Navigation Links
Indication of considerable added benefit of vemurafenib in advanced melanoma
Date:1/8/2013

erences between the treatment groups - and hence also no indication of an added benefit of vemurafenib. As regards the quality of life (including physical and emotional well-being), there were no differences, so here, too, an added benefit is not proven.

Major potential harm in the form of side effects

Overall, the side effect profile of vemurafenib is less favourable than that of dacarbazine, because severe adverse events (according to the Common Terminology Criteria for Adverse Events (CTCAE) Grade ≥ 3) and serious adverse events were more frequent in patients who received vemurafenib. The proportion of those who discontinued the treatment due to side effects was comparable in the treatment groups. All in all, IQWiG sees an indication of greater harm from vemurafenib and rates its extent as "major".

Potential for harm reduces the extent of the added benefit

In order to derive proof of benefit from a single study, it must meet special requirements. This particular study does not fulfil them. Therefore no conclusions with the highest probability (proof) are possible - for example, on added benefit; at most indications can be derived from the study.

In summary, there are positive and negative results of the same degree of certainty (indications). On the positive side, the greatest extent - namely "major" - is attained for overall survival. On the negative side, due to side effects, there is an indication of greater harm, and this is also of major extent. For this reason, the Institute downgrades the overall added benefit of vemurafenib relative to the appropriate comparator therapy with dacarbazine from "major" to "considerable".

G-BA decides on the extent of added benefit

The dossier assessment is part of the overall procedure for early benefit assessment conducted by the G-BA. After publication of the manufacturer's dossier and its assessment by IQWiG, the G-BA initiates a
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antibody-coated stents: Indication of disadvantages
2. Abiraterone: Indication of considerable added benefit in certain patients
3. Considerable added benefit of ipilimumab in advanced melanoma
4. Marketing Xocolate International Corporation (MXI-Corp) Introduces Xe Healthy Energy Drink, A Rich And Delicious Antioxidant Beverage, Now Added to Xoçai™ Product Line
5. Capsiplex Plus Reviews for Improved Weight Loss Supplement Added to BestAppetiteSuppressantPills.com
6. UV-Aid Cold and Flu Prevention Added to List of Biomimicry Strategies on AskNature.Org
7. Healthy Chocolate Omega Squares, a Decedent Dark Chocolate Added to Marketing Xocolate International Corporation (MXI Corp) Product Lines
8. Rilpivirine for HIV: Added benefit for single agent proven
9. US Drug Watchdog Has Added Wright, Stryker, Biomet, and Zimmer To Their Initiative For All Metal Hip Implant Failures Victims & Offers Them The Names Of The Best Lawyers
10. CFO 911 Solutions' Charles K. Dargan II, CEO, and Reid Dabney, Managing Director Have Been Added to the Financial Entrepreneur Platform ("FEP") of Merriman Capital, Inc., a Wholly Owned Subsidiary of Merriman Holdings, Inc. (OTCQX: MERR)
11. Vandetanib in thyroid cancer: No proof of added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... York, New York (PRWEB) April 19, 2015 ... Panel on Multidistrict Litigation (JPML) indicate that Lipitor lawsuits ... litigation underway in U.S. District Court, District of South ... 2,185 new cases have been filed in the proceeding ... diabetes due to their use of the cholesterol-lowering statin. ...
(Date:4/19/2015)... 19, 2015 Family and friends of Brad ... in Memory of Brad Baddeley event to honor his ... , Bowling for Brains is cheduled to take place on ... Street in Lincoln, Nebraska. Participants may arrive at 12:30pm on ... , The cost is only $4 per game and 100% ...
(Date:4/18/2015)... 2015 Carinsurancequotesinfo.com has released a new ... physical injuries caused by a car accident. ... for a vehicle. A policy can pay for car ... Drivers should always carry appropriate coverage when they are ... be bought with several important riders that offer extra ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Review of ... hosting a ‘Strategies for Success’ program for cataract surgeons ... meeting in San Diego, where eye surgeon Jeffrey L. ... this invitation-only event. Dr. Martin is the Managing Partner ... of Ophthalmology chose Dr. Martin to lead this year’s ...
(Date:4/18/2015)... York, New York (PRWEB) April 18, 2015 ... ) filed on behalf of individuals who were ... replacement system continue to move forward in the U.S. ... Order dated April 10th, the Court has amended an ... of unrelated cases. Among other things, the new amendment ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 2Health News:Lipitor Lawsuits Mount, as New Court Report Shows More Than 100 Filings Added to Federal Litigation Since March 3Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 2Health News:Lincoln, NE’s Bowling for Brains to benefit Renowned Brain Aneurysm Foundation 3Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3
... chiefs have said “negative” to allegations that a perceived problem ... will upset the immunization// schedule of thousands of babies and ... of the Health IT initiative by the Government, to track ... problem, it is estimated that nearly 3,000 children would find ...
... to be believed neural transplants could be used to ... for a number of people came from a group ... provide improvement and a period of stability in Huntington's ... bad thing to happen to anyone. It is a ...
... scientists are of the opinion that women are in a ... that was conducted using rodents they found that female rodents ... shed light on health differences between males and females. ... 120 rats and measured in them what is known as ...
... to disclose the results of study findings with participants ... published in the April 1, 2006 issue of CANCER,// ... that such disclosures may actually do more harm than ... ,Maurie Markman, M.D., of the University of ...
... Claudia Twiby, eighteen months old was kept alive with a Berlin ... ,Four weeks later she received a new donated heart ... Lansdale, 32, and Shaun Twiby, 42. ,Claudia was only ... at London's Great Ormond Street Hospital, which first carried out the ...
... European regulators have not given the green signal to a ... . This is a step retrograde to a budding industry ... animals , ,GTC Biotherapeutics, proponents of this drug, ... the verdict came about only on the basis of a ...
Cached Medicine News:Health News:Men Are Less Capable Of Handling Stress Than Women – New Stud 2Health News:Regulators Object Drug Produced from Genetically Engineered Farm Animals 2
(Date:4/17/2015)... , Apr. 16, 2015 Research and Markets ... the "Corporate Reputation of Pharma in 2014 - ... Edition" report to their offering. For ... opinions on the corporate reputation of the pharmaceutical industry ... health with the views of patient organisations representing all ...
(Date:4/17/2015)... TAIPEI , April 17, 2015 TWi ... fully-owned subsidiary, TWi Pharmaceuticals USA , ... in the United States.  It has been in close ... wholesalers and expects to have its own label specialty ... soon in the U.S. pharma market. According ...
(Date:4/16/2015)... A drug commonly taken to prevent seizures in epilepsy may ... according to a study released today that will be presented ... Washington, DC , April 18 to 25, ... experience at some point in their life a condition called ... the eye to the brain gets inflamed," said study author ...
Breaking Medicine Technology:Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Epilepsy Drug May Preserve Eyesight for People with MS 2
... catheter is made of two probes which ... of sensor distance., ,VersaFlex disposable catheters ... ,Alpine's VersaFlex catheters are the smallest diameter ... and are the perfect combination of flexibility ...
... Slimline single-use pH catheters are ... cross-contamination and allow greater patient comfort ... ,Medtronic pH measurement systems have been ... that allow an accurate room-temperature calibration. ...
FLEXILOG spare part....
Complete calibration kits are available for both pH and manometry systems....
Medicine Products: