Navigation Links
Mayo Clinic: Researchers to study body's defense system to find new treatments for Alzheimer's
Date:11/12/2013

JACKSONVILLE, Fla. Researchers at Mayo Clinic in Florida, the University of Florida in Gainesville, and the Institute for Systems Biology in Seattle have received a $7.5 million grant from the National Institutes of Health to take a new and more expanded approach to identifying drug targets to treat and possibly prevent Alzheimer's disease.

VIDEO ALERT: Video resources including an interviewwith Dr. Ertekin-Taner describing the study can be found on the Mayo Clinic News Network.

The investigators are working together to understand the role that innate immunity the body's defense system plays in Alzheimer's disease, a disorder of dementia that is rapidly increasing as the population ages.

The teams are focused on uncovering and manipulating the key molecular players in innate immunity with an ultimate goal of developing novel therapies for Alzheimer's disease, says neurologist and neuroscientist Nilufer Ertekin-Taner, M.D., Ph.D., one of the grant's two principal investigators from Mayo Clinic in Florida. The other is Steven Younkin, M.D., Ph.D.

"When activated, human innate immunity results in inflammation, and previous research on this response to development of Alzheimer's disease has been contradictory because no one has yet looked at the whole picture of this effect over time," says Dr. Ertekin-Taner. "It may be that an initial inflammatory response is beneficial, perhaps even protective, but a lengthy response to toxic proteins acts to kill healthy neurons.

"Our goal is to understand exactly if and when an innate immune response is good, and when it is bad, and to identify drug targets that enhance this protective effect and shut down the destructive side of this inflammation."

To do that, the study's leaders which include Todd Golde, M.D., Ph.D., director for Translational Research in Neurodegenerative Disease at the University of Florida, and Nathan Price, Ph.D., from the Institute for Systems Biology have designed a systems level approach.

"We want to look at all the different components together," Dr. Ertekin-Taner explains. For example, using brain samples of Alzheimer's disease patients from Mayo Clinic's brain bank directed by Dennis Dickson, M.D., and clinical samples from collaborators in Neurology, Dr. Ertekin-Taner and Dr. Younkin will generate biological information. This will include identification of key genes and RNA transcripts involved in the innate immune response to the disease.

Dr. Golde, a former chair of the Department of Neuroscience at Mayo Clinic, will use animal models of Alzheimer's disease to find similar expression data; he will also test findings from the Mayo researchers in the animals. Dr. Price will employ advanced computational methods to synthesize data generated by the teams to identify key molecules involved in this pathway. Dr. Golde will then test these results in the animal models, and see what happens when molecular targets are manipulated with novel agents.

"This grant is a beautiful example of bringing together large data and expertise from different groups into a single goal to really understand key aspects of this important pathway," Dr. Ertekin-Taner says. "We have great hope for such a novel and cutting-edge approach like this, and can't wait to get started."


'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Mayo Clinic: Less-invasive option as effective as esophagus removal in early esophageal cancer
2. Mayo Clinic: Enhanced recovery pathway for gynecologic surgery gets patients back to health faster
3. Mayo Clinic: Preclinical tests may lead to new approach to treat CNS lymphoma
4. Mayo Clinic: Rotavirus vaccine given to newborns in Africa is effective
5. Mayo Clinic: How gold nanoparticles can help fight ovarian cancer
6. Mayo Clinic: Inflammatory bowel disease raises risk of melanoma
7. Mayo Clinic: Scheduled imaging studies provide little help detecting relapse of aggressive lymphoma
8. Mayo Clinic: New multiple myeloma treatment guidelines personalize therapy for patients
9. Mayo Clinic: Skin problems, joint disorders top list of reasons people visit doctors
10. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
11. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2020)... ... August 12, 2020 , ... Floreo Inc., a leading science-backed ... autism spectrum disorder (ASD), today announced it has entered into a collaborative research ... of the National Institutes of Health (NIH). Under the CRADA, Floreo and NHGRI ...
(Date:8/11/2020)... ... August 11, 2020 , ... MemoryCare.com , a ... the Best Memory Care Facilities in San Antonio, Texas. The guide identifies 19 ... , According to the Alzheimer’s Association , 5.6 million people aged ...
(Date:8/11/2020)... (PRWEB) , ... August 11, 2020 , ... 2020 has seen a drastic change in ... April, the CDC recommended that everyone wears a face mask in public. Now, most states ... than before. , Earlier this year, all medical professionals in the U.S.A realized the ...
(Date:8/7/2020)... ... August 07, 2020 , ... Belle ... new patients for same-day dental implants with no referral necessary. This will make ... need in a single, convenient location. This advantage is especially crucial during the ...
(Date:8/7/2020)... ... 2020 , ... Mary J's Cannabis , Kingston’s premium recreational cannabis shop, ... Consulting . , The store, which operates out of a 100-year-old house in ... locations as the company plans to expand across Canada. , “At Mary J’s ...
Breaking Medicine News(10 mins):
(Date:8/5/2020)... ... , ... Help.org , a trusted online resource for individuals who struggle ... Ohio for 2020. The informational guide recognizes the top 18 rehab facilities based on ... studies , drug overdose is the leading cause of death among people under age ...
(Date:8/5/2020)... ... August 05, 2020 , ... ... COVID-19, An FDAnews Webinar, Wednesday, Aug. 19, 2020, 1:30 p.m.-3:00 p.m. EDT, ... never simple and COVID-19 has made it more challenging. From COVID-19 monitoring ...
(Date:8/3/2020)... ... ... Hide-a-Mask, a hat with a hidden face mask built-in, has tripled its goal ... Hide-a-Mask is ideal for anyone who is forgetful or reluctant to wear a mask. ... a mask at your fingertips is a great way to navigate stores, airports and ...
Breaking Medicine Technology: