Navigation Links
Indication of considerable added benefit of vemurafenib in advanced melanoma
Date:1/8/2013

The drug vemurafenib (trade name Zelboraf) has been approved since February 2012 for the treatment of advanced melanoma (cancer of the skin cells that produce the dark pigment, melanin). It can be an option for adults whose melanoma cannot be removed by surgery or has formed secondaries (metastases) and in whose cancer a change (mutation) has occurred in a certain gene (BRAF-V600). The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG). According to the findings, major advantages in terms of overall survival are accompanied by major potential harm in the form of side effects. Overall, there is an indication that vemurafenib offers considerable added benefit.

Vemurafenib in comparison with dacarbazine

The Federal Joint Committee (G-BA) has specified the drug dacarbazine as the appropriate comparator therapy. One study that compared vemurafenib directly with dacarbazine was available for the benefit assessment. This is a randomized and open-label study, i.e. patients were randomly assigned to one of the two treatment groups and both they and their doctors knew which of the two drugs was used in each case.

Longer survival means major added benefit

IQWiG always assesses a drug with a view to patient-relevant outcomes such as survival (mortality), symptoms and complications (morbidity) as well as quality of life. The study provides an indication that vemurafenib can prolong life. While half of the patients who received dacarbazine died after less than 10 months, in the vemurafenib group this was the case only after more than 13 months. The differing course of the two survival curves provides an indication of a major added benefit of vemurafenib.

Pain was the only outcome recorded in the study in relation to morbidity. There were, however, no statistically significant diff
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antibody-coated stents: Indication of disadvantages
2. Abiraterone: Indication of considerable added benefit in certain patients
3. Considerable added benefit of ipilimumab in advanced melanoma
4. Marketing Xocolate International Corporation (MXI-Corp) Introduces Xe Healthy Energy Drink, A Rich And Delicious Antioxidant Beverage, Now Added to Xoçai™ Product Line
5. Capsiplex Plus Reviews for Improved Weight Loss Supplement Added to BestAppetiteSuppressantPills.com
6. UV-Aid Cold and Flu Prevention Added to List of Biomimicry Strategies on AskNature.Org
7. Healthy Chocolate Omega Squares, a Decedent Dark Chocolate Added to Marketing Xocolate International Corporation (MXI Corp) Product Lines
8. Rilpivirine for HIV: Added benefit for single agent proven
9. US Drug Watchdog Has Added Wright, Stryker, Biomet, and Zimmer To Their Initiative For All Metal Hip Implant Failures Victims & Offers Them The Names Of The Best Lawyers
10. CFO 911 Solutions' Charles K. Dargan II, CEO, and Reid Dabney, Managing Director Have Been Added to the Financial Entrepreneur Platform ("FEP") of Merriman Capital, Inc., a Wholly Owned Subsidiary of Merriman Holdings, Inc. (OTCQX: MERR)
11. Vandetanib in thyroid cancer: No proof of added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... 03, 2015 On February 24, 2015, ... the United States District Court for the Northern District ... as well as insurance companies Balboa, QBE, and Newport ... Case No. 3:14-cv-152.) , The Plaintiff, a Ms. Dolores ... to force her to buy too much insurance at ...
(Date:3/3/2015)... York (PRWEB) March 03, 2015 ... used to market the atypical antipsychotic medication continue ... According to court documents, the South Carolina Supreme ... that Johnson & Johnson’s Janssen Pharmaceuticals unit had ... risks. However, while the Court’s February 25th decision ...
(Date:3/3/2015)... 03, 2015 Loma Linda University Health ... and well being, it will be offering new, healthier ... campuses. , Over the past year, a cross-section of ... creating dietary criteria, listening to vendors, sampling their products, ... organization. , Most recently, a food fair was ...
(Date:3/3/2015)... 2015 Today, Steve Weatherford, current New ... wide receiver, announced the donation of their brains to ... Injury Awareness Month. In an effort to raise awareness ... of brain health, Rice and Weatherford spoke of their ... to make brain health a priority to avoid the ...
(Date:3/3/2015)... Portland, Oregon (PRWEB) March 03, 2015 ... compassionate community leaders to help find cures and ensure ... the quality of life for patents and their families. ... a maximum impact in the fight for a world ... to the top fundraisers in the country, to be ...
Breaking Medicine News(10 mins):Health News:Borrower Accuses Mortgage Lenders of Racketeering in Forcing Insurance on Homeowners 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Comments on Ruling Upholding South Carolina Jury Decision in Risperdal Marketing Case 2Health News:Risperdal Lawsuit News: Bernstein Liebhard LLP Comments on Ruling Upholding South Carolina Jury Decision in Risperdal Marketing Case 3Health News:Loma Linda University Health Rejuvenates Its Vending Machines with Healthier Selections 2Health News:Steve Weatherford and Sidney Rice Reveal Donation for Brain Injury Awareness Month 2Health News:The Leukemia & Lymphoma Society’s Oregon and SW Washington Chapter Kicks Off Their Eleventh Annual Man, Woman & Student of the Year Campaign 2Health News:The Leukemia & Lymphoma Society’s Oregon and SW Washington Chapter Kicks Off Their Eleventh Annual Man, Woman & Student of the Year Campaign 3
... M. Redstone to Accept Award At June 9 ... ... Global Business,Coalition on HIV/AIDS, Tuberculosis and Malaria (GBC) announced today that,it will ... Excellence at its June 9th annual,celebration. The GBC, an organization of more ...
... at Karolinska Institutet in Sweden and Miami University have discovered ... a way hitherto unknown. The discovery can eventually be of ... of the project was to find out how the healthy ... for a long time that glucose is regulated with the ...
... Monitoring extreme weather, such as periods of high ... intensity of infectious diseases like cryptosporidiosis, an intestinal disease ... researchers have created a model that takes into account ... people who will fall ill during an outbreak. With ...
... report shows the cost of glaucoma will more than double ... Economic Impact of Primary Open Angle Glaucoma, shows associated healthcare ... to climb to $4.3 billion per annum by 2025, if ... the optic nerve, connecting the brain to the eyes, and ...
... school children who took part in two health surveys carried ... to research published in the latest Journal of Advanced Nursing. ... first or second survey and a further five per cent ... eating problems were more likely to report multiple psychological problems ...
... finding contradicts conventional wisdom , , WEDNESDAY, June 4 (HealthDay News) ... salt may be worse for your heart than eating lots ... , "No one should run out and buy a salt ... think it,s reasonable to say that different people have different ...
Cached Medicine News:Health News:Viacom to Receive Leadership Award for Business Excellence from The Global Business Coalition on HIV/AIDS, Tuberculosis and Malaria for Its 25 Years of Work on HIV/AIDS Education and Advocacy 2Health News:Viacom to Receive Leadership Award for Business Excellence from The Global Business Coalition on HIV/AIDS, Tuberculosis and Malaria for Its 25 Years of Work on HIV/AIDS Education and Advocacy 3Health News:Discovery of new signal pathway important to diabetes research 2Health News:Weather, stomach bugs and climate change: Refining the model 2Health News:Glaucoma report points to increased costs 2Health News:Nearly 1 in 5 teenagers admit eating problems, but anxiety is a bigger problem than appearance 2Health News:Low-Salt Diet May Not Be Best for Heart 2
(Date:3/3/2015)... 3, 2015  UnaliWear announces the market preview of ... seniors that guards against wandering and provides support for ... wearable – the Kanega watch ( http://www.UnaliWear.com ) – ... an easy speech interface rather than buttons, use cellular ... input. The watch goes wherever the ...
(Date:3/3/2015)... -- American Biosurgical, LLC ("ABI") ( www.americanbiosurgical.com ) a ... in the design, development and production of innovative ... device companies has announced the acquisition of MTI ... cable manufacturer based in North Carolina.  The new ... name MTI Medical Cables.  The ...
(Date:3/3/2015)... March 3, 2015  Michigan brothers Dominique Larkin , ... arrhythmogenic right ventricular dysplasia, or ARVD, a disease that causes ... death among young athletes. In 2007, doctors discovered ... game. They later tested Dominique and found his "condition was ... 19, 2015 story in The Ann Arbor News , ...
Breaking Medicine Technology:UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2American Biosurgical Acquires MTI Corporation 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 2Younger of 2 Brothers on the SynCardia Total Artificial Heart Gets a Donor Heart Transplant 3
This revolutionary system combines the CSZ Head Wrap and Patient Vest for a non-invasive whole body hypothermia system. This method of cooling the patient allows for early treatment that is fast, cos...
The fabric is antistatic and non-linting and is both oil and water repellent.These superior blankets are an environmental friendly alternative to disposable blankets....
The Bair Hugger outpatient blanket makes it easy to give your patients the benefit of prewarming and enhance patient comfort during outpatient procedures....
Cocoon Disposable Patient Warming Blankets are specially designed to prevent hypothermia and maintain normothermia in your patients. The soft warm coloured material is strong and resists tearing and ...
Medicine Products: