Navigation Links
MRI may predict continued decline in patients with mild cognitive impairment
Date:10/4/2010

OAK BROOK, Ill. Using advanced MRI and an artificial intelligence technique, researchers in Geneva, Switzerland, have identified a method that may help identify which individuals with mild cognitive impairment (MCI) will continue to decline, according to a study published online and in the December issue of Radiology.

"We know that about half of all individuals with early-stage mild cognitive impairment will progress to Alzheimer's disease," said lead researcher Sven Haller, M.D, M.Sc., a radiologist at University Hospitals of Geneva. "But not knowing which patients will continue to decline makes it difficult to treat Alzheimer's early in the disease process."

Haller and a team of researchers used two novel techniques to image the brains of 35 control participants (mean age 63.7) and 69 patients with MCI (mean age 65 years), including 38 women and 31 men. Patients were diagnosed with MCI based on a battery of neuropsychological tests, which were repeated on 67 of the patients one year later to determine whether their disease was stable (40 patients) or progressive (27 patients).

Using an advanced technique called susceptibility-weighted MRI, the researchers were able to generate scans with greater detail of the many blood vessels in the brain, including the presence of tiny leaks called microhemorrhages or microbleeds.

"The number of cerebral microbleeds was significantly higher in the individuals with mild cognitive impairment than those in the control group," Dr. Haller said.

The MRI scans revealed microbleeds in 33 percent of individuals with stable MCI and 54 percent of those with progressive MCI. Only 14 percent of the control participants had microbleeds.

The susceptibility-weighted MRI also revealed that compared to the control participants, individuals with MCI had significantly increased iron concentration in certain areas deep within the structure of the brain and reduced levels of iron in others.

"Altered iron distribution in the subcortical nuclei was another distinguishing feature between the healthy control individuals and patients with mild cognitive impairment," Dr. Haller said.

Haller's team also analyzed the MRI data with support vector machines (SVM), an artificial intelligence technique that uses algorithms to identify patterns within a group and create classifications. SVM analysis of baseline MRI data acquired at the initial exam distinguished patients with progressive MCI from those with stable MCI with 85 percent accuracy.

"The goal of my work is to identify biomarkers of mild cognitive impairment that will help us diagnose individual patients at risk for further decline," Dr. Haller said. "Using SVM to analyze iron deposits in the brain may be such a biomarker."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Early life stress may predict cardiovascular disease
2. SIBLING proteins may predict oral cancer
3. Researchers receive NIH grant to study predictors and outcomes of autoimmune lung disease
4. Fatigue May Predict Heart Attack in Dialysis Patients
5. Predicted Red Tide Could Make Shellfish a Dangerous Dish
6. New tool to predict early death or hospital readmission
7. MSU scientists develop more effective method of predicting lead-poisoning risk
8. Newer Blood Test Predicts Diabetes, Heart Disease
9. Proteins May Predict Spread of Colon Cancer
10. After a fight with a partner, brain activity predicts emotional resiliency
11. Study Predicts Half of Physician Continuing Education Will Be Online by 2016
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... As President Trump challenges the ... how his administration could impact the employee benefits industry. James Slotnick, AVP, Government ... likely to make it through Congress. His discussion will focus on the current ...
(Date:4/25/2017)... Lutz, FL (PRWEB) , ... April 25, 2017 , ... ... transform their smiles by using Invisalign® in Lutz, FL. With the help ... oral health and aesthetics with fewer potential complications, more discretion and less pain. ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... in unveiling cutting-edge birth defects research related to Zika virus during pregnancy, as ... premier society for this important science. , The Teratology Society ...
(Date:4/25/2017)... ... 25, 2017 , ... Saad B. Chaudhary, MD is committed to providing the highest quality of ... I focus on preventative care with all my patients to alleviate possible future issues. I ... free to contact my office and my trained staff will assist you in any way ...
(Date:4/25/2017)... ... April 25, 2017 , ... There is no better place in South ... special report in the May issue of Consumer Reports focused on heart health. ... results achieved during and after coronary bypass and aortic valve replacement procedures. , ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017  Cardinal Health (NYSE: ... fiscal 2017 earnings per share (EPS) guidance and ... This is in conjunction with this morning,s announcement of ... Thrombosis and Nutritional Insufficiency businesses. Cardinal Health ... operations will be at the bottom of its previous ...
(Date:4/18/2017)... April 18, 2017 Viverae ® , a ... the integration of IBM ® Watson Campaign Automation, ... targeted communications for a personalized experience. Through digital engagement, ... their health in real time. The enhanced experience drives ... to members, wherever they are in their journey to ...
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., ... case series to be presented at the 2017 National ... begins today and continues through April 22. Physicians will ... , used to assess risk for acute kidney injury ... heart failure (ADHF). Elevated levels of ...
Breaking Medicine Technology: