Navigation Links
Long distance signals protect brain from viral infections
Date:2/10/2014

The brain contains a defense system that prevents at least two unrelated virusesand possibly many morefrom invading the brain at large. The research is published online ahead of print in the Journal of Virology.

"Our work points to the remarkable ability of the immune system, even within the brain, to protect us against opportunistic viruses," says Anthony van den Pol of Yale University, an author on the study.

The research explains a long-standing mystery. The olfactory mucosa in the nose can serve as a conduit for a number of viruses to enter the brain including rabies, polio and influenza viruses. Yet infections in the central nervous system rarely occur. The mechanism responsible for protecting the brain from viruses that successfully invade the olfactory bulb (OB), the first site of infection in nasal mucosa, remains elusive.

Van den Pol and his colleagues have discovered that, in response to viral infection, cells in the olfactory bulb release long-distance signaling molecules that tell cells in uninfected parts of the brain to produce anti-viral interferon, a first line of defense against invading viruses.

In the study, normal mice expunged the infection, while mice lacking receptors for the initial signaling molecules succumbed as the viruses spread throughout the brain, proving the critical role of these molecules.

These signaling molecules are different than regular neurotransmitters. Van den Pol notes that during neuronal signaling, neurotransmitters released by one cell travel across a mere 20 nanometers of synapse to the next nerve cell. Yet, the long-distance signaling molecules diffuse up to 15 millimeters.

"That distance is almost a million times greater than the distance across a synapse," he says.

"The success of the immune system in blocking two unrelated viruses, vesicular stomatitis virus and cytomegalovirus, suggests that our results may generalize to many other viruses that can enter the brain through the olfactory nerve," says van den Pol.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Blade Runner Golf Announces a Tour Model Chipper That Is Versatile from 7 Iron Distances and Provides Success for Any Players Skill Level
2. MedMar Healing Center Co-founder Rafael Hernandez Goes the Distance for Leukemia and Lymphoma Society, Running Three Marathons for Nonprofit Health Organization
3. Med Transport Center Introduces a $500 Holiday Gift Certificate on 4 Long Distance Medical Transportation Services
4. Green Swan, Inc. Introduces The Cell Spacer™, a Device That Puts Distance Between a Mobile Phone User’s Head and Headset
5. Broad-Connect Telecom Introduces Essential Voice SIP, Long Distance SIP and Toll-Free SIP
6. More Than 55 Percent of STD Positives Not Worried About Distance for Match
7. Elite Long Distance Runner Amy Hastings Signs With ZAMST
8. How Does Psychological Distance Work Between Non-millionaires and Millionaires in Dating?
9. Machine-Like Performance in Skateboarding Receives Guinness World Record™ Status for Performance at The International Distance Skateboard Association Ultraskate
10. Global Autism Project Announces Distance Supervision for Autism Professionals
11. Urology-owned radiation oncology self-referral can increase patients travel distance for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... April 24, 2017 , ... Salus Telehealth, ... the company’s VideoMedicine mobile platform has launched Quick Care, a new service offering ... Quick Care provides patients with the option to request and begin a consultation ...
(Date:4/24/2017)... ... 24, 2017 , ... MAP Health Management announced today a ... with addiction who are served by MAP’s patient engagement ecosystem. Lief Therapeutics is ... heart and breath rates to identify anxiety levels and can provide biofeedback exercises ...
(Date:4/24/2017)... NJ (PRWEB) , ... April 24, 2017 , ... Come ... Plaza Hotel, 4200 Jim Walter Blvd, for an educational and exciting 2-day program. ... of our staff hearing this before they approach patients” about the course entitled Ain't ...
(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each person ... author, Jerri Broglin, a survivor of great loss who gained insight on how to ... those searching for answers, as we are finding the answers that are so deep ...
(Date:4/24/2017)... ... April 24, 2017 , ... Life of Purpose Treatment is proud ... event will be held at 7:30 pm on May 10th at the University Auditorium. ... of Sister Hazel, will support the UF Collegiate Recovery Community (UFCRC). The concert will ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 Companion animal ... in pets such as canine, avian and feline. ... types such as Attenuated Live Vaccines, Conjugate Vaccines, ... and Recombinant Vaccines. Attenuated live vaccines are derived ... which have been weakend under laboratory conditions. Conjugate ...
(Date:4/18/2017)... 18, 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), ... Urology, Uro/Gyn and Gynecology markets with innovative and proprietary ... ended March 31, 2017 after the market close on ... will host a conference call and webcast to discuss ... 2, 2017 at 4:30 p.m. Eastern Time (3:30 p.m. ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc. and ... started in 2016, in which Socionext extracts and ... The companies achieved initial results in reading ultrasound ... Artificial Brain SOINN. The results will be introduced ... April 19-21, at booths 4505 & 4507. ...
Breaking Medicine Technology: