of diabetic ... unnoticed, but new technology, coupled with yearly, comprehensive ... to earlier detection of eye diseases, including those ... Americans. If left untreated, these diseases can potentially ... Recently, optometric researchers have deployed a ...
Breaking Medicine Technology:Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
... NEWS, Va., March 31, 2011 The U.S. Department ... story in the field of medical technology and innovation ... to the government agency, Dilon and similar entrepreneurs, "build ... solve some of our toughest global challenges." ...
... and MUNICH, March 31, 2011 Advanced Cell ... and Definiens, a leading provider for biomedical image ... to develop image analysis applications that will enable ... individual cells in routine clinical specimen. The partnership ...
Cached Medicine Technology:U.S. Department of Energy Hails Dilon Diagnostics as a Medical Technology Pioneer and Top National Innovator 2Advanced Cell Diagnostics and Definiens Partner to Develop Tool for Quantitative Biomarker Analysis 2Advanced Cell Diagnostics and Definiens Partner to Develop Tool for Quantitative Biomarker Analysis 3
Classic is proud to provide top-quality vision eyewear to physicians, health maintenance organizations (HMOs), and numerous state and federal government programs. Classic Laboratory produces over 150...
Bambi database allows images, analytical results, and eyebank or clinical information to be stored in an easy-to-access database. In most cases, the analytical results from any of our analysis progra...
... system that finally meets the challenge of comprehensively ... be a totally integrated system it is suitable ... to increase net profit, increase efficiency and increase ... has been designed to be used by all ...
... Ordering/Dispensing has gained recognition as the industry ... system. It enables opticians to place instant ... electronic communications technology. When used in conjunction ... frame tracers, lens shapes are automatically transmitted ...
Medicine Products: