Navigation Links
Injectable Vaccines More Effective for Adult Flu Than Nasal Sprays
Date:9/23/2009

Results may be different in children and in H1N1 swine flu vaccines, researchers say

WEDNESDAY, Sept. 23 (HealthDay News) -- If you have the choice between a seasonal flu vaccine that comes in a nasal spray or an injection, go for the injection, new research shows.

In a study of adults tracked over one flu season, vaccines made from inactivated, or "killed," flu virus -- the injectable form -- provided better protection against the seasonal flu than vaccines made from live attenuated virus, the type of vaccine available in a nasal spray.

"The nasal spray vaccine is effective but isn't as effective as the injected vaccine," said lead study author Arnold S. Monto, an epidemiology professor at the University of Michigan School of Public Health. "But it's better to get some vaccine than no vaccine, so if you're averse to getting an injection, get the nasal spray."

The researchers stressed that their findings, published in the Sept. 24 issue of the New England Journal of Medicine, applied to seasonal flu vaccine efficacy in adults only. The same may not hold true for children, who may respond just as well to a nasal spray vaccine, or for the H1N1 swine flu vaccines that are on the way.

Researchers gave 1,952 adults aged 18 to 49 either an injected flu vaccine, a placebo injection, a flu vaccine nasal spray or a placebo nasal spray during the 2007-2008 flu season. That season, vaccines were well-matched to the predominant flu in circulation, according to the study.

Participants were reminded each week to come in for an exam and lab tests if they showed signs of respiratory illness. About 6.1 percent of participants, 119 in all, got the flu, mostly influenza A/H3N2.

Among those who got sick, participants who'd received the injected flu vaccine were 68 percent less likely to have the flu compared to those who'd received a placebo, according to the study. The flu virus was confirmed using lab tests.

Participants who'd received the nasal spray vaccine were 36 percent less likely to get the flu than those who'd received a placebo.

The injection was 50 percent better in preventing the flu than the nasal spray, according to the study.

Though researchers did not test vaccines in children, nasal sprays may work just as well in children as injections, Monto said.

There are two different types of vaccines, usually referred to as live attenuated, which contain very weakened or modified live virus, and inactivated, which contain bits of dead virus.

Live attenuated influenza vaccine, which comes in nasal sprays, must replicate in the body in order to provoke the immune system to produce antibodies against the virus. In adults who may already have some immunity against that or other flu strains, the live attenuated virus may not be strong enough to cause that response, Monto said.

Children are more likely to lack antibodies to the virus. Without any natural immunity, the nasal spray may be equally effective, Monto said.

Live attenuated vaccines "must infect in order to protect," Monto said. "Adults, unlike children, have antibodies to the virus included in the vaccine. They are not infected by it and therefore are not protected. This would explain why the LAIV [live attenuated influenza vaccine] is highly effective in younger children."

In some cases, the live attenuated influenza vaccine may even provide enhanced protection, said Dr. Kenneth Bromberg, director of the Vaccine Research Center at the Brooklyn Hospital Center in New York City.

In addition to immunity involving antibodies, live attenuated vaccines can also provide cell-mediated immunity, an added type of immune response that can boost effectiveness.

"They are different approaches, and in the case of a well-matched strain, the inactivated vaccine worked better than the live attenuated," Bromberg said. "There could be situations, such as with a mismatched strain, in which the live attenuated could perform just as well, or perhaps even better, than the injected."

And what about for H1N1 swine flu vaccines?

With the swine flu, vaccines made with live attenuated virus may work just as well as injected vaccines because children and most adults have no antibodies or natural immunity to the new strain, Monto noted.

"We are totally susceptible," he said. "That's why we are having these school outbreaks with high attack rates."

More information

The U.S. Centers for Disease Control and Prevention has more on seasonal flu.



SOURCES: Arnold S. Monto, M.D., professor, epidemiology, University of Michigan School of Public Health, Ann Arbor; Kenneth Bromberg, M.D., director, Vaccine Research Center, The Brooklyn Hospital Center, New York City; Sept. 24, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
2. Injectable Antibiotic Protects Against Lyme Disease in Mice
3. Clarity on Cosmetic Injectable Labeling and Use
4. Dr. Arnold Klein Warns of Dangers With Permanent and Longer Lasting Injectable Fillers
5. New Survey Suggests That Consumers Are Naive to the Risk of Botox Parties and the Importance of FDA Approval for Cosmetic Injectables
6. New Injectable Collagen Filler Offers Natural Results
7. Prism Pharmaceuticals Study of Injectable Clopidogrel Accepted for Presentation at the American College of Cardiology
8. Study finds injectable birth control causes significant weight gain and changes in body mass
9. The Texas Institute of Dermatology Team Finds Easy-to-Apply, Topical Drug Just as Good as Injectable Compound for a Disfigurating Skin Infection
10. Video: Injectable-Grade Filler, Now Without the Injections
11. Physicians Coalition for Injectable Safety Says There are No Substitutes for Cosmetic Injections, Offers Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Injectable Vaccines More Effective for Adult Flu Than Nasal Sprays
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
Breaking Medicine Technology: