Navigation Links
Mayo researchers find biomarkers for personalizing radiation cancer treatment
Date:10/4/2010

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered biomarkers that could lead to personalized radiation treatments for cancer patients. The findings appear today online in the journal Genome Research.

"Overcoming resistance to radiation therapy would make treatment more effective for some individuals," says Liewei Wang, M.D., Ph.D., Mayo Clinic genomic researcher and senior author of the study. "Our findings may make it possible to one day develop novel therapies aimed at selected subgroups of cancer patients."

Roughly half of all cancer patients undergo radiation therapy, but the response -- the impact on the patient and the cancer -- can vary greatly. It's thought that genetic variants -- differences in personal genomes -- may be the reason in most cases. Dr. Wang and her team investigated 277 different human lymphoblastoid cell lines in an attempt to learn more about why some patients respond differently.

As part of their genome-wide association study, they integrated data on gene expression, cell toxicity outcomes, and 1.3 million single nucleotide polymorphisms (SNPs), the brief sections of genetic code representing variants. They then narrowed the field and validated likely biomarkers in three cell lines to confirm radiation response. In the end, they identified five genes in which gene expression related directly to radiation response.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Insurance, Race and Poverty Affect Cancer Care, Researchers Report
2. Johns Hopkins researchers turn off severe food allergies in mice
3. UTHealth researchers awarded $15 million for teen pregnancy prevention
4. Researchers discover genetic changes that make some forms of brain cancer more aggressive
5. Researchers find no difference in drugs for macular degeneration
6. Researchers advance biosynthesis of potent anti-cancer drug Taxol
7. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
8. Researchers at the University of Granada associate trigger points with shoulder injury
9. Researchers to study effects of Mass. health reform
10. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
11. Researchers use CT to predict heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... Center for Autism and Related ... those affected by autism spectrum disorder (ASD) and other developmental disabilities. The group, which ... give parents and other caregivers the opportunity to share stories and advice, seek help, ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of two ostomy patients, standing as living proof that attitude and determination can ... diseases and issues that spike around the holidays. This campaign will offer patients ...
(Date:12/2/2016)... ... December 02, 2016 , ... CloudLIMS.com, a class-leading provider of ... Lite. CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep track of ... new version is a faster and a more efficient product, allowing batch processing ...
(Date:12/2/2016)... ... December 02, 2016 , ... Rijuven Corp launches rejiva ( http://www.rejiva.com ... and night. No other wearable health technology on the market can deliver all that ... poeple more meaningful insights about their health than the usual heart rate and steps ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... needy individuals and families from eight different sites throughout Miami-Dade and Broward counties. ... 1,000 volunteers worked very hard on Thanksgiving morning by putting together individual meals ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... Research titled "Global Market Study on Automated Endoscope Reprocessors: Single ... a CAGR of 8.6% Between 2016 and 2024 " the global automated ... and is expected to expand at a CAGR of 7.2% ... valuation of US$ 1,367.6 Mn by 2024. ...
(Date:12/2/2016)... , Dec. 2, 2016 In the ... sources apart from those derived from C. sativa, the ... Universita` di Napoli Federico II , the Universita` ... the first comprehensive, critical, integrated and unified inventory of ... article focuses on the remarkable chemical and structural ...
(Date:12/2/2016)... British Columbia , December 2, 2016 bioLytical ... den INSTI HIV-Selbsttest, bei den Mitgliedern des Apothekenbundes von Kenia eingeführt. ... ... INSTI HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ...      (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) ...
Breaking Medicine Technology: