Navigation Links
High-salt diet and ulcer bug combine to increase risk of cancer
Date:4/18/2013

Numerous epidemiologic studies have shown that a diet high in salt is associated with an increased risk of gastric cancer. Now Timothy L. Cover and colleagues of Vanderbilt University show that high dietary salt combined with infection by the ulcer-causing bacterium Helicobacter pylori greatly increases the risk of cancer. The study was published ahead of print in the journal Infection and Immunity.

In the study, the researchers infected Mongolian gerbils with H. pylori. One set of gerbils received a regular diet; the other, a high salt diet. At the end of the experiment the researchers analyzed the animals' stomach tissues. Every animal on the high salt diet developed cancer, compared with just 58 percent of those on the regular diet.

It appears development of gastric cancer required the presence of a particular bacterial oncoprotein, known as CagA, which is produced by H. pylori. Gastric cancer did not develop in animals on the high salt diet that were infected with a mutant H. pylori which did not produce CagA. In earlier studies, Cover and others had shown that culturing H. pylori in a high salt environment boosts production of CagA. "This was one of the driving forces that led us to undertake the current studies," says Cover.

The investigators note that while no studies, to their knowledge, have examined relationships among a high salt diet, and infection with H. pylori expressing cagA, "in several parts of the world that have high rates of gastric cancer, there is a high prevalence of cagA+ strains and a large proportion of the population consumes a high-salt diet."

The investigators also detected significantly higher levels of gastric inflammation in H. pylori-infected gerbils on a high salt diet than in those on a regular diet, a finding which Cover says is relevant to many types of cancer. They also showed that transcription of various inflammatory cytokines,
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Other stomach microbiota modulate resistance to H. pylori-driven ulcers
2. Zion Health Announces Release of New Line of Home Remedies: Kanwa Whole Body Detox teas for Stomach Pain, Ulcers, and Skin Allergies Now available at Bee Health E in Doug
3. Pressure Ulcer Treatment and Prevention Cushions Designed by EHOB Now Offered by Rehabmart.com
4. Stroke drug kills bacteria that cause ulcers and tuberculosis
5. Foot Ulcers Tied to Increased Death Risk for People With Diabetes
6. New Pill Appears Effective, Safe for Ulcerative Colitis: Study
7. NYU School of Medicine announces new clinical trial for ulcerative colitis
8. Spray-on Skin May Someday Heal Stubborn Leg Ulcers
9. Gastric feeding tubes may raise pressure ulcer risk
10. Spencer Institute Lifestyle Fitness Coach Certification Combines Life Coaching and Fitness Coaching in One Powerful Online Training
11. Asbestos exposure, asbestosis, and smoking combined greatly increase lung cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2015)... 07, 2015 Protein identification is ... production, life science research including drug discovery, diagnostics, ... characterization market was valued at $1,569.00 million in ... CAGR of 10.63% to reach $2,600.28 million in ... characterization of protein based on protein size, shape, ...
(Date:3/6/2015)... Sanjay Gupta, MD, CNN’s Emmy award-winning ... at ATA 2015, the American Telemedicine Association's (ATA) ... world’s largest telemedicine, telehealth and mHealth meeting. , ... for several of CNN’s headlining programs including New ... DuPont Award winning WEED series. He has created ...
(Date:3/6/2015)... March 06, 2015 Ticket Down is a ... Oregon at the Moda Center. After being away ... Brooks is showing no signs of letting up on his ... legend and his wife, Trisha Yearwood, to venues around the ... bringing their critically acclaimed tour to the Moda Center in ...
(Date:3/6/2015)... NY (PRWEB) March 06, 2015 Ticket Down ... . This popular ticket exchange has extended their customer appreciation ... from Hebden Bridge, West Yorkshire England and he began his ... In the past couple of years Ed Sheeran has ... whenever Ed Sheeran is on stage he is having the ...
(Date:3/6/2015)... March 06, 2015 At Natural ... announced today the launch of its powerful, location-aware ... healthy and sustainable products at any retailer that ... exhibiting at Expo West Booth 6054. , ... gluten-free, Kosher, non-GMO, organic, Paleo, and vegan, among ...
Breaking Medicine News(10 mins):Health News:Protein Identification Market worth $2,600.28 Million By 2019 - New Research Report by MarketsandMarkets 2Health News:Protein Identification Market worth $2,600.28 Million By 2019 - New Research Report by MarketsandMarkets 3Health News:CNN’s Dr. Sanjay Gupta Among Headliners at American Telemedicine Association 2015 Annual Meeting 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 2Health News:Garth Brooks Tickets in Portland, OR at the Moda Center: Ticket Down Slashes Garth Brooks Ticket Prices at the Moda Center in Portland 3Health News:Ed Sheeran Tickets in Indianapolis, Austin, Albany, St. Louis, London, Des Moines, Salt Lake City, Saskatoon, Regina and Denver/Morrison Now On Sale at Ticket Down 2Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 2Health News:Makeena Launches App that Makes Healthy and Sustainable Products More Affordable for Shoppers 3
... Morbidity and Mortality Weekly Report released by the U.S. Centers ... Down's syndrome are the leading birth defects in the country.// ... conditions so we can understand the import they have on ... perinatal data center at the March of Dimes Birth Defects ...
... an accusatory report by a consumer group UK supermarkets ... ,The claims made by the group include that ... in pre-packaged sandwiches with a combination of water, starch ... artificial flavorings. ,The results came after a ...
... Ramadoss as assured the radiologist during the 59th Annual ... at Chennai that the current 12% tax on radiology// ... diagnostic equipment in Government hospitals will be repaired and ... up in all Government hospitals which would aid in ...
... in the crown of physical exercisers. A new study in ... wound-healing process by as much as 25 percent//. ... will become infected. ,The results appear in a ... ,This is the first time such an enhancement associated ...
... Health has announced that the number of AIDS-related deaths in the ... Thailand's The Nation//. ,The health ministry's Disease Control ... in the number of new HIV cases in to about 18,000 ... who developed AIDS dwindled from 13,364 in 2004 to 8,681 in ...
... men, and this may be due to genetic factors, according ... In the January issue of the journal, researchers reported that ... men, where it is approximately 29%. ,"Our ... represents the largest epidemiological study of depression in twins done ...
Cached Medicine News:Health News:Wounds Heal 25% Faster In Older Adults Who Exercise Regularly 2Health News:Wounds Heal 25% Faster In Older Adults Who Exercise Regularly 3
(Date:3/6/2015)... 2015  The onset of puberty can make young athletes ... and thus more inclined toward a variety of injuries. ... body,s center of gravity is altered. It,s a period of ... quickly than the rest of the body and, in some ... year. And while these sudden changes are a natural part ...
(Date:3/6/2015)... 2015   Hospira, Inc. (NYSE: HSP ... (FDA) on today,s FDA approval of the first biosimilar in ... watershed moment for improving patient access to safe, effective and ... biosimilars, Hospira has seen first-hand the positive impact of biosimilars ... these early stages of the development of a pathway for ...
(Date:3/6/2015)... Washington , 6. März 2015 /PRNewswire/ ... von Röntgenstrahlen, feierte auf dem European Congress ... , Österreich, die 1.000. Installation seines ... Logo - http://photos.prnewswire.com/prnh/20150304/179432LOGO ... Dosimeter, der in Echtzeit Informationen über die ...
Breaking Medicine Technology:Puberty can result in variety of athletic injuries 2Hospira Statement on FDA Approval of the First Biosimilar in the United States 2Hospira Statement on FDA Approval of the First Biosimilar in the United States 3Unfors RaySafe, ein Unternehmen von Fluke Biomedical, feiert 1.000. Installation seines Systems zur Echtzeit-Strahlendosimetrie 2Unfors RaySafe, ein Unternehmen von Fluke Biomedical, feiert 1.000. Installation seines Systems zur Echtzeit-Strahlendosimetrie 3
... , SAN DIEGO , July 14 ... the Marketing Authorization Application (MAA) for OraVerse has been accepted ... Kingdom (UK), Germany , Italy , ... and only local anesthesia reversal agent that accelerates the return ...
... 13 Program officials have confirmed that they will announce the ... conference tomorrow in Atlanta .  Georgia Drug Card is being launched ... medications. , , , ... obtain prescription cards at various hospitals, clinics, and other card distribution sites ...
Cached Medicine Technology:Sanofi-Aventis and Novalar File Marketing Authorization Application for OraVerse® in Five Key European Countries 2Sanofi-Aventis and Novalar File Marketing Authorization Application for OraVerse® in Five Key European Countries 3Sanofi-Aventis and Novalar File Marketing Authorization Application for OraVerse® in Five Key European Countries 4
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: