Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

, Washington, DC.

To be presented: Tuesday, April 20, 2:00 5:00 pm; Exhibit Hall A-C, Poster Section 2; Board 5


Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway (Abstract # 3409)

EMBARGO: Tuesday, April 20, 2010; 9:00 am ET

Author's summary: "The protein GLI1 is important for the growth of many cancers such as pancreatic and brain tumors. We have previously published that the protein GLI1 is important for the growth of Ewing Sarcoma. We show data that an already FDA approved drug Arsenic Trioxide which is used to treat a specific type of leukemia can inhibit the protein GLI1. Arsenic Trioxide can inhibit the growth of a specific type of pediatric brain cancer called Medulloblastoma as well as Ewing sarcoma in mice. Therefore Arsenic Trioxide can be investigated in clinical trials to treat Ewing Sarcoma as well as other types of cancers that depend on hyperactivity of the protein GLI1." Elspeth M. Beauchamp

Authors: Elspeth M. Beauchamp, Olga Rodriguez, Christopher Albanese, Jeffrey A. Toretsky, and Aykut ren, from. Georgetown Lombardi Comp. Cancer Ctr., Washington, DCBeauchamp

To be presented: Tuesday, April 20, 9:00 am - 12:00 pm ET, Exhibit Hall A-C, Poster Section 18, Board 10


EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein (Abstract #2681)

EMBARGO: Monday, April 19, 2010; 2:00 pm ET

Author's summary: "Ewing's sarcoma family of tumors are characterized by the EWS-FLI1 oncogenic fusion protein. Previous studies show that RNA Helicase A (RHA) binds with EWS-FLI1 to enhances the oncogensis of EWS-FLI1 and the interaction between these two proteins can be disrupted by small molecule inhibitors. To test analogues of the lead small molecule, a biophysical assay is necessary to determine binding. AlphaScreen technology allows for a peptide displacement assay to study binding in a 96 well plate format
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... With thoughts of getting the kids ... of many Washingtonians, it’s easy to forget that this ... managers to be booking their organizations’ holiday parties throughout ... DC, area locations are preparing for the holiday rush. ... holiday parties, the space appears to be going faster ...
(Date:9/2/2014)... Request A Test , a leading national provider of direct to ... drug testing in September 2014. To take advantage of ... when placing their order. Request A Test offers a variety ... is typically done in panels which screen for multiple types of ... the 5 Panel Urine Screening and 10 Panel ...
(Date:9/2/2014)... ZAMST, a leader in high-performance sports prevention/protective equipment, ... star Nolan Arenado . Widely considered to ... will be working with Zamst to continue their growth ... Arenado was selected by Colorado in the second round ... was awarded the Gold Glove, putting him among an ...
(Date:9/2/2014)... September 02, 2014 Kicking blog MichaelHusted.com ... of Cantele Kicking on his role as a kicking coach, ... Series (NCS) Associate according to retired NFL kicker Michael Husted ... Kansas State University and is one of the top pro ... chance to meet with Anthony at our 2014 Pro Camp ...
(Date:9/2/2014)... Barcelona, Spain Tuesday 2 September 2014: Health ... heart failure guidelines, according to the results of ... Congress by Professor Aldo Maggioni. Clinical variables explained ... said: "This is a unique evaluation which combines ... countries. It provides a fuller picture of the ...
Breaking Medicine News(10 mins):Health News:Fall in Washington, DC, Is When a Meeting Planner’s Mind Turns to … the Winter Holidays? 2Health News:Fall in Washington, DC, Is When a Meeting Planner’s Mind Turns to … the Winter Holidays? 3Health News:Fall in Washington, DC, Is When a Meeting Planner’s Mind Turns to … the Winter Holidays? 4Health News:Fall in Washington, DC, Is When a Meeting Planner’s Mind Turns to … the Winter Holidays? 5Health News:Request A Test Offers 10% Off Drug Testing in September 2014 2Health News:Request A Test Offers 10% Off Drug Testing in September 2014 3Health News:Gold Glove Baseball Star Nolan Arenado Signs With Zamst 2Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 2Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 3Health News:Health structures explain nearly 20 percent of non-adherence to heart failure guidelines 2
... better handled following discovery of a novel chemical compound ... the potential to be the basis of new therapies ... neurobiologists. ,Because exposure to people, places and objects ... memory-based cravings, many former drug users often relapse into ...
... a new method of Cryopreservation of ovaries for few years ... would be very useful for women with cancer, because during ... infertile is very high. This method involves removing the ovaries ... is finished the ovaries can be implanted back into them ...
... research letter published in the latest edition of The Lancet, ... male prisoners of prisons in UK is much higher than ... country, bringing to notice the existing conditions of the prisons ... in England and Wales, one of the highest proportions in ...
... has always remained a problem for parents because of the ... susceptibility to get easily influenced by peers // . A ... enjoy popularity are more likely to smoke than less popular ... in 16 Southern California middle schools. Over 1,486 students in ...
... has shown that marital problems affect men and women equally, ... the wife more than the husband. Furthermore, spouses in bad ... ,This finding could mean that couples face a greater ... that in addition to the carryover of work stress into ...
... cancer cases has reached about 1.2 million worldwide and Statistics ... in urban India and has overtaken cancer of the cervix ... metros according to a study conducted on women and cancer ... delayed motherhood are some factors that can lead to a ...
Cached Medicine News:Health News:Neurobiology Provides Answers To Block Memory-Related Drug Cravings 2Health News:Cryopreservation of Ovaries for Cancer patients undergoing treatment 2Health News:Suicide Rate Amongst Male Prisoners Of UK Is Quite High 2Health News:Popularity Among Peers Increases Susceptibility To Smoking Habit Among School Children 2
(Date:9/2/2014)... Biotech Ltd. (NASDAQ: SVA ), a leading provider ... announced that the Company,s management will participate in the following ... Healthcare Conference, to be held at the Grand Hyatt New ... Stanley Asia Pacific Healthcare Day, to be held at the ... Healthcare & Technology Conference, to be held at the Wynn ...
(Date:9/1/2014)... , Sept. 1, 2014 Reportbuyer.com has ... Brazil Aesthetic Lasers and Energy Devices Market ... https://www.reportbuyer.com/product/2343455/Brazil-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html Brazil Aesthetic Lasers and ... Summary GlobalData,s new report, "Brazil ... 2020", provides key market data on the Brazil ...
(Date:8/30/2014)...  Boston Scientific has released the primary endpoint ... Failure (NECTAR-HF) clinical trial, the first and only ... (VNS) for the treatment of heart failure patients.  ... Cardiology and Director of the Clinical Investigation Center ... de la Recherche Medicale presented the results at ...
Breaking Medicine Technology:Sinovac to Participate in Upcoming Investor Conferences 2Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 2Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 3Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 4Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 5Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 6Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 7Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 8Brazil Aesthetic Lasers and Energy Devices Market Outlook to 2020 9Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 2Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 3Boston Scientific Announces Primary Endpoint Results of NECTAR-HF Clinical Trial 4
... , the leading online Medical Transcription and Editing training ... NexGen Speech Recognition Editing and Medical Transcription Program. In ... MTEC is moving their curriculum to the next level. ... this important industry migration and is being provided to ...
... Medical Messenger , an innovative healthcare technology ... 4 is now certified to meet 2011-2012 criteria supporting ... and Reinvestment Act (ARRA) as a Complete EHR by ... record (EHR) software capable of enabling providers to meet ...
Cached Medicine Technology:MTEC Announces Release of NexGen Speech Recognition Editing and Medical Transcription Training Program 2Medical Messenger's AstralJet V4 Receives ONC-ATCB 2011/2012 Certification 2
... CONMED's family of products allows you to ... generators feature proprietary Energy Synchronous Processing Technology. ... current and voltage in all operational modes. ... to sample current and voltage over 450,000 ...
... achieves a secure clot, targeted to the ... hemostasis is needed, when control of bleeding ... and cautery, is ineffective or impractical., CROSSEAL* ... of human Biologically Active Component (BAC) and ...
GluStitch® is indicated for the closure of uncomplicated skin lacerations where there is little or no tissue loss....
... pacemaker family offers some ... automatic devices. Featuring the ... advanced technologies ever seen, ... incorporates the exclusive ventricular ...
Medicine Products: