Navigation Links
Lymph Node Test Doesnt Improve Breast Cancer Care, Study Finds
Date:7/26/2011

By Maureen Salamon
HealthDay Reporter

TUESDAY, July 26 (HealthDay News) -- A lymph node-sparing test hailed as revolutionary for its conservative approach does not lead to longer survival times for women undergoing lumpectomies whose early-stage breast cancer has spread microscopically, a large, new study suggests.

Examining the medical records of more than 5,200 patients who underwent breast-conserving surgery for early, invasive breast cancer, researchers found that tiny cancer cells in the sentinel lymph node -- the first node to which malignant cells are likely to spread from a primary tumor -- detected with a diagnostic procedure called immunohistochemical (IHC) staining had no effect on overall survival.

The biopsy procedure known as sentinel lymph node (SLN) dissection has been praised for averting the removal of large numbers of armpit lymph nodes during breast cancer surgery, which can lead to a painful buildup of fluid called lymphedema.

"I think I'd have to say it was highly controversial whether these occult [hidden] metastases would be clinically relevant," said study author Dr. Armando Giuliano, chief of surgical oncology at Cedars-Sinai Medical Center in Los Angeles. "If it's not going to affect mortality, it shouldn't affect treatment."

The study is published in the July 27 issue of the Journal of the American Medical Association.

The observational study included data from women included in the American College of Surgeons Oncology Group trial at 126 sites from May 1999 to May 2003, and all patients were followed until April 2010. Results were blinded to treating physicians to avoid the bias of overtreatment, Giuliano said.

At a midpoint follow-up of 6.3 years, 435 women had died and 376 experienced recurrence of their cancer. Based on IHC staining, five-year overall survival rates of those whose samples tested positive for node involvement were 95.1 percent, compared to 95.7 percent for those whose SLN biopsies tested negative. Corresponding five-year rates of disease-free survival were 90.4 percent and 92.2 percent, respectively.

Giuliano said the research, when adopted clinically, can save patients several hundred dollars or more in unnecessary tests. Women with microscopic metastases in their SLNs can also be spared from certain more aggressive treatments that were thought to increase their survival rates, he said.

Dr. Lora Weiselberg, chief of breast cancer service at the Monter Cancer Center of North Shore-LIJ Health System in Lake Success, N.Y., said many physicians have questioned the significance of the SLN biopsies evaluated in the study.

"In certain cases . . . we would want to do them anyway, but otherwise I think this is very strong evidence," Weiselberg said. "I think more and more pathology laboratories are going to go in that direction [of fewer tests] because adding another costly test, if it's not going to help the patient, is unnecessary."

More information

The U.S. National Cancer Institute has more on sentinel lymph node biopsies.

SOURCES: Armando Giuliano, M.D., chief, surgical oncology, and executive vice chair, surgery for surgical oncology, Cedars-Sinai Medical Center, Los Angeles; Lora Weiselberg, M.D., chief, breast cancer service, Monter Cancer Center, North Shore-LIJ Health System, Lake Success, N.Y.; July 27, 2011, Journal of the American Medical Association


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tumors hide out from the immune system by mimicking lymph nodes
2. Specific lymph node radiotherapy is well tolerated after surgery in early breast cancer patients
3. New class of drug kills lymphoma cells
4. Routine breast cancer biopsy might predict lymph node cancer spread
5. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
6. The Cancer Help Store Debuts New Blog with Information About Lymphedema and Cancer
7. Scott & White Healthcare clinical trials target lymphoma, leukemia
8. Lifestyle factors significantly impact survival of non-Hodgkins lymphoma patients, study finds
9. Lifestyle Affects Survival in Non-Hodgkins Lymphoma
10. Study identifies promising treatment for aggressive lymphoma
11. Pitt researchers discover gene mutation linked to lymphatic dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lymph Node Test Doesnt Improve Breast Cancer Care, Study Finds
(Date:12/5/2018)... ... December 05, 2018 , ... Domenic ... In this role, he will be responsible for the executive oversight of operations ... conducted an extensive, nationwide search for this position,” Tom Doran, president, HM Insurance ...
(Date:12/5/2018)... , ... December 05, 2018 , ... ... reinforces the theme of Unitek’s transformative conference at the DoubleTree Hilton Hotel in ... LL (AAN), Distinguished Professor and Founder/Director of Watson Caring Science Institute, participants and ...
(Date:11/29/2018)... ... November 29, 2018 , ... The National Association of Chronic ... Future: Why Preventing Chronic Disease is Essential - Prevention Works ,” to support ... health promotion. , The paper outlines some of the strongest public health, ...
(Date:11/29/2018)... BRIGHTON, Mich. (PRWEB) , ... November 29, 2018 , ... ... deodorant, toothbrush, toothpaste, body wash and a razor for distribution to eight Michigan homeless ... an additional $1,500 to one or more of the organizations to be selected by ...
(Date:11/28/2018)... ... November 29, 2018 , ... The awards keep coming ... a total of thirteen awards for the company in the past four years. This ... Category. , Exposure to prolonged levels of stress can have long-term health effects, which ...
Breaking Medicine News(10 mins):
(Date:11/29/2018)... , ... November 29, 2018 , ... ... and electronic health records (EHR) technology for acute care, post-acute care, and long-term ... of Customer Support and Service. Hynds will lead Cantata Health’s highly regarded customer ...
(Date:11/29/2018)... YORK (PRWEB) , ... November 29, 2018 , ... More ... which calls on the largest diabetes organizations to significantly increase funding for type 1 ... and has remained mostly flat since then. , An estimated two million Americans are ...
(Date:11/28/2018)... ... , ... Satin Fine Foods, a manufacturer of cake decorating products based in ... on Sept 28th, 2018 at the HVNY office in Walden NY. , The proceeds ... O’Reilly, Founder and CEO of Satin Fine Foods, Inc. , “Giving back is an ...
Breaking Medicine Technology: