Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

ormations

AUTHOR CONTACT:
Mark L. Kahn
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.898.9007; Fax: 215.573.2094; E-mail: markkahn@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/39679?key=953594aa09229ff769cd


MUSCLE BIOLOGY: Understanding how mutant proteins cause muscular dystrophy

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease characterized by progressive muscle weakness. Most patients become confined to a wheelchair in their third decade of life. Although LGMD2A is known to be caused by mutations in the gene CAPN3, which controls the generation of the protein p94, how mutant p94 proteins lead to disease has not been determined. Now, a team of researchers, led by Hiroyuki Sorimachi, at the Tokyo Metropolitan Institute of Medical Science, Japan, has determined that in mice, mutant p94 protein that is unable to cleave other proteins (a key function of p94) causes a disease that resembles LGMD2A and is exacerbated by exercise. The exercise-induced muscle degeneration was associated with inefficient relocalization of the mutant p94 protein. The authors therefore conclude that exercise-induced dynamic redistribution of p94 is dependent on its ability to cleave other proteins and essential to protect muscle from degeneration.

TITLE: Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

AUTHOR CONTACT:
Hiroyuki Sorimachi
The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan.
Phone: 81.3.5316.3277; Fax: 81.3.5316.3613; E-mail: sorimachi-hr@igakuken.or.jp.

V
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... (PRWEB) March 30, 2015 The pharmaceutical ... and flexible biological manufacturing plants. This is primarily due ... business. , This has forced facilities to produce and ... The existing facilities have been forced to expand production, ... change of ownership. , Most of these facilities have ...
(Date:3/30/2015)... GoHooper.com announces new website for Grace Pediatrics. Grace ... infants, children and adolescents and partners with parents to ... owner/provider Mark Hughes, MD, FAAP and a his team ... in the extensive range of pediatric care from newborn ... who meet the medical field's highest standards, and who ...
(Date:3/30/2015)... Marcos, CA (PRWEB) March 30, 2015 Dr. ... California, offers no cost 15 minute second opinion consultations ... work. , “The statistics on dental second opinions show ... second opinion on major dental works. Only 6%” – says ... a second opinion even when fully trusting the dental care ...
(Date:3/30/2015)... Southern Med Law, a law firm representing ... filed a Mirena IUD lawsuit on behalf ... premature birth in 2012. The complaint, which is currently ... Mirena IUD failed to prevent pregnancy due to problems ... to remove. The inability to remove the IUD from ...
(Date:3/30/2015)... iCareTech ” was featured on NewsWatch as part of its ... and coolest technology products and services available to consumers. Scott ... review and shared with viewers how this is the very ... fields. , Wearable technology has been one of the most ... Well, at CES, NewsWatch TV came across the first medical ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces: Aging Aseptic and Biological Manufacturing Facilities: Design and Renovation for Compliance Webinar, April 16, 2015 2Health News:FDAnews Announces: Aging Aseptic and Biological Manufacturing Facilities: Design and Renovation for Compliance Webinar, April 16, 2015 3Health News:Nashville Web Design Company Announces New Site Launch For Pediatrics Doctor 2Health News:Allred Dental Offers Complimentary 15 Minute Consults with Dr. Jeffrey Allred in San Marcos, CA 2Health News:Mirena Lawsuit Filed By Southern Med Law Seeks Compensation For Purported Wrongful Death Following Premature Birth Of Infant 2Health News:Mirena Lawsuit Filed By Southern Med Law Seeks Compensation For Purported Wrongful Death Following Premature Birth Of Infant 3Health News:Mirena Lawsuit Filed By Southern Med Law Seeks Compensation For Purported Wrongful Death Following Premature Birth Of Infant 4Health News:World’s First Medical Intelligent Band was Featured on NewsWatch Television on January 30, 2015 2
... NEW YORK, July 21 BET News correspondent, Andre Showell will lead ... in Washington on Wednesday, July 22 ( ) at ... re-air an encore broadcast of the entire news conference along with pre ... 10:00 p.m. The President is expected to discuss health ...
... , ST. LOUIS, July 21 Young Innovations, Inc. ... quarter and for the first six-months ended June 30, 2009. , ... were $24.6 million, a decrease of 4.9% over the $25.9 million reported ... $5.4 million from $5.2 million in the prior year. Net income for ...
... , , , , ... SMA ), a leading independent provider of products to the global orthopaedic ... second quarter 2009 financial results for the period ending July 4, 2009 ... host an accompanying conference call at 8:00 a.m. ET on Thursday, August ...
... July 21 / PRNewswire / -- Spheris, a leading global ... release of its financial results for the second quarter ended June 30, ... issue its earnings release for the second quarter of 2009 after the ... a conference call on Friday, August 7, 2009, at 8 a.m. CT. ...
... , , OAKLAND, ... provide care at hospitals owned by Tenet Healthcare Corporation organized ... access to sick leave. , , ... Nurses Organizing Committee/California Nurses Association (NNOC/CNA) and Service Employees International ...
... , , , , ... VRX ) today announced that it will host a conference call ... August 4, 2009 at 10:00 a.m. EDT (7:00 a.m. PDT) to discuss ... The dial-in number to participate on this call is (877) 295-5743, ...
Cached Medicine News:Health News:BET Networks Airs Special Coverage of President Obama's News Conference on Health Care 2Health News:Young Innovations, Inc. Announces Record Earnings for the Quarter and Six-Months Ended June 30, 2009 2Health News:Young Innovations, Inc. Announces Record Earnings for the Quarter and Six-Months Ended June 30, 2009 3Health News:Young Innovations, Inc. Announces Record Earnings for the Quarter and Six-Months Ended June 30, 2009 4Health News:Young Innovations, Inc. Announces Record Earnings for the Quarter and Six-Months Ended June 30, 2009 5Health News:Young Innovations, Inc. Announces Record Earnings for the Quarter and Six-Months Ended June 30, 2009 6Health News:Symmetry Medical to Report Second Quarter 2009 Financial Results on August 6, 2009 2Health News:Spheris Sets Second Quarter 2009 Earnings Release and Conference Call Dates 2Health News:Tenet Nurses, Healthcare Workers Take Action to Protest Sick Leave Cuts 2Health News:Valeant Pharmaceuticals to Announce 2009 Second Quarter Results on August 4, 2009 2
(Date:3/30/2015)... -- MedAptus® today announced the launch of Assign, the ... for busy inpatient provider teams. Assign was developed ... hospitalists or other rounding providers based on needs ... as ensuring patient safety, proper reimbursement and overall ... In an increasingly risk-based healthcare market, ...
(Date:3/30/2015)... N.C. , March 30, 2015  Edison ... announced a worldwide search for product innovations to ... most promising ideas uncovered during the 8-week search ... for potential commercialization.  Invention ideas can be submitted ... now through May 28, 2015. ...
(Date:3/30/2015)... 30, 2015 Nutrastar International Inc. (OTCQB: NUIN) ... of premium branded consumer products, including commercially cultivated Cordyceps ... foods, today announced its results for the full year ... for the Full Year Ended December 31, 2014 ... as compared to $43.35 million in full year 2013. ...
Breaking Medicine Technology:MedAptus Launches Automated Patient Assignment Solution for Hospitalists, Other Rounding Specialists 2MedAptus Launches Automated Patient Assignment Solution for Hospitalists, Other Rounding Specialists 3Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 2Edison Nation Medical Announces Open Innovation Search Focused on Senior Mobility Products 3Nutrastar International, Inc. Announces Full Year 2014 Results 2Nutrastar International, Inc. Announces Full Year 2014 Results 3Nutrastar International, Inc. Announces Full Year 2014 Results 4Nutrastar International, Inc. Announces Full Year 2014 Results 5Nutrastar International, Inc. Announces Full Year 2014 Results 6Nutrastar International, Inc. Announces Full Year 2014 Results 7Nutrastar International, Inc. Announces Full Year 2014 Results 8Nutrastar International, Inc. Announces Full Year 2014 Results 9
... 2, 2007-The U.S. Food and Drug,Administration (FDA) today ... existing black box warning on,their products' labeling to ... behavior, known as suicidality, in young,adults ages 18 ... to two months). , The proposed labeling changes ...
... FDA notified,healthcare professionals of important new safety ... recent,clinical study in patients with limited-stage small ... phase,II clinical trial study combined chemotherapy and ... serious adverse events of TE,fistula (one fatal) ...
Cached Medicine Technology:FDA Proposes New Warnings About Suicidal Thinking, Behavior in,Young Adults Who Take Antidepressant Medications 2FDA Proposes New Warnings About Suicidal Thinking, Behavior in,Young Adults Who Take Antidepressant Medications 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: