Navigation Links
Kidney cancer reveals its weak link
Date:2/18/2014

A team of researchers at Chalmers University of Technology has found that kidney cancer cells have a quite different metabolism than other types of malignancies. The findings pave the way for new methods of diagnosing kidney cancer at an early stage, a feat that had eluded researchers earlier, and thereby fresh approaches to treatment.

Cancer is a result of mutations in the genes of healthy cells. The transition to cancer cells involves a fundamental transformation of their metabolism, the way that they use nourishment and energy. The uninhibited growth of cancer cells is based on their particular metabolism.

The Chalmers researchers have explored the metabolism associated with ten types of cancer cells. When analyzing regulation of metabolism by healthy cells after having become malignant, the researchers made an unexpected discovery.

"One type of cancer stood out from all the rest," says Professor Jens Nielsen, who headed up the team. "Cells affected by kidney cancer reprogram their metabolism in a very special way, which is the weak link in the disease. What fascinated us most was that we can potentially measure this vulnerability by taking a simple blood sample."

In order to look more closely at possible methods of using metabolism to diagnose renal cell carcinoma the most common type of kidney cancer the Chalmers team has begun collaborating with researchers at a hospital in Padua, Italy.

"To determine whether our predictions are valid," Professor Nielsen says, "the hospital will conduct a clinical trial to analyze blood samples and urine specimens from kidney cancer patients. We anticipate that a simple method of deciding whether someone has kidney cancer will be available within a few years."

Early detection of kidney cancer significantly improves its prognosis. Surgery to prevent the malignancy from metastasizing can still be successful at that point. The study also suggests that a feasible long-term goal is the ability to destroy cancer cells by changing their metabolism.

"Because kidney cancer cells metabolize abnormally, they have to fight for their survival," says Francesco Gatto, who constructed the cell models. "As a result, it should be possible to customize a way of taking advantage of their vulnerabilities so as to kill them without damaging healthy cells."

With that idea in mind, the Chalmers team is also collaborating with British researchers to identify the mechanisms decisive to destroying kidney cancer cells. The objective is to discover and develop drugs that can attack renal cell carcinoma.


'/>"/>

Contact: Christian Borg
christian.borg@chalmers.se
46-317-723-395
Chalmers University of Technology
Source:Eurekalert  

Related medicine news :

1. Herbal Remedy Ingredient Tied to Cancer, Kidney Failure
2. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
3. Kidney cancer patients do better when whole kidney is not removed, U-M study shows
4. Role of Screening, Monitoring in Early Kidney Disease Unclear
5. Kidney Cancer Patients Fare Better With Tumor Removal Only
6. Donor Kidney Re-Used in Second Patient After Failing in First
7. Routine Kidney Disease Screening Not Worthwhile, Experts Say
8. Surprising results for use of dialysis for kidney failure in developing world
9. Everyday fish oil capsule may provide kidney-related benefits
10. First, Second Kidney Transplants Have Similar Success: Study
11. Women fare better than men, but need more blood after kidney cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kidney cancer reveals its weak link
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... ... On Saturday, October 21, the Health & Wellness Center at Florida Hospital ... for the American Heart Association Heart Walk. Teams of up to 10 people can ... their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on Saturday, ...
(Date:10/12/2017)... ... October 12, 2017 , ... In ... taxes a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, ... overseas retirement havens have extremely low property-tax rates, which contributes to the relatively ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Centers for Disease Control and Prevention (CDC), influenza vaccination should take ... communities across Massachusetts , Connecticut , ... through the end of the month. *Some exclusions apply ... ... by the end of October, according to the Centers for Disease Control ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the ... analysis system called the HORIZON at MIBio 2017 in ... subvisible and visible particulate matter in biopharmaceutical samples with unprecedented speed ... of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... solutions, today announced that its MyDario product is expected to appear on ... for when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. ... ...
Breaking Medicine Technology: