Navigation Links
Indication of considerable added benefit of vemurafenib in advanced melanoma
Date:1/8/2013

The drug vemurafenib (trade name Zelboraf) has been approved since February 2012 for the treatment of advanced melanoma (cancer of the skin cells that produce the dark pigment, melanin). It can be an option for adults whose melanoma cannot be removed by surgery or has formed secondaries (metastases) and in whose cancer a change (mutation) has occurred in a certain gene (BRAF-V600). The German Institute for Quality and Efficiency in Health Care (IQWiG) has examined the added benefit of the drug pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG). According to the findings, major advantages in terms of overall survival are accompanied by major potential harm in the form of side effects. Overall, there is an indication that vemurafenib offers considerable added benefit.

Vemurafenib in comparison with dacarbazine

The Federal Joint Committee (G-BA) has specified the drug dacarbazine as the appropriate comparator therapy. One study that compared vemurafenib directly with dacarbazine was available for the benefit assessment. This is a randomized and open-label study, i.e. patients were randomly assigned to one of the two treatment groups and both they and their doctors knew which of the two drugs was used in each case.

Longer survival means major added benefit

IQWiG always assesses a drug with a view to patient-relevant outcomes such as survival (mortality), symptoms and complications (morbidity) as well as quality of life. The study provides an indication that vemurafenib can prolong life. While half of the patients who received dacarbazine died after less than 10 months, in the vemurafenib group this was the case only after more than 13 months. The differing course of the two survival curves provides an indication of a major added benefit of vemurafenib.

Pain was the only outcome recorded in the study in relation to morbidity. There were, however, no statistically significant diff
'/>"/>

Contact: Dr. Anna-Sabine Ernst
presse@iqwig.de
0049-221-356-850
Institute for Quality and Efficiency in Health Care
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antibody-coated stents: Indication of disadvantages
2. Abiraterone: Indication of considerable added benefit in certain patients
3. Considerable added benefit of ipilimumab in advanced melanoma
4. Marketing Xocolate International Corporation (MXI-Corp) Introduces Xe Healthy Energy Drink, A Rich And Delicious Antioxidant Beverage, Now Added to Xoçai™ Product Line
5. Capsiplex Plus Reviews for Improved Weight Loss Supplement Added to BestAppetiteSuppressantPills.com
6. UV-Aid Cold and Flu Prevention Added to List of Biomimicry Strategies on AskNature.Org
7. Healthy Chocolate Omega Squares, a Decedent Dark Chocolate Added to Marketing Xocolate International Corporation (MXI Corp) Product Lines
8. Rilpivirine for HIV: Added benefit for single agent proven
9. US Drug Watchdog Has Added Wright, Stryker, Biomet, and Zimmer To Their Initiative For All Metal Hip Implant Failures Victims & Offers Them The Names Of The Best Lawyers
10. CFO 911 Solutions' Charles K. Dargan II, CEO, and Reid Dabney, Managing Director Have Been Added to the Financial Entrepreneur Platform ("FEP") of Merriman Capital, Inc., a Wholly Owned Subsidiary of Merriman Holdings, Inc. (OTCQX: MERR)
11. Vandetanib in thyroid cancer: No proof of added benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Discovia, a ... announced today that it has hired Scott Sanderson, an experienced business development professional ... Sanderson will be responsible for establishing and managing new client relationships in the ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, Inc., a national ... medical management team as an Associate Medical Director. , WorkCare specializes in ... the U.S. and abroad. , Dr. Nelson has a diverse background. He ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... SC&H Group, ... (IPA), which includes being named a “Best of the Best” firm in the U.S., ... has named the “Best of the Best” in the U.S., selected exclusively on performance ...
(Date:9/1/2015)... ... ... Mercy Health (formerly Catholic Health Partners) – a Catholic healthcare ministry serving Ohio ... Be Well videos to prostate cancer awareness. Prostate cancer is the most-common, non-skin cancer ... Mercy Health’s YouTube channel, Mercy Health experts address issues, such as:, ...
(Date:9/1/2015)... ... September 01, 2015 , ... USA ... informational video this week to coincide with back-to-school and the start of “sick ... to the CDC, elementary school children are sick an average of 8 to ...
Breaking Medicine News(10 mins):Health News:Former NFL Standout Scott Sanderson Joins eDiscovery Leader Discovia 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:SC&H Group Receives Multiple Honors from INSIDE Public Accounting 2Health News:New Mercy Health Video Explains Most-Common Cancer Found in Men 2Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2
... Idaho (central) and health officials are advising people to get ... have been // reported totally by central district health ... and Valley counties in southwest Idaho. Statistics shows that the ... the 10 year average period of 23 cases/year. ...
... charge as he was suffering from Parasomnia, but the victim is ... case against him in Canadian Supreme court. Jan Luedecke was said ... they were both in a drunken state in the same sofa. ... could remember of the act. Parasomnia is a condition in which ...
... the ageing population in Kerala which has the best literacy ... are non-vegetarians. ,Almost 90 percent of both ... meals a day, according to ‘Kerala Ageing Survey’, funded by ... the health of the elderly population. ,Headed by ...
... Scott Belcher, PhD, did a study that Bisphenol A ... doses.' , ,Worded by Dr. Belcher, 'These new ... rapid signalling mechanisms are active in the developing and ... with sexual differences or reproductive functions,' ,'BPA ...
... the University of Alberta has revealed that different parts of ... performing the same tasks. This goes to prove that the ... differently. The volunteers for the study were called upon to ... memory tasks, while the functional Magnetic Resonance Imaging (fMRI) technology ...
... and milk container linings generally use the chemical Bisphenol A ... the University of Cincinnati (UC) // , reports in the ... Bisphenol A (BPA) is identified to disrupt estrogen action on ... disease and developmental problems. ,These studies also paved ...
Cached Medicine News:Health News:Three meals daily Keeps 'Kerala's elderly Healthy 2Health News:Food packaging with Bisphenol A damages the brain 2Health News:Bisphenol A In Food Containers Has Adverse Effect On Brain Tissue 2
(Date:9/1/2015)... Alpha Imaging LLC , a leading distributor of advanced medical imaging ... they have been awarded exclusive rights to represent the complete Shimadzu ... territory supplements Alpha Imaging,s existing Shimadzu sales and service responsibilities with ... Indiana , Pennsylvania , ... West Virginia , Delaware and ...
(Date:9/1/2015)... -- Results from an interim analysis of the Phase ... idarucizumab enabled emergency surgery to be initiated rapidly ... (Pradaxa ® dabigatran etexilate mesylate). The specific and ... enabled patients to be urgently brought to necessary ... between administration of idarucizumab and start of procedure. ...
(Date:9/1/2015)... Belgium , Sept. 1, 2015 VolitionRx ... on developing blood-based diagnostic tests for a broad range of ... Executive Officer, Cameron Reynolds , is scheduled to attend ... is being held September 9-10, 2015 in Boston, ... on September 10. Wells Fargo Securities Research ...
Breaking Medicine Technology:Alpha Imaging Expands Shimadzu Territory 2New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 2New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 3New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 4New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 5New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 6New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 7New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 8New Analysis Shows Idarucizumab* Enables Rapid Initiation of Emergency Surgery in Dabigatran-Treated Patients 9VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 2VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 3VolitionRx to Attend 10th Annual Wells Fargo Healthcare Conference on September 9-10, 2015 4
... Oct. 11 ECRI Institute® ( www.ecri.org ), an ... improving patient care, is pleased to announce Kaiser Permanente ... health plan,  as the winner of the 5th annual ... health technology management. The Health Devices Achievement Award ...
... N.C., Oct. 11 Talecris Biotherapeutics Holdings Corp. (Nasdaq: ... release before the market opens on October 28, 2010. Due ... be hosting a conference call to discuss its third quarter ... Inspiration. Dedication. Innovation. Talecris Biotherapeutics is ...
Cached Medicine Technology:ECRI Institute Names Kaiser Permanente Winner of 5th Annual Health Devices Achievement Award 2ECRI Institute Names Kaiser Permanente Winner of 5th Annual Health Devices Achievement Award 3
Complete Blink-N-Clean lens drops cleans and clears lenses in a blink. It is a unique blend of gentle to the eye ingredients that conveniently cleans, clears and keeps lenses feeling comfortable thro...
... preservative free lubricating and rewetting ... eyes while you're wearing soft ... free formula is ideal for ... to preservatives and for frequent ...
Saline Solution to rinse and store soft contact lenses and for heat disinfection....
Sensitive Eyes Plus Saline Solution to rinse soft contact lenses The unique, gentle, pH-balanced formula contains potassium, an ingredient found in tears....
Medicine Products: