Navigation Links
Mayo researchers find biomarkers for personalizing radiation cancer treatment
Date:10/4/2010

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered biomarkers that could lead to personalized radiation treatments for cancer patients. The findings appear today online in the journal Genome Research.

"Overcoming resistance to radiation therapy would make treatment more effective for some individuals," says Liewei Wang, M.D., Ph.D., Mayo Clinic genomic researcher and senior author of the study. "Our findings may make it possible to one day develop novel therapies aimed at selected subgroups of cancer patients."

Roughly half of all cancer patients undergo radiation therapy, but the response -- the impact on the patient and the cancer -- can vary greatly. It's thought that genetic variants -- differences in personal genomes -- may be the reason in most cases. Dr. Wang and her team investigated 277 different human lymphoblastoid cell lines in an attempt to learn more about why some patients respond differently.

As part of their genome-wide association study, they integrated data on gene expression, cell toxicity outcomes, and 1.3 million single nucleotide polymorphisms (SNPs), the brief sections of genetic code representing variants. They then narrowed the field and validated likely biomarkers in three cell lines to confirm radiation response. In the end, they identified five genes in which gene expression related directly to radiation response.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Insurance, Race and Poverty Affect Cancer Care, Researchers Report
2. Johns Hopkins researchers turn off severe food allergies in mice
3. UTHealth researchers awarded $15 million for teen pregnancy prevention
4. Researchers discover genetic changes that make some forms of brain cancer more aggressive
5. Researchers find no difference in drugs for macular degeneration
6. Researchers advance biosynthesis of potent anti-cancer drug Taxol
7. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
8. Researchers at the University of Granada associate trigger points with shoulder injury
9. Researchers to study effects of Mass. health reform
10. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
11. Researchers use CT to predict heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... Farifax, VA (PRWEB) , ... February 24, 2017 , ... ... winners for excellence in radiology marketing programs at the annual Building Better ... the Worthington Renaissance Fort Worth Hotel in Fort Worth, Texas. Nine awards are given ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... into the Senior International Elite division on February 12th. Ms. Esparza qualified ... at the elite qualifier competition held in Las Vegas, Nevada. Frida is one ...
(Date:2/23/2017)... ... February 23, 2017 , ... Thinksport, the most award-winning sunscreen ... Fondo of Marin. For the second year in a row, cyclists will stay ... “We are thrilled to provide our safe, non-toxic sunscreen to over 2,000 cycling ...
(Date:2/23/2017)... ... February 23, 2017 , ... The 89th Academy Awards will be celebrated ... National Education Policy Center Bunkum Award. We invite you to enjoy our 11th annual ... Bunkum winner is the Center for American Progress (CAP), for its report, Lessons From ...
(Date:2/23/2017)... ... 23, 2017 , ... Rare Disease Report®, which is the ... Rare Disease Day events, hosted by the Rare Disease Legislative Advocates (RDLA) on ... weekly e-newsletter and quarterly publication, will be conducting interviews with patients and advocates ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Südkorea, 23. Februar 2017 LG Innotek hat ... vorgestellt. Die Sterilisationsleistung beträgt das 1,5-fache des 45-mW-Moduls der ... im Bereich zwischen 200 und 280 nm und eignet sich ... indem es ihre DNA zerstört. Das Produkt von LG ... ...
(Date:2/23/2017)... -- Im Rahmen seiner Schlüsselwachstumsstrategie arbeitet die ... chinesischen Provinz Guizhou, 2017 mit dem Angebot von Anreize schaffenden ... Entwicklung einer eingebetteten Hightech-Schlüsselindustrie. Foto - http://mma.prnewswire.com/media/471342/First_CRH__CHina_Railway_High_Speed__Train_Enters_Guian.jpg ... ... ...
(Date:2/23/2017)... 2017 Obese people are seldom ... varicose veins in their body. The rising number of ... adoption of endovenous laser therapy for treatment of varicose ... therapy market, published by Future Market Insights, indicates ... consequences of obesity have collectively factored the growth in ...
Breaking Medicine Technology: