Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

atic beta-cells by decreasing their proliferation and enhancing their death. The authors therefore suggest that targeting TRB3 might help prevent two of the central characteristics of type 2 diabetes and thereby provide therapeutic benefit.

TITLE: The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells

AUTHOR CONTACT:
Rohit N. Kulkarni
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Phone: 617.713.3460; Fax: 617.713.3476; E-mail: Rohit.Kulkarni@joslin.harvard.edu.

View this article at: http://www.jci.org/articles/view/36849?key=53f83115ab8916a3b1e0


ONCOLOGY: Silencing genes that protect from cancer: a role for the protein hNaa10p

Tumor suppressor genes are genes that generate proteins that protect cells from becoming cancerous. Loss or reduction in their expression contributes to the onset of cancer. One mechanism by which tumor suppressor genes are silenced in cancer cells is excessive modification of their promoter (the region of the gene that drives expression) with molecules known as methyl groups. Understanding the mechanism underlying hypermethylation of tumor suppressor gene promoters might provide new approaches to cancer treatment.

In this regard, a team of researchers, led by Cheng-Wen Wu and Li-Jung Juan, at Academia Sinica, Taiwan, has now identified a role for the protein hNaa10p in mediating tumor suppressor gene silencing by promoting the function of the protein DNMT1, which transfers methyl groups to DNA. Importantly, depletion of hNaa10p impaired human lung cancer cell proliferation in vitro and upon transplantation into mice. Consistent with hNaa10p having a role in promoting lung tumor development, it was found to be overexpressed in
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... San Diego School of Medicine report that older women, ... major loss are more likely to be compassionate toward ... published in this month,s issue of the International ... are associated with better health and well-being as we ... improve the outcomes of individuals whose deficits in compassion ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood to ... UC Irvine and the Salk Institute have opened the ... stroke-induced brain damage. , A complex and devastating neurological ... primary reason for disability in the U.S. The blood-brain ... blood-borne material into the brain, causing the permanent deficits ...
(Date:4/17/2014)... research team led by Cesar A. Arias, M.D., Ph.D., ... Houston (UTHealth) has identified a new superbug that caused ... appeared in the April 17 issue of The ... superbug is part of a class of highly-resistant bacteria ... which is a major cause of hospital and community-associated ...
(Date:4/17/2014)... is less than 40 years away from a food ... governments, according to a top scientist at the U.S. ... human history, food production will be limited on a ... energy," said Dr. Fred Davies, senior science advisor for ... become as politically destabilizing by 2050 as energy issues ...
Breaking Medicine News(10 mins):Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2Health News:Food shortages could be most critical world issue by mid-century 2
... ... of their new, pharmaceutical website, featuring an extensive selection of medications for the treatment ... ... popularly sold medications, with a particular emphasis on Erectile Dysfunction treatments. Erectile dysfunction, ...
... 9 The medical imaging market in Kenya is ... driven by an aging population demanding greater access to ... in the market remain high due to the sizeable ... financial constraints faced by many healthcare institutions in the ...
... 8 The Council for American Medical Innovation applauds President ... of life-threatening illnesses in Muslim nations. , , ... , In his address to the Muslim nation in ... must recognize that education and innovation will be the currency ...
... , SALT LAKE CITY, June 8 Qqest Software Systems ... company,s TimeForce time and attendance software, as well as the ... Colorado GI performs over 5,000 medical procedures each year. Prior ... were using a manual time clock and paper time cards ...
... KUNMING, China, June 8 /PRNewswire-Asia-FirstCall/ ... KUN) ("China Shenghuo" or,the "Company"), which is engaged ... nutritional supplement and cosmetic products,in the People,s Republic ... Amex,LLC (the "NYSE Amex" or "Exchange") has accepted ...
... Attorney General Eric Holder will be honored and deliver brief remarks ... Ceremony on TUESDAY, JUNE 9, 2009 at ... will present the Joel A. Toubin Memorial Award to the Attorney ... Holder , , WHAT: To be honored and ...
Cached Medicine News:Health News:Pro-Medics Launches Its New Line of Male Impotence Treatment Products 2Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 2Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 3Health News:Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry 4Health News:Council for American Medical Innovation Applauds President Obama's Pledge to Invest in Science, Technology and Health Abroad 2Health News:Colorado Gastroenterology Chooses Qqest's TimeForce, Payroll Services 2Health News:NYSE Amex Accepts China Shenghuo's Compliance Plan for Continued Listing 2Health News:NYSE Amex Accepts China Shenghuo's Compliance Plan for Continued Listing 3
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... used on patients in order to treat dental impairments, ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
... LLC, through its website lawsuitssettlementfunding.com announced today ... in need of lawsuit cash advances ... leader; however they are striving to set themselves apart ... that they have ramped up their operations involving Avandia ...
... N.C. and THE WOODLANDS, Texas, April 20, 2011 ... affiliate of the United Network of US Oncology ... in the Triangle with locations in Raleigh, North Raleigh, Cary, ... (WROS) from Wake Radiology , the oldest and ...
Cached Medicine Technology:Legal-Bay LLC Announces Opening of Jones Act Lawsuit Funding Division 2Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 2Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 3Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 4Cancer Centers of North Carolina Acquires Wake Radiology Oncology Services of Cary, N.C. 5
Sensitive Eyes Plus Saline Solution to rinse soft contact lenses The unique, gentle, pH-balanced formula contains potassium, an ingredient found in tears....
ReNu 1 Step Enzymatic Cleaner with ReNu Multi-Purpose Solution removes protein deposits while lenses are being disinfected. Its a one-step process that saves time. Removes stubborn deposits from dai...
...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
Medicine Products: