Navigation Links
Key mechanism behind herpes revealed
Date:10/2/2013

Researchers at Lund University in Sweden have for the first time managed to measure the internal pressure that enables the herpes virus to infect cells in the human body. The discovery paves the way for the development of new medicines to combat viral infections. The results indicate good chances to stop herpes infections in the future.

A virus comprises a thin shell of protein, within which are its genes. A long-standing theory has been that a virus has high internal pressure because it is so tightly packed with genetic material. The pressure means that they can infect a cell by ejecting the genes at high force and speed. The cell is then duped into becoming a small 'virus factory' that produces new viruses, multiplying the number. However, no one has previously succeeded in measuring the internal pressure of a virus that can infect humans.

Biochemist Alex Evilevitch from Lund University and Carnegie Mellon University in Pittsburgh, USA, has measured the pressure inside the herpes virus HSV-1 (herpes simplex virus 1) together with a research team in the US. The study has been published in the Journal of the American Chemical Society, JACS.

"The pressure explains the way all eight known herpes viruses that infect humans inject their genes into our cells", said Alex Evilevitch.

This includes both of the two most common forms of herpes, which cause cold sores and genital herpes, as well as Varicella zostervirus, which causes chickenpox and shingles, Epstein-Barr virus, which leads to glandular fever, and viruses linked to various forms of cancer.

In previous studies, Alex Evilevitch has also demonstrated that bacteriophages, viruses that infect bacteria, have a high internal pressure. Bacteriophages and herpes viruses separated in evolution billions of years ago, but have retained the same pressure-driven method of ejecting their genes. Evilevitch therefore believes this must be a key mechanism for viral infection.

The discovery could lead to new drugs. The medication that exists to combat viral infections is very specialised and if a virus mutates, which often happens, the medicine can become less effective. However, if a treatment could be developed that reduces the pressure within the virus shell, it would probably be possible to fight many different types of viral infection with the same drug. In addition, the medication would work even if the virus mutated, because mutations do not affect the internal pressure of a virus.

"The results of the present study are the first step towards the goal of developing a drug of this type, and we already have positive preliminary data that shows that the herpes infection can be stopped. It feels great to know that this research will help to fight infections that are as yet incurable", said Alex Evilevitch.


'/>"/>

Contact: Alex Evilevitch
Alex.Evilevitch@biochemistry.lu.se
Lund University
Source:Eurekalert

Related medicine news :

1. Joslin scientists identify important mechanism that affects the aging process
2. Researchers gain better understanding of mechanism behind tau spreading in the brain
3. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
4. Study supports urate protection against Parkinsons disease, hints at novel mechanism
5. Probing the mechanism of ADAM28-mediated cancer metastasis
6. Fruit flies reveal mechanism behind ALS-like disease
7. Scientists discover mechanism that promotes lung cancer growth and survival
8. Abnormal gene product associated with prostate cancer generated by unusual mechanism
9. New mechanism of bacterial pathogenesis discovered
10. Scientists identify new cancer stem cell mechanism
11. Zebrafish reveal promising mechanism for healing spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement ... Vice President of North American Capital Sales at HTG Molecular . ... in the commercialization of the HTG EdgeSeq system and associated reagents in North America. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
Breaking Medicine Technology: