Navigation Links
Investigational agent targets gene signaling pathways to improve response for patients with CLL
Date:12/8/2012

ls and communications pathways in cancer, we are improving our ability to effectively treat the disease while avoiding the toxicities of chemotherapy and potential relapse," said John C. Byrd, MD, lead author and Director of the Division of Hematology at The Ohio State University Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute in Columbus. "If we can replicate these high survival rates and good tolerability with ibrutinib through larger scale Phase III studies, we may find it to be an extremely valuable new therapy for not just elderly, but for all CLL patients."

Dr. Byrd will present this study in an oral presentation on Sunday, December 9, at 5:00 p.m. EST at the Georgia World Congress Center in Thomas Murphy Ballroom 4, Level 5, Building B.

The BTK Inhibitor Ibrutinib (PCI-32765) in Combination with Rituximab is Well−Tolerated and Displays Profound Activity in High-Risk Chronic Lymphocytic Leukemia (CLL) Patients [Abstract 187]

The combination of the novel investigational agent ibrutinib with an established therapeutic antibody, rituximab, may present a safer and more effective option than the current standard chemotherapy-based treatment regimen for patients with high-risk CLL.

While current chemotherapy-based treatment options for CLL patients are effective, they come with toxic side effects that are challenging for elderly patients. Physicians have long awaited new options that offer better tolerability. Ibrutinib is designed to selectively target leukemia cell growth, with the aim of effectively treating the disease without the toxicities of chemotherapy. Data from earlier studies of ibrutinib have shown it to be equally effective in both low- and high-risk CLL.

High-risk CLL patients typically have unfavorable responses to standard CLL therapies and a dismal outcome. S
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
2. Rilpivirine for HIV: Added benefit for single agent proven
3. Travel Services (MyTSOnline) in Valencia Teams Up With Vendors to Become the Number One Travel Agent in the Santa Clarita Valley
4. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
5. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
6. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
7. New substances 15,000 times more effective in destroying chemical warfare agents
8. Difficult to diagnose cases of infectious endocarditis solved with SPECT/CT imaging agent
9. Imaging agents predict breast cancer response to endocrine therapy
10. Pig stomach mucins are effective as anti-viral agents for consumer products
11. Method developed by VTT targets diagnosis of early Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 22, 2015 Pro3rd Impression ... exclusively for Final Cut Pro X. Pro3rd Impression's clean ... , Intuitive on-screen-controls allow users to customize scale, ... colors, layouts, and much more can be edited using ... Pro3rd Impression comes packed with 30 simplistically ...
(Date:5/21/2015)... York, New York (PRWEB) May 21, 2015 ... distributor of patented products, launches the Troll Motor Guide, ... convenient way of boating. , "The recreational boating industry ... Scott J. Cooper, CEO and Creative Director of ... water in record numbers and predicts continued steady growth ...
(Date:5/21/2015)... WellCare Health Plans, Inc. (NYSE: WCG) announced ... the Florida Healthy Kids Corporation (FHKC) to continue to provide ... part of the Florida Healthy Kids (FHK) program. Pending execution, ... may be extended for two additional years at FHKC’s discretion. ... the FHK program who live in Regions 1, 2, 3, ...
(Date:5/21/2015)... Baltimore, Md. (PRWEB) May 21, 2015 ... and the University of Maryland, Baltimore Commercial Advisory Board ... (VA) Maryland Health Care System as one of two ... for their ankle robot research, known as Anklebot. ... of Excellence, in collaboration with the University of Maryland ...
(Date:5/21/2015)... ChiliPad is a temperature-regulated ... side of the bed so that users sleep comfortably ... of the bed can pick their ideal sleep temperature ... faster and stay asleep longer. , Unlike other products, ... the temperature which produces a more concentrated temperature than ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release Pro3rd Impression for Final Cut Pro X. 2Health News:Great Ways To Celebrate On Memorial Day Weekend- Starting With World Patent Marketing's New Boat Patent 2Health News:Great Ways To Celebrate On Memorial Day Weekend- Starting With World Patent Marketing's New Boat Patent 3Health News:WellCare Selected to Continue Participating in the Florida Healthy Kids Program, Will Serve Nine Florida Regions Under the New Contract 2Health News:VA Maryland Health Care System Researchers Selected for Abell Foundation Innovation Award 2Health News:VA Maryland Health Care System Researchers Selected for Abell Foundation Innovation Award 3Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 2Health News:ChiliPad, a Dual-Zone Temperature-Controlled Mattress Pad, Promotes Better Sleep, Health Benefits, and Saves on Cooling Costs in Upcoming Hot Summer Weather 3
... ... Ken Meares, the Founder and CEO of Great HealthWorks, was recently ... of Broward County,s 2010 Heart Ball - Heart Society. Mr. Meares, company, ... kind, all-natural products, including Omega XL®, which gives consumers the freedom to ...
... - Following strong quarterly results, SXC increases guidance for fiscal, ... SXC Health Solutions Corp. ("SXC" or the "Company") (NASDAQ: SXCI, TSX: ... ended September 30, 2009. Financial references are in U.S. dollars unless ... ------------------, - Revenue was ...
... A national survey of recent hospital patients commissioned by TransUnion ... greater transparency in their hospital bill while only three in ... for charity care programs. , The results of ... of a new healthcare patient payment estimator at the HFMA ...
... ... will donate $3.00 for every diabetes story published on GlucoStories.com , ... Pompano Beach, Fla. (PRWEB) November 5, ... diabetes stories , and announced they will donate $3.00 for every story published ...
... November 11th (11/11) ... Worldwide 11/11 Meditation for the Divine Feminine on November 11 at 11:11pm EST. On ... works for everyone. , ... (PRWEB) November 6, 2009 -- November 11th (11/11) is a portal, a gateway, and a potent ...
... ... HMSA HI-IQ EHR Adoption and Reimbursement Program Helps Fund Ali2i,s Implementation , ... Dallas and ... a leading developer of electronic health record (EHR) and practice management (PM) systems ...
Cached Medicine News:Health News:Great HealthWorks CEO Ken Meares Named To Executive Cabinet Of American Heart Association - Broward County's 2010 Heart Ball Heart Society 2Health News:Great HealthWorks CEO Ken Meares Named To Executive Cabinet Of American Heart Association - Broward County's 2010 Heart Ball Heart Society 3Health News:SXC Health solutions announces record third quarter financial results 2Health News:SXC Health solutions announces record third quarter financial results 3Health News:SXC Health solutions announces record third quarter financial results 4Health News:SXC Health solutions announces record third quarter financial results 5Health News:SXC Health solutions announces record third quarter financial results 6Health News:SXC Health solutions announces record third quarter financial results 7Health News:SXC Health solutions announces record third quarter financial results 8Health News:SXC Health solutions announces record third quarter financial results 9Health News:SXC Health solutions announces record third quarter financial results 10Health News:SXC Health solutions announces record third quarter financial results 11Health News:SXC Health solutions announces record third quarter financial results 12Health News:SXC Health solutions announces record third quarter financial results 13Health News:SXC Health solutions announces record third quarter financial results 14Health News:SXC Health solutions announces record third quarter financial results 15Health News:SXC Health solutions announces record third quarter financial results 16Health News:SXC Health solutions announces record third quarter financial results 17Health News:SXC Health solutions announces record third quarter financial results 18Health News:SXC Health solutions announces record third quarter financial results 19Health News:SXC Health solutions announces record third quarter financial results 20Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 2Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 3Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 4Health News:GlucoStories Donation Campaign Aims to Raise Diabetes Awareness and Money for Diabetes Causes 2Health News:November 11 at 11:11 Join a Worldwide Meditation for the Divine Feminine and Envision a World that Works for All 2Health News:Ali′i Health Chooses Aprima Medical Software EHR/PM Solution from Local Reseller, Blue Cliff 2Health News:Ali′i Health Chooses Aprima Medical Software EHR/PM Solution from Local Reseller, Blue Cliff 3Health News:Ali′i Health Chooses Aprima Medical Software EHR/PM Solution from Local Reseller, Blue Cliff 4
(Date:5/21/2015)... May 21, 2015 Research and Markets ... of the "Global Next Generation Sequencing Market ... The global next generation sequencing market to grow ... 2014-2019 This report covers the present ... next generation sequencing market for the period 2015-2019. ...
(Date:5/21/2015)... Fla. , May 21, 2015 Bankers Healthcare ... is publishing a new blog series from medical writer ... The series will analyze the decision making process, ... and provide insight as to how healthcare practitioners can make ... the series was published May 7, 2015: " Being More ...
(Date:5/21/2015)... Research and Markets( http://www.researchandmarkets.com/research/pw67sw/xray_market ) has announced the addition of ... Trends and Forecast 2014 - 2022" report to their ... the largest share of 34.6% of the global X-ray market ... and Europe . North America ... Canada that have a large number ...
Breaking Medicine Technology:Global Next Generation Sequencing Market 2015-2019 2Medical Writer Dr. Pat Bass Publishes A New Series On The Bankers Healthcare Group BHG360 Blog 2Medical Writer Dr. Pat Bass Publishes A New Series On The Bankers Healthcare Group BHG360 Blog 3X-Ray Market: Global Industry Analysis 2014 - 2022 2
... Texas, Nov. 1, 2011 Vermillion, Inc. (NASDAQ: ... Group to lead a new investor relations and financial communications ... approved OVA1® blood test and the recent positive results from ... made solid progress since the beginning of the year," said ...
... FRANCISCO, Nov. 1, 2011 Allscripts ... & Toland Physicians , one of the largest independent physician ... powered by dbMotion to deliver end-to-end information ... (Logo: http://photos.prnewswire.com/prnh/20100901/CG58147LOGO ) ...
Cached Medicine Technology:Vermillion Engages Liolios Group to Lead Investor Relations Program 2Vermillion Engages Liolios Group to Lead Investor Relations Program 3Brown & Toland Physicians Selects Allscripts Community Record to Connect 1,500 Bay Area Physicians 2Brown & Toland Physicians Selects Allscripts Community Record to Connect 1,500 Bay Area Physicians 3Brown & Toland Physicians Selects Allscripts Community Record to Connect 1,500 Bay Area Physicians 4Brown & Toland Physicians Selects Allscripts Community Record to Connect 1,500 Bay Area Physicians 5
CRP Liquid Conrtols level 3...
Therapeutic Drug Calibrator Series...
The IRN method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of iron in serum....
The AST method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of aspartate aminotransferase activity in serum or plasma...
Medicine Products: