Navigation Links
Growing up as a neural stem cell: The importance of clinging together and then letting go
Date:4/25/2012

em Cell Research Center scientist and senior author of the study. "If the neurons don't form at the proper time, it could lead to deficits in their numbers and to catastrophic, potentially fatal neurological defects."

During the first trimester of development, the neural stem and progenitor cells form a niche, or safe zone, within the nervous system. The neural stem and precursor cells adhere to each other in a way that allows them to expand their numbers and keep from differentiating. A protein called N-cadherin facilitates this adhesion, Novitch said.

When it is time for the neural precursors to become motor neurons, two proteins that repress gene expression, called Foxp2 and Foxp4, become elevated and then silence N-cadherin expression, causing the clustered neural stem and precursor cells to break apart and begin differentiating.

"We have these cells in a dividing state, making more of themselves, and to make neurons that process has to be stopped and those contacts between the cells disassembled," Novitch said. "Until now, it has not been clear how the cells are pulled apart."

Novitch and his team showed that if you eliminate Foxp protein function, motor neurons and other mature cells in the nervous system are not properly formed because the N-cadherin gene is not silenced, confirming the delicate balancing act that must be achieved for normal development of both the stem and precursor cells and their neuronal progeny.

"It's a fundamental discovery. Most studies have focused on defining what promotes the adhesiveness and self-renewal of neural stem cells, rather than what breaks these contacts," Novitch said. "We were also surprised to see how small changes in the degree of cell adhesion can markedly alter the development and structure of the nervous system. It's all about balance, if you have too many or too few stem and precursor cells, the result could be disastrous."

Going forward, Novitch and his
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Use of anesthesia providers during GI procedures is growing, but may be unnecessary
2. Kids Using Synthetic Pot a Growing Public Health Concern
3. Study reveals new wrinkle in growing US health gap
4. Scientific plagiarism: A growing problem in an era of shrinking research funding
5. Chronic Heartburn a Growing Problem in U.S.
6. Worlds Tiniest Preemies Growing Up Healthy: Report
7. Growing US violent extremism by the numbers: UMD database
8. Worlds tiniest preemies are growing up and doing fine
9. CU-Boulder led study of smoking twins points to growing influence of genetic factors
10. What can we learn from Americas fastest growing and least understood age group?
11. Sport tourism development book reveals new insights on growing leisure activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat ... the fastest fat loss program ever developed. It promises to ... , There is no wonder after all that this has ... The new nutrition and workout fat loss program was created ... , According to the author of this fat loss system, ...
(Date:10/31/2014)... Joseph, Missouri (PRWEB) October 31, 2014 ... for school, one Midwest optometrist feels they may overlook ... problems to affect areas like concentration, school performance and ... may be too brief to identify progressive vision problems, ... St. Joseph, Mo., announces a new initiative: The Awesome ...
(Date:10/31/2014)... News) -- Sleep apnea may make it hard for you ... car or left your house keys, a small study suggests. ... that this ability -- called spatial memory -- was impaired ... when other stages of sleep weren,t affected. REM sleep is ... "We,ve shown for the first time that sleep apnea, ...
(Date:10/31/2014)... Americans say that either they or a family member ... the latest issue of The Gerontological Society of America,s ... ), which goes on to show that Americans strongly ... patients, end-of-life health care wishes. , This PP&AR ... ," features 12 articles that present new ways of ...
(Date:10/31/2014)... North Shore Eye Care today announced ... Island and the addition of leading ophthalmologist, William S. ... North Shore Eye Care Medical Director, Jeffrey Martin, MD. ... the Department of Ophthalmology of Winthrop-University Hospital and has ... for more than 30 years. He has been named ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Advance directives can benefit patients, families, and health care system 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3
... CEO Brings More Than 20 Years of Public Company Experience, ... IRIX ) announced today the appointment of James B.,Hawkins, president ... to its,Board of Directors. "We are excited that Jim ... said Theodore A. Boutacoff, chairman of the board at,IRIDEX. "Jim ...
... 15 Greater China Corporation,(Pink Sheets: GCHC.PK) announced ... TRT USA Corp. The new company, which is,owned ... wellness centers,that will provide treatments and products based ... acupuncture, massage,acupressure, Tuina, Tai-Chii, Qigong, reflexology and many ...
... for Rapidly Growing Profession; ... Protect Consumers, ... accreditation program for private healthcare,advocates. The announcement was made today by ... the US become more complex and access to,appropriate healthcare continues to ...
... to travel by caravan from Toledo, Ohio to Washington, ... nation,s largest nursing home chain; Wash., DC rally set for ... and,their supporters from across the nation are traveling to Toledo, ... nation,s largest,nursing home chain as the shareholders of HCR Manor ...
... new treatment options for patients, researchers say , , ... may one day find nicotine patches or hot ... say. , Nicotine patches and the hot pepper-derivative ... to two studies presented at the American Society ...
... Nine of Texas, 181,legislators are being honored ... of their accomplishments on behalf of health care,during ... Texas Hospital,Association created the award in 1997 to ... outstanding leadership on issues important,to hospitals and health ...
Cached Medicine News:Health News:James B. Hawkins Appointed to IRIDEX Board of Directors 2Health News:James B. Hawkins Appointed to IRIDEX Board of Directors 3Health News:Greater China Corporation Forms TongRenTang Wellness Corporation 2Health News:Healthcare Liaison Launches Nation's First Accreditation Program for Private Healthcare Advocates - October 27-28 2Health News:Nursing Home Workers From Across the Nation to Rally in for Improved Nursing Home Care 2Health News:Nicotine, Chili Peppers Offer Post-Surgery Pain Relief 2Health News:Nicotine, Chili Peppers Offer Post-Surgery Pain Relief 3Health News:THA Honors Nine Legislators for Contributions to Health Care 2
(Date:10/30/2014)... 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the pharmaceutical, biotechnology, and medical ... and the United States , ... the Tel Aviv area of ... WuXi,s broad platform of integrated R&D services to local ...
(Date:10/30/2014)... -- Boston Scientific Corporation (NYSE: BSX ) ... Annual Healthcare Conference on Tuesday, November 11, 2014 in ... , executive vice president and chief financial officer, will ... 8:00 a.m. PT followed by a question and answer ... and question and answer session will be available to ...
(Date:10/30/2014)... 2014   ViaDerma, Inc. (OTCQB: VDRM), ... products to market, has recently released a revolutionary ... a topical liquid tetracycline-based antibiotic that uses a ... oral medication active ingredients into topical drugs. The ... antibiotic to help prevent skin infection in minor ...
Breaking Medicine Technology:WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3
...   CPhI Worldwide, ICSE, P-MEC Europe and InnoPack had ... attendees at the Messe Frankfurt in October 2011. Post show ... and 94% of visitors agreeing that the event is the ... announced that the event will return to Frankfurt, Germany from ...
... 2012 Reportlinker.com announces that a ... in its catalogue: ... Market Size, Segment And Country Analysis ... http://www.reportlinker.com/p0797078/Nutraceuticals-Product-Market-Western-Europe-Market-Size-Segment-And-Country-Analysis-And-Forecasts-2007-2017.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Nutraceutical   ...
Cached Medicine Technology:Leading Pharma Events CPhI Worldwide, ICSE, P-MEC Europe & InnoPack to Return to Frankfurt in 2013 after Record Breaking Year 2Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 2Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 3Nutraceuticals Product Market: Western Europe Market Size, Segment And Country Analysis And Forecasts (2007-2017) 4
This storage freezer, which is based on our premium freezer line, maintain red cells safely below regulatory standards at -86C (-123F). Recorder is standard for model 8627. Model 8627 is UL Listed, C...
... Designed for the precise requirements ... Thermo Forma Blood Bank Equipment meets ... American National Red Cross (ANRC) and ... standards. Refrigerators, storage freezers, and platelet ...
TBR-120-1-GD is large capacity upright style refrigerator with an operating temperature of +4C. It is a specially designed refrigerator for the storage of blood in standard 500ml bags, complying with...
DSL-10-49300 is a rapid, direct enzyme immunoassay (EIA) kit that provides materials for the quantitative measurement of testosterone in saliva. This assay requires no sample extraction or pretreat...
Medicine Products: