Navigation Links
How does fibrosis occur in Crohn's disease?
Date:1/30/2013

New research has shown that a protein, known as IL-13, could be the key to the development of fibrosis in Crohn's disease. This breakthrough could help to advance new medicines to treat people suffering with the disease.

Crohn's disease is a chronic, debilitating condition characterised by inflammation and ulceration occurring at any point in the gastrointestinal tract. Currently there is no cure. One of the major complications of Crohn's disease is the development of fibrosis hardening and thickening in the bowel wall. This causes the intestine to lose its mobility and it eventually becomes so narrow that food and faeces are unable to pass.

Fibrosis occurs when there is an overproduction of the proteins which are normally involved in the tissue healing process, including collagens.

The research team, led by the School of Veterinary Sciences at the University of Bristol, found an increase in collagen synthesis and a lack of control of collagen deposition in fibrotic intestine taken from Crohn's disease patients when compared to normal intestine. The researchers believe that this is related to an increase in a soluble mediator, interleukin 13 (IL-13), previously identified as promoting fibrosis in the lung, liver and kidney.

Increased levels of IL-13 were found in fibrotic Crohn's gut when compared to normal gut, and tissue culture experiments showed that IL-13 reduced factors necessary to prevent inappropriate collagen deposition.

Dr Jenny Bailey, a researcher in the School of Veterinary Sciences at the University of Bristol, said: "We have identified a novel population of IL-13-producing cells which, in intestinal samples, were found at very high levels in fibrotic muscle. We believe these cells are key to the development of fibrosis.

"Understanding how fibrosis occurs will help us to develop new medicines to treat patients."

Since many patients developing fibrosis will require surgery, early intervention strategies may prevent severe morbidity, to which end IL-13 and IL-13-producing cells provide a promising therapeutic target.

Although there is some success in treating the inflammation in Crohn's disease, there are no current effective drugs to treat fibrosis. In cases of severe fibrosis, the only remedy is surgical excision of the strictured gut and around 30 per cent of Crohn's disease sufferers will undergo surgery at least once. Unfortunately, removal of the fibrotic tissue does not prevent fibrosis recurring in another part of the intestine and Crohn's patients frequently have to endure repeated surgery, eventually resulting in a short bowel which is no longer able to sustain adequate function.


'/>"/>
Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-011-733-17276
University of Bristol
Source:Eurekalert

Related medicine news :

1. Scientists identify new strategy to fight deadly infection in cystic fibrosis
2. Impaired blood vessel function found in cystic fibrosis patients
3. Researchers implicate well-known protein in fibrosis
4. Game changer for arthritis and anti-fibrosis drugs
5. Cystic fibrosis patients of low SES are less likely to be accepted for lung transplant
6. New drug successfully halts fibrosis in animal model of liver disease
7. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
8. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
9. Study evaluates use of inhaled saline for young children with cystic fibrosis
10. Early menopause may occur in women with BRCA gene, new study finds
11. Preventable Surgical Errors Continue to Occur: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... ... Cal Dining at the University of California Berkeley, and other leading institutions in ... the buying power of institutions to change the way animals are raised for ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... CHICAGO , Oct. 11, 2017  Hill-Rom Holdings, ... its Aspen Surgical facility in Las Piedras, ... surgical scalpels and blades. ... confirmed that the facility sustained minor structural damage, temporary ... Hurricane Maria. Repairs have been completed, manufacturing operations have ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
Breaking Medicine Technology: