Navigation Links
Long distance signals protect brain from viral infections
Date:2/10/2014

The brain contains a defense system that prevents at least two unrelated virusesand possibly many morefrom invading the brain at large. The research is published online ahead of print in the Journal of Virology.

"Our work points to the remarkable ability of the immune system, even within the brain, to protect us against opportunistic viruses," says Anthony van den Pol of Yale University, an author on the study.

The research explains a long-standing mystery. The olfactory mucosa in the nose can serve as a conduit for a number of viruses to enter the brain including rabies, polio and influenza viruses. Yet infections in the central nervous system rarely occur. The mechanism responsible for protecting the brain from viruses that successfully invade the olfactory bulb (OB), the first site of infection in nasal mucosa, remains elusive.

Van den Pol and his colleagues have discovered that, in response to viral infection, cells in the olfactory bulb release long-distance signaling molecules that tell cells in uninfected parts of the brain to produce anti-viral interferon, a first line of defense against invading viruses.

In the study, normal mice expunged the infection, while mice lacking receptors for the initial signaling molecules succumbed as the viruses spread throughout the brain, proving the critical role of these molecules.

These signaling molecules are different than regular neurotransmitters. Van den Pol notes that during neuronal signaling, neurotransmitters released by one cell travel across a mere 20 nanometers of synapse to the next nerve cell. Yet, the long-distance signaling molecules diffuse up to 15 millimeters.

"That distance is almost a million times greater than the distance across a synapse," he says.

"The success of the immune system in blocking two unrelated viruses, vesicular stomatitis virus and cytomegalovirus, suggests that our results may generalize to many other viruses that can enter the brain through the olfactory nerve," says van den Pol.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Blade Runner Golf Announces a Tour Model Chipper That Is Versatile from 7 Iron Distances and Provides Success for Any Players Skill Level
2. MedMar Healing Center Co-founder Rafael Hernandez Goes the Distance for Leukemia and Lymphoma Society, Running Three Marathons for Nonprofit Health Organization
3. Med Transport Center Introduces a $500 Holiday Gift Certificate on 4 Long Distance Medical Transportation Services
4. Green Swan, Inc. Introduces The Cell Spacer™, a Device That Puts Distance Between a Mobile Phone User’s Head and Headset
5. Broad-Connect Telecom Introduces Essential Voice SIP, Long Distance SIP and Toll-Free SIP
6. More Than 55 Percent of STD Positives Not Worried About Distance for Match
7. Elite Long Distance Runner Amy Hastings Signs With ZAMST
8. How Does Psychological Distance Work Between Non-millionaires and Millionaires in Dating?
9. Machine-Like Performance in Skateboarding Receives Guinness World Record™ Status for Performance at The International Distance Skateboard Association Ultraskate
10. Global Autism Project Announces Distance Supervision for Autism Professionals
11. Urology-owned radiation oncology self-referral can increase patients travel distance for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Super-Sod will attend the ... event in Athens, Georgia. , A shift from Super-Sod’s simple Athens Home Show booth ... For the booth, grass seed plant manager Chris Roquemore constructed furniture from recycled pallet ...
(Date:2/22/2017)... ... February 22, 2017 , ... In today’s ... different solutions on the market, it is easy to start feeling frustrated and ... offers a complimentary security consultation. , Home Security Hardware Choices, There are ...
(Date:2/21/2017)... ... February 22, 2017 , ... Author Michèle Wolff has ... for every household and family to know all about it for optimal health. Wanting ... the release of “ Detox, Digestive and Wellness Solutions ” (published by Balboa Press ...
(Date:2/21/2017)... ... February 21, 2017 , ... As recently as 2015, rhinoplasty ... the American Society of Plastic Surgeons. Some patients want to make a change in ... nose and improve their breathing ability. The team at usrhinoplasty.org is expanding ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... trial solutions, today announced the further expansion of its eHealth App xChange™, ... leverage as part of Bioclinica’s extensive and growing eHealth platform. Applications that ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... 22, 2017 Des scanners sur smartphone destinés aux ... Europe , au Moyen-Orient et en Afrique  ... Clarius Mobile Health , une société de ... , au Canada , a annoncé aujourd,hui qu,elle a ... Sans fil Clarius C3 et L7, destinés à être utilisés par des ...
(Date:2/22/2017)...  Soligenix, Inc. (Nasdaq: SNGX ) ... focused on developing and commercializing products to treat ... need, announced today that its proprietary formulation of ... for the treatment of psoriasis. The issued patent, ... skin conditions, complements the method of treatment claims ...
(Date:2/21/2017)... -- The global infusion pumps market is estimated to ... 2021, to reach USD 10.84 billion by 2021 from ... diseases along with increasing geriatric population, increasing adoption of ... in surgical procedural volumes, and rising applications of infusion ... factors driving the growth of this market. However, patient ...
Breaking Medicine Technology: