Navigation Links
Hundreds of alterations and potential drug targets to starve cancer tumors identified
Date:4/21/2013

NEW YORKA massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, also identified hundreds of potential drug targets that could cut off a tumor's fuel supply or interfere with its ability to synthesize essential building blocks. The study was published today in the online edition of Nature Biotechnology.

The results should ramp up research into drugs that interfere with cancer metabolism, a field that dominated cancer research in the early 20th century and has recently undergone a renaissance. [Fuel Lines of Tumors Are New Target: http://nyti.ms/10QMkY1]

"The importance of this new study is its scope," said Dennis Vitkup, PhD, associate professor of biomedical informatics (in the Initiative in Systems Biology) at CUMC, the study's lead investigator. "So far, people have focused mainly on a few genes involved in major metabolic processes. Our study provides a comprehensive, global view of diverse metabolic alterations at the level of gene expression."

Cell metabolism is a dynamic network of reactions inside cells that process nutrients, such as glucose, to obtain energy and synthesize building blocks needed to produce new cellular components. To support uncontrolled proliferation, cancer needs to significantly reprogram and "supercharge" a cell's normal metabolic pathways.

The first researcher to notice cancer's special metabolism was German biochemist Otto Warburg, who in 1924 observed that cancer cells had a peculiar way of utilizing glucose to make energy for the cell. "Although a list of biochemical pathways in normal cells was comprehensively mapped during the last century," said Dr. Vitkup. "We still lack a complete understanding of their usage, regulation, and reprogramming in cancer."

"
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Hundreds of random mutations in leukemia linked to aging, not cancer
2. Physicians at Pain Care Bring Hope to Hundreds of Pain Management Patients Who Previously Had None Through Use of a New Procedure Called Spinal Cord Stimulation
3. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
4. Medtronic Infuse Bone Graft Lawsuits: Bernstein Liebhard LLP Notes New Report Predicting Hundreds of Medtronic Infuse Lawsuits
5. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
6. Vanderbilt study finds diverse genetic alterations in triple-negative breast cancers
7. Study identifies potential treatment for lethal childhood leukemia
8. McMaster researchers find potential for new uses of old drug
9. Army researcher develops potential vaccine carrier
10. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
11. New study of NIH funding allocations suggests potential efficiency gains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... Amityville, NY (PRWEB) February 27, 2015 The ... in mold growth and expansion. When mold grows, it can ... winter, be sure to avoid the consequences of mold growth ... on Long Island, is offering tips on the best ways ... a wet season, which makes perfect conditions for mold to ...
(Date:2/27/2015)... February 27, 2015 Victorian Hotel recently ... for couples who wanted to spend the auspicious day ... to get a jump on Valentine’s Day with a ... in one of their luxurious rooms. , The ... inviting guests for a mouthwatering 3 course meal at ...
(Date:2/27/2015)... 27, 2015 Florida Hospital North Pinellas ... - Stroke Gold Plus hospital. In order to receive ... higher adherence to all Get With The Guidelines - ... 12-month intervals and achieved 75-percent or higher compliance with ... Quality Measures. These are reporting initiatives to measure quality ...
(Date:2/27/2015)... The UC Davis Huntington’s Disease Center, whose ... a beacon of hope for people with Huntington’s disease ... the national society committed to the values that it ... America — as a Level 1 Huntington’s Disease Center ... service to over 300 families coping with Huntington's disease ...
(Date:2/27/2015)... Nashville, TN (PRWEB) February 27, 2015 ... Oral Health, has announced a scholarship for rising freshmen ... is Nashville’s leading periodontist office specializing in many periodontal ... , and treatment of gum disease . In ... single $1,000 college scholarship for eligible rising freshmen undergraduate ...
Breaking Medicine News(10 mins):Health News:Enviro-Test Offers Tips for Winter Mold Prevention 2Health News:Victorian Hotel Celebrated Valentine’s Day in 2015 With Unique Overnight Deal 2Health News:Florida Hospital North Pinellas Receives Get With The Guidelines - Stroke Gold Plus Quality Achievement Award 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 3Health News:Nashville Periodontist Office AIOH Announces 2015 Scholarship 2
... CARROLLTON, Ga., March 31 Greenway Medical Technologies,announced ... such,as the Physician Quality Reporting Initiative (PQRI) and ... and influence health,information technology (HIT) adoption., The ... Bush,s signing,of the Medicare, Medicaid, and SCHIP Extension ...
... March 31 /Xinhua-PRNewswire/ -- WuXi PharmaTech, the,leading ... with operations in China and the United ... W. C. MacMillan, a renowned researcher from ... Series speaker who,delivered a lecture to the ...
... Lube International Convention, COLORADO SPRINGS, Colo., March ... American Heart Association with a $1 million check,benefiting ... Jiffy Lube,International 2008 Convention and Trade Show. More ... Jiffy Lube Maintenance Partners for,Life campaign, which raised ...
... Medical, Inc., a leading,innovator of physiological monitoring ... interoperability with other medical equipment.,Nonin continues to ... information flow without the need of proprietary,interfaces., ... Nonin Medical has,collaborated with some of the ...
... Caraco Pharmaceutical,Laboratories, Ltd. (Amex: CPD ) announced ... on behalf of Sun Pharmaceutical Industries,Ltd. (Sun Pharma). ... IV,marketing agreement with Sun Pharma that was signed ... from the US Food and Drug,Administration (FDA) for ...
... Ill. (March 31, 2008) A new ... risk of arterial renarrowing after stenting has turned ... trial, but the multi-reservoir stent that was used ... , Pimecrolimus, an anti-inflammatory medication, was expected to ...
Cached Medicine News:Health News:Greenway Medical Technologies Expands Support for Physician Quality Reporting Initiative and Pay for Performance Programs 2Health News:Greenway Medical Technologies Expands Support for Physician Quality Reporting Initiative and Pay for Performance Programs 3Health News:Greenway Medical Technologies Expands Support for Physician Quality Reporting Initiative and Pay for Performance Programs 4Health News:Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists 2Health News:Jiffy Lube(R) Raises $1 Million for American Heart Association's Go Red For Women(TM) Movement to Fight Heart Disease 2Health News:Jiffy Lube(R) Raises $1 Million for American Heart Association's Go Red For Women(TM) Movement to Fight Heart Disease 3Health News:Jiffy Lube(R) Raises $1 Million for American Heart Association's Go Red For Women(TM) Movement to Fight Heart Disease 4Health News:Nonin Medical, Inc. Is Recognized for Its Role in Promoting Interoperability 2Health News:Caraco Pharmaceutical Laboratories Ltd. To Market Generic Ethyol(R) 2Health News:Investigational anti-restenosis drug pimecrolimus disappoints 2Health News:Investigational anti-restenosis drug pimecrolimus disappoints 3
(Date:2/27/2015)... - La ... monitoraggio dell,infarto congestizio (CHF - Congestive Heart Failure) ...   Vectorious Medical Technologies, società ... il monitoraggio cardiaco destinato a pazienti affetti da ... concluso una raccolta di finanziamenti per 5 milioni ...
(Date:2/27/2015)... 27, 2015 Isis Pharmaceuticals, Inc. (Nasdaq: ... its pro forma net operating loss (NOL) guidance and ... financial position.  Isis, significantly improved financial results were due ... in payments the Company received from its partners.  Isis, ... a nearly 60% improvement over its 2013 NOL of ...
(Date:2/27/2015)... 2015 An aggressive campaign to reduce the ... of infection with a dangerous drug-resistant bacteria at The ... difficile, or C.diff, is a bacterium that can cause ... colon. A recent article in the New England Journal ... the United States " asserts that ...
Breaking Medicine Technology:Vectorious Medical Technologies completa una raccolta di 5 milioni di dollari 2Isis Reports Financial Results and Highlights for 2014 2Isis Reports Financial Results and Highlights for 2014 3Isis Reports Financial Results and Highlights for 2014 4Isis Reports Financial Results and Highlights for 2014 5Isis Reports Financial Results and Highlights for 2014 6Isis Reports Financial Results and Highlights for 2014 7Isis Reports Financial Results and Highlights for 2014 8Isis Reports Financial Results and Highlights for 2014 9Isis Reports Financial Results and Highlights for 2014 10Isis Reports Financial Results and Highlights for 2014 11Isis Reports Financial Results and Highlights for 2014 12Isis Reports Financial Results and Highlights for 2014 13Isis Reports Financial Results and Highlights for 2014 14Isis Reports Financial Results and Highlights for 2014 15Isis Reports Financial Results and Highlights for 2014 16Isis Reports Financial Results and Highlights for 2014 17Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 2Curb Overuse Of Antibiotics To Reduce Drug-Resistant Superbug 3
... June 2, 2011 Dilon Diagnostics will introduce the ... at the Society of Nuclear Medicine (SNM) Meeting in ... Dilon 6800® Acella Gamma Camera system. To complement the ... the new camera will feature a much larger MBI ...
... 2011 /PRNewswire-Asia/ -- China Kanghui Holdings (NYSE: ... developer, manufacturer and marketer of orthopedic implants in China, ... Jefferies 2011 Global Healthcare Conference to be ... in New York City.  Management is scheduled to present ...
Cached Medicine Technology:The World Leader in Molecular Breast Imaging to Premiere Largest Detector in the Industry 2
... aluminum cuffs that can be bent to ... joint alignment, unique slot/screw adjustment mechanism allows ... cuff position. Cuffs are configured to offer ... with contractures.,The hinge can be locked in ...
... ACTION Elbow Wrap replaces messy taping and ... and others experiencing epicondylitis. Preferred by doctors ... non-bulky fit. Two overlay straps allow you ... foam lining holds the Elbow Wrap comfortably ...
... is designed to handle post-op elbow arthroscopy, ... Bledsoe Extender Arm Brace should be used ... the elbow is desired. In most cases, ... formed, fitted and adjusted in 5 minutes ...
... contour design of this lightweight brace allows it ... It stabilizes the ankle joint following severe sprains, ... semi-rigid spiral stays move with the ankle and ... help the splint control rotational strains on the ...
Medicine Products: