Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

, Washington, DC.

To be presented: Tuesday, April 20, 2:00 5:00 pm; Exhibit Hall A-C, Poster Section 2; Board 5


Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway (Abstract # 3409)

EMBARGO: Tuesday, April 20, 2010; 9:00 am ET

Author's summary: "The protein GLI1 is important for the growth of many cancers such as pancreatic and brain tumors. We have previously published that the protein GLI1 is important for the growth of Ewing Sarcoma. We show data that an already FDA approved drug Arsenic Trioxide which is used to treat a specific type of leukemia can inhibit the protein GLI1. Arsenic Trioxide can inhibit the growth of a specific type of pediatric brain cancer called Medulloblastoma as well as Ewing sarcoma in mice. Therefore Arsenic Trioxide can be investigated in clinical trials to treat Ewing Sarcoma as well as other types of cancers that depend on hyperactivity of the protein GLI1." Elspeth M. Beauchamp

Authors: Elspeth M. Beauchamp, Olga Rodriguez, Christopher Albanese, Jeffrey A. Toretsky, and Aykut ren, from. Georgetown Lombardi Comp. Cancer Ctr., Washington, DCBeauchamp

To be presented: Tuesday, April 20, 9:00 am - 12:00 pm ET, Exhibit Hall A-C, Poster Section 18, Board 10


EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein (Abstract #2681)

EMBARGO: Monday, April 19, 2010; 2:00 pm ET

Author's summary: "Ewing's sarcoma family of tumors are characterized by the EWS-FLI1 oncogenic fusion protein. Previous studies show that RNA Helicase A (RHA) binds with EWS-FLI1 to enhances the oncogensis of EWS-FLI1 and the interaction between these two proteins can be disrupted by small molecule inhibitors. To test analogues of the lead small molecule, a biophysical assay is necessary to determine binding. AlphaScreen technology allows for a peptide displacement assay to study binding in a 96 well plate format
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 International efforts ... virus epidemic are receiving further support from ... nongovernmental organizations (NGOs) and other charitable organizations. ... workers, emergency responders, patients and others can ... the CmTP MediDefense system , which ...
(Date:12/22/2014)... 2014 The Bob Woodruff Foundation ... invested more than $5 million in programs and ... their families. , This includes $1.3 million in ... helping with: veteran entrepreneurship; community impact; vocational training; ... severely injured veterans. , “The needs of those ...
(Date:12/22/2014)... Naples, Florida (PRWEB) December 22, 2014 ... this holiday season, the gift of health and vitality. ... is offering its three top-selling anti-aging formulas in special ... with free rush delivery. , Each bottle contains ... digestion, areas that don't work as well as we ...
(Date:12/22/2014)... Xarelto Lawsuit News : Alonso Krangle ... granted a request to centralize pending and subsequent ... District of Louisiana. The U.S. Judicial Panel On Multidistrict ... transfer over 50 Xarelto cases–21 lawsuits and 30 potential ... for consolidation under U.S. District Judge Eldon E. Fallon. ...
(Date:12/22/2014)... Christmas is days away, and last minute ... easy solution that will please: the Sublime Gift Card ... from $25 up to $350," says Kathy Heshelow, founder of ... a wide array of skin care products and Skin Brushes." ... dates. , Gift delivery past shipping deadlines, or those ...
Breaking Medicine News(10 mins):Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 2Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 3Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 4Health News:Novel Biostatic Antimicrobial Technology From Clearstream-mPact Technology Partnership (CmTP) Offers Effective Protection Against Transmission of Ebola Virus 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4
... , One in eight new moms ... CHICAGO, Sept. 9 Up to 80 percent of women experience ... major depression within weeks of delivery. Caused by multiple factors, including ... a minor presentation, known as postpartum blues, to major depression and ...
... stem cell discovered in the prostate of adult mice ... a new study by researchers at the Herbert Irving ... NewYork-Presbyterian Hospital. Led by Michael Shen, Ph.D., professor ... Medical Center, the researchers found the rare stem cells, ...
... formulation seems to thwart pneumonia in high-risk group with ... -- A recently developed pneumonia vaccine may be more ... pulmonary disease (COPD) than the vaccine that is typically ... be an ongoing problem for people with COPD, a ...
... Mass., Sept. 9 Echo Therapeutics, Inc. (OTC Bulletin ... Symphony(TM) tCGM System as a non-invasive, wireless, transdermal continuous ... for transdermal drug delivery, announced today that it has ... 2009 Annual Global Investment Conference. Patrick T. Mooney, ...
... , WASHINGTON, Sept. 9 The Advisory ... a multi-hospital system based in Coral Gables, to a ... System, Cleveland Clinic, Intermountain Health Care, Inc., Memorial Hermann ... Health System. These member health systems use the ...
... LAVAL, QC, Sept. 9 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: ... three separate posters will be presented at three upcoming ... trazodone formulation. , , Two posters will be ... entitled: Modeling and Simulation to Optimize Efficacy and Tolerability ...
Cached Medicine News:Health News:Prentice Women's Hospital Launches New Initiative to Better Identify and Address Postpartum Depression 2Health News:Prentice Women's Hospital Launches New Initiative to Better Identify and Address Postpartum Depression 3Health News:Prentice Women's Hospital Launches New Initiative to Better Identify and Address Postpartum Depression 4Health News:New type of adult stem cells found in the prostate may be involved in prostate cancer development 2Health News:New Vaccine May Work Better Against Lung Disease 2Health News:Echo Therapeutics Announces New Presentation Time at Rodman & Renshaw 2009 Annual Global Investment Conference 2Health News:The CRIMSON Initiative - the First Physician Performance Data Management Platform Developed By Physicians For Physicians - is Now Working With Over 200 Hospitals and Over 25,000 Doctors 2Health News:The CRIMSON Initiative - the First Physician Performance Data Management Platform Developed By Physicians For Physicians - is Now Working With Over 200 Hospitals and Over 25,000 Doctors 3Health News:The CRIMSON Initiative - the First Physician Performance Data Management Platform Developed By Physicians For Physicians - is Now Working With Over 200 Hospitals and Over 25,000 Doctors 4Health News:Labopharm to present data on its novel trazodone formulation at three upcoming international medical meetings 2Health News:Labopharm to present data on its novel trazodone formulation at three upcoming international medical meetings 3
(Date:12/19/2014)... Dec. 19, 2014  Newport Corporation (NASDAQ: ... Ph.D. has joined the company,s Board of Directors.  ... and a director of Evans Analytical Group, a ... and analytical services to companies in a wide ... joining Evans Analytical Group, Dr. Kadia spent nine ...
(Date:12/19/2014)... LAKE FOREST, Ill. , Dec. 19, 2014 /PRNewswire/ ... the world,s leading provider of injectable drugs and infusion ... the J.P. Morgan 33rd Annual Healthcare Conference on Wednesday, ... The presentation is scheduled to begin at 10:30 ... will be available to all interested parties through a ...
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. , Dec. ... SRNE ;  Sorrento), an oncology company developing ... Conkwest, Inc., a privately-held immuno-oncology company developing proprietary ... cell-line based therapy, announced today that the companies ... develop next generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies ...
Breaking Medicine Technology:Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... Aug. 25, 2011 Wolters Kluwer Pharma Solutions, Inc., ... and healthcare professionals, today announced that Rep. Ben ... met this week with its healthcare analytics management team to ... in America.  Congressman Quayle visited the company,s offices on Camelback ...
... Aug. 25, 2011 BioRestorative Therapies, Inc. ... into a Tangible Property License Agreement with the University ... Therapies to obtain adipose (fat) tissue that will be ... ThermoStem Program , which is an adult derived ...
Cached Medicine Technology:Congressman Quayle Talks With Wolters Kluwer Pharma Solutions About Importance of Health Information 2Congressman Quayle Talks With Wolters Kluwer Pharma Solutions About Importance of Health Information 3BioRestorative Therapies Signs License Agreement With University of Utah to Obtain Adipose (Fat) Tissue for its ThermoStem Program to Treat Obesity and Metabolic Disorders 2
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
The Welch Allyn 125 BIO is designed to achieve precise binocular viewing and stereopsis easier than ever before. Its observation paths can be adjusted from 48 mm to 74 mm to handle the widest and nar...
... Seeing clearly into ... Using the same technology ... versions, the Video Ophthalmoscope ... of the inner eye ...
Welch Allyn quality in a convenient pocket size. The PocketScope fits into your pocket! Easy to use, lightweight, and perfect for general and specialist use. Take your PocketScope with you everywhere...
Medicine Products: