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JCI online early table of contents: July 1, 2010
Date:7/1/2010

many human lung tumor samples, and patients with the highest levels of hNaa10p expression had poor prognosis and survival. The authors therefore conclude that hNaa10P promotes tumor formation, although they caution that while this might be true for the lung, it might not be true in other tissues.

TITLE: hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing

AUTHOR CONTACT:
Cheng-Wen Wu
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Phone: 886.2.2652.3015; Fax: 886.2.2652.3075; E-mail: ken@ibms.sinica.edu.tw.

Li-Jung Juan
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Phone: 886.2.2787.1234; Fax: 866.2.2789.8811; E-mail: ljjuan@gate.sinica.edu.tw.

View this article at: http://www.jci.org/articles/view/42275?key=9cf8b56f73f4f7952258


ONCOLOGY: TGF-beta a DAB(2) hand at tumor promotion

The soluble factor TGF-beta has a complex role in tumor formation and progression. It seems to suppress tumor formation and early development but promote later tumor progression. A team of researchers, led by Gareth Inman, at The Beatson Institute for Cancer Research, United Kingdom, has now identified a mechanism by which TGF-beta switches from being a suppressor of tumor development to a promoter of tumor progression by studying human squamous cell carcinoma (the second most common type of skin cancer) cells in vitro and in vivo in mice. Specifically, they found that downregulation of the protein DAB2, which they determined occurs in human squamous cell carcinomas and predicted poor prognosis, abrogated the tumor suppressor function of TGF-beta. The authors suggest that determining whether or not DAB2 is downregulated might provide a way to stratif
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