Navigation Links
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Date:6/16/2008

ns of the brain that involve cognition, executive functioning, memory, and involuntary muscle control. TDP-43 pathology was not observed in any of the controls that did not have ALS.

The pathological TDP-43 observed in ALS brains is different in two ways from normal TDP-43 that is found in most cells. The ALS-associated TDP-43 includes fragments of normal TDP-43 as well as other abnormally modified forms of TDP-43, and it is located in the cytoplasm of neurons; whereas, normal TDP-43 is found almost exclusively in the cell nucleus. In ALS, the pathological TDP-43 accumulates in large "globs," mainly in cell bodies.

"Our observation of TDP-43 in the brains of ALS patients suggests that ALS and two other neurodegenerative diseases called ALS- PLUS [ALS with cognitive impairments] and FTLD [frontotemporal lobar disease] may all have the same underlying molecular pathology involving abnormal TDP-43," says Trojanowski. "This constitutes a paradigm shift in the way we think about these diseases."

Current research is focused on understanding the basic biology of TDP-43 in cell culture systems. The research team is now trying to find out whether pathological TDP-43 causes nerve cells to lose their normal function or if they take on a toxic function. "The over-riding goal that drives our work is helping ALS patients," says Trojanowski.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
(Date:7/31/2015)... ... 2015 , ... Cosmetic Town has proven itself as the ... surgery procedures including, but not limited to, abdominoplasty, blepharoplasty, rhinoplasty and septoplasty. ... fillers. , Staying up to date with the latest cosmetic trends has ...
(Date:7/31/2015)... ... July 31, 2015 , ... Creating one of the most modern fertility ... a visionary image that goes beyond the boundaries of fertility medicine. , As ... extraordinary heights with dependable patient support, affordable treatments, unending hope, and high fertility success ...
(Date:7/31/2015)... ... July 31, 2015 , ... The Mount Sinai Health System ... that evaluate the potential of related, experimental treatments. The collaboration moves into the next ... award Columbia Care one of five state licenses to produce and dispense medical marijuana. ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... Northern District of Ohio, Western Division (Case No. 3:15-cv-00397) involving the Implanon® ... women experienced spontaneous migration of their Implanon® implants, inability to locate the implants, ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... a novel catheter that was developed for targeted delivery of fluids to selected ... being treated at Florida Hospital Tampa with the device that provides direct, local ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town: Now Providing Interactive And Vital Medical Knowledge 2Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 2Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 3Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 2Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 3Health News:Florida Hospital Tampa Expands Treatment Options for Patients with Pancreatic Cancer Using New Catheter Technology 4
... people over 50 years. , ... (Vocus) March 6, 2009 -- We are proud ... front cover of respected magazine, Life after 50. Rajesh Khanna, M.D. As you ... founder and medical director of The Khanna Institute of Lasik and Refractive Surgery. ...
... Gold is a precious metal, but some people don,t realize how precious it ... best wrinkle creams and anti-aging formulas on the market. , ... New York (PRWEB) March ... hear about the price of Gold. It,s common to hear that it ...
... excess weight around their waists: Not only is abdominal ... host of other health problems collectively known as "metabolic ... waist circumference is strongly associated with decreased lung functionindependent ... other complicating factors. , The study analyzed health ...
... 5 For Shannon Kenitz of Madison, Wisconsin, winning the ... Road Warrior contest has meant hope for a brighter future ... of a special needs child herself, and she,s donated all ... and one million American Airlines AAdvantage miles to the ...
... of Reproductive Medicine (SIRM) announced today the introduction of the ... guarantees qualified IVF patients a baby or offers a ... is an acronym for Comparative Genomic Hybridization--a genetic process that ... to it being transferred to a woman,s uterus in the ...
... Hispanic health advocates is committed to achieving meaningful health ... work to do to cover the uninsured, improve access ... has access it is to the type of services ... Delgado, President and CEO of the National Alliance for ...
Cached Medicine News:Health News:Dr. Khanna Featured on Front Cover of Life after 50 2Health News:Gold Not Only Valuable, It's a Healthy Skin Care Ingredient 2Health News:Love handles put the squeeze on lungs 2Health News:Mother of Sick Child Donates Millions to Children 2Health News:New DNA Test Is Basis for Groundbreaking IVF Refund Plan, Easing Financial Burden for Patients 2Health News:New DNA Test Is Basis for Groundbreaking IVF Refund Plan, Easing Financial Burden for Patients 3Health News:Alliance President and CEO Dr. Jane L. Delgado Joins President Obama at White House to Launch Health Reform Agenda 2
(Date:7/30/2015)... SAN DIEGO, July 30, 2015  ResMed Inc. (NYSE: ... ended June 30, 2015.  Revenue for the quarter was ... quarter ended June 30, 2014 (a 17 percent increase ... million, consistent with the quarter ended June 30, 2014. ... consistent with the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... and VANCOUVER , July 30, 2015 ... today that it will report its second quarter 2015 ... will host a conference call and live webcast at ... financial results, clinical development programs and a general corporate ... on to the Investor Relations page of the OncoGenex ...
(Date:7/30/2015)... , July 30, 2015  Cleveland Clinic President ... keynote address last month that industry is compelled to ... to gain the efficiencies—and develop the transformational innovations -- ... Barsoum,s comments were preceded by Doug Kohrs , ... OMTEC moderator, who stressed that industry must add "episode ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... Realty Trust, Inc. (NYSE: BMR ) today ... option to purchase additional shares of common stock in ... on September 23, 2010. In total, the company sold ... of approximately $301.9 million. Wells Fargo Securities, ...
... 29 The Gulf Coast Regional Center of Innovation ... who will receive up to a total of $2.9 ... Fund (TETF).   (Logo:   http://photos.prnewswire.com/prnh/20090604/AQ28157LOGO ) ... The TETF program was established by Gov. Perry ...
Cached Medicine Technology:BioMed Realty Trust Announces Exercise of Over-Allotment Option for Common Stock 2BioMed Realty Trust Announces Exercise of Over-Allotment Option for Common Stock 3Gulf Coast Regional Center of Innovation and Commercialization and Houston Technology Center Announce Recipients of TETF Awards 2Gulf Coast Regional Center of Innovation and Commercialization and Houston Technology Center Announce Recipients of TETF Awards 3
... 3200 sets a benchmark of innovative, ... for WBC, RBC, PLT and Reticulocyte ... needs of today's laboratory. The instrument ... analysis, automated sample handling, comprehensive data ...
... Data Management System provides comprehensive program management ... and the Precision PCx. The QC Manager ... collect, analyze, and report quality control data ... essential laboratory tool for managing data and ...
... The CELL-DYN SMS consistently produces high-quality ... ensuring consistent blood films every time, eliminating ... with significantly high or low hematocrit values. ... autoloader mixes, identifies the sample, and aspirates ...
... The QuickVue In-Line Strep A Test allows for ... directly from patient throat swab specimens. , ,QuickVue ... and is the first strep A test waived ... rapid procedure allow testing to take place at ...
Medicine Products: