Navigation Links
Lombardi research teams hone in on treatments for osteosarcoma and Ewing's sarcoma
Date:4/20/2010

Washington, DC Most cancers arise from the epithelium, the tissue that lines the body and the organs, but sarcomas come from connective tissue cells, like the bones. At Georgetown Lombardi Comprehensive Cancer Center, research have engaged in a full-court press to develop new therapies to treat osteosarcoma and Ewing's sarcoma, the two most common bone tumors in children, adolescents and young adults.

At the AACR 101st Annual Meeting 2010, they offer new molecular insights into the translocation that causes Ewing's sarcoma, a genetic exchange between chromosomes that results in a fused gene that produces an oncogenic protein. These findings, coupled with use of sophisticated drug design technology, have led to identification of three new targets for potential treatment of this rare cancer. Additionally, researchers have identified two small molecules that have the potential to prevent or treat spread of osteosarcoma, a very aggressive cancer. (Embargoes listed with each abstract summary that follows).

"Scientific studies in the past decade identified very promising molecular targets that play a major role in tumor progression and invasion. With the help of a multidisciplinary team of scientists at Lombardi, we are now focusing on developing small molecules that can hit these targets," says Aykut ren, M.D., assistant professor in the Department of Oncology at Lombardi. "With this truly translational experimental approach, we may be able to optimize our small molecules for clinical trials in the near future."

ABSTRACT SUMMARIES

Targeting of EWS-FLI1 with small molecule YK-4-279 reduces xenograft growth by disruption of disordered protein-protein interactions (abstract #3411)

EMBARGO: Tuesday, April 20, 2010, 9:00 am ET

Author's summary: "Because the oncoprotein that causes the Ewing's sarcoma is so disordered, we reasoned that it might be possible to use a small molecule to target that protein and
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Lombardis Shields leads special journal focused on tobacco research
2. GUMCs Lombardi Hosts Symposium Exploring Future of Cancer Research and Personalized Medicine
3. New research identifies modifiable risk factors for heart disease
4. Nuvo Research announces early redemption of 5% convertible debentures
5. Researcher to track spread of disease, malware and power outages
6. UCSF Researchers Identify Regulator of Human Sperm Cells
7. Octapharma Accepting Applications for Research Grants Through March 31
8. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
9. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
10. University of Maryland chemist receives Astellas Award for blindness prevention research
11. Developing a cyberinfrastructure for comparative effectiveness in cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... August 27, 2014 Shawna's new book, ... is about Seed Digging, which a brand-new technique she ... models, yet works to bring permanent healing quickly. , ... and mental health disorders cured on a daily basis. ... own minds and find incredible inner peace with only ...
(Date:8/27/2014)... Best SEO Hosting, a well-known SEO Hosts Review Site, has ... and GoDaddy are the most recommended suppliers for webmasters from ... hosting (including VPS and cloud hosting). , As one ... serving hosting small business websites since 1998. With more than ... the hosting industry for its affordable and easy to manage ...
(Date:8/27/2014)... The Latinos In Action Festival 2014 is being ... Florida State Fair Grounds from 9am - 9pm. Latinos ... from around the world. Latinos in Action Festival is ... and Univision Mobile, a service provided by T-Mobile company. ... 4,000 people from different backgrounds, cultures and nationalities. Come ...
(Date:8/27/2014)... HealthDay Reporter WEDNESDAY, Aug. ... in a dark alley will likely never want to return ... attacked. But neuroscientists working with mice say they,ve discovered ... positive and negative emotions. And in rodent tests, they,ve manipulated ... In essence, they made once-reluctant mice want to return ...
(Date:8/27/2014)... Dallas, Texas (PRWEB) August 28, 2014 ... Market Outlook to 2020?, provides key market data on ... millions of US dollars, volume (in units) and average ... (Rigid Tip Video Laparoscopes and Flexible Tip Video Laparoscopes), ... There are a number of advantages to the patient ...
Breaking Medicine News(10 mins):Health News:Shawna Burns, Counselor, Releases Debut Book, "Seed Digging," to Improve Lives of Children and Adults with Addictions and Mental Health Disorders 2Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 2Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 3Health News:Laparoscopes & Endoscopic Reprocessors Market in BRIC (Brazil, Russia, India & China) to 2020 Report Available at RnRMarketResearch.com 4
... Offered to Cancer Patients in HELIOS HospitalsBERLIN, March 10 ... Germany will gain access to the most modern radiotherapy ... that it is acquiring nine linear accelerators from Varian ... of them equipped with RapidArc(TM) technology for fast and ...
... are embracing technological advances, such as electronic medical records, ... their needs.Those are the results found in a recent ... The findings were published in the March/April issue of ... conducted the same survey back in 2004. Five years ...
... Inc. (TSX: DDS; NASDAQ: DDSS ) today announced ... will present at the Cowen and Company 29th Annual Health ... March 18, 2009 at 11:00 a.m. ET. , Interested parties ... the "Events" section of the homepage of the Company,s website ...
... Pressure Profile Systems, Inc. Combines Tactile and 3D ... Footbeds to ConsumersLOS ANGELES and SCOTTSDALE, Ariz., March ... (PPS) together with its partner eSoles, LLC, today ... (R) Kiosk Scanning System. The free-standing, ...
... KONG, March 10 /PRNewswire-Asia/ -- Obio Pharmaceutical Holdings Ltd,("Obio"/ ... of a drug,TG21, against main strains of influenza virus ... H5N1. The process leading to clinical,trials for TG21 has ... and will continue to engage prestigious institutions in USA ...
... Awareness of the KeepingYouWell.com Website for People Seeking Quality Care ... ... Blue Search Engine Marketing is pleased to announce Adventist Midwest Health ... on for a unique, highly targeted search engine optimization campaign, and ...
Cached Medicine News:Health News:Leading German Healthcare Group Selects Equipment and Software from Varian Medical Systems for Major Replacement Project 2Health News:Survey Results: Health Care Technology Advances as Physician Frustration Grows 2Health News:World's Most Advanced Foot Scanning Kiosk Made Available to Retailers by eSoles and Pressure Profile Systems, Inc. 2Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 2Health News:Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus 3Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 2Health News:Adventist Midwest Health Engages Medium Blue Search Engine Marketing in Geographically-Targeted SEO Campaign 3
(Date:8/27/2014)... and NINGBO, China , ... the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced ... development of generic pharmaceuticals, primarily targeting the ... the agreement, Amerigen and Menovo will jointly develop products ... States . Menovo will be responsible for manufacturing ...
(Date:8/27/2014)... Aug. 27, 2014 Ambit Biosciences (Nasdaq: AMBI ... drugs targeting unmet needs in oncology, autoimmune and inflammatory disease, ... Care Conference to be held at The New York Palace ... September 3-4, 2014. Alan Fuhrman , Ambit,s ... lead drug candidate, quizartinib, at 1:10 p.m. ET on Wednesday, ...
(Date:8/27/2014)... WARSAW, Ind. , Aug. 27, 2014  Zimmer ... in musculoskeletal care, announced that it will be participating ... the Grand Hyatt in New York, New ... David Dvorak , President and CEO of Zimmer, will ... Binder , President and CEO of Biomet, will join ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Ambit Announces Participation At Baird 2014 Health Care Conference 2
... head design has been carefully considered with both ... head ensures the optimum viewing angle and the ... laser aligned for perfect focus where it is ... paper. This along with Keeler's wide angle ...
The Beta 200S combines Heine's patented aspherical optics (U.S. Pat. 4.963.014) and a single-step Rekoss disk with a range of 36 to +38 dpt. to provide perfectly-focused images even in cases of high ...
... 200S is the first hand-held ... of patented aspherical optics (U.S. ... of corrective lenses from 36 ... diopter steps. A perfectly-focused image ...
... The ophthalmoscope with superior aspherical optics. ... illumination and observation beam by means of ... iris reflex (Gullstrand-principle). The Beta 200 allows ... illuminated section of the retina even with ...
Medicine Products: