Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

ormations

AUTHOR CONTACT:
Mark L. Kahn
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: 215.898.9007; Fax: 215.573.2094; E-mail: markkahn@mail.med.upenn.edu.

View this article at: http://www.jci.org/articles/view/39679?key=953594aa09229ff769cd


MUSCLE BIOLOGY: Understanding how mutant proteins cause muscular dystrophy

Limb-girdle muscular dystrophy type 2A (LGMD2A) is a genetic disease characterized by progressive muscle weakness. Most patients become confined to a wheelchair in their third decade of life. Although LGMD2A is known to be caused by mutations in the gene CAPN3, which controls the generation of the protein p94, how mutant p94 proteins lead to disease has not been determined. Now, a team of researchers, led by Hiroyuki Sorimachi, at the Tokyo Metropolitan Institute of Medical Science, Japan, has determined that in mice, mutant p94 protein that is unable to cleave other proteins (a key function of p94) causes a disease that resembles LGMD2A and is exacerbated by exercise. The exercise-induced muscle degeneration was associated with inefficient relocalization of the mutant p94 protein. The authors therefore conclude that exercise-induced dynamic redistribution of p94 is dependent on its ability to cleave other proteins and essential to protect muscle from degeneration.

TITLE: Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy

AUTHOR CONTACT:
Hiroyuki Sorimachi
The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan.
Phone: 81.3.5316.3277; Fax: 81.3.5316.3613; E-mail: sorimachi-hr@igakuken.or.jp.

V
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... at UT Southwestern Medical Center previously discovered that the ... adult heart lacks this ability. New research by the ... its incredible regenerative capability in adulthood, and the answer ... It is well-known that a major function of the ... But at the same time, oxygen is a highly ...
(Date:4/24/2014)... April 24, 2014 ,Take me out to ... slices and kale chips. The more likely culprits include ... , Unfortunately for children who play youth baseball, ... contributing to weight problems, according to researchers at Wake ... current online edition of Childhood Obesity , found ...
(Date:4/24/2014)... in the new Institute for Biomedical Sciences at ... million federal grant to develop novel therapeutics against ... from the Eunice Kennedy Shriver National Institute Of ... Institutes of Health will support Plemper,s drug development ... least one distinct alternative compound. , Infections by ...
(Date:4/24/2014)... national response to the epidemic of prescription opioid overdose ... Journal of Medicine by leaders of agencies in ... The commentary calls upon health care providers to expand ... reduce overdose deaths, and describes a number of misperceptions ... The commentary also discusses how medications can be used ...
(Date:4/24/2014)... researchers was the first in the world to discover ... of the jaw. , Ameloblastoma is an odontogenic tumour ... is most often found in the posterior of the ... in tissue deficiencies in the jaws as well as ... reduce the need for surgery and the recurrence of ...
Breaking Medicine News(10 mins):Health News:Oxygen diminishes the heart's ability to regenerate, researchers discover 2Health News:Take the bat, leave the candy 2Health News:HHS leaders call for expanded use of medications to combat opioid overdose epidemic 2Health News:HHS leaders call for expanded use of medications to combat opioid overdose epidemic 3Health News:HHS leaders call for expanded use of medications to combat opioid overdose epidemic 4
... The Authority in 2007 developed and began implementing ... in Patient Safety Advisories to,improve patient safety while ... and nursing homes began, HARRISBURG, Pa., April ... 2007 Annual Report today outlining,its Strategic Plan that ...
... EAU Technologies, a leading provider,of Electrolyzed Water - ... announced that Wade Bradley, President and,CEO, will be ... Financial,Conference to be held at the Monterey Plaza ... Bradley will review the company,s corporate strategy, strengths,and ...
... feelings are ,fragile, it,s no better than having a poor ... -- There,s a big difference between "secure" high self-esteem and ... that those with the secure form are less likely to ... self-esteem, and in this study, we found that for those ...
... also available in French . , Contrary ... dont necessarily eat a healthier diet than their less-active ... between body mass index (BMI) values and levels of ... 900 Vancouver-area teenagers in Grades 10 through 12 was ...
... technology enhances the state of health care ... 30 SeQual Technologies Inc., a San,Diego-based ... worldwide for their reliability, quality, revolutionary design ... its new rugged,light-weight, battery operated oxygen concentrator, ...
... Systems,Corporation (NYSE: PER ) today announced ... #1 ranking in the KLAS survey of ... Known throughout,the Healthcare industry for its stringent ... decisions by independently,monitoring vendor performance through the ...
Cached Medicine News:Health News:Patient Safety Authority Issues Annual Report for 2007 2Health News:Patient Safety Authority Issues Annual Report for 2007 3Health News:Patient Safety Authority Issues Annual Report for 2007 4Health News:Patient Safety Authority Issues Annual Report for 2007 5Health News:Patient Safety Authority Issues Annual Report for 2007 6Health News:Patient Safety Authority Issues Annual Report for 2007 7Health News:Patient Safety Authority Issues Annual Report for 2007 8Health News:Patient Safety Authority Issues Annual Report for 2007 9Health News:Patient Safety Authority Issues Annual Report for 2007 10Health News:Patient Safety Authority Issues Annual Report for 2007 11Health News:Patient Safety Authority Issues Annual Report for 2007 12Health News:Patient Safety Authority Issues Annual Report for 2007 13Health News:Patient Safety Authority Issues Annual Report for 2007 14Health News:Patient Safety Authority Issues Annual Report for 2007 15Health News:Patient Safety Authority Issues Annual Report for 2007 16Health News:Patient Safety Authority Issues Annual Report for 2007 17Health News:Patient Safety Authority Issues Annual Report for 2007 18Health News:EAU Technologies to Present at AeA Micro Cap Conference 2Health News:EAU Technologies to Present at AeA Micro Cap Conference 3Health News:High Self-Esteem May Mask Defensiveness 2Health News:Physical activity, healthy eating and BMI not linked in older teens: study 2Health News:US Army Purchases SeQual's Cutting-Edge Oxygen Generation Technology for MRAP Deployment 2Health News:Perot Systems Ranked #1 for Clinical Implementation Services By KLAS 2Health News:Perot Systems Ranked #1 for Clinical Implementation Services By KLAS 3
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
(Date:1/15/2014)... 15, 2014 Tegra Medical is very pleased to announce ... its new Chief Executive Officer.  Mark was promoted from his ... overseen the company,s four facilities in Massachusetts ... King joined Tegra Medical in 2012 with 20+ years of ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... Bacterin International Holdings, Inc. (NYSE Amex: ... of revolutionary bone graft material and antimicrobial coatings for ... American Medical Concepts (AMC), the largest multi-specialty Orthopedic, Spine ... the U.S. The award gives Bacterin ,pre-approved, ...
... Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) ... (FDA) has scheduled a meeting of the Psychopharmacologic Drugs ... the ADASUVE New Drug Application (NDA) will be discussed. ... had accepted the resubmission of the ADASUVE NDA and ...
Cached Medicine Technology:Bacterin Awarded Approved Vendor Status for American Medical Concepts' Network of Hospitals in the Northwest U.S. 2Alexza Announces the Adasuve™ (Staccato® Loxapine) PDAC Meeting Date of December 12, 2011 2Alexza Announces the Adasuve™ (Staccato® Loxapine) PDAC Meeting Date of December 12, 2011 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: