Navigation Links
Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
Date:7/29/2009

DALLAS July 30, 2009 The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

The finding, reported online and in the August edition of Antimicrobial Agents and Chemotherapy, is particularly important for those living in societies plagued by obesity, said Dr. Tawanda Gumbo, associate professor of internal medicine at UT Southwestern and the study's lead author.

"What really drives the variability of this particular drug is patient weight and gender, so in our simulations we took that into account," Dr. Gumbo said. "What we found is that we're really using doses for very skinny people 105 to 110 pounds. I haven't met many adults who are at that weight."

About one-third of the world's population is infected with Mycobacterium tuberculosis, the bacterium that causes TB, and as many as 2 million people die from the disease each year. TB, which is the leading cause of death among people infected with HIV/AIDS, kills more people than any other disease caused by a single infectious agent, according to the National Institutes of Health. Treatment usually lasts six to 12 months and includes a combination of antibiotics such as Pyrazinamide, the drug examined in this study.

Because treatment typically includes multiple drugs, introducing new ones to existing regimens has made it harder to identify which, if any, of the drugs are working at the current dosage levels. Researchers also have struggled to identify the needed dosage as well as exactly where in the body these drugs work to combat the bacterium.

The new model developed at UT Southwestern uses cultured cells to gauge the effectiveness and proper dosage of anti-tuberculosis drugs.

"With this model, we can directly test molecules that have the potential to shorten therapy and go straight to coming up with the dos
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Connectyx Technologies Holdings Group, Inc. to Begin Process to Become Fully Reporting and Up List to a Higher Exchange - As Stated on Wallstreetcorner.com
2. Beta-Blockers Tied to Higher Cataract Risk
3. Deaths, Injuries Increase With Higher Speed Limits
4. Lower IQ Linked to Higher Risk of Heart Deaths
5. Children of undocumented parents may be at higher developmental risk
6. Mothers of children with autism have higher parental stress, psychological distress
7. Rate of Breast Cancer in Italy Significantly Higher Than Previously Reported
8. Obese Get Higher Doses of Radiation for X-Rays
9. Low Blood Sugar in Hospital Tied to Higher Death Risk for Diabetics
10. Abused Kids Face Higher Cancer Risk
11. Study Finds Skin Cancer Rates Higher Among Athletes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Georgia (PRWEB) September 18, 2014 Technology ... the winners of its 2nd TAG Social Savvy Awards ... Junior Achievement’s Chick-fil-A Foundation Discovery Center in Downtown Atlanta. ... media. , Turner Sports was honored with the ... This year’s event also recognized innovators in 6 other ...
(Date:9/18/2014)... Researchers are trying to learn more about a condition ... in young athletes. In people with sickle cell ... muscle breakdown that can lead to kidney damage and ... players in the United States collapsed and died during ... trait. "More student-athletes with sickle cell trait have ...
(Date:9/18/2014)... NC (PRWEB) September 18, 2014 October ... also Domestic Violence Awareness Month. And the Centers for ... tells a scary story. , According to the CDC ... fourth of men in the U.S. experience some form ... intimate relationship. The same survey shows that about half ...
(Date:9/18/2014)... September 18, 2014 Fall is here, and ... bike is here to stay. Just as the temperature ... up, says Bikesdirect.com . Women across America are discovering ... calls a city bike. , Windsor Bicycles USA says, "City ... are higher than the typical road bike, and the seat ...
(Date:9/18/2014)... technology has shed new light on how certain symptoms ... according to a new study. PTSD is ... range of debilitating symptoms, such as flashbacks to a ... and avoiding certain situation and people, according to background ... opioid receptor in the brain linked to emotion that ...
Breaking Medicine News(10 mins):Health News:Winners Honored at 2014 TAG Social Savvy Awards 2Health News:Winners Honored at 2014 TAG Social Savvy Awards 3Health News:Scientists Studying Sickle Cell Trait 2Health News:What you should know about domestic violence 2Health News:What you should know about domestic violence 3Health News:What you should know about domestic violence 4Health News:What you should know about domestic violence 5Health News:City Bikes Become a Must-have for Women This Fall, Says Bikesdirect.com 2Health News:Research Shows Possible Neurological Patterns for PTSD Symptoms 2Health News:Research Shows Possible Neurological Patterns for PTSD Symptoms 3
... WASHINGTON, DC) The Society for Cardiovascular Angiography and ... announced today that they will hold a unified interventional ... meeting will be known as The SCAI Annual Scientific ... be held concomitantly with the ACC Annual Scientific Session. ...
... men who have sex with men (MSM) in New York City, ... among MSM under age 30 have increased by 33% during the ... to almost 500 in 2006. New diagnoses have doubled among MSM ... under-30 group now accounts for 44% of all new diagnoses among ...
... Sept. 11 The Department of,Public Welfare today ... system whose personal information may have been contained,on ... office building in Harrisburg., The burglary remains ... the information on the stolen computers has been ...
... PT. RICHMOND, Calif., Sept. 11 Transcept,Pharmaceuticals, Inc., ... from proven CNS drugs, today announced,that Glenn A. ... present at the UBS 2007 Global Life Sciences ... Tuesday, September 25, 2007 at 4:00 p.m. ET. ...
... Is the Most Comprehensive Ever, NEW YORK, ... research,-- the most comprehensive ever conducted -- once ... safe, even among its heaviest users. The ... Use,Levels, Regulations, and Toxicological and Epidemiological Studies,",published in ...
... opportunities for immigrants to obtain legal residency and citizenship ... access to health care, according to an article published ... Affairs. , Immigrants now make up 12 percent ... lead author of the article and a policy researcher ...
Cached Medicine News:Health News:SCAI and ACC announce new interventional cardiology meeting 2Health News:New HIV diagnoses rising in New York City among young men who have sex with men 2Health News:New HIV diagnoses rising in New York City among young men who have sex with men 3Health News:New HIV diagnoses rising in New York City among young men who have sex with men 4Health News:PA Department of Public Welfare Begins Outreach to Medical Assistance Consumers Following Burglary at State Office Building 2Health News:New Study of Aspartame Research Reaffirms Safety, Even Among Heaviest Users 2Health News:New Study of Aspartame Research Reaffirms Safety, Even Among Heaviest Users 3Health News:RAND researchers offer options to improve immigrant health care quality, access 2
(Date:9/18/2014)... 2014 This BCC Research report discusses the medical device ... growth and size, and opportunities for different devices and regions. ... Patent analysis in the report focuses on technological trends in ... Europe and Japan . ... the global medical device technologies market. - Analyze market structure, ...
(Date:9/18/2014)...  Iliad Neurosciences, Inc., a company focused on the ... Spectrum Disorders (ASD) announced today that it has entered ... for The State University of New York. ... to identify an abnormality in folate transport to the ... expected to be available for research use by physicians ...
(Date:9/18/2014)... , September 18, 2014 ... audience, has updated the incredibly successful Serialisation Countdown calendar ... interactive PDF, available at pharmaserialisation.com shows the ... which they will be coming into force. ... longer a matter of "if", but "when" they will ...
Breaking Medicine Technology:Medical Devices: Technologies and Global Markets 2Medical Devices: Technologies and Global Markets 3Medical Devices: Technologies and Global Markets 4Iliad Neurosciences, Inc. enters into an Exclusive License Agreement with The Research Foundation for The State University of New York 2Iliad Neurosciences, Inc. enters into an Exclusive License Agreement with The Research Foundation for The State University of New York 3Pharma IQ Displays Worldwide Serialisation Deadlines in their 2014 - 2018 Countdown Calendar 2
... MADISON, N.J., Jan. 6, 2012 Quest Diagnostics Incorporated ... of diagnostic testing, information and services, announced today the ... Health System to acquire S.E.D. Medical Laboratories. Under the ... assets of S.E.D. Medical Laboratories and will manage in-patient ...
... 2012 In preparation for meetings starting Monday, ... scheduled for 10:00 a.m. Thursday, January 12 at ... Questcor Pharmaceuticals, Inc. (NASDAQ: QCOR ) ... the fourth quarter 2011:       -Approximately 935-950 ...
Cached Medicine Technology:Quest Diagnostics Completes Acquisition of S.E.D. Medical Laboratories 2Questcor Pharmaceuticals Reports Strong Finish to 2011 2Questcor Pharmaceuticals Reports Strong Finish to 2011 3Questcor Pharmaceuticals Reports Strong Finish to 2011 4Questcor Pharmaceuticals Reports Strong Finish to 2011 5Questcor Pharmaceuticals Reports Strong Finish to 2011 6
The MULTI-LINK RX PENTA Coronary Stent Systems with new ACCESS-LINK Stent Design are indicated for improving coronary luminal diameter....
Now available in 2.75-mm diameters, the S660 small vessel coronary stent expands your treatment options for accurate sizing and precision stenting....
The MULTI-LINK PIXEL Coronary Stent System was designed to address the challenges of small vessel treatment in patients with abrupt or threatened abrupt closure (ATC)....
... EVS has an ergonomic stapler ... mechanism which requires a single ... locks onto the target vessel ... site before, during and after ...
Medicine Products: