Navigation Links
Indication of considerable added benefit of vemurafenib in advanced melanoma
Date:1/8/2013

The drug vemurafenib (trade name Zelboraf) has been approved since February 2012 for the treatment of advanced melanoma (cancer of the skin cells that produce the dark pigment, melanin). It can be an option for adults whose melanoma cannot be removed by surgery or has formed secondaries (metastases) and in whose cancer a change (mutation) has occurred in a certain gene (BRAF-V600). The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG). According to the findings, major advantages in terms of overall survival are accompanied by major potential harm in the form of side effects. Overall, there is an indication that vemurafenib offers considerable added benefit.

Vemurafenib in comparison with dacarbazine

The Federal Joint Committee (G-BA) has specified the drug dacarbazine as the appropriate comparator therapy. One study that compared vemurafenib directly with dacarbazine was available for the benefit assessment. This is a randomized and open-label study, i.e. patients were randomly assigned to one of the two treatment groups and both they and their doctors knew which of the two drugs was used in each case.

Longer survival means major added benefit

IQWiG always assesses a drug with a view to patient-relevant outcomes such as survival (mortality), symptoms and complications (morbidity) as well as quality of life. The study provides an indication that vemurafenib can prolong life. While half of the patients who received dacarbazine died after less than 10 months, in the vemurafenib group this was the case only after more than 13 months. The differing course of the two survival curves provides an indication of a major added benefit of vemurafenib.

Pain was the only outcome recorded in the study in relation to morbidity. There were, however, no statistically significant diff
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Antibody-coated stents: Indication of disadvantages
2. Abiraterone: Indication of considerable added benefit in certain patients
3. Considerable added benefit of ipilimumab in advanced melanoma
4. Marketing Xocolate International Corporation (MXI-Corp) Introduces Xe Healthy Energy Drink, A Rich And Delicious Antioxidant Beverage, Now Added to Xoçai™ Product Line
5. Capsiplex Plus Reviews for Improved Weight Loss Supplement Added to BestAppetiteSuppressantPills.com
6. UV-Aid Cold and Flu Prevention Added to List of Biomimicry Strategies on AskNature.Org
7. Healthy Chocolate Omega Squares, a Decedent Dark Chocolate Added to Marketing Xocolate International Corporation (MXI Corp) Product Lines
8. Rilpivirine for HIV: Added benefit for single agent proven
9. US Drug Watchdog Has Added Wright, Stryker, Biomet, and Zimmer To Their Initiative For All Metal Hip Implant Failures Victims & Offers Them The Names Of The Best Lawyers
10. CFO 911 Solutions' Charles K. Dargan II, CEO, and Reid Dabney, Managing Director Have Been Added to the Financial Entrepreneur Platform ("FEP") of Merriman Capital, Inc., a Wholly Owned Subsidiary of Merriman Holdings, Inc. (OTCQX: MERR)
11. Vandetanib in thyroid cancer: No proof of added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... have today released updated guidelines on Hormone Replacement Therapy ... the benefits and the risks. The new guidelines appear ... published by SAGE. , Over the last 11 ... of youth" to being considered extremely risky and only ... of the Women,s Health Initiative (WHI) trial in 2002, ...
(Date:5/24/2013)... May 24, 2013 Today marks the ... online Itinerary Builder. , The redesigned and enhanced ... unique vacation itineraries on their computer or mobile device ... The interactive tool allows users to fill in their ... through and select their choice of vacation packages, accommodations, ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 DiaperBuys.com is ... Baby Photo Contest. Lindsey Willis of Olathe, Kansas, won ... from DiaperBuys. Second prize was a three-month supply ... North Las Vegas, Nev.; and third prize, a one-month ... The contest was run through the company’s Facebook page. ...
(Date:5/24/2013)... 2013 Wednesday, 15th May 2013 | 10am ... to access webinar playback: http://bit.ly/10Rt0ZH , Ongoing regulatory ... markets. Across the globe and particularly in Europe, a number ... M&A activity . For dealmakers, understanding how the likes of ... Tax’ affects your corner of the market will give you ...
(Date:5/24/2013)... 24, 2013 http://www.resource4thepeople.com/defectivedrugs/Zithromax-lawsuits.html ... latest update involving allegations that the use of ... can allegedly cause potentially fatal irregular heart ... May 17, 2013* that Health Canada has joined ... that Zithromax can cause abnormal changes in the ...
Breaking Medicine News(10 mins):Health News:Create and Win the Perfect Halifax Getaway with the All-New Itinerary Builder 2Health News:DiaperBuys.com Announces Photo Contest Winners 2Health News:Register to Access Webinar Playback - The Impact of Financial Regulation on M&A in 2013 2Health News:Register to Access Webinar Playback - The Impact of Financial Regulation on M&A in 2013 3Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 3Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 4
... now choose a gender of their liking and some can ... procedure developed at the All India Institute of Medical Sciences ... already given proper gender identities as males or females and ... the premier research and referral institute said. ,"Treatment ...
... now looking at lactate with a much more positive ... brain in the immediate //hours after a traumatic brain ... are right, it could change how emergency room physicians ... in the first critical hours after injury. ...
... screen all 20,000-plus human genes for biological activity, scientists have ... cancer cells are to certain chemotherapy drugs.// ,In ... edition of the journal Nature, researchers at UT Southwestern Medical ... molecules – the first used by a university research center ...
... in full bloom, the American Academy of Otolaryngology – Head ... can do to cope with the pollen in the air, ... // ,This spring, pollen from blooming trees and plants ... causing itching eyes, sneezing, nasal stuffiness, nasal congestion and drainage, ...
... may result in erectile dysfunction, decreased libido, anemia, sarcopenia, ... ,While a low serum testosterone level is ... hypogonadism on overall physical functioning and fall risk has ... 23 issue of the Archives of Internal Medicine, Orwoll ...
... than one-third of Queensland men have never been screened for ... ,Screening for colorectal cancer currently has stronger scientific ... prostate or skin cancer, but a new study in the ... undergo the colorectal cancer test than the other two. ...
Cached Medicine News:Health News:New Procedure Paves Way for Eunuchs to Choose a Gender and Conceive 2Health News:Study Challenges Conventional Treatment of Traumatic Brain Injury 2Health News:Gene Screening Points Way to More Effective Chemotherapy 2Health News:April Showers Bring May Flowers – And Plenty of Pollen, To 2Health News:Low Serum Testosterone Levels Associated With Fall Risk in Elderly Men 2
(Date:5/23/2013)... May 23, 2013  Ameritox, the nation,s leader ... Progressive Medical, Inc. to become part of its ... manage pharmacy costs and improve the clinical outcomes ... leading pharmacy benefit manager in the workers, compensation ... compliance and pain management strategy for several years. ...
(Date:5/23/2013)... Md. , May 23, 2013  BioElectronics Corporation ... consumer medical devices, comments on the FDA panel meeting ... Advisory Panel Reclassification – Pulsed Shortwave Therapy Meeting was ... MD , USA.  The focus of the meeting ... the panel to focus solely on the application of ...
(Date:5/23/2013)... 2013  CAS Medical Systems, Inc. (NASDAQ: CASM ... monitoring, today announced that Thomas M. Patton ... 2 nd Annual Marcum MicroCap Conference on Thursday, May ... New York City . The presentation is ... 10 room and will be available via a live webcast ...
Breaking Medicine Technology:Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 2Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 3BioElectronics and Pulsed Shortwave Therapy Make Progress 2CASMED to Present at the 2nd Annual Marcum MicroCap Conference 2
... Dr. Rolf Badenhoop M.D., a 20-year veteran of the ... sales and marketing consulting firm ZS Associates ... Frankfurt office. "I am excited to work ... better understand and respond to business challenges posed by ...
... VOLC ) today announced its intention to offer, ... amount of convertible senior notes due September 1, 2015 in ... amended (the "Securities Act"). Prior to June 1, 2015, the ... holders will receive up to the principal amount of the ...
Cached Medicine Technology:ZS Associates Appoints Pharmaceutical Industry Veteran to Serve the Firm's Growing Client Base in Germany 2Volcano Corporation to Offer $100 Million Convertible Senior Notes Due 2015 2Volcano Corporation to Offer $100 Million Convertible Senior Notes Due 2015 3Volcano Corporation to Offer $100 Million Convertible Senior Notes Due 2015 4
... Rochester Medical's line of ... intermittent catheters you would ... four product configurations - ... antibacterial hydro - are ...
The latex-free, PVC-free Antibacterial Hydro Personal catheter combines two remarkable innovations into one exclusive catheter that delivers an antibacterial agent while providing the virtually frict...
The Antibacterial Personal Catheter® features a unique silicone composition that provides an antibacterial coated soft outer layer of silicone combined with a firm inner layer....
... Rochester Medical's line ... the intermittent catheters you ... All four product configurations ... and antibacterial hydro - ...
Medicine Products: