Navigation Links
Kentucky team inhibits Alzheimer's biomarkers in animal model by targeting astrocytes
Date:12/11/2012

LEXINGTON, Ky. (Dec. 10, 2012) A research team composed of University of Kentucky researchers has published a paper which provides the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease. The UK Sanders-Brown Center on Aging has also received significant new National Institutes of Health (NIH) funding to further this line of study.

Chris Norris, an associate professor in the UK College of Medicine Department of Molecular and Biomedical Pharmacology, as well as a member of the faculty at the UK Sanders-Brown Center on Aging, is the senior author on a paper published recently in the Journal of Neuroscience, entitled "Targeting astrocytes to ameliorate neurologic changes in a mouse model of Alzheimer's disease." The first author on the article, Jennifer L. Furman, was a graduate student in the Norris laboratory during completion of the study.

The astrocyte is a very abundant non-neuronal cell type that performs absolutely critical functions for maintaining healthy nervous tissue. However, in neurodegenerative diseases, like Alzheimer's disease, many astrocytes exhibit clear physical changes often referred to as "astrocyte activation." The appearance of activated astrocytes at very early stages of Alzheimer's has led to the idea that astrocytes contribute to the emergence and/or maintenance of other pathological markers of the disease, including synaptic dysfunction, neuroinflammation and accumulation of amyloid plaques.

Using an animal model, researchers directly modulated the activation state of hippocampal astrocytes using a form of gene therapy.

Mice received the gene therapy at a very young age, before the development of extensive amyloid plaque pathology, and were assessed 10 months later on a variety of Alzheimer's biomarkers.

The research team found that inhibition of astrocyte activation blunted the activation of microglia (a cell that mediates neuroinflammati
'/>"/>

Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Kentucky study finds common drug increases deaths in atrial fibrillation patients
2. InsuranceCalculator.net Now Provides Competitive Car Insurance Quotes To Kentucky Drivers
3. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
4. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
5. Molecule found that inhibits recovery from stroke
6. Bloodstream scavenger inhibits clotting without increased bleeding
7. Metabolic biomarkers for preventive molecular medicine
8. Tracking down smallest biomarkers
9. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
10. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
11. Using biomarkers to identify and treat schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Hispanics develop alcoholic liver disease (ALD), ... 12 years earlier than Whites/Caucasians or African Americans, according ... , While previous research indicated that Hispanics tend to ... study -- published online in the journal Alcoholism: Clinical ... first to pinpoint racial and ethnic disparities in the ...
(Date:2/27/2015)... Beverly Hills, CA (PRWEB) February 27, 2015 ... was in the air for those suffering from Sjögren’s ... had been discovered by researchers at the University of ... the next phase of research was to develop a ... to precisely detect the presence of new autoantibodies. Researchers ...
(Date:2/27/2015)... Clinovo, a leading provider of cloud-based eClinical ... (EDC) at the CALBIO2015 conference taking place ... 3rd at Booth # 141. , ClinCapture ... edit-check builder allowing Clinical Trials Managers to create CRFs ... any programming experience. Clinovo’s new pricing model offers a ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 In honor of American ... Primary Care (CPC) South office, is offering tips on how to ... of death, but that doesn't mean people have to accept it ... some risk factors — such as family history, sex or age ... , Dr. Scott has six helpful tips to improve heart ...
(Date:2/27/2015)... February 27, 2015 The federal court ... that allege use of the statin medication can increase ... issued a new order pertaining discovery in the cases ... Liebhard LLP comments. The Order, which was issued in ... February 25th, directs the parties to schedule certain witness ...
Breaking Medicine News(10 mins):Health News:UC Davis Study Finds Hispanics Develop Alcoholic Liver Disease at Younger Ages than Caucasians or African Americans 2Health News:Breakthrough Blood Test for Early Detection of Sjögren’s Syndrome Now Available 2Health News:Clinovo to Demo Its Self-Service, Cloud-Based EDC Solution at CALBIO2015 on March 2nd and 3rd, 2015 2Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 2Health News:Federal Lipitor Litigation Issues New Order Pertaining to Discovery in Bellwether Cases, Bernstein Liebhard LLP Comments 3
... , ST. PAUL, Minn., Dec. 10 /PRNewswire-USNewswire/ -- ... their 6th annual blood drive event with the Minnesota Vikings ... at the St. Paul Donor Center (I-94 and Hwy. 280), ... cheerleaders scheduled to arrive around 2 PM. All presenting ...
... ... announces that, after a national search, the Board of Trustees of Abington Health voted to ... ... H. Durham, chairman, Board of Trustees of Abington Health and Abington Memorial Hospital, announces that, ...
... , ARLINGTON, Va., Dec. 10 Americans ... but are highly aware of the risks of not receiving care, ... Mental Illness (NAMI). , See full survey results at ... people of diverse communities. , Though depression is common and highly ...
... , Helps PSI, DFID and USAID highlight progress in ... 10 Emmy Award winning actress and PSI (Population Services ... and individuals who have contributed to the substantial decline in ... six years Zimbabwe has seen a dramatic reduction in the ...
... the emissions leaving a car tailpipe or factory smokestack affect ... the atmosphere. But until now, scientists have struggled to know ... once they leave their source, leading to models for predicting ... accurate. A major collaborative effort of more than ...
... Pennsylvania School of Medicine have developed a new model of ... molecule called Src kinase is activated in human skin-cancer samples. ... are activated in human squamous cell carcinomas of the skin. ... gene Fyn, a member of Src family of proteins, in ...
Cached Medicine News:Health News:Minnesota Vikings Team With Memorial Blood Centers Again for Annual Blood Drive 2Health News:Abington Health Announces New President and CEO 2Health News:Abington Health Announces New President and CEO 3Health News:Depression Survey: Implications for Diverse Communities 2Health News:Emmy Award Winning Actress Debra Messing Visits Zimbabwe 2Health News:Emmy Award Winning Actress Debra Messing Visits Zimbabwe 3Health News:New approach to emissions makes climate and air quality models more accurate, major study finds 2Health News:New approach to emissions makes climate and air quality models more accurate, major study finds 3Health News:New model of skin cancer provides insights on second-most common type of cancer 2
(Date:2/27/2015)... LONDON , February 27, 2015 ... - new study showing you trends, R&D progress, and ... medicine heading? What are the commercial prospects for ... shows you potential revenues and other trends to 2025, ... ,s report lets you assess regenerative medicine : ...
(Date:2/27/2015)... - Covalon Technologies Ltd. (the "Company" or "Covalon") (TSXV: COV), ... for its first quarter ended December 31, 2014. ... 2014, revenue was $1,336,685. Operating expenses were $1,063,393.  Net ... share.  Covalon,s President and CEO, ... the significant progress we have made over the past ...
(Date:2/27/2015)... , February 27, 2015 ... bahnbrechendes Überwachungssystem für kongestive Herzinsuffizienz (CHF) in ...     ... ein neuartiges Herzüberwachungssystem für Patienten mit kongestiver ... dass sie ein Finanzierungsvorhaben über 5 Mio. ...
Breaking Medicine Technology:Translational Regenerative Medicine: Market Prospects 2015-2025 2Translational Regenerative Medicine: Market Prospects 2015-2025 3Translational Regenerative Medicine: Market Prospects 2015-2025 4Translational Regenerative Medicine: Market Prospects 2015-2025 5Translational Regenerative Medicine: Market Prospects 2015-2025 6Translational Regenerative Medicine: Market Prospects 2015-2025 7Translational Regenerative Medicine: Market Prospects 2015-2025 8Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3Vectorious Medical Technologies schließt Finanzierungsvorhaben über 5 Mio. USD ab 2
... 28, 2010 /PRNewswire-Asia/ -- Chindex International, Inc. ("Chindex") ... American provider of Western healthcare products and services ... Fosun Pharmaceutical (Group) Co., Ltd. ("Fosun Pharma"), a ... medicine and devices in China, today announced the ...
... that new in-demand ResearchInChina reports on China industries ... Beer Industry Report, 2009-2010 . The report discusses development of ... in China. The study provides data on sales volume and ... product features and marketing strategies. China ...
Cached Medicine Technology:Chindex and Fosun Pharma Form Joint Venture 2Chindex and Fosun Pharma Form Joint Venture 3Chindex and Fosun Pharma Form Joint Venture 4Chindex and Fosun Pharma Form Joint Venture 5Topical China Industries Research Reports Published at MarketPublishers.com 2
Ideal for abdominal and back procedures....
Female High Waist Briefs...
Provides upper and lower arm support. Extends to the lower arm and across the shoulders. Has two columns of hook & eye closure for added adjustability....
Short-Sleeve Bolero for targeted compression in the upper arms, back and shoulder areas. Plush-shielded hook and eye front closure for comfort and convenient application....
Medicine Products: