Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

, Washington, DC.

To be presented: Tuesday, April 20, 2:00 5:00 pm; Exhibit Hall A-C, Poster Section 2; Board 5


Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway (Abstract # 3409)

EMBARGO: Tuesday, April 20, 2010; 9:00 am ET

Author's summary: "The protein GLI1 is important for the growth of many cancers such as pancreatic and brain tumors. We have previously published that the protein GLI1 is important for the growth of Ewing Sarcoma. We show data that an already FDA approved drug Arsenic Trioxide which is used to treat a specific type of leukemia can inhibit the protein GLI1. Arsenic Trioxide can inhibit the growth of a specific type of pediatric brain cancer called Medulloblastoma as well as Ewing sarcoma in mice. Therefore Arsenic Trioxide can be investigated in clinical trials to treat Ewing Sarcoma as well as other types of cancers that depend on hyperactivity of the protein GLI1." Elspeth M. Beauchamp

Authors: Elspeth M. Beauchamp, Olga Rodriguez, Christopher Albanese, Jeffrey A. Toretsky, and Aykut ren, from. Georgetown Lombardi Comp. Cancer Ctr., Washington, DCBeauchamp

To be presented: Tuesday, April 20, 9:00 am - 12:00 pm ET, Exhibit Hall A-C, Poster Section 18, Board 10


EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein (Abstract #2681)

EMBARGO: Monday, April 19, 2010; 2:00 pm ET

Author's summary: "Ewing's sarcoma family of tumors are characterized by the EWS-FLI1 oncogenic fusion protein. Previous studies show that RNA Helicase A (RHA) binds with EWS-FLI1 to enhances the oncogensis of EWS-FLI1 and the interaction between these two proteins can be disrupted by small molecule inhibitors. To test analogues of the lead small molecule, a biophysical assay is necessary to determine binding. AlphaScreen technology allows for a peptide displacement assay to study binding in a 96 well plate format
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair Care, has ... business donation to kick off the campaign for healing and Well-Being. , BeverlyD has ... complete line of raw, organic hair care products, as well as her book, Hair ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and warm-season turfgrasses, ... of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. Incidentally, ... of this new type of sod, Super-Sod is giving away red Adirondack chairs with ...
(Date:7/31/2015)... GA (PRWEB) , ... July 31, 2015 , ... ... five new industry players to know in predictive health analytics , Jvion ... learning technologies. The firm creates predictive software that targets patient and population level ...
(Date:7/31/2015)... ... 31, 2015 , ... Jacksonville-based drug and alcohol rehabilitation center, ... Center. The medical community, social workers, law enforcement, and government officials are all ... the effort to better understand and combat sex trafficking. Lead by sex trafficking ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to the article published July 27 ... Pasadena courthouse was contained and extinguished by the city’s fire department before it caused major ... at the time of the fire, and it was a fire alarm system that tipped ...
Breaking Medicine News(10 mins):Health News:March4thforWellBeing Foundation Kickoff 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... Research Group is,an exciting newcomer in the field ... information service established to,provide the general public with ... choose for a variety of medical problems resulting ... the website will be,obtained through an online survey ...
... of the,Board and Chief Executive Officer, A.G. Lafley, addressed ... at its annual meeting today. Lafley,said, "P&G is a ... long term,-- consistently, reliably and sustainably." Growth in ... fiscal 2007. P&G increased,net sales by 12 percent to ...
... UPCARE(R) E2E, an end-to-end, financial and clinical ... for laboratories. -- ... Mich., Oct. 9 Today, UPCARE Technology, Inc.,unveiled its new ... part on the success of its parent company, Marquette,General Health ...
... three scientists receiving the 2007 Nobel Prize for Physiology or ... their careers, bringing to 42 the number of Nobel Laureates ... Capecchi, Ph.D. of the University of Utah and Oliver Smithies, ... with Sir Martin J. Evans of Cardiff University in Wales ...
... Nutrition,(OTC Bulletin Board: NNTN) http://www.interactivenutrition.com will ... 2007 at,11:00 a.m. Eastern time. U.S. and Canadian ... 800-750-4065 and International Shareholders may dial in at,404-920- ... 767872#. Executives,from Natural Nutrition will be available for ...
... Exchange Symbol: AKL, MONTREAL, Oct. 9 /PRNewswire-FirstCall/ ... company focused on developing therapies for the,inhalation, pain ... 2007, its issued and outstanding common shares will ... common share for every seven (7),pre-consolidation common shares. ...
Cached Medicine News:Health News:Nursesavvy.com Promoting Quality Healthcare for Everyone 2Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 2Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 3Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 4Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 5Health News:Lafley Tells Shareholders That 'P&G is Designed to Grow' 6Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 2Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 3Health News:UPCARE Technology to Share the Secrets of its Parent's Success in Lab Outreach 4Health News:Natural Nutrition to Hold International Shareholder Conference Call Thursday, October 11, 2007 at 11:00 a.m. Eastern Time 2Health News:Akela Pharma Inc. Completes Share Consolidation 2
(Date:7/31/2015)... , July 31, 2015 Today, the ... (NABP ® ) issued a report urging greater ... action is taken against websites illegally selling medications ... Drug Outlet Identification Program Progress Report for State ... thousands of websites illegally distribute medications and ...
(Date:7/31/2015)... -- Boston Children,s Hospital physicians report the first cases ... anatomy before undergoing high-risk brain procedures. The four ... brain,s blood vessels) that posed special treatment challenges. ... Journal of Neurosurgery: Pediatrics , the physicians describe ... to create custom, high-fidelity models of the children,s ...
(Date:7/31/2015)... -- Quietly, sedately, Morocco,s pharmaceutical sector is ... industry is strong, with a well-developed base of local ... One place where the quality of Moroccan ... has quietly become the second largest African exporter of ... Indeed, Moroccan pharma companies have been making inroads as ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 33D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3
... ARAY ), a global leader in the field ... its third quarter of fiscal 2011, ended March 31, 2011 ... A conference call to review the results will begin ... by Euan S. Thomson, Ph.D., president and chief executive officer ...
... Awarepoint Corporation,s CTO and SVP of Engineering, Matt Perkins, will ... location-based services (LBS), a market projected to exceed $12 billion ... "Challenges and Opportunities of Indoor Location" ... 7:30 p.m. PDT in San Diego.  Panel participants will examine ...
Cached Medicine Technology:Accuray Incorporated to Report Financial Results for Third Quarter of Fiscal 2011 2Awarepoint CTO, Matt Perkins, to Serve as Panelist at CommNexus San Diego Event 2
For use with catalog #0454....
Lupus Anticoagulant-Sensitive APTT Reagent.Cephalin with particulate activator (silica), freeze-dried....
Antigenic Free Protein S, ELISA Method...
Colorimetric Assay of Protein C Activity by STA© Analyzers. Highly purified extract of Agkistrodon c. contortrix venom for specific activation of protein C, with an activator selected specially ...
Medicine Products: