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Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

S is generally results from respiratory failure due to spread of cancer to the lungs. Ezrin is a protein in the cell that contributes to the biology of cancer, especially to its growth and spread to other body parts. Accumulating evidence from experimental animal models and human cases suggest that ezrin is a key factor in spread of OS cells. Here we report the discovery of two lead compounds that directly bind to ezrin protein and inhibit its function in multiple assays. These small molecules have the potential to prevent or treat OS spreading to the lungs and significantly improve survival of OS patients." - Glay Bulut

Authors: Glay Bulut, Kevin Chen, Eric Glasgow, Jeffrey A. Toretsky, and Aykut ren, Georgetown Lombardi Comprehensive Cancer Center; Sung-Hyeok Hong, Chand Khanna, Hyun-Shik Lee, and Ira Daar, National Cancer Institute.

To be presented: Monday, April 19, 2010 9:00 am - 12:00 pm ET; Exhibit Hall A-C, Poster Section 23; Board 3


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Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

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