Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

ffects each brain region mediates has not been clearly determined. However, Lori Zeltser and Laurence Ring have now generated mice in which leptin signaling is disrupted in only the hypothalamic region of the brain and shown that leptin signals in the hypothalamus are required to prevent the development of obesity up to 8 weeks of age. After 8 weeks of age, leptin signals in regions of the brain other than the hypothalamus were able to control further development of obesity, although they could not reverse obesity established prior to 8 weeks of age. The authors suggest that these data might have implications for combating childhood obesity.

TITLE: Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

AUTHOR CONTACT:
Lori M. Zeltser
Columbia University, New York, New York, USA.
Phone: 212.851.5314; Fax: 212.851.5306; E-mail: lz146@columbia.edu.

View this article at: http://www.jci.org/articles/view/41985?key=ee928b6505cbee5baee5


METABOLIC DISEASE: A tale of tribbles 3: understanding its role in type 2 diabetes

Type 2 diabetes is characterized by insufficient secretion of the hormone insulin, which controls glucose levels in the blood, and reduced mass of insulin-secreting pancreatic beta-cells. A team of researchers, led by Rohit Kulkarni, at Harvard Medical School, Boston, has now confirmed recent data indicating that a genetic variant of the tribbles 3 (TRB3) gene is associated with increased risk of developing type 2 diabetes and determined the reasons underlying this. Specifically, the protein generated by the genetic variant was shown to impair the release of insulin from mouse and human pancreatic beta-cells in which it was expressed and to reduce the mass of pancre
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... 2014) The American Gastroenterological Association (AGA) Research ... Research Scholars. The AGA Research Scholar Awards program, ... independent and productive research careers in digestive diseases. ... an additional year allowing for three consecutive years ... junior faculty who are paving the way for ...
(Date:4/23/2014)... a country as wealthy as the United States, it may ... not have access to adequate food due to lack of ... , Recent research at the University of Illinois using data ... that the seniors who are dealing with hunger are also ... 8.35 percent of Americans over age 60 faced the threat ...
(Date:4/23/2014)... and physicians concerned about an increase in adolescents, marijuana ... a sigh of relief. According to a new study ... of data from states with and without medical marijuana ... use among adolescents. The study is published online in ... Health . , "Any time a state considers ...
(Date:4/23/2014)... the depletion of self-control, according to research published in ... for Psychological Science. , Self-control can be difficult ... on a boring textbook are hard things to do. ... Exerting self-control for a long period seems to "deplete" ... , "It is as if self-control is a limited ...
(Date:4/22/2014)... high school sport in the United States with 1 ... in the Center for Injury Research and Policy at ... describe the occurrence and distribution patterns of basketball-related injuries ... training setting among adolescents and teens. , The study, ... , examined data relating to adolescents 13-19 years of ...
Breaking Medicine News(10 mins):Health News:AGA announces 2014 Class of AGA Research Scholars 2Health News:More Americans in their golden years are going hungry 2Health News:RI Hospital physician: Legalizing medical marijuana doesn't increase use among adolescents 2Health News:ADHD drug may help preserve our self-control resources 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 3
... , ... Health GPS uses the latest technology to help women locate the closest medical ... was developed by the Breast Health & Healing Foundation, (BHH&F) www.breasthealthandhealing.com , a ... , ...
... (TSX Venture: DIV, OTC Bulletin Board: DVNTF) is increasing its focus on secure mobile healthcare, the company announced today at CTIA Wireless 2010. , ... , ... ... ...
... to better predict the effects of strokes and other ... for study of brain organization, neurologists at Washington University ... The technique, known as resting-state functional connectivity (FC), reveals ... of the brain collaborate. Previous studies have shown that ...
... ,CAMDEN Americans consume innumerable amounts of medicine, but only ... marks the 50th anniversary of oral contraception, an innovative collaboration ... the development of the 20th century. As ... comprehensive biography on Rock has its origins at Rutgers UniversityCamden. ...
... ago, findings suggest , TUESDAY, March 23 (HealthDay ... are the earliest direct evidence that our tree-dwelling ancestors ... fossil footprints preserved in volcanic ash were discovered in ... have debated whether the tracks indicate a modern human-like ...
... ... the survivors of the earthquake in Haiti. The Grand Canyon University community has donated more ... struck on January 12, 2010. , ... Phoenix, AZ (PRWEB) March 23, 2010 -- Grand Canyon University,s Compassion and ...
Cached Medicine News:Health News:IPhone App is New Tool in the Fight Against Breast Cancer 2Health News:Diversinet Expands Mobile Healthcare Focus 2Health News:Diversinet Expands Mobile Healthcare Focus 3Health News:Diversinet Expands Mobile Healthcare Focus 4Health News:Diversinet Expands Mobile Healthcare Focus 5Health News:Diversinet Expands Mobile Healthcare Focus 6Health News:Diversinet Expands Mobile Healthcare Focus 7Health News:Diversinet Expands Mobile Healthcare Focus 8Health News:Diversinet Expands Mobile Healthcare Focus 9Health News:Diversinet Expands Mobile Healthcare Focus 10Health News:Scans of brain networks may help predict injury's effects 2Health News:Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet 2Health News:Rutgers historian puts 50th anniversary of the pill into cultural medicine cabinet 3Health News:Grand Canyon University (GCU) Creates Special Relief Fund and Raises Money for Haiti Earthquake Survivors 2
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3
... China Nuvo Solar Energy, Inc. (OTCQB: CNUV) today ... Bluewater Surgical, Inc. to a western distributorship. Bluewater surgical ... medicine, trauma surgery and more to acute care hospitals ... the high priced medical device providers in the marketplace. ...
... 4, 2011 Scrip , a leading global ... philanthropic foundation, the Abbott Fund, with a 2011 ... Scrip,s seventh annual awards ceremony in London ... of the significant results achieved through a decade-long, public-private ...
Cached Medicine Technology:China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 2China Nuvo Solar Energy, Inc. Announces Third-Party Distribution Agreement With Bluewater Surgical, Inc. 3Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 2Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 3Abbott Honored With Scrip Award for Leadership in Corporate Social Responsibility 4
... Gore's EXCLUDER AAA Endoprosthesis is an ... invasive treatment option for patients with abdominal ... a durable ePTFE bifurcated graft with an ... both device flexibility and material durability. The ...
... remove a cast from an arm or leg ... are cut or burned by the cast saw ... to remove any cast with confidence. This innovative, ... and burns from the cast saw and can ...
... choice plays an important part in ... particularly where reduced capsule formation, inflammation ... considerations. GORE-TEX Suture, a nonabsorbable, ePTFE ... characteristics sought by a variety of ...
... Patch utilizes advanced fluoropolymer technology, ... penetrating suture and decrease suture ... as 88 percent. This improvement, ... multi-directional strength and low thrombogenicity, ...
Medicine Products: