Navigation Links
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
Date:6/16/2008

PHILADELPHIA - Two years ago researchers at the University of Pennsylvania School of Medicine discovered that misfolded proteins called TDP-43 accumulated in the motor areas of the brains of patients with amyotropic lateral sclerosis (ALS), or Lou Gehrig's disease. Now, the same group has shown that TDP-43 accumulates throughout the brain, suggesting ALS has broader neurological effects than previously appreciated and treatments need to take into account more than motor neuron areas. Their article appeared in last month's issue of the Archives of Neurology.

"The primary implication for ALS patients is that we have identified a molecular target for new therapies," says co-author John Q. Trojanowski, MD, PhD, Director of Penn's Institute on Aging. "The other implication is that new therapies for ALS now need to go beyond treating only motor neurons."

Traditionally, ALS has been diagnosed based on muscle weakness and neurodegeneration of the upper and lower motor neurons that extend from the motor cortex to the spinal cord and brainstem motor neurons, which directly innervate voluntary muscles. For example, if you want to wiggle your big toe, the signal travels from the motor neuron in the cortex at the top of your head to a synapse on the lower spinal cord motor neurons in the lower back, which, in turn transmit the "wiggle" command by sending a signal to the muscles that move your big toe. Patients with ALS cannot wiggle their big toe or complete other voluntary muscle movements, including those carried out by their other extremities and eventually, by the diaphragm that moves air in and of their lungs.

The study was conducted by examining post-mortem brain tissue of 31 ALS patients. The accumulation of TDP-43 was imaged by detecting TDP-43 with an antibody specific for this protein. TDP-43 pathology was observed not only in the areas of the brain and spinal cord that control voluntary movements, as expected, but also in regio
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lou Gehrig's protein found throughout brain, suggesting effects beyond motor neurons
(Date:4/23/2014)... Purdue University researchers have identified an important enzyme pathway ... or too few chromosomes, a condition that has been ... Hall, associate professor of biochemistry, found that near the ... an enzyme that ensures any breaks in DNA are ... the genome to daughter cells. This process helps safeguard ...
(Date:4/23/2014)... computer program could help doctors predict which patients might ... , The program, which assesses brain scans using ... security and passport control, has been developed by researchers ... funded by the Wellcome Trust, which used the software ... , Stroke affects over 15 million people each ...
(Date:4/23/2014)... vegetables are often displayed in the popular Swedish ... plenty of high-sugar foods. A new study from ... portrayed in children,s TV programmes as well as ... habits and weight status. , Steingerdur Olafsdottir,s doctoral ... the popular Swedish children,s TV show Bolibompa. Healthy ...
(Date:4/23/2014)... Parents and physicians concerned about an increase in adolescents, ... breathe a sigh of relief. According to a new ... worth of data from states with and without medical ... increased use among adolescents. The study is published online ... Adolescent Health . , "Any time a state ...
(Date:4/23/2014)... Previous studies have shown that proliferation of endogenous ... damage to neurons and axons. From the perspective ... from Sun Yat-sen University in China observed the ... neural precursor cell proliferation and expression of basic ... the rat brain on the infarct side. The ...
Breaking Medicine News(10 mins):Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2Health News:Airport security-style technology could help doctors decide on stroke treatment 2Health News:Airport security-style technology could help doctors decide on stroke treatment 3Health News:High-calorie and low-nutrient foods in kids' TV 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2
... Legislation Will Help Hundreds of Thousands of Idahoans Struggling with ... , BOISE, Idaho, Nov. 6 As ... and the House readies to vote on critical health care ... on Idaho,s U.S. Representatives to support the bill. The ...
... does the need to exert more pressure from the lungs, ... fluctuations make it harder for women to sing during pregnancy, ... difficulty singing while pregnant, but it hasn,t been known whether ... decreased lung capacity as the baby grows. , In this ...
... , ... three public school students with swine flu vaccine, and medical malpractice lawyers, including David Perceman, ... ... 2009 -- Across New York, medical malpractice lawyers are unsurprised that three students ...
... , LOS ANGELES, Nov. 6 With the number of ... U.S., a basic eye exam, including a red reflex test, ... Angela Buffenn, M.D., M.P.H., Director of the Orbit and Eye ... Angeles. , "Advances in medicine have enabled many medically fragile ...
... releases the following statement in observance of Pancreatic Cancer Awareness Month ... and perplexing disease, yet it is the fourth leading cause of ... 42,000 Americans will be diagnosed with the disease and more than ... , "To find a cure for pancreatic cancer researchers have ...
... more susceptible to bronchiolitis, study finds , FRIDAY, Nov. ... alongside auto traffic as a risk factor for bronchiolitis, ... hospitalization in the first year of life, a new ... to wood-burning appliances were more likely to show up ...
Cached Medicine News:Health News:AARP Calls On Idaho's U.S. Reps To Back House Health Care Reform Bill 2Health News:New York Medical Malpractice Lawyer Comments on School Nurses Injecting Students with Swine Flu Vaccine without Consent 2Health News:New York Medical Malpractice Lawyer Comments on School Nurses Injecting Students with Swine Flu Vaccine without Consent 3Health News:Red Reflex Vision Exam Should Be Given to All Newborns, Report Recommends 2Health News:Red Reflex Vision Exam Should Be Given to All Newborns, Report Recommends 3Health News:Wood Fires Can Harm the Youngest Lungs 2
(Date:1/15/2014)... (the "Company") (NASDAQ: CLSN ) today announced ... purchase an aggregate of approximately $15 million of the ... led by a dedicated health care fund. ... investors pursuant to which the Company agreed to sell ...
(Date:1/15/2014)... 2014 BreedIT Corp (OTC: BRDT), through ... of highly sophisticated agro-breeding solutions for plant breeders and ... Company,s board of directors appointed chemistry and pharmaceutical industry ... member of the board. From 1975 to ...
(Date:1/15/2014)... Jan. 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin ... provisional patent application concerning composition of matter, biological targets, ... tumor cell death.  This patent application ... stranded RNA molecules (VSRNAs) which interfere with the basic ...
Breaking Medicine Technology:Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
... CVS Caremark (NYSE: CVS ) today ... of CVS/pharmacy effective October 1, 2011.  With more than ... and Puerto Rico, CVS/pharmacy is one of the largest ... http://photos.prnewswire.com/prnh/20090226/NE75914LOGO) Cosby, 52, most recently served as ...
... Oncobiologics, Inc. and Fox Chase Cancer Center ... next-generation bi-specific antibody cancer platform with enhanced therapeutic ... is designed to handle multiple targets, representing a ... is now underway, with preclinical studies expected in ...
Cached Medicine Technology:CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 2CVS Caremark Appoints Mark S. Cosby as President of CVS/pharmacy 3Oncobiologics, Inc. and Fox Chase Cancer Center Announce Co-Development of a Novel Cancer Therapy Platform 2Oncobiologics, Inc. and Fox Chase Cancer Center Announce Co-Development of a Novel Cancer Therapy Platform 3
White Standard Girdle...
Black Spandex Above the Knee Compression Girdles with Contact Closure with Zipper...
Short Girdle, Mid-thigh, Front Closure...
Male Body Shaper, Front Closure...
Medicine Products: