Navigation Links
Induced Pluripotent Stem Cells Combo Could Yield Much-needed Models to Study Vascular Disease
Date:6/19/2017

A study recently published in STEM CELLS Translational Medicine shows smooth muscle and vascular endothelial cells induced from pluripotent stem cells perform similarly to their naturally evolving counterparts under conditions that mimic hardening of the arteries and other blood vessel diseases. The finding opens the door to modeling rare vascular diseases necessary for research, as well as assists in screening new drugs and developing personalized cell-based therapies.

Researchers have difficulty studying vascular diseases – those affecting the blood vessels – because of a scarcity of human tissue samples and difficulty in accurately modeling the disease of interest. The potential toxic effects when testing a new drug is another reason why a substitute for real blood vessels is desperately needed.

Recent advances in stem cell biology, however, are beginning to change things. Induced pluripotent stem cells (iPSCs), which can differentiate into various adult human cell types, allow scientists to grow human tissue in the lab for research. Additionally, iPSC lines produced from patients with genetic diseases offer the ability to investigate specific genetic alterations of interest and their effect in disease onset and progression.

Research has already shown that vascular endothelial cells (iECs) and smooth muscle cells (iSMCs) can be created from human iPSCs. (Endothelial cells form the interior lining of a blood vessel while smooth muscle cells reside within the wall of the blood vessel.) However, because these cells are not derived from an intact blood vessel, they represent what is known as “an immature phenotype,” which means they don’t have all the properties of their naturally formed – or “primary” – counterparts.

The STEM CELLS Translational Medicine study, conducted by researchers from HemoShear Therapeutics, Charlottesville, Va., and the University of Cambridge, was designed to learn whether a “co-culture” of iECs grown on one side of a porous membrane and iSMCs on the other side exposed to blood flow as seen in the healthy and diseased blood vessel would come close to mimicking how primary vascular cells function.

“While many studies demonstrate the utility of iECs and iSMCs for vascular applications, none to date have provided a direct comparison of primary to iPSC-derived EC and SMCs,” said Brian R. Wamhoff, Ph.D., co-founder of HemoShear and a principal investigator in the study. “We did this by simulating normal blood flow through both the co-culture of iPSC-derived cells or primary cells and then again by simulating blood flow through them under advanced inflammatory conditions, such as hardening of the arteries and exposure to drug treatments.”

“While we found that the iPSC-derived cells didn’t perform quite as well as the primary cells under normal blood flow conditions, when it came to advanced inflammatory and drug-related conditions, the iPSCs performed very well,” Dr. Wamhoff said. “Thus, we believe this co-culture may have promise for modeling atherosclerosis or other diseases where no primary cells exist or are challenging to procure.”

“Toxicity of drugs to the blood vessels is a major impediment to the development of new therapies,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. “This research may result in a viable system for modeling rare vascular diseases and testing new therapeutic approaches.”

###

The full article, “Exposure of iPSC-derived vascular endothelial and smooth muscle cells in co-culture to hemodynamics induces primary vascular cell-like phenotypes,” can be accessed at: http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 35th year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 22nd year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2017/06/prweb14431837.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related medicine news :

1. Imaging shows long-term impact of blast-induced brain injuries in veterans
2. Global Stem Cells Market (Adult, Human Embryonic , Induced Pluripotent, Rat-Neural etc)- Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018
3. Testosterone-regulated genes may affect vaccine-induced immunity
4. Obesity-induced fatty liver disease reversed in mice
5. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
6. The Pael-R gene does not mediate the changes in rotenone-induced PD model cells
7. New research sets stage for noninvasive monitoring of HIV-induced peripheral neuropathy
8. Ultraviolet light-induced mutation drives many skin cancers, Stanford researchers find
9. Genetics reveals patients susceptible to drug-induced pancreatitis
10. Flakka Induced Mother Abandons Baby, found by Florida Drug Treatment Center; New Video Released
11. Diet Doc Acknowledges Men’s Health Week By Targeting Weight-Induced Heart Disease and Heart Attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... ... June 25, 2017 , ... CareSet Labs released the Root NPI Graph today ... a new, greatly improved version of the Doctor Referral teaming dataset commonly available from ... and subsequently called the the “Doctor Referral Dataset” as released by Medicare and “DocGraph” ...
(Date:6/24/2017)... ... June 24, 2017 , ... The Pennsylvania Athletic ... Erie Bayfront and Erie Convention Center on June 8-10. The weekend consisted ... quiz bowl, award and scholarship presentations, and professional networking. , On Friday ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Rhode Island ... Care Management Alerts and Dashboards, an innovative new service enabling healthcare providers to ... Care Management Alerts and Dashboards provide near real-time data about patients admitted to ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids ... risk of visual loss in these patients. , But how often do ophthalmologists and ... cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... 2017 , ... Everybody has their own personal preference when it comes to ... some people don't like it at all. FindaTopDoc took a look at what makes ... can give readers a taste of their deepest, darkest fantasies and has the ability ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 More ... a further effort to help spread lessons learned from ... the International Diabetes Federation (IDF) and Eli Lilly and ... for the second phase of the Bringing Research in ... reaffirming their commitment to helping people with diabetes effectively ...
(Date:6/8/2017)... 2017   Responding to Heath Ledger,s father,s ... of singer Chris Cornell in May, the mental ... a free online psychiatric drug side effects ... about psychotropic drug risks. The father of ... an accidental overdose, has called for tighter rules on prescription ...
(Date:6/7/2017)... , June 7, 2017 Endo International plc ... 7, 2017, the Hon. Joseph R. Goodwin , ... West Virginia , entered a case ... Pelvic Repair System Products Liability Litigation (the "MDL") that ... cases to provide expert disclosures on specific causation within ...
Breaking Medicine Technology: