Navigation Links
Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
Date:2/28/2014

Researchers from UCLA's Jonsson Comprehensive Cancer Center have developed an innovative cancer-fighting technique in which custom-designed nanoparticles carry chemotherapy drugs directly to tumor cells and release their cargo when triggered by a two-photon laser in the infrared red wavelength.

The research findings by UCLA's Jeffrey Zink, a professor of chemistry and biochemistry, and Fuyu Tamanoi, a professor of microbiology, immunology and molecular genetics, and their colleagues were published online Feb. 20 in the journal Small and will appear in a later print edition.

Light-activated drug delivery holds promise for treating cancer because it give doctors control over precisely when and where in the body drugs are released. Delivering and releasing chemotherapy drugs so that they hit only tumor cells and not surrounding healthy tissues can greatly reduce treatment side effects and increase the drugs' cancer-killing effect. But the development of a drug-delivery system that responds to tissue-penetrating light has been a major challenge.

To address this, the teams of Tamanoi and Zink, which included scientists from the Jonsson Cancer Center's cancer nanotechnology and signal transduction and therapeutics programs, collaborated with Jean-Olivier Durand from France's University of Montpellier to develop a new type of nanoparticle that can absorb energy from tissue-penetrating light.

These new nanoparticles are equipped with thousands of pores, or tiny tubes, that can hold chemotherapy drugs. The ends of the pores are capped with nanovalves that keep the drugs in, like a cork in a bottle. The nanovalves contain special molecules that respond to energy from two-photon light exposure, which prompts the valves to open and release the drugs.

The operation of the nanoparticles was demonstrated in the laboratory using human breast cancer cells.

Because the effective range of the two-pho
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dr. Carol Francis Radio Talk Show Discusses Sexual Abuse as Related to "Coach" Jerry Sandusky; Interview With Abuse Survivor Teresa Joyce, Author of "There's A Fine Line"
2. New findings by GW researcher break tanning misconceptions: There is no such thing as a safe tan
3. Are there gender differences in anti-HIV drug efficacy?
4. Theres an app for that: Apple iPod Touch helps adults with autism function in the workplace
5. Youth with autism gravitate toward STEM majors in college -- if they get there
6. Are there racial disparities in osteoporosis screening and treatment?
7. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
8. Is there a period of increased vulnerability for repeat traumatic brain injury?
9. Why are there redheads? Birds might hold the clues
10. When It Comes to Spine Surgery, There Is No July Effect: Study
11. Theres room for improvement in womens heart disease awareness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... York (PRWEB) August 27, 2014 As ... society today, big business has taken notice. With 23 ... of medical cannabis friendly legislation on their books the ... states such as New York and Florida are in ... medical marijuana laws a void of reliable information and ...
(Date:8/27/2014)... Lee Antimicrobial Solutions LLC (“LAMS”), ... Technology and a Leader in Environmental Disinfection Device ... a device developed for home use available for ... unveiled DHP Technology, a revolutionary means to disinfect ... of bacteria, viruses, microbes and offensive odors. A ...
(Date:8/27/2014)... 2014 Picture, if you will, a detective ... but more of a Mr. Inside, a Doc Blanchard type, ... personalities and world view. This Mr. Inside was an internationally ... Austin, and Mr. Outside was an Austin Police Department lieutenant. ... girlfriend, and a gaggle of teenagers embarked on a mission ...
(Date:8/27/2014)... Abington, PA (PRWEB) August 27, 2014 ... Lower Gwynedd, PA on Monday, September 8, 2014. This ... outpatient campus that features three primary care practices and ... outpatient facility is a very exciting endeavor for Abington ... Merlis, president and CEO, Abington Health. “Establishing a location ...
(Date:8/27/2014)... inherited from our parents shapes many aspects of our ... an epigenome that is set during development, but can ... perhaps by those of our parents and grandparents. , ... and supporting proteins that determine whether genes are expressed ... for our own health, but also that it may ...
Breaking Medicine News(10 mins):Health News:The Marijuana Real Estate Market Opens Up 2Health News:The Marijuana Real Estate Market Opens Up 3Health News:A New York Based Company Announces The Release Of An Advanced, Environmentally Friendly Disinfection Technology For In-Home Use 2Health News:A New York Based Company Announces The Release Of An Advanced, Environmentally Friendly Disinfection Technology For In-Home Use 3Health News:UW Rankin Self-Publishes Debut Novel, Sublimity: Perchance to Dream, A Speculative Science Mystery 2Health News:Abington Health Opens New Health Center in Lower Gwynedd 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 3Health News:Scientists map the 'editing marks' on fly, worm, human genomes 4
... LUGANO, SWITZERLAND, June 4, 2008 Finbarr Cotter, M.D., ... Science at Barts and The London School of Medicine, ... in CLL by GCS-100: a Phase 2 Study" at ... The promising interim results from this ongoing clinical trial ...
... Will be Held in Berlin ... from 22 to 24 September, BERLIN, June ... disablement? Experts from,throughout the world will address this question at the 4th ... Berlin,Congress Centre from 22 to 24 September 2008. The IFDM will be ...
... Offerings, MOUNTAINSIDE, N.J., June 4 L&M ... the opening of a new full-service Midwest office ... as Vice President, Client Services., These enhancements ... and better meet the needs of their growing ...
... M. Redstone to Accept Award At June 9 ... ... Global Business,Coalition on HIV/AIDS, Tuberculosis and Malaria (GBC) announced today that,it will ... Excellence at its June 9th annual,celebration. The GBC, an organization of more ...
... Scientists at Karolinska Institutet in Sweden and Miami University have ... in a way hitherto unknown. The discovery can eventually be ... aim of the project was to find out how the ... known for a long time that glucose is regulated with ...
... Monitoring extreme weather, such as periods of high ... intensity of infectious diseases like cryptosporidiosis, an intestinal disease ... researchers have created a model that takes into account ... people who will fall ill during an outbreak. With ...
Cached Medicine News:Health News:Clinical study shows biological and clinical activity in relapsed leukemia patients 2Health News:Clinical study shows biological and clinical activity in relapsed leukemia patients 3Health News:Retaining Employees' Capacity For Work Following Sickness 2Health News:L&M Healthcare Communications LLC Expands With Hiring of New Executive Staff & Opening of Midwest Office 2Health News:Viacom to Receive Leadership Award for Business Excellence from The Global Business Coalition on HIV/AIDS, Tuberculosis and Malaria for Its 25 Years of Work on HIV/AIDS Education and Advocacy 2Health News:Viacom to Receive Leadership Award for Business Excellence from The Global Business Coalition on HIV/AIDS, Tuberculosis and Malaria for Its 25 Years of Work on HIV/AIDS Education and Advocacy 3Health News:Discovery of new signal pathway important to diabetes research 2Health News:Weather, stomach bugs and climate change: Refining the model 2
(Date:8/27/2014)... , Aug. 27, 2014 IRIDEX Corporation (NASDAQ: ... James H. Mackaness is scheduled to make an investor ... at 2:55 p.m. Eastern Time on Wednesday, September 3, in ... of the investor presentation will be available in the Investors ... About IRIDEX IRIDEX Corporation was founded ...
(Date:8/27/2014)... Pa. , Aug. 27, 2014   Auxilium Pharmaceuticals ... integrated specialty biopharmaceutical company, today announced that certain members ... Morgan Stanley Healthcare Conference to be held September 8-10, ... Adrian Adams , Chief Executive Officer and President, is ... its product portfolio at 10:55 a.m. ET on Wednesday, ...
(Date:8/27/2014)... Asterias Biotherapeutics Inc. (OTCBB: ASTY) has received ... to initiate a Phase 1/2a clinical trial of its ... injury.  The approved trial follows the successful completion of ... is designed to assess safety and activity of escalating ... cord injuries, the first targeted indication for AST-OPC1 and ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 3Asterias Biotherapeutics Receives U.S. FDA Clearance to Initiate Phase 1/2a Clinical Trial of AST-OPC1 in Patients with Cervical Complete Spinal Cord Injury 2Asterias Biotherapeutics Receives U.S. FDA Clearance to Initiate Phase 1/2a Clinical Trial of AST-OPC1 in Patients with Cervical Complete Spinal Cord Injury 3Asterias Biotherapeutics Receives U.S. FDA Clearance to Initiate Phase 1/2a Clinical Trial of AST-OPC1 in Patients with Cervical Complete Spinal Cord Injury 4Asterias Biotherapeutics Receives U.S. FDA Clearance to Initiate Phase 1/2a Clinical Trial of AST-OPC1 in Patients with Cervical Complete Spinal Cord Injury 5
... IRVINE, Calif., Aug. 11, 2011 ChromaDex Corporation ... provides proprietary, science-based solutions and ingredients to the ... industries, today announced financial results for the second ... calculated in accordance with U.S. Generally Accepted Accounting ...
... 2011 Reportlinker.com announces that a ... available in its catalogue: ... - Global Opportunity Assessment, Competitive ... 2017 ...
Cached Medicine Technology:ChromaDex Announces Financial Results for Second Quarter 2011 2ChromaDex Announces Financial Results for Second Quarter 2011 3ChromaDex Announces Financial Results for Second Quarter 2011 4Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 2Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 3Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 4Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 5Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 6Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 7Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 8Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 9Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017 10
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: