Navigation Links
Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
Date:2/28/2014

Researchers from UCLA's Jonsson Comprehensive Cancer Center have developed an innovative cancer-fighting technique in which custom-designed nanoparticles carry chemotherapy drugs directly to tumor cells and release their cargo when triggered by a two-photon laser in the infrared red wavelength.

The research findings by UCLA's Jeffrey Zink, a professor of chemistry and biochemistry, and Fuyu Tamanoi, a professor of microbiology, immunology and molecular genetics, and their colleagues were published online Feb. 20 in the journal Small and will appear in a later print edition.

Light-activated drug delivery holds promise for treating cancer because it give doctors control over precisely when and where in the body drugs are released. Delivering and releasing chemotherapy drugs so that they hit only tumor cells and not surrounding healthy tissues can greatly reduce treatment side effects and increase the drugs' cancer-killing effect. But the development of a drug-delivery system that responds to tissue-penetrating light has been a major challenge.

To address this, the teams of Tamanoi and Zink, which included scientists from the Jonsson Cancer Center's cancer nanotechnology and signal transduction and therapeutics programs, collaborated with Jean-Olivier Durand from France's University of Montpellier to develop a new type of nanoparticle that can absorb energy from tissue-penetrating light.

These new nanoparticles are equipped with thousands of pores, or tiny tubes, that can hold chemotherapy drugs. The ends of the pores are capped with nanovalves that keep the drugs in, like a cork in a bottle. The nanovalves contain special molecules that respond to energy from two-photon light exposure, which prompts the valves to open and release the drugs.

The operation of the nanoparticles was demonstrated in the laboratory using human breast cancer cells.

Because the effective range of the two-pho
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dr. Carol Francis Radio Talk Show Discusses Sexual Abuse as Related to "Coach" Jerry Sandusky; Interview With Abuse Survivor Teresa Joyce, Author of "There's A Fine Line"
2. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
3. Are there gender differences in anti-HIV drug efficacy?
4. Theres an app for that: Apple iPod Touch helps adults with autism function in the workplace
5. Youth with autism gravitate toward STEM majors in college -- if they get there
6. Are there racial disparities in osteoporosis screening and treatment?
7. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
8. Is there a period of increased vulnerability for repeat traumatic brain injury?
9. Why are there redheads? Birds might hold the clues
10. When It Comes to Spine Surgery, There Is No July Effect: Study
11. Theres room for improvement in womens heart disease awareness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... Statement by ... applauds the introduction of the Mental Health Reform Act of 2015 by ... comprehensive mental health reform a reality in America. , “This legislation and ...
(Date:8/4/2015)... Birmingham, OH (PRWEB) , ... August 04, 2015 ... ... announce that it has joined the American Association of Tissue Banks (AATB) as ... AATB and its mission “to honor donors, and to save and improve lives ...
(Date:8/4/2015)... ... August 04, 2015 , ... Rhode Island Medical Imaging (RIMI) is ... Washington Medical Building on Wake Robin Road in Lincoln, RI. This satellite office ... offer the most extensive out-patient x-ray hours in the state, which includes evenings and ...
(Date:8/4/2015)... Angeles, California (PRWEB) , ... August 04, 2015 ... ... drawer slides to Los Angeles commercial customers. Finding reliable hardware can be ... unfortunate liabilities. When putting an office together or designing a new facility, ...
(Date:8/4/2015)... ... August 04, 2015 , ... PerceptiMed, Inc. ... Carmona, M.D., M.P.H., FACS, to its Board of Directors effective August 1, 2015. ... Dr. Carmona said. "I strongly believe in the mission of the company and ...
Breaking Medicine News(10 mins):Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 2Health News:MHA Applauds Introduction of Mental Health Reform Act of 2015 3Health News:Exsurco Medical Joins AATB as Affiliate Member 2Health News:Rhode Island Medical Imaging Opens Satellite Imaging Center on Wake Robin Road in Lincoln 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 2Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 3Health News:Ryadon, Inc. is Now Offering their Ball Bearing Drawer Slides to Los Angeles, CA Commercial Customers 4Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 2Health News:Dr. Richard Carmona, 17th Surgeon General of the United States, Joins PerceptiMed, Inc.’s Board of Directors 3
... may be getting a little closer when robots will ... remote locations, such as on the battlefield or in ... University believe that the results of feasibility studies conducted ... achieving this space age vision of the future. Also, ...
... Successfully Tackling This Valuable ... Part of Her Job, ... -- from carpool queen to coach, counselor to chef. It,s all been,part ... inadequate nutrition, many moms have taken on yet another,important role -- that ...
... DC, May 6 , - International Reach ... AstraZeneca Support, For the first time, a ... Psychiatric Association,s (APA) prestigious "Young Minds in,Psychiatry" awards, ... Annual,Meeting in Washington, DC. The awards, supported by ...
... Market Research Reveals, CHICAGO, May 6 ... in the new three-dimensional research study --,Understanding Gluten ... international findings deliver an innovative 360 degree view,of ... qualitative,insights from customers living with food allergies, celiac ...
... CHARLOTTE, N.C., May 6 This spring graduation season,Park ... with Levine,Children,s Hospital to raise money for the Children,s ... ($27), which includes Author Anna,Quindlen,s commencement address, "A Short ... Guide to a Short Life, A Response to Ms.,Quindlen,s ...
... Opportunities at 120 Hospital-Affiliated ... ... Clarient, Inc.,(Nasdaq: CLRT ), a premier anatomic pathology and ... announced that it has signed a one-year agreement with Joint ...
Cached Medicine News:Health News:First steps toward autonomous robot surgeries 2Health News:First steps toward autonomous robot surgeries 3Health News:Got Milk? Campaign Will Recognize and Reward Moms for Their Role as the Family's Chief Health Officer 2Health News:Got Milk? Campaign Will Recognize and Reward Moms for Their Role as the Family's Chief Health Officer 3Health News:The American Psychiatric Association's Awards for Young Scientists Encourage Research Expertise in China 2Health News:The American Psychiatric Association's Awards for Young Scientists Encourage Research Expertise in China 3Health News:The American Psychiatric Association's Awards for Young Scientists Encourage Research Expertise in China 4Health News:The American Psychiatric Association's Awards for Young Scientists Encourage Research Expertise in China 5Health News:80% of Customers Eat Out Less Due to Food Allergies and Celiac / Coeliac Disease Impacting Quality of Life 2Health News:Graduation Gift Books to Benefit Levine Children's Hospital 2Health News:Clarient Partners With Joint Venture Hospital Laboratories to Offer Pathologists Wide Array of Cancer Assays 2Health News:Clarient Partners With Joint Venture Hospital Laboratories to Offer Pathologists Wide Array of Cancer Assays 3Health News:Clarient Partners With Joint Venture Hospital Laboratories to Offer Pathologists Wide Array of Cancer Assays 4
(Date:8/4/2015)... Aug. 4, 2015 Concord Medical Services Holdings Limited ... hospital management solution provider and operator of the largest network ... , today announced it will release its financial results ... on August 17, 2015. Management will hold a ... 8:00 a.m. EDT on August 18, 2015 (8:00 p.m. in ...
(Date:8/4/2015)... 2015 BioElectronics Corporation (OTC Pink: BIEL), ... Therapy medical devices, announced today that its registry ... trial device has been published in the prominent ... http://www.futuremedicine.com/doi/full/10.2217/PMT.15.35 .  More than 5,000 chronic pain ... assessment.  Chronic pain is a ...
(Date:8/4/2015)... 2015 Research and ... of Jain PharmaBiotech,s new report "Animal Biotechnology ... offering. This report describes and evaluates ... and pharmaceuticals as well as improvement in food ... the application of biotechnology to manage genetic disorders ...
Breaking Medicine Technology:Concord Medical to Report Second Quarter 2015 Financial Results on August 17, 2015 2BioElectronics' Landmark 5,000+ Chronic Pain Patient Study Published in Pain Management Medical Journal 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 2Animal Biotechnology 2014-2024 - 2015 Technologies, Markets and Companies Analysis 3
... Md., Nov. 24 In addition to family, friends and ... her Thanksgiving gratitude list. , "They heard the facts ... them," she said of Monday,s verdicts totaling $103 million in ... women nationwide who have sued Wyeth and Pfizer pharmaceuticals, makers ...
... , RALEIGH, N.C., ... training solutions for the pharmaceutical and biotech industry, today announced ... . The new Hospital Marketplace e-course is ... series, a comprehensive series of e-courses designed to fill ...
Cached Medicine Technology:Maryland Woman Thankful for Wyeth Verdicts 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 3
... ACUSON CV70 cardiovascular ultrasound system provides ... a powerful, all-digital ultrasound system offering ... flow sensitivity and spatial resolution ... family of cardiovascular products. Designed ...
... VH series, it is a ... independent C-arms and image intensifiers, ... for Cardiovascular and Angiography. There ... the examinations for cerebral, cardiac, ...
This catheter is intended for ultrasound examination of coronary intravascular pathology ONLY. Intravascular ultrasound imaging is indicated in patients who are candidates for transluminal coronary i...
Rubidium Rb 82 Generator. ,The only generator-based Positron Emission Tomography agent reimbursed for the evaluation of coronary artery disease....
Medicine Products: