Navigation Links
JCI online early table of contents: July 1, 2010
Date:7/1/2010

ffects each brain region mediates has not been clearly determined. However, Lori Zeltser and Laurence Ring have now generated mice in which leptin signaling is disrupted in only the hypothalamic region of the brain and shown that leptin signals in the hypothalamus are required to prevent the development of obesity up to 8 weeks of age. After 8 weeks of age, leptin signals in regions of the brain other than the hypothalamus were able to control further development of obesity, although they could not reverse obesity established prior to 8 weeks of age. The authors suggest that these data might have implications for combating childhood obesity.

TITLE: Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

AUTHOR CONTACT:
Lori M. Zeltser
Columbia University, New York, New York, USA.
Phone: 212.851.5314; Fax: 212.851.5306; E-mail: lz146@columbia.edu.

View this article at: http://www.jci.org/articles/view/41985?key=ee928b6505cbee5baee5


METABOLIC DISEASE: A tale of tribbles 3: understanding its role in type 2 diabetes

Type 2 diabetes is characterized by insufficient secretion of the hormone insulin, which controls glucose levels in the blood, and reduced mass of insulin-secreting pancreatic beta-cells. A team of researchers, led by Rohit Kulkarni, at Harvard Medical School, Boston, has now confirmed recent data indicating that a genetic variant of the tribbles 3 (TRB3) gene is associated with increased risk of developing type 2 diabetes and determined the reasons underlying this. Specifically, the protein generated by the genetic variant was shown to impair the release of insulin from mouse and human pancreatic beta-cells in which it was expressed and to reduce the mass of pancre
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
2. ConnectedIn Divorce Resource Offers Online Expert Website for People Considering or Going Through Divorce
3. Highlighting a Bright Spot in a Down Economy, Career Step to Re-launch Online Healthcare Training Program
4. DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs
5. AAP Offers New Online Pediatric Symptom Checker on HealthyChildren.org
6. Hospice Education Network (HEN) and the End-of-Life Nursing Education Consortium (ELNEC) announce online Geriatric Palliative Care Curriculum
7. Online Broker Lets Consumers Choose The Price of Life Insurance
8. X-ISS Launches Free Online Disaster Recovery Planning Assessment Tools for Small Businesses
9. Onlineshoes.com and Saucony Host Tweet-a-Thon for Kids' Health
10. Agilis Solutions Launches Ask Eileen! Online Q&A Column Answers Questions on Cloud, SaaS, Software Development and Outsourcing Issues and Trends
11. Natural Health Online Retailer VitaminsForLife.co.uk Expands Inventory to Meet UK Demands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... (PRWEB) April 02, 2015 The Rat Basketball ... Friday, April 3 at 11am at the Science Museum of ... will test new-school skills against the traditional tactics of the ... teams of their college compatriots as they go head to ... technique will come out on top? Will the rats’ tournament ...
(Date:4/2/2015)... 02, 2015 Aureus Medical Group ... including medical laboratory jobs, has announced that it ... Society for Clinical Laboratory Science of Mississippi and ... April 13-16, 2015 at the Shreveport Convention Center ... educational programming, new methods and shared practices, networking ...
(Date:4/2/2015)... 2015 uBiome launched the ... 2015, two years after it made history with a ... startup sparked the era of microbiome-based personalized medicine in ... provide easily accessible information about their own bodies using ... than two weeks from launch, the company has raised ...
(Date:4/2/2015)... Veale Outdoor Advertising, the Northern California ... to its name, announces its digital display in Dixon, ... Similar to the first 14-by-48 foot digital billboard ... the addition means, in total, the Network reaches over ... tourist population traveling through the San Francisco, Sonoma, Marin, ...
(Date:4/2/2015)... Atlanta-based Kanga, the first SaaS-based platform for management ... Up in Atlanta by General Assembly Atlanta. Six companies ... LOV, Ticket Alternative, and TripTap. T General Assembly presented ... 500 at their Atlanta Launch Party at Ponce City ... platform for initiating, managing and tracking last mile deliveries ...
Breaking Medicine News(10 mins):Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the American Society for Clinical Laboratory Science of Mississippi and Louisiana Bi-State Annual Meeting 2Health News:uBiome’s Dental Campaign to Give Portion of Proceeds to Charitable Dental Organization 2Health News:uBiome’s Dental Campaign to Give Portion of Proceeds to Charitable Dental Organization 3Health News:uBiome’s Dental Campaign to Give Portion of Proceeds to Charitable Dental Organization 4Health News:Veale Outdoor Advertising State of the Art Digital Billboards Reach 12 Million in SF Bay Area 2Health News:Kanga Wins Best Start Up in Atlanta 2
... to Raise funds for Latino Mental Health Training Program, ... and,for the sixth year in a row since her ... the race" for Dr. Cynthia,Lucero, the talented young psychologist ... funds for her legacy. That legacy is training --,through ...
... danger rises if the drugs are used with certain ... -- Antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs), ... the risk of gastrointestinal bleeding, and the threat is ... and similar pain medications at the same time as ...
... who gave hundreds of thousands of dollars, time and in-kind donations to ... ... America watched -- and cried,-- Sunday, Oct. 7, as Boey and her family ... did it take to build the,Byers, family dream home? The Oregon premiere ...
... Calif., Oct. 12 Omnicell, Inc.,(Nasdaq: OMCL ), a leading ... call Thursday, October 18 to discuss the,company,s third quarter financial results. ... and webcast, When: October 18, 2007, 2:30 ... and chief executive officer ...
... ... has not had an opportunity for a detailed review of ... any definitive comment on this specific study, we can say ... of,various data. This process does not necessarily demonstrate a true,cause-and- ...
... metabolism reacts differently to the sweet treat , , FRIDAY, Oct. ... you eat, your body will. That,s the message from a ... the metabolic system, attuning people to the food they prefer ... of chocolate fans reacted differently when they ate the candy, ...
Cached Medicine News:Health News:Sunday, October 14, MSPP holds Sixth Annual Lucero Memorial Run and Latino Leadership Breakfast 2Health News:Antidepressants Boost GI Bleeding Risk 2Health News:A History of Philanthropy Made Green-certified Legend Homes an Easy Choice for Extreme Makeover: Home Edition 2Health News:A History of Philanthropy Made Green-certified Legend Homes an Easy Choice for Extreme Makeover: Home Edition 3Health News:Omnicell Schedules Third Quarter Earnings Call 2Health News:Consumer Specialty Products Association Responds to European Study Investigating Spray Products and Asthma 2Health News:Chocolate Lovers May Be Hard-Wired That Way 2
(Date:4/1/2015)... and Markets ( http://www.researchandmarkets.com/research/n9mxqs/an_introduction ) has announced ... Medical Device Directives" conference to their offering. ... European medical device legislation. It will explain the Directives ... Bodies, how to choose one and outline what a ... necessary to apply for the CE mark. ...
(Date:4/1/2015)... DUBLIN , Mar. 30, 2015 Research ... announced the addition of the "Medical Device ... This course has been designed specifically ... evidence required for medical devices and in-vitro diagnostic ... devices and the emphasis on high quality, appropriate ...
(Date:4/1/2015)...  Philips Respironics, a division of Royal Philips ... Pico nasal mask is now available in ... sleep apnea (OSA). Designed to maximize comfort and effectiveness, Pico ... (CPAP) mask available on the market to treat OSA*. Philips ... be on display at Medtrade Spring (Booth #235) ...
Breaking Medicine Technology:An Introduction to the Medical Device Directives Training: London, UK - 13th, 14th, 15th of May 2015 2Medical Device Studies: Clinical Evidence Seminar - London, UK, 13th, 14th of May 2015 2Philips Pico CPAP Nasal Mask Now Available in the United States 2Philips Pico CPAP Nasal Mask Now Available in the United States 3
... 15, 2011 Reportlinker.com announces that ... available in its catalogue: ... Facial Aesthetics and Medical Laser Devices ... The combined ...
... 2011 /PRNewswire-iReach/ -- URINOZINC® Prostate Formula ... (Photo:   http://photos.prnewswire.com/prnh/20110614/CG20097 ) The original, ... all corporate-owned GNC Live Well stores and at ... has more than 6,000 stores spread over 49 ...
Cached Medicine Technology:Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 2Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 3Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 4Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 5Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 6Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 7Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 8Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 9Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 10Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 11Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 12Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 13Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 14Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 15Reportlinker Adds European Markets for Cosmetic Surgery, Facial Aesthetics and Medical Laser Devices 2011 16Patented URINOZINC® Prostate Formula Now Available at GNC Stores 2Patented URINOZINC® Prostate Formula Now Available at GNC Stores 3
The NeurOptics Pupillometer is a portable instrument used to measure pupils to screen candidates for refractive procedures and other ophthalmic applications....
... to closely match the natural anatomy ... design. Titanium construction incorporates an 8-degree ... screw design prevents screws from backing ... need for X-ray control of the ...
... First-Call Medical, Nationwide 24-Hour Holter, Event, ... a cardiac scanning laboratory located in ... finest diagnostic equipment to assist physicians ... the cardiac patient. The diagnostic services ...
... has developed a new, integrated technology ... heartbeat-by-heartbeat, ECG monitoring, analysis and response, ... service is initially focused on helping ... arrhythmia. Time is of the essence ...
Medicine Products: