Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

ffects each brain region mediates has not been clearly determined. However, Lori Zeltser and Laurence Ring have now generated mice in which leptin signaling is disrupted in only the hypothalamic region of the brain and shown that leptin signals in the hypothalamus are required to prevent the development of obesity up to 8 weeks of age. After 8 weeks of age, leptin signals in regions of the brain other than the hypothalamus were able to control further development of obesity, although they could not reverse obesity established prior to 8 weeks of age. The authors suggest that these data might have implications for combating childhood obesity.

TITLE: Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

AUTHOR CONTACT:
Lori M. Zeltser
Columbia University, New York, New York, USA.
Phone: 212.851.5314; Fax: 212.851.5306; E-mail: lz146@columbia.edu.

View this article at: http://www.jci.org/articles/view/41985?key=ee928b6505cbee5baee5


METABOLIC DISEASE: A tale of tribbles 3: understanding its role in type 2 diabetes

Type 2 diabetes is characterized by insufficient secretion of the hormone insulin, which controls glucose levels in the blood, and reduced mass of insulin-secreting pancreatic beta-cells. A team of researchers, led by Rohit Kulkarni, at Harvard Medical School, Boston, has now confirmed recent data indicating that a genetic variant of the tribbles 3 (TRB3) gene is associated with increased risk of developing type 2 diabetes and determined the reasons underlying this. Specifically, the protein generated by the genetic variant was shown to impair the release of insulin from mouse and human pancreatic beta-cells in which it was expressed and to reduce the mass of pancre
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... intact cells to treat and cure disease is ... is hindered by the inability of doctors and scientists ... these cells in patients without resorting to invasive procedures, ... 17 in the online journal Magnetic Resonance in ... Diego School of Medicine, University of Pittsburgh and elsewhere ...
(Date:9/19/2014)... Domestic violence occurs at least as frequently, and ... to opposite-sex couples, according to a review of ... Previous studies, when analyzed together, indicate that domestic ... lesbian, gay and bisexual individuals. However, a lack ... an incomplete picture of the true landscape, suggesting ...
(Date:9/19/2014)... 2014 As summer vacations end and everyone ... NY now reminds area patients about the reality and impact ... population affected by gum disease, there is simply not an ... 20 years Dr. Krishnan has treated patients with varying degrees ... patients that come in due to common symptoms such as ...
(Date:9/19/2014)... Shahram Majidi, M.D., a second-year resident in ... University School of Medicine and Health Sciences, received ... to study the presence of diffuse brain swelling ... , "According to epidemiological studies, intracerebral hemorrhage accounts ... but is the least treatable form of stroke, ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 BCC Research ... TECHNOLOGIES AND GLOBAL MARKETS , the global market for ... $13.9 billion by 2018, with a five-year compound annual ... segment is growing at a steady 3.8% CAGR. , ... presenting lower sales, coupled with the incidence of increasing ...
Breaking Medicine News(10 mins):Health News:A better way to track emerging cell therapies using MRIs 2Health News:Domestic violence likely more frequent for same-sex couples 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:GW researcher receives grant to study brain swelling following bleeding in the brain 2Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 2Health News:Global Market for Human Antifungal Therapeutics to Reach Nearly $13.9 Billion in 2018; Over-The-Counter (OTC) Segment Growing At 3.8% CAGR 3
... has apparently told his neighbours in the US, that charges ... due to negligence, have been dropped. Dr Patel, dubbed Dr. ... Hospital, Queensland. ,The government of Peter Beattie, Premier ... US. According to an AAP news report, Dr. Patel has ...
... said 22 cases of Chikungunya disease were confirmed in ... the 20 villages in Kolhapur district from where an ... found 22 cases from only 12 villages, which tested ... Pune's National Institute of Virology (NIV)," said Maharashtra health ...
... confessed to aborting over 250 female fetuses, adding he has lost ... his nursing home over the last decade. ,A.K. Singh ... in Pataudi town near here and discovered the dumped fetuses from ... has confessed that he has aborted more than 250 unborn female ...
... Moved by the plight of a one-year-old child whose ... , the Delhi High Court has asked the government ... not be paid to his parents for his upbringing. ... a division bench of Justices T.S. Thakur and S.N. ...
... describes how an impaired anti-inflammatory response plays a role ... ,Published in the Journal of Immunology, the study ... bind to specific receptors on cells and set off ... ,Interleukins, interferons, tumour necrosis factors, and some growth ...
... obesity, high blood pressure, high cholesterol, and inactivity are a ... 24. , The study was conducted by ... Reilly and Jesse Morrell, at the University of New Hampshire. ... from more than 800 undergraduates enrolled in a general-education nutrition ...
Cached Medicine News:Health News:Quack of Gurgaon Confesses of Aborting 250 Female Fetuses 2Health News:Child Seeks Compensation for Medical Negligence 2Health News:Cytokine Resistance Contributes to Pathology of Type 2 Diabetes 2
(Date:9/19/2014)... 19, 2014 Larry J. Merlo , President ... will speak before the National Press Club in ... recent move to stop selling tobacco products and its leadership ... health. "Dramatic changes in our health care system ... government," Merlo has said. "CVS Health has a truly unique ...
(Date:9/19/2014)... , Sept. 19, 2014  Pressure BioSciences, ... announced it has received and approved all parts ... instruments and has begun to manufacture the new ... instrument will be ready for shipment by mid-October ... and released at a rate of about one ...
(Date:9/19/2014)... ORLANDO, Fla. , Sept. 19, 2014 ... continues to grow, with the publication of two papers ... Otolaryngology – Head and Neck Surgery ... of both objective and subjective measures of sleep disordered ... therapy for the reduction in obstructive sleep apnea severity ...
Breaking Medicine Technology:CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4
... Choices for This Common and Successful Surgery, ... the September issue of Mayo Clinic Health Letter. ... wish. Reprinting is allowed for a,fee. Mayo Clinic ... information as your editorial policies permit: Visit, http://www.HealthLetter.MayoClinic.com ...
... Clinical Lab,Products magazine features Biomoda, Inc. ... its proprietary early lung cancer screening,assay as ... the cancer diagnostic,technology. The August national magazine ... assay,s simplicity that leads to large scale ...
Cached Medicine Technology:September 2008 Mayo Clinic Health Letter Highlights Cataract Removal, Severe Headache and Dual Energy X-Ray Imaging 2September 2008 Mayo Clinic Health Letter Highlights Cataract Removal, Severe Headache and Dual Energy X-Ray Imaging 3September 2008 Mayo Clinic Health Letter Highlights Cataract Removal, Severe Headache and Dual Energy X-Ray Imaging 4Clinical Lab Products Magazine Features Biomoda 2
23 gauge thin wall irrigation. 25 gauge thin wall aspiration. Angled 30 degree shaft 8 mm from tip to bend. Irrigation tip set 0.5 mm behind aspiration tip. Dual hub construction. Polished finish. Ov...
This specially designed 23 gauge spoon-shaped cannula is connected to a balanced salt solution bottle and with a low-flow of fluid, is designed to allow a controlled cleaning of the stromal interface...
... with five legs for extra stability. Adjustable ... vertical travel 6"). 2" ball bearing swivel ... retardant upholstery, available in black vinyl as ... Features a contoured, padded, upholstered backrest, with ...
Anterior Stromal Puncture Cannula, 25 g. For treatment of recurrent corneal erosion. Overall length 24 mm. 5/box....
Medicine Products: