Navigation Links
Long-term NSAID use by hypertensive patients with CAD increases risk of adverse events
Date:7/13/2011

New York, NY, July 12, 2011 A study published in the July issue of The American Journal of Medicine, reports that among hypertensive patients with coronary artery disease, chronic self-reported use of non-steroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of adverse events during long-term follow-up. Long-term NSAIDs use is common for treatment of chronic pain.

Researchers from the Division of Cardiovascular Medicine, College of Medicine and the Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, found that after a mean of 2.7 years of follow-up, in hypertensive patients with coronary artery disease (average age of 65 years), chronic self-reported NSAID use was associated with a 47% increase in the occurrence of death, nonfatal myocardial infarction, or nonfatal stroke. This was due to a 90% increase in all-cause mortality (which persisted into extended follow-up of more than 5 years), a 126% increase in cardiovascular mortality, and a 66% increase in total myocardial infarctions. There was no significant difference in the occurrence of stroke.

"Among coronary artery disease patients with hypertension, chronic self-reported use of NSAIDs was associated with harmful outcomes, and this practice should be avoided where possible," commented Anthony A. Bavry, MD, MPH, Assistant Professor, Division of Cardiovascular Medicine, College of Medicine at the University of Florida, Gainesville. "This association did not appear to be due to elevated blood pressure because chronic NSAID users actually had slightly lower on-treatment blood pressure over a mean of 2.7 years of follow-up. Until further data are available, alternative modes of pain relief should be considered for these patients."

Currently, there is a paucity of data about possible harmful effects of chronic NSAIDs in patients with hypertension and coronary artery disease. This observati
'/>"/>

Contact: Pamela Poppalardo
ajmmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cuddling May Be Key to Long-Term Happy Relationship
2. Study shows long-term benefits of breast screening
3. Study: Long-term inhaled corticosteroid use increases fracture risk in lung disease patients
4. Chips, Fries, Soda Most to Blame for Long-Term Weight Gain
5. Angioplasty with stents may be safe in long-term for low-risk heart patients
6. Its not about the money for long-term care nurses
7. New study aims to improve long-term treatment for patients with bipolar disorder
8. Enlarged prostate: Study demonstrates immediate and long-term benefits of laser treatment
9. Antibody production gets confused during long-term spaceflight
10. Simple fitness test could predict long-term risk for heart attack, stroke in middle-aged people
11. High pregnancy weight gain can lead to long-term obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... at the University of York reveals that a process ... the nervous system may also play a pivotal role ... team, led by Dr Will Brackenbury, a Medical Research ... has studied how voltage-gated sodium channels assist in the ... the membranes of excitable cells, such as neurons, where ...
(Date:4/23/2014)... stool from healthy, unrelated donors was safe and ... caused by Clostridium difficile , according to ... Infectious Diseases and available online. Known as ... whether given via a colonoscope or a nasogastric ... this promising treatment more readily available to patients. ...
(Date:4/23/2014)... researchers say clinical trials for a new experimental ... very promising. Patients treated with CPX-351, a combination ... showing better responses than patients treated with the ... myeloid leukemia is an aggressive blood cancer with ... older patients," explained Jeffrey Lancet, M.D., senior member ...
(Date:4/23/2014)... M.D., scientific director at the National Institute of Arthritis ... the 2014 recipient of the Ross Prize in Molecular ... Molecular Medicine . The award will be given ... Sciences in Manhattan, followed by scientific presentations by Dr. ... the National Institutes of Health. , The award, which ...
(Date:4/23/2014)... 2014 The American Society for Radiation Oncology (ASTRO) ... Postoperative Radiation Therapy for Endometrial Cancer: An ASTRO ... radiation therapy in the treatment of endometrial cancer. ... May-June 2014 issue of Practical Radiation Oncology ... ASTRO. The full-length guideline is available as an ...
Breaking Medicine News(10 mins):Health News:Breast cancer replicates brain development process 2Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3
... But what about homosexual partnerships? Are they made for each ... a while, and now it seems like the battle lines ... ,The U.S. president, during a recent radio address, has ... Bush said 'This national question requires a national solution, and ...
... the London School of Medicine and Dentistry has called ... the UK//. Len Doyal a professor of medical ethics ... ,The professor believes that doctors should be able ... in an article that was published today in the ...
... an United nation official, a campaign to warn Indonesians ... year after the virus infected //the first of 49 people ... country in the world. ,According to John Budd, ... Jakarta, thousands of government workers and several members of ...
... and Jehangir Sabavala displayed their work on ‘Visual Trajectories’ ... held at Durban for a period of 3 weeks ... co-operation between Indian and South African Governments, an agreement ... African National Gallery (Iziko Sang) and National Gallery of ...
... The discovery of a 170cm tall adult human skeleton ... conspicuous', says Mishra. // ,'A lot of ... related to the culture, customs, lineage or gene-pool, birth, ... Mishra says., ,The Abhaipur site preserves evidence of ...
... become mandatory for the doctors to recommend the mothers of ... the first six months, excluding any solid foods. But that ... saying that feeding the babies on cereals in the earlier ... ,Jill Poole, M.D., assistant professor in the pulmonary, critical ...
Cached Medicine News:Health News:Differently Wired and Gay – Are They Children of a Lesser God 2Health News:Earlier Introduction of Solid Foods in Infants Could Prevent Wheat Allergy 2
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... 2014  Novation, the leading health care supply chain expertise, ... reseller (VAR) national contracts that expand its portfolio to ... lower costs. These include manufacturer product and service agreements, ... and ongoing IT consulting support. New ...
(Date:1/15/2014)... , January 15, 2014 BreedIT Corp ... exclusive worldwide distributor of highly sophisticated agro-breeding solutions for ... 7, 2014, the Company,s board of directors appointed chemistry ... as its new member of the board. ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... be an alternative therapy for Parkinson,s , NEW YORK, ... University Medical Center have reached a milestone in the development ... the limitations of current therapy. , The team, which received ... Foundation,s 2007 LEAPS (Linked Efforts to Accelerate Parkinson,s Solutions) ...
... Sept. 30 InteKrin Therapeutics Inc. announced today positive ... safety studies. Data will be presented at the ... Meeting in Vienna, Austria at 12:45 PM ... Officer, Linda Higgins, PhD, in a presentation "Chronic Cardiovascular ...
Cached Medicine Technology:Michael J. Fox Foundation-Funded Team Pursuing Glutamate-Based Treatment for Parkinson's Disease Hits Major Milestone 2InteKrin Therapeutics Presents Positive Long Term INT131 Preclinical Cardiovascular Safety Data at the 45th Annual European Association for the Study of Diabetes Meeting 2
... The Vitros ECi brings true ... to immunodiagnostic testing. Highly sensitive assays ... oncology and bone metabolism testing are ... under development. The Vitros ECi can ...
... is a flexible system that ... environments small hospitals, backup ... satellite locations. The Vitros 250 ... can be automated or placed ...
... an effort to improve on the ... toxicology, abused drugs, and immunosuppressants tests, ... which incorporates random access capabilities. Although ... undergone several important changes in the ...
The IMx system is an automated analyzer designed to perform microparticle enzyme immunoassay (MEIA), fluorescence polarization immunoassay (FPIA) and ion capture technologies....
Medicine Products: