Navigation Links
Long distance signals protect brain from viral infections
Date:2/10/2014

The brain contains a defense system that prevents at least two unrelated virusesand possibly many morefrom invading the brain at large. The research is published online ahead of print in the Journal of Virology.

"Our work points to the remarkable ability of the immune system, even within the brain, to protect us against opportunistic viruses," says Anthony van den Pol of Yale University, an author on the study.

The research explains a long-standing mystery. The olfactory mucosa in the nose can serve as a conduit for a number of viruses to enter the brain including rabies, polio and influenza viruses. Yet infections in the central nervous system rarely occur. The mechanism responsible for protecting the brain from viruses that successfully invade the olfactory bulb (OB), the first site of infection in nasal mucosa, remains elusive.

Van den Pol and his colleagues have discovered that, in response to viral infection, cells in the olfactory bulb release long-distance signaling molecules that tell cells in uninfected parts of the brain to produce anti-viral interferon, a first line of defense against invading viruses.

In the study, normal mice expunged the infection, while mice lacking receptors for the initial signaling molecules succumbed as the viruses spread throughout the brain, proving the critical role of these molecules.

These signaling molecules are different than regular neurotransmitters. Van den Pol notes that during neuronal signaling, neurotransmitters released by one cell travel across a mere 20 nanometers of synapse to the next nerve cell. Yet, the long-distance signaling molecules diffuse up to 15 millimeters.

"That distance is almost a million times greater than the distance across a synapse," he says.

"The success of the immune system in blocking two unrelated viruses, vesicular stomatitis virus and cytomegalovirus, suggests that our results may generalize to many other viruses that can enter the brain through the olfactory nerve," says van den Pol.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related medicine news :

1. Blade Runner Golf Announces a Tour Model Chipper That Is Versatile from 7 Iron Distances and Provides Success for Any Players Skill Level
2. MedMar Healing Center Co-founder Rafael Hernandez Goes the Distance for Leukemia and Lymphoma Society, Running Three Marathons for Nonprofit Health Organization
3. Med Transport Center Introduces a $500 Holiday Gift Certificate on 4 Long Distance Medical Transportation Services
4. Green Swan, Inc. Introduces The Cell Spacer™, a Device That Puts Distance Between a Mobile Phone User’s Head and Headset
5. Broad-Connect Telecom Introduces Essential Voice SIP, Long Distance SIP and Toll-Free SIP
6. More Than 55 Percent of STD Positives Not Worried About Distance for Match
7. Elite Long Distance Runner Amy Hastings Signs With ZAMST
8. How Does Psychological Distance Work Between Non-millionaires and Millionaires in Dating?
9. Machine-Like Performance in Skateboarding Receives Guinness World Record™ Status for Performance at The International Distance Skateboard Association Ultraskate
10. Global Autism Project Announces Distance Supervision for Autism Professionals
11. Urology-owned radiation oncology self-referral can increase patients travel distance for treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... gather at Boston CEO 2017 on May 30th and 31st at The Four ... forum for leading executives in the life sciences, offering exclusive access to key ...
(Date:5/26/2017)... ... 26, 2017 , ... Amir Qureshi, MD is the first physician in Arkansas ... stimulation system. The Nuvectra™ Algovita SCS System has been FDA approved as a treatment ... in Arkansas to introduce the most powerful SCS system and the only stretchable lead ...
(Date:5/26/2017)... ... , ... A new analysis of community health data reveals that four out ... Midwest. With the average cost of healthcare rising and the U.S. senior population expected ... and affordability of where they live. An annual 2017 report looked at a variety ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... ever copper, antimicrobial, mesh back 24/7 task chair specifically designed for clinical areas. ... “We are thrilled to partner with Cupron® to provide customers with a game ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... After raising ... Antzy Top gadget will continue to be available at a discounted crowdfunding price on ... with stress wherever they are, I also wanted to bring a fidget toy to ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... it has earned a spot on Forbes, ... was ranked among 500 U.S. employers as well as ... and Services. The annual Forbes ... survey of over 30,000 employees across 25 industries. The ...
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
(Date:5/6/2017)... Texas , May 5, 2017   Provista , ... with more than 200,000 customers, today announced Jim Cunniff ... a wealth of executive and business experience to Provista, including ... compounding pharmacy in California . He assumed ... "Jim is a great fit for Provista," says ...
Breaking Medicine Technology: