Navigation Links
How does fibrosis occur in Crohn's disease?
Date:1/30/2013

New research has shown that a protein, known as IL-13, could be the key to the development of fibrosis in Crohn's disease. This breakthrough could help to advance new medicines to treat people suffering with the disease.

Crohn's disease is a chronic, debilitating condition characterised by inflammation and ulceration occurring at any point in the gastrointestinal tract. Currently there is no cure. One of the major complications of Crohn's disease is the development of fibrosis hardening and thickening in the bowel wall. This causes the intestine to lose its mobility and it eventually becomes so narrow that food and faeces are unable to pass.

Fibrosis occurs when there is an overproduction of the proteins which are normally involved in the tissue healing process, including collagens.

The research team, led by the School of Veterinary Sciences at the University of Bristol, found an increase in collagen synthesis and a lack of control of collagen deposition in fibrotic intestine taken from Crohn's disease patients when compared to normal intestine. The researchers believe that this is related to an increase in a soluble mediator, interleukin 13 (IL-13), previously identified as promoting fibrosis in the lung, liver and kidney.

Increased levels of IL-13 were found in fibrotic Crohn's gut when compared to normal gut, and tissue culture experiments showed that IL-13 reduced factors necessary to prevent inappropriate collagen deposition.

Dr Jenny Bailey, a researcher in the School of Veterinary Sciences at the University of Bristol, said: "We have identified a novel population of IL-13-producing cells which, in intestinal samples, were found at very high levels in fibrotic muscle. We believe these cells are key to the development of fibrosis.

"Understanding how fibrosis occurs will help us to develop new medicines to treat patients."

Since many patients developing fibrosis will require surgery,
'/>"/>

Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-011-733-17276
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify new strategy to fight deadly infection in cystic fibrosis
2. Impaired blood vessel function found in cystic fibrosis patients
3. Researchers implicate well-known protein in fibrosis
4. Game changer for arthritis and anti-fibrosis drugs
5. Cystic fibrosis patients of low SES are less likely to be accepted for lung transplant
6. New drug successfully halts fibrosis in animal model of liver disease
7. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
8. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
9. Study evaluates use of inhaled saline for young children with cystic fibrosis
10. Early menopause may occur in women with BRCA gene, new study finds
11. Preventable Surgical Errors Continue to Occur: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... Bioinformatics refers to an interdisciplinary ... and genetic data. A major part of this ... tools to generate and process useful biological data. ... computation. While bioinformatics simply makes use of computers ... related concepts, biological computation refers to the subfield ...
(Date:9/1/2014)... September 01, 2014 Ontraport , ... marketers that was developed to automate the small intricacies ... attention of Shane Michaels, prompting an investigative review. ... daily duty of managing all of the small details ... quite overwhelming,” reports Michaels. “That’s why Ontraport has become ...
(Date:9/1/2014)... California (PRWEB) September 01, 2014 Developers of ... new tutorial video for the ProWorld Plugin from Pixel Film ... Cut Pro X can do and users now have the ... images.” Said Christina Austin, CEO of Pixel Film Studios. “Blurring ... game changer.” , Learn how to turn a 2D HDRI ...
(Date:8/31/2014)... MYMOBILEUNI (MMU) strategy is to ... marketing tools access to digital, resources, courses, videos, ... all tools to reach and collaborate with educational ... learning channels. , MMU, today announced the availability ... tool that applies social networking concepts to the ...
(Date:8/31/2014)... Recently, BambooIndustry.com, one of the most popular suppliers ... selection of bamboo veneers . Additionally, it has deiced ... these high quality products. The promotion will last from today ... that its top quality veneers are hot in the global ... of bamboo veneers. All these items are made according to ...
Breaking Medicine News(10 mins):Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4Health News:Ontraport: Review Exposes Automated Platform for Online Marketing Management 2Health News:Pixel Film Studios Released a New Tutorial Entitled ProWorld Lesson Exclusively for Final Cut Pro X 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 2Health News:My Mobile University Announces Global Strategic Plan and Unveils New Android App to Enhance and Impact Lives World-Wide Through Education for All as Learning Platform 3Health News:High Quality Bamboo Veneers from Bambooindustry.com Receive International Attention 2
... Leaders Call on President Obama to Support Effective, Life-saving ... administration,s first budget will flat-line funding for global health, ... Vice President Biden and Secretary of State Hillary Clinton ... President,s Emergency Plan for AIDS Relief (PEPFAR) and accelerate ...
... lifespan is limited by telomeres, DNA sequences that cap ... may be copied. A new study reported in ... describes how telomere dysfunction in skin cells can lead ... from Spain investigated the molecular mechanisms underlying skin cell ...
... seek out health information from the internet and news media, ... the latest treatments for their disease. Published in the April ... of the American Cancer Society, the study indicates that patients ... ways. , In their review, authors led by Stacy Gray, ...
... Those without FTO gene stay slim without dieting or added ... -- Mice without a particular form of an obesity-linked gene ... exercise similarly and gobble up just as much food. , ... Feb. 22 issue of Nature . According to ...
... small family of lab-made proteins that neutralize a broad ... virus, the 1918 pandemic influenza virus and seasonal H1N1 ... derived from the same cell lineage, also were found ... other influenza A viruses. Because large quantities of monoclonal ...
... drugs and universal vaccine, they say, , , SUNDAY, Feb. ... lead to medications to fight the flu as well as ... year because it could target a broad range of flu ... not just bird flu, but any of the seasonal influenza ...
Cached Medicine News:Health News:Global AIDS Alliance Sounds Alarm on Potential Budget Cuts 2Health News:Global AIDS Alliance Sounds Alarm on Potential Budget Cuts 3Health News:Global AIDS Alliance Sounds Alarm on Potential Budget Cuts 4Health News:Patient knowledge of health information influences cancer treatment 2Health News:Mice Study Shows How 'Fat Gene' Works 2Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 2Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 3Health News:Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu 4Health News:Scientists May Have New Way to Fight the Flu 2Health News:Scientists May Have New Way to Fight the Flu 3
(Date:8/29/2014)... -- Research and Markets has announced the ... 2014-2018" report to their offering. ... results in demyelination, axonal transection, and neurodegeneration. The myelin ... the immune system, which targets neurons within the central ... in which the damage of the myelin sheath causes ...
(Date:8/29/2014)... UNION CITY, Calif. , Aug. 29, 2014 /PRNewswire/ ... products company manufacturing point-of-care blood instrumentation and consumables to ... Clint Severson , Chairman and Chief Executive Officer, ... Annual Best Ideas Conference 2014 on Tuesday, September 9, ... held at the Omni Berkshire Place Hotel in ...
(Date:8/29/2014)... British Columbia and MENLO PARK, ... DelMar Pharmaceuticals, Inc. (OTCQB: DMPI) ("DelMar" "the ... fiscal year-end financial statements.  The Company recently changed its ... facilitate an application to list its common stock on ... DelMar,s financial statements as filed with the ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5
... TriReme Medical, Inc. (TMI) today announced approval by ... Glider™ PTCA Catheter, indicated for treating the stenotic portion ... perfusion. Glider™ is the world,s only torqueable ... art tip technology, Glider™ is designed to perform, even ...
... HAYWARD, Calif., and SHANGHAI, May 23, 2012 ... next-generation antibiotics, today announced that the U.S. Patent ... matter patent covering its clinical candidate, MRX-I. MRX-I ... due to multi-drug resistant Gram-positive pathogens. ...
Cached Medicine Technology:TriReme Medical, Inc. Receives FDA Approval for Glider™ PTCA Catheter 2MicuRx Pharmaceuticals Announces Issuance Of U.S. Patent For Its Next-Generation Antibacterial Agent 2
... is a powerful, multi-modality system capable of performing ... EMG, EEG, and train of four testing tests ... a priority. The base weighs only 4.25 lbs. ... lbs. A desktop PC-based system with a custom ...
... Endeavor is a neuromonitoring system especially designed ... Endeavor amplifier has 16 channels and is ... electrode inputs. Each channel can be independently ... a true differential channel. Endeavor amplifiers are ...
... Inc. is the largest independently ... to ophthalmic surgical instrumentation. Katena ... 7,000 customers in the United ... network of distributors, to customers ...
... stress . . . Theyre all factors ... Unfortunately, its difficult, and often overwhelming, to ... daily basis. Its even more difficult to ... information to a care provider quickly so ...
Medicine Products: