Navigation Links
Making treatment of rare blood disorder more affordable and effective
Date:2/27/2014

Eculizumab is costly (currently the most expensive drug used in the US at more than $400,000 per year per patient), and one third of PNH patients continue to require blood transfusions to manage their anemia. As first described by co-author Antonio Risitano, MD, at the University of Naples in Italy, this non-response is due to fragments of complement C3 proteins on the surface of their red blood cells, which are eventually attacked by immune cells.

Lambris and colleagues have thought that inhibition of the "complement cascade" at the level of C3 proteins using small inhibitory molecules might be a superior strategy as it prevents both hemolysis and immune cell recognition while being potentially more cost-effective when compared to the current antibody-based treatment.

The team investigated the effect of a C3 inhibitor called Cp40 and its long-acting form PEG-Cp40 on self attack and resulting hemolysis using human PNH cells. Both compounds demonstrated inhibition of hemolysis and efficiently prevented deposition of C3 fragments on PNH red blood cells. In non-human primates, a single injection of PEG-Cp40 into the blood stream resulted in a longer time that the drug stayed in circulation, a property important for drug development.

"We think these two compounds are excellent and potentially cost-effective candidates for further clinical investigation," says Lambris, who hopes that the compounds could be tested in clinical trials by 2015.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain Changes May Hamper Decision-Making in Old Age
2. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
3. After 25 years, World No Tobacco Day is making an impact
4. Making bad worse for expectant mothers
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. New Electronic Cigarette Free Trial Kit Adds More Years to Smokers Life by Making it Easy to Quit Smoking
7. First Is Viewed as Best When Making Quick Decisions
8. Neuroeconomics to study decision-making in anxious individuals
9. Making it easier to learn to read
10. The making and unmaking of stem-like, aggressive breast cancer cells
11. UH students spent summer making a difference with hands-on research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... Researchers who discovered antibiotics in farmed and wild ... The use of antibiotics in animals, including ... to the development of antibiotic-resistant bacteria that threaten ... study. Each year in the United States, ... kill about 23,000, according to the Infectious Diseases ...
(Date:10/25/2014)... 23, 2014 (HealthDay News) -- Current osteoporosis screening ... postmenopausal women at risk for osteoporosis-related fractures, a ... prevent fractures, we need tools that help us ... so that we can target these at-risk people ... professor of medicine in the division of general ...
(Date:10/25/2014)... October,s shorter, darker days can trigger a type of ... expert. People affected by seasonal affective disorder, ... and even have trouble getting out of bed. In ... Angelos Halaris, a professor in the department of psychiatry ... of Medicine. "Seasonal affective disorder should not be ...
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville ... health and fitness fair ¡Vive tu vida! Get Up! Get ... nutrition for better health and wellness for people of all ... open to the public, will be held at Dean Porter ... to 1:00 pm. , “¡Vive tu Vida! Get Up! ...
(Date:10/22/2014)... Omaha, Nebraska (PRWEB) October 22, 2014 ... Travel Nurse staffing company, is happy to announce ... been named to Staffing Industry Analysts’ Staffing 100 ... list, featuring the “100 most influential people in ... Anderson’s leadership, Medical Solutions, the 13th-largest healthcare staffing ...
Breaking Medicine News(10 mins):Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3
... 15, 2012, the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) celebrated its ... all employees in the Technische Sammlungen Dresden (Dresden ... outstanding scientific achievements of the last year were ... Rector of the TU Dresden [Dresden University of ...
... HealthDay Reporter , MONDAY, March 19 (HealthDay News) -- ... treat hernias results in less chronic pain and a faster ... however, said the older strategy may still be the best ... L. Michael Brunt, a professor at Washington University in St. ...
... judogi (the traditional judo uniform) and one in blue. They ... looks like an awkward dance, before the fighter in blue ... mixed martial arts have become increasingly popular over the past ... were actually filmed as part of a science experiment that ...
... , HOUSTON - Identification of a non-traditional pathway for ... to a possible combination therapy for esophageal cancer and ... attack the Hedgehog pathway. A team of researchers ... reports in the March 20 Cancer Cell that the ...
... By Steven Reinberg HealthDay Reporter , MONDAY, ... might help thwart Alzheimer,s disease, but a new study finds ... acid has no effect on certain indicators of the brain ... the researchers said. "The benefit on oxidative stress in ...
... , MONDAY, March 19 (HealthDay News) -- ... new survey finds that some women can also experience ... is sometimes referred to as a "coregasm" because of ... said study author Debby Herbenick, co-director of the Center ...
Cached Medicine News:Health News:Dresden's Helmholtz Center celebrates anniversary and presents HZDR awards 2Health News:Dresden's Helmholtz Center celebrates anniversary and presents HZDR awards 3Health News:Less Invasive Hernia Procedure Easier on Patients: Study 2Health News:Scientists measure how energy is spent in martial arts 2Health News:Scientists link 2 cancer-promoting pathways in esophageal cancer 2Health News:Scientists link 2 cancer-promoting pathways in esophageal cancer 3Health News:Antioxidants May Not Help Alzheimer's Patients 2Health News:Antioxidants May Not Help Alzheimer's Patients 3Health News:Exercise May Trigger Orgasm in Some Women 2
(Date:10/22/2014)...  Quest Diagnostics (NYSE: DGX ), the ... that its Board of Directors has elected Jeffrey M. ... 1, 2014. Including Dr. Leiden, the Board has 11 ... and CEO of Vertex Pharmaceuticals.   Dr. Leiden has ... in the pharmaceutical and biotechnology industries as well as ...
(Date:10/22/2014)... Calif. , Oct 22, 2014 Antigen ... Irvine, California , announced the receipt of ... Business Innovation Research award (SBIR) from the National Institute of Dental ... fund the development of a Pan-HIV Protein Microarray Chip, ... HIV-1 and HIV-2 subtypes and aid in the development ...
(Date:10/22/2014)... , Oct. 22, 2014   Reproductive Medicine ... leader in the field of infertility, presents new ... embryonic screening. The research abstract, released during the ... Medicine (ASRM) meeting in Honolulu, Hawaii ... single gene defect (SGD) pre-implantation genetic diagnosis (PGD). ...
Breaking Medicine Technology:Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3
... patented ratchet design provides fingertip ratchet disengagement ... I Instrument program offers state-of-the-art quality in ... maintaining strength and durability. Low profile cutting ... joint spaces. Series I instruments are available ...
Leg holder for arthroscopy....
Irrigation pump for arthroscopy....
The 300 watt Xenon light source will provide intense illumination necessary for demanding, advanced endoscopic procedures....
Medicine Products: