Navigation Links
Making treatment of rare blood disorder more affordable and effective
Date:2/27/2014

PHILADELPHIA A University of Pennsylvania research team has defined a possible new way to fight a disease that is currently treatable only with the most expensive drug available for sale in the United States. In a study published this month in Blood, the Penn team describes the strategy, based on the oldest part of the human immune system called "complement" -- that could turn out to be less costly and more effective for the majority of patients with a rare blood disorder.

Complement is a network of more than 50 proteins in the blood and on cell surfaces that quietly cruise the body, keeping a low profile until triggered into action. On the other hand, this system can turn, contributing to a broad spectrum of immune, inflammatory, and age-related diseases.

John Lambris, PhD, the Dr. Ralph and Sallie Weaver Professor of Research Medicine in the Department of Pathology and Laboratory Medicine in the Perelman School of Medicine, studies this early-warning system and how to correct it when its response goes overboard.

This is known to be the case with paroxysmal nocturnal hemoglobinuria (PNH), a rare but life-threatening hematological disorder, which is estimated to affect between 1 and 5 per million people. In PNH, defective expression of regulatory proteins on the surface of blood cells leaves them vulnerable to complement attack. This can lead to premature death of the red blood cells, a process called hemolysis, which clinically results in severe anemia and contributes to a high risk of clotting.

Lambris and Daniel Ricklin, PhD, research assistant professor of Pathology and Laboratory Medicine, are developing novel therapeutics to tame this inappropriate complement activation and protect cell surfaces from attack.

Eculizumab (Soliris, an Alexion Pharmaceuticals drug) -- to date the only approved therapeutic for PNH -- reduces hemolysis and gives relief from blood transfusions for most PNH patients. However,
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain Changes May Hamper Decision-Making in Old Age
2. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
3. After 25 years, World No Tobacco Day is making an impact
4. Making bad worse for expectant mothers
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. New Electronic Cigarette Free Trial Kit Adds More Years to Smokers Life by Making it Easy to Quit Smoking
7. First Is Viewed as Best When Making Quick Decisions
8. Neuroeconomics to study decision-making in anxious individuals
9. Making it easier to learn to read
10. The making and unmaking of stem-like, aggressive breast cancer cells
11. UH students spent summer making a difference with hands-on research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... New Haven, CT (PRWEB) October 30, 2014 ... product categories are raising questions about the impact of ... as the marketing method most likely to influence a ... online research poll of 525 consumers conducted by radio ... in four product categories, isolating the results of respondents ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Home Care ... leading provider of non-medical, in-home senior care, is weighing ... increased brain health. , The study, performed by the ... of 60 and 78 over a week-long period and ... to daily physical activity. By examining the structural soundness ...
(Date:10/30/2014)... USARAD Holdings Inc ., ... specialty telemedicine solutions provider, including SecondOpinions.com ®, ... teleradiology services at Mission Bend ER, it is ... services, to the state-of-the-art, 24/7, freestanding ER chain ... this innovative partnership, there will be many benefits ...
(Date:10/30/2014)... Woodlands, TX (PRWEB) October 30, 2014 ... system, released today its 2014 third quarter infection ... across Texas boasted infection rates of only two ... reported patient satisfaction scores exceeding 98 percent. , ... past quarter, which included rising satisfaction scores,” said ...
(Date:10/30/2014)... Norton HealthDay Reporter WEDNESDAY, ... plastics, chemical during pregnancy may have effects on genital development ... that baby boys born to moms with greater exposure to ... distance -- the space between the genitals and anus. Anogenital ... marker of exposure to androgens ("male" hormones) during pregnancy. ...
Breaking Medicine News(10 mins):Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 2Health News:Home Care Assistance – Halton/Peel Region, a Top Provider of In-Home Care, Responds to Study Linking Exercise to Healthier Senior Brains 3Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 3Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 2Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 3Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 3
... play a role in screening for colorectal cancer (CRC), ... rates, the American Gastroenterological Association (AGA) Institute issued minimum ... competence, a minimum of 75 endoscopically confirmed cases should ... fact that CT colonography has not yet been endorsed ...
... than other chronic conditions , , FRIDAY, Sept. 7 (HealthDay ... may well be the most disabling disease in the ... chronic physical diseases such as angina, arthritis, asthma and ... from depression, the team of international researchers found. , ...
... Home and the ... Workplace-- ... Sept. 7 Quick, convenient, quality,health care has come to the Oklahoma ... the CVS/pharmacy store in Moore at 1040,SW 19th Street. MinuteClinic ( http://www.minuteclinic.com ...
... Group, the,international generic pharmaceuticals company, today announced that ... from the U.S. Food &,Drug Administration. Distribution of ... tablets, the generic equivalent of Pfizer,s,Norvasc(R) tablets, will ... 10 mg strengths,and are indicated for the treatment ...
... BELLEVILLE, ON, Sept. 7 /PRNewswire-FirstCall/ - Bioniche ... Canadian,biopharmaceutical company, today announced that it has ... Economic Development (RED) Program of the,Ontario Ministry ... grant,announced by the Honourable Leona Dombrowsky, Minister ...
... Medicine at The University of Nottingham, has been recognised ... of newborn babies, particularly those born prematurely, with an ... award, by the Good Clinical Practice Journal (GCPj), acknowledges ... in drug development and clinical trials. It is given ...
Cached Medicine News:Health News:Gastroenterology sets standards for CT colonography 2Health News:Gastroenterology sets standards for CT colonography 3Health News:Depression May Be World's Most Disabling Disease 2Health News:Depression May Be World's Most Disabling Disease 3Health News:An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region 2Health News:An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region 3Health News:An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region 4Health News:An Innovation in Health Care Opens at a CVS/pharmacy Store in the Oklahoma City Region 5Health News:Actavis Launches Amlodipine Tablets in the U.S. 2Health News:Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine 2Health News:Academic Researcher of the Year 2007 2
(Date:10/27/2014)... , Oct. 27, 2014  RenovoRx, a leading developer ... and delivery of fluids to selected sites in the ... Directors has appointed Shaun Bagai as Chief ... RenovoRx Board of Directors. Bagai brings more than 15 ... Bagai joined RenovoRx in June 2014 and in ...
(Date:10/27/2014)... DUBLIN , Oct. 27, 2014 Research ... "Global H1N1 Vaccines Market 2014-2018" report to their offering. ... in humans caused by a variant of the swine H1N1 ... contagious virus which infects nose, throat, and lungs. H1N1 virus ... A viruses infect different animal species such as humans, swine, ...
(Date:10/27/2014)...  Demonstrations by more than 50 companies of ... week in Chicago during ... 7,000 emergency physicians are discussing the top issues ... These best-of-the-best innovations are being showcased ... environments, including three equipped trauma bays. Participants will ...
Breaking Medicine Technology:RenovoRx Board Names Shaun R. Bagai as CEO 2Global H1N1 Vaccines Market 2014-2018: Key Vendors are AstraZeneca, GlaxoSmithKline, Novartis and Sanofi Pasteur 2Global H1N1 Vaccines Market 2014-2018: Key Vendors are AstraZeneca, GlaxoSmithKline, Novartis and Sanofi Pasteur 3Emergency Medicine of the Future Demonstrated at ACEP14 2Emergency Medicine of the Future Demonstrated at ACEP14 3Emergency Medicine of the Future Demonstrated at ACEP14 4Emergency Medicine of the Future Demonstrated at ACEP14 5Emergency Medicine of the Future Demonstrated at ACEP14 6Emergency Medicine of the Future Demonstrated at ACEP14 7Emergency Medicine of the Future Demonstrated at ACEP14 8Emergency Medicine of the Future Demonstrated at ACEP14 9Emergency Medicine of the Future Demonstrated at ACEP14 10Emergency Medicine of the Future Demonstrated at ACEP14 11Emergency Medicine of the Future Demonstrated at ACEP14 12Emergency Medicine of the Future Demonstrated at ACEP14 13Emergency Medicine of the Future Demonstrated at ACEP14 14Emergency Medicine of the Future Demonstrated at ACEP14 15
Cemented hip system...
... new generation of posterior stabilized knee ... the following: Patellar flange mates with ... machined condyles assure precise, repeatable kinematics ... and patella to reduce wear. Constant ...
... The Foundation® PS knee offers a femoral option ... cam action that engages at 60 degrees of ... motion and allow for 130 degrees of flexion. ... design with prominent lateral flare. The constrained tibial ...
... The Biopro TKO implant ... conservative knee implants available. The ... posterior cruciate ligaments. The implant ... for patients while preserving bone ...
Medicine Products: