Navigation Links
Mayo researchers find biomarkers for personalizing radiation cancer treatment
Date:10/4/2010

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered biomarkers that could lead to personalized radiation treatments for cancer patients. The findings appear today online in the journal Genome Research.

"Overcoming resistance to radiation therapy would make treatment more effective for some individuals," says Liewei Wang, M.D., Ph.D., Mayo Clinic genomic researcher and senior author of the study. "Our findings may make it possible to one day develop novel therapies aimed at selected subgroups of cancer patients."

Roughly half of all cancer patients undergo radiation therapy, but the response -- the impact on the patient and the cancer -- can vary greatly. It's thought that genetic variants -- differences in personal genomes -- may be the reason in most cases. Dr. Wang and her team investigated 277 different human lymphoblastoid cell lines in an attempt to learn more about why some patients respond differently.

As part of their genome-wide association study, they integrated data on gene expression, cell toxicity outcomes, and 1.3 million single nucleotide polymorphisms (SNPs), the brief sections of genetic code representing variants. They then narrowed the field and validated likely biomarkers in three cell lines to confirm radiation response. In the end, they identified five genes in which gene expression related directly to radiation response.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Insurance, Race and Poverty Affect Cancer Care, Researchers Report
2. Johns Hopkins researchers turn off severe food allergies in mice
3. UTHealth researchers awarded $15 million for teen pregnancy prevention
4. Researchers discover genetic changes that make some forms of brain cancer more aggressive
5. Researchers find no difference in drugs for macular degeneration
6. Researchers advance biosynthesis of potent anti-cancer drug Taxol
7. Researchers engineer microbes for low-cost production of anti-cancer drug, Taxol
8. Researchers at the University of Granada associate trigger points with shoulder injury
9. Researchers to study effects of Mass. health reform
10. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
11. Researchers use CT to predict heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... Coast Dental Fort Stewart ... at its new location in the Exchange Furniture Mall at 112 Vilseck Road in ... 50-inch Samsung Smart TV. Plus attendees will have the opportunity to meet general dentists ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Wharton ... $30,000 Perlman Grand Prize of the 2016 Wharton Business Plan Competition —as ... People’s Choice Award, and the Committee Award for Most ‘Wow Factor,’ making them ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Gluten-Free Certification Program ... to announce the launch of the GFCP Scoop in response to ... purpose of the GFCP Scoop site is to keep the gluten-free ...
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the ... of funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... base and accelerate its technology and product roadmap. , “Jvion is ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral drug delivery ... upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... New York . Nadav Kidron , ... conference. Presentation Details:   PIONEERS ...
(Date:4/27/2016)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... second quarter ended March 26, 2016.  GAAP diluted ... and non-GAAP diluted EPS of $0.47 increased 14.6%.  ... reported basis, and 6.3% on a constant currency ... quarter, highlighted by 14.6% growth in non-GAAP EPS," ...
(Date:4/27/2016)... York , April 27, 2016 ... report titled, "Skincare Devices Market - Global Industry Analysis, ... According to the report, the global skincare devices market ... is anticipated to expand at a CAGR of 10.1% ... in 2023. Browse the full Skincare Devices Market ...
Breaking Medicine Technology: