Navigation Links
Investigational agent targets gene signaling pathways to improve response for patients with CLL
Date:12/8/2012

(ATLANTA, December 8, 2012) The promising investigational targeted therapy ibrutinib and its mechanism of silencing gene communication pathways critical to the development of cancer may be an effective way to combat chronic lymphocytic leukemia (CLL), according to studies presented today at the 54th Annual Meeting of the American Society of Hematology (ASH).

CLL is a blood cancer that causes abnormal white blood cells called lymphocytes to accumulate in the blood, bone marrow, and in the lymph nodes or other organs, causing these organs to enlarge. Approximately 15,000 Americans are diagnosed with CLL every year; nearly 70 percent of those affected are 65 and older. , For some patients with slower growing disease, physicians employ "watch and wait" strategies to minimize unnecessary treatment. However, patients with high-risk features such as rapidly progressing disease require prompt treatment to manage symptoms and reduce organ damage.

Ibrutinib is a specialized anti-cancer therapy that targets the Bruton's tyrosine kinase (BTK, an enzyme important in the development of CLL). As an inhibitor of BTK, ibrutinib selectively targets leukemia cells, promoting their death and preventing them from growing while leaving normal cells unharmed. Studies suggest this design allows the drug to more effectively treat the disease, with encouraging early results in harder-to-treat patient groups such as elderly untreated patients and those whose disease has become resistant to other therapies or those who have experienced disease recurrence after receiving other therapies. Two studies will present efficacy and safety results testing the compound alone and in combination with other currently used therapies for CLL.

"The evidence collected to date on ibrutinib demonstrates that it may have the potential to improve long-term prognosis for patients who are not sensitive to standard treatment," said Claire E. Dearden, MD, moderator of the press conf
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
2. Rilpivirine for HIV: Added benefit for single agent proven
3. Travel Services (MyTSOnline) in Valencia Teams Up With Vendors to Become the Number One Travel Agent in the Santa Clarita Valley
4. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
5. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
6. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
7. New substances 15,000 times more effective in destroying chemical warfare agents
8. Difficult to diagnose cases of infectious endocarditis solved with SPECT/CT imaging agent
9. Imaging agents predict breast cancer response to endocrine therapy
10. Pig stomach mucins are effective as anti-viral agents for consumer products
11. Method developed by VTT targets diagnosis of early Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
(Date:12/22/2014)... 2014 7,178 small business owners and ... Friday shopping and opted instead to join Digital Marketer, ... for their 5th annual “Black Friday Boot Camp”. ... to attend the 5 hour online training event and ... to support two Central Texas based charities dedicated to ...
(Date:12/22/2014)... December 22, 2014 NAPW ... Professional Woman of the Year. Ms. Foley is recognized ... the largest, most-recognized networking organization of professional women in ... National Association of Professional Women is a powerfully vibrant ... Local Chapters. , “As a nurse, I felt like ...
(Date:12/22/2014)... Washington, DC (PRWEB) December 22, 2014 ... Nursing Leadership Conference, next month in San ... strategies to address dynamics that often stand in ... authority, and competition. , This premier faculty ... Center for Transformational Leadership, whose mission is to ...
(Date:12/21/2014)... an outstanding online supplier of wedding dresses and women’s ... of Cocktail Dresses for the winter 2014. All these ... trends. , “We take pride in releasing ... of them are offered at greatly discounted rates, up ... to offer a nice shopping experience for global customers.” ...
Breaking Medicine News(10 mins):Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:National Association of Professional Women Announces Michelle M. Foley, Vice President of Operations of OTTR Chronic Care Solutions, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:Stunning Cocktail Party Dresses from Weddingshe.com 2
... , MONDAY, Feb. 27 (HealthDay News) -- Rapid diagnostic ... flu season could lead to earlier treatment for patients and ... suggest. The 2012 flu season is just beginning and, ... 5 million people worldwide, experts say. Most patients will recover, ...
... news digest: , Summary of a study being ... Clinical Oncology , showing that women who underwent a once-common ... slightly lower on cognitive tests that measure word learning, memory ... cancer. While CMF is no longer the standard ...
... MONDAY, Feb. 27 (HealthDay News) -- If a luxurious-looking car ... That,s the message of a new observational study that contends ... cut off pedestrians and ignore stop-sign etiquette. The new ... experiments done by the researchers found that study participants ...
... By Jenifer Goodwin HealthDay Reporter , SUNDAY, Feb. ... cells from adult human ovaries that can mature into eggs ... which upend longstanding scientific theory, could potentially lead to ... woman,s fertility. It was long believed that women were ...
... -- A second company has issued a voluntary recall of ... lead to incorrect dosing and expose women to unintended pregnancies. ... control pill packets, sold as Norgestimate and Ethinyl Estradiol, do ... these oral contraceptives should immediately switch to another form of ...
... TAK-875, a new treatment for type 2 diabetes, improves blood ... a significantly lower risk of creating a dangerous drop in ... The results of the phase 2 randomized trial were published ... 2 diabetes is the most common form of diabetes accounting ...
Cached Medicine News:Health News:Rapid Flu Tests a Good First Step: Study 2Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 2Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 3Health News:First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen 4Health News:Are the Rich Really Different From You and Me? 2Health News:Are the Rich Really Different From You and Me? 3Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 2Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 3Health News:Another Batch of Birth Control Pills Recalled for Faulty Packaging 2Health News:Another Batch of Birth Control Pills Recalled for Faulty Packaging 3Health News:Diabetes drug gets patients with Type 2 diabetes on target 2
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah Associates ... providing a summary of the 2015 marketplace exchange ... trends.  According to a recent ... and Evaluation, Department of Health and Human Services) ... in individual medical plans through the Marketplace as ...
(Date:12/22/2014)... 22, 2014 TWi Biotechnology, Inc., today ... for AC-201, TWi Biotechnology,s lead drug candidate, from ... China for patent application numbered 201180018154.8.  ... salts, active metabolite for treatment of type II ... treatment using AC-201 for type II diabetes, and ...
(Date:12/19/2014)... 19, 2014 You,re visiting the dentist for ... when he or she says you need a root ... you may have several questions and feel apprehensive about ... know it,s nothing to worry about. The Pennsylvania Dental ... alleviate any anxiety the public may have surrounding this ...
Breaking Medicine Technology:Insights into the Marketplace and Individual Market Growth 2TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 2TWi Biotechnology Receives Notice of Patent Allowance for Its Lead Drug Candidate AC-201 for the Indication of Type II Diabetes in China 3Root Canals Have Become More Routine 2
... 22, 2011  PTC Therapeutics, Inc. (PTC) today announced ... Discovery (SDD) Award from the Wellcome Trust to ... life-threatening infections caused by multidrug-resistant (MDR) Gram-negative bacteria. ... from the Wellcome Trust to support its BMI1 ...
... (NASDAQ: HSKA ), a provider of ... announced that Robert Grieve, Heska,s Chairman and CEO, will present ... at 3:20 p.m. ET on Monday, January 9, 2012 in ... Hotel.  Heska management will be available during the day for ...
Cached Medicine Technology:PTC Therapeutics' Antibacterial Program Receives $5 Million Award from the Wellcome Trust 2Heska to Present at the Sidoti & Company, LLC Semi-Annual New York Micro-Cap Conference 2
... The FR-120F, Fujinon's new fiberoptic Naso-Pharyngo-Laryngoscope ... and patient comfort. The latest in ... an increased light guide, and a wide ... very impressive 3.3mm distal tip diameter. ...
... Tip Laryngoscopes are the most ... The articulating tip aids during ... improved view of epiglottis. Available ... styles. We guarantee your complete ...
German Style MacIntosh Fiber Optic Blade Laryngoscopes...
CCR Medical fiberoptic green system laryngoscope handles., ,OUTSTANDING PERFORMANCE, QUALITY, AND PRICING MAKE OUR FIBEROPTIC SELECTION MOST ECONOMICAL....
Medicine Products: