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JCI online early table of contents: July 1, 2010
Date:7/1/2010

EDITOR'S PICK: Identifying preterm infants at risk of life-threatening conditions

Infants born prematurely are highly susceptible to life-threatening conditions that are clinically difficult to detect. These include late-onset septicemia, a condition in which infectious microbes are present in the blood, and necrotizing enterocolitis, a condition in which portions of the intestines die. But now, Terrence Poon and colleagues, at the The Chinese University of Hong Kong, Hong Kong, have identified in the blood biomarkers of these devastating conditions. Importantly, the biomakers discovered in the initial analysis were validated in a prospective cohort study. Although the biomarkers need to be confirmed in further multicenter trials, the authors hope that their use will help diagnose preterm infants with these devastating conditions, thereby identifying those who require urgent treatment.

TITLE: Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants

AUTHOR CONTACT:
Terence Chuen Wai Poon
Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Phone: 852.2632.1205; Fax: 852.2648.8842; E-mail: tcwpoon@cuhk.edu.hk.

View this article at: http://www.jci.org/articles/view/40196?key=d4a5eb4e565373716d96


METABOLIC DISEASE: Childhood obesity: possible new insight from mice

Given the current 'epidemic' of obesity and its related diseases (including type 2 diabetes and heart disease), understanding how food intake, body composition, and energy expenditure are regulated has become a research priority. One soluble molecule found to regulate all these processes, and more, is leptin. Leptin causes many of its effects by acting on nerve cells in different regions of the brain, but exactly what e
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Contact: Karen Honey
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Journal of Clinical Investigation
Source:Eurekalert

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