Navigation Links
High-salt diet and ulcer bug combine to increase risk of cancer
Date:4/18/2013

Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer. Now Timothy L. Cover and colleagues of Vanderbilt University show that high dietary salt combined with infection by the ulcer-causing bacterium Helicobacter pylori greatly increases the risk of cancer. The study was published ahead of print in the journal Infection and Immunity.

In the study, the researchers infected Mongolian gerbils with H. pylori. One set of gerbils received a regular diet; the other, a high salt diet. At the end of the experiment the researchers analyzed the animals' stomach tissues. Every animal on the high salt diet developed cancer, compared with just 58 percent of those on the regular diet.

It appears development of gastric cancer required the presence of a particular bacterial oncoprotein, known as CagA, which is produced by H. pylori. Gastric cancer did not develop in animals on the high salt diet that were infected with a mutant H. pylori which did not produce CagA. In earlier studies, Cover and others had shown that culturing H. pylori in a high salt environment boosts production of CagA. "This was one of the driving forces that led us to undertake the current studies," says Cover.

The investigators note that while no studies, to their knowledge, have examined relationships among a high salt diet, and infection with H. pylori expressing cagA, "in several parts of the world that have high rates of gastric cancer, there is a high prevalence of cagA+ strains and a large proportion of the population consumes a high-salt diet."

The investigators also detected significantly higher levels of gastric inflammation in H. pylori-infected gerbils on a high salt diet than in those on a regular diet, a finding which Cover says is relevant to many types of cancer. They also showed that transcription of various inflammatory cytokines,
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
2. Zion Health Announces Release of New Line of Home Remedies: Kanwa Whole Body Detox teas for Stomach Pain, Ulcers, and Skin Allergies Now available at Bee Health E in Doug
3. Pressure Ulcer Treatment and Prevention Cushions Designed by EHOB Now Offered by Rehabmart.com
4. Stroke drug kills bacteria that cause ulcers and tuberculosis
5. Foot Ulcers Tied to Increased Death Risk for People With Diabetes
6. New Pill Appears Effective, Safe for Ulcerative Colitis: Study
7. NYU School of Medicine announces new clinical trial for ulcerative colitis
8. Spray-on Skin May Someday Heal Stubborn Leg Ulcers
9. Gastric feeding tubes may raise pressure ulcer risk
10. Spencer Institute Lifestyle Fitness Coach Certification Combines Life Coaching and Fitness Coaching in One Powerful Online Training
11. Asbestos exposure, asbestosis, and smoking combined greatly increase lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... NM (PRWEB) August 21, 2014 ... by the Centers for Disease Control and Prevention ... in assessing their compliance with the immunization standards ... and the CDC's General Recommendations on Immunizations. , ... of the many procedures in place to protect ...
(Date:8/21/2014)... 2014 Recently, BambooIndustry.com, one of the ... added a new range of hand scraped bamboo ... has launched an Autumn special offer for these elegant ... can get a discounted price, up to 25% off; ... 05. , Providing natural looks and available in ...
(Date:8/20/2014)... Skmen.com, the popular online supplier of men’s and women’s ... dresses online. Along with this, the company has also ... the fresh products are offered with great discounts and low ... offer before August 31. , Skmen.com has more than ... large proportion of its clothes are selling well in the ...
(Date:8/20/2014)... 2014 Coolercovers.com, a division of ... availability of select products on Amazon.com . ... to increase product availability and customer resources. , ... canvas covers for air conditioners and evaporative coolers ... Payne, Armstrong, Amana, Carrier, Trane, Mitsubishi, Goodman, Day ...
(Date:8/20/2014)... August 20, 2014 An Elle Magazine online ... Skin Looking Young at Every Age,” offers a ... healthy skin . These recommendations are offered as ... for women ages 25-45 and beyond. The first group of ... any age and includes using sunscreen religiously, getting sufficient exercise ...
Breaking Medicine News(10 mins):Health News:ACC Health Raises the Bar Again by Completing the CQIIP Certification Program 2Health News:Cheap Hand Scraped Bamboo Floorings Recently Unveiled by BambooIndustry.com 2Health News:Skmen.com: New Designs Of Mini Party Dresses Provided Online 2Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 2Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 3Health News:Simon Ourian, Kim Kardashian’s Doctor, On Healthy Skin Suggestions for Every Age 2
... Away From Home, ... Doctor,s Office, ... Foundation for Research and Development announced a,promising new diagnostic tool to ... to be accurate for only 40 percent of,diagnoses. MUSC,s new test ...
... her legislative,accomplishments on mental health issues, Colorado State ... Legislator of the Year Award of the,American Psychological ... the award in recognition of her advocacy work ... "Senator Keller has been a champion of ...
... international ... travelers, ... travel health insurance providers, alerts,parents and students that they should purchase ... Most health insurance,programs do not provide coverage outside of the continental ...
... be getting them, study says , , MONDAY, March 10 (HealthDay ... choices for kidney cancer more than clinical factors such as ... finds. , This means many patients who are candidates ... where only part of the kidney is removed, may not ...
... Over One ... Million, PHILADELPHIA, ... have a form of,lupus, the chronic (incurable) disease that can result in ... and other health effects, including organ failure and death.,Lupus mostly strikes women ...
... a mouse model for human malignant mesothelioma (MM) that ... along with new directions for design of therapeutic strategies. ... issue of Cancer Cell, may eventually lead to a ... , MM is an aggressive cancer originating from ...
Cached Medicine News:Health News:Cell Receptor on Track for Painless Bladder Cancer Test 2Health News:Colorado State Senator Keller Recognized for Advocacy Work on Mental Health Issues 2Health News:Seven Corners Alerts Spring Breakers that They Need Travel Insurance to Vacation Abroad 2Health News:Seven Corners Alerts Spring Breakers that They Need Travel Insurance to Vacation Abroad 3Health News:Surgeon's Preferences Dictate Choice of Kidney Cancer Surgery 2Health News:Surgeon's Preferences Dictate Choice of Kidney Cancer Surgery 3Health News:Lupus Foundation to Host Community Outreach Initiatives 2Health News:Lupus Foundation to Host Community Outreach Initiatives 3Health News:Lupus Foundation to Host Community Outreach Initiatives 4Health News:Mouse model for mesothelioma reproduces human disease 2
(Date:8/20/2014)... Aug. 20, 2014 Torrance Memorial Medical ... advanced, ventilator technology from Covidien to provide a ... patients. The acute care ventilator is ... to conventional mechanical ventilation, and help clinicians move ... Patients on mechanical ventilation are often sedated to ...
(Date:8/20/2014)... , Aug. 20, 2014 Children aren,t ... receive vaccinations to help prevent disease. The Centers ... for all adults, but currently, many adults are ... is National Immunization Awareness Month, and the American ... adults, especially those with lung disease, to talk ...
(Date:8/20/2014)... Research and Markets  has announced the addition ... to their offering. Global Market Report of ... globally and regionally ( Europe , ... Latin America etc.). It captures Pralmorelin market ... focuses on three primary areas; manufacture methods & technology development, ...
Breaking Medicine Technology:Torrance Memorial Medical Center Acquires Advanced Ventilator Technology to Enhance Patient Care 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Market Report of Pralmorelin 2
... letter is being released by CEL-SCI Corporation (NYSE AMEX: ... important event has just transpired for our company. Dendreon ... advanced prostate cancer met its primary endpoint of improving overall ... from the 512 patient study will be presented on April ...
... Sweden, has been granted Orphan Drug designation by,the ... ovarian cancer. Orphan Drug,designation can entail additional assistance ... upon approval a seven year market exclusivity,is granted. ... ) , Orphan ...
Cached Medicine Technology:CEL-SCI Corporation Releases Letter to Shareholders 2CEL-SCI Corporation Releases Letter to Shareholders 3Oasmia: FDA Grants Paclical(R) Orphan Drug Designation for Ovarian Cancer in the USA 2
... portable TeleMon companion monitor, and IntelliVue ... and monitoring solution for ambulating patients ... and SpO2. Clinicians can get access ... from the central station, monitoring cockpit, ...
ISI DuraHand is the reusable, easy to sterilize surgical hand immobilizer....
MagPrep® Streptavidin Beads are encapsulated super-paramagnetic polystyrol particles coated with streptavidin. The beads have a diameter of 1 m and are provided as a stabilized aqueous suspensio...
For general purposes...
Medicine Products: