Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

disrupt a key protein-protein interaction, leading to decreased cancer growth. Using state-of-the art tools, we screened 3000 compounds and found one, YK-4-279, that significantly inhibited this protein-protein binding. We have now demonstrated that YK-4-279 has a detrimental effect on Ewing's sarcoma both in vitro and in vivo, providing us with an oncogenic target and a lead compound for therapeutic testing." Jeffrey Toretsky

Authors: Jeffrey A. Toretsky, Hayriye V. Erkizan, Yali Kong, Julie S. Barber-Rotenberg, Milton L. Brown, and Aykut ren, of Georgetown Lombardi Comprehensive Cancer Center; Melinda Merchant, of Pediatric Oncology Branch, National Institutes of Health

To be presented: Tuesday, April 20, 9:00 am -12:00 pm; Exhibit Hall A-C, Poster Section 18; Board 12


EWS-FLI1 is regulated by acetylation (Abstract # 3897)

EMBARGO: Tuesday, April 20, 2010; 2:00 pm ET

Author's summary: "EWS-FLI1 is a protein specific to Ewing's Sarcoma Family of Tumors (ESFT). EWS-FLI1 is a transcription factor and thereby a central regulator of ESFT cell survival and tumor growth. The mechanisms controlling its function and stability are not well understood. We show, for the first time, that EWS-FLI1 is modified by acetylation, a process that can in fact regulate both stability and function of proteins. Drugs called Histone Deacetylase Inhibitors (HDI) inhibit the reverse process, the deacetylation of proteins, and are promising in the treatment of a variety of cancers. HDI act mainly (but not solely) by deacetylating histone protein, and are very active in inducing cell death of ESFT cells. We investigate how acetylation regulates EWS-FLI1 and the possibility of EWS-FLI1 being a specific target for the activity of HDI in ESFT cells." Silke Schlottmann

Authors: Silke Schlottmann, Hayriye V. Erkizan, Julie Barber-Rotenberg, Aykut Uren, Maria L. Avantaggiati, and Jeffrey A. Toretsky. Georgetown Lombardi Comp. Cancer Ctr.
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... wide variety and complexity of foods served at holiday ... allergies, an expert warns. "Every person is different ... that it can be really difficult to avoid all ... allergy and clinical immunology at Wake Forest Baptist Medical ... you know you have food allergies, caution should overrule ...
(Date:11/22/2014)... 22, 2014 Hastings and Hastings, a ... experience announces providing clients with the option of leaving ... clients a flexible, intuitive and easy to navigate website ... access to Google + allows clients to research the ... a more informed decision when retaining an attorney. Those ...
(Date:11/22/2014)... 2014 Sandbridge Capital, a private ... the consumer brand sector, acquired a minority stake ... used to help fund BackJoy’s global growth and ... its proprietary apparel and footwear lines. Sandbridge Capital ... of Directors. , BackJoy is a high-growth health ...
(Date:11/22/2014)... November 22, 2014 Wright & Schulte ... side-effects lawsuits have been scheduled between October 2016 ... District of Illinois. U.S. District Judge Matthew F. Kennelly, ... Case Management Order (CMO) on November 6, 2014 that ... attorneys to submit documents and other activities in preparation ...
(Date:11/22/2014)... Those air-blown hand dryers in public restrooms may spread ... study suggests. British researchers placed a harmless type ... to simulate poorly washed hands. They then had them ... to dry their hands. The investigators measured airborne ... both types of dryers than around towel dispensers. ...
Breaking Medicine News(10 mins):Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 3Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 2Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 4Health News:Restroom Hand Dryers Spread More Germs Than Paper Towels, Study Finds 2
... PepsiCo (NYSE: PEP ), the world,s second-largest food and beverage company, today announced new global goals in the areas of nutrition, the environment, and workplace practices at ... ... ... ...
... 22 Accident claims solicitors, First Personal Injury, want to see more advice made readily available to parents and pupils about asbestos exposure ... reasons. , ... , , ... ...
... , March 22 InterAction joins other U.S.-based non-governmental organizations (NGOs) in calling for ... sanitation and hygiene (WASH) crisis. World Water Day provides us with an opportunity to ... safe drinking water and basic sanitation. , ... ...
... For Epilepsy Awareness , ... , ... ... NEW YORK , March 22 This week, bakeries across the United States are cooking ...
... ... on-premise and SaaS archiving provider in the market to archive and stub for all ... archiving for all Unix/Linux-based email servers and file servers for NTFS/NFS/NDS/Netware, , ... Salt Lake City, Utah, and ...
... today by Thomson Reuters. The year-over-year increase topped the 2008 rate of 6.1 percent and occurred in a year when the U.S. inflation rate was negative.   , ... , ... ... ...
Cached Medicine News:Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 2Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 3Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 4Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 5Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 6Health News:PepsiCo Unveils Global Nutrition, Environment and Workplace Goals 7Health News:First Personal Injury on Asbestos in Schools 2Health News:Global Development Successes Depend on Access to Water 2Health News:Global Development Successes Depend on Access to Water 3Health News:Purple Cupcake Production on the Rise Nationwide 2Health News:Purple Cupcake Production on the Rise Nationwide 3Health News:MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010 2Health News:MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010 3Health News:MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010 4Health News:MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010 5Health News:MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010 6Health News:Employer Healthcare Costs Jump 7.3% in 2009, According to Thomson Reuters Study 2Health News:Employer Healthcare Costs Jump 7.3% in 2009, According to Thomson Reuters Study 3
(Date:11/21/2014)... Nov. 20, 2014  The acceptance of two ... AAGL Global Congress demonstrates continued interest in the ... provide bowel control. One of the abstracts, presented by ... Division Chief of Urogynecology and Reconstructive Pelvic Surgery ... Award for Best Written Abstract on Urogynecology/Pelvic Floor ...
(Date:11/21/2014)... -- Oxis International, Inc. (OXIS) (OXI.PA) announced today the resignation ... J. Cataldo as Chief Executive Officer, and Steven ... Ken Eaton resigned his positions as Chief Executive ... International, Inc. to pursue new opportunities. Mr. ... of Oxis International, Inc. Mr. Cataldo will continue to serve ...
(Date:11/18/2014)... 18, 2014  NxStage ® Medical Inc. ... of innovative dialysis products , today announced ... dialyzer for the in-center, hemodialysis market.  Streamline Express ... designed to reduce the amount of labor required ... of touch point contamination sites.  The dialyzer enables ...
Breaking Medicine Technology:LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 2LIFE Study Prominently Featured at Minimally Invasive Gynecology Conference 3OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3NxStage Launches New Streamline Express Dialyzer With Pre-attached Blood Tubing Set 2
... with its Investor Day being held tomorrow in New York ... forward-looking earnings expectations for the fourth quarter of Fiscal Year ... for Fiscal Year 2013.  The Company reconfirmed ... and for all of Fiscal Year 2012, as issued in ...
... hospitals handed a resolute vote of confidence over ... enterprise clinical and financial system. Healthmark Regional Medical ... Kit Carson Memorial Hospital plan on leveraging the ... meeting the meaningful use requirements associated with the ...
Cached Medicine Technology:PAREXEL International Issues Earnings Guidance In Conjunction With Investor Day 2PAREXEL International Issues Earnings Guidance In Conjunction With Investor Day 3PAREXEL International Issues Earnings Guidance In Conjunction With Investor Day 4Hospitals Across the Country Select Prognosis HIS Enterprise Clinical and Financial System 2Hospitals Across the Country Select Prognosis HIS Enterprise Clinical and Financial System 3
S-ROM acetabular cups provide a variety of geometrical options to help address many anatomical situations and defects....
S-ROM acetabular cups provide a variety of geometrical options to help address many anatomical situations and defects....
The Trident ceramic acetabular system provides several important benefits and meets greater demands of younger, more active patients....
Optimal solution for normal acetabulum and younger patients....
Medicine Products: