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Major variation in bladder cancer subtype trends highlights need for focused research
Date:1/4/2012

ancer cases. The majority of the patients (74%) were male and white (92%). Nearly two-thirds of the tumours (65%) were PTCC and 29% were TCC. The other 6% included squamous cell, adenocarcinoma and small cell carcinoma.
  • The overall age-adjusted incidence rates for bladder cancer fell by about 9% between 1973 and 2007 from 16.7 per 100,000 to 15.2. Similar trends were noted in both genders and racial groups.
  • However, significant differences emerged when the research team looked at the two main subtypes. While the age-adjusted rates for NPTCC fell by about 53%, from 7.9 per 100,000 in 1973 to 3.7 per 100,000 in 2007, PTCC increased by 56% from 6.8 to 10.6 per 100,000 over the same period. Similar trends were noted in both genders and racial groups and in different stages of the disease localised, regional and distant.
  • A dramatic increase in the incidence rates of grade four tumours was found between 1998 and 2007, with decreasing trends for grade one, two and three tumours. This is probably due to changes in the grading system introduced in 1998, but the lack of reduction in more aggressive bladder cancer is of great concern. Similar increases were observed for NPTCC and PTCC, genders, racial groups and different disease stages.

    "The striking differences in the trends between PTCC and NPTCC suggest that they may be two disease entitles with different causes" concludes Dr Zhang. "Recent survival analysis has also shown that survival rates are substantially higher for PTCC than NPTCC.

    "Despite this, no epidemiological studies have investigated the risk factors of these two subtypes separately. Our study suggests that future research must make clear distinctions between PTCC and NPTCC and not just treat them as subtypes of transitional cell carcinoma."


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  • Contact: Annette Whibley
    annette.wizard@gmail.com
    Wiley-Blackwell
    Source:Eurekalert

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