Navigation Links
Growing up as a neural stem cell: The importance of clinging together and then letting go
Date:4/25/2012

Can one feel too attached? Does one need to let go to mature? Neural stem cells have this problem, too.

As immature cells, neural stem cells must stick together in a protected environment called a niche in order to divide so they can make all of the cells that populate the nervous system. But when it's time to mature, or differentiate, the neural stem cells must stop dividing, detach from their neighbors and migrate to where they are needed to form the circuits necessary for humans to think, feel and interact with the world.

Now, stem cell researchers at UCLA have identified new components of the genetic pathway that controls the adhesive properties and proliferation of neural stem cells and the formation of neurons in early development.

The finding by scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA could be important because errors in this pathway can lead to a variety of birth defects that affect the structure of the nervous system, as well as more subtle changes that impair cognitive and motor functions associated with disorders such as autism.

The results of the four-year study are published April 26, 2012 in the peer-reviewed journal Neuron.

The UCLA team found that a delicate balance of gene expression enables the pool of neural stem and progenitor cells in early development to initially increase and then quickly stop dividing to form neurons at defined times.

"One of the greatest mysteries in developmental biology is what constitutes the switch between stem cell proliferation and differentiation. In our studies of the formation of motor neurons, the cells that are essential for movement, we were able to uncover what controls the early expansion of neural stem and progenitor cells, and more importantly what stops their proliferation when there are enough precursors built up," said Bennett G. Novitch, an assistant professor of neurobiology, a Broad St
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Use of anesthesia providers during GI procedures is growing, but may be unnecessary
2. Kids Using Synthetic Pot a Growing Public Health Concern
3. Study reveals new wrinkle in growing US health gap
4. Scientific plagiarism: A growing problem in an era of shrinking research funding
5. Chronic Heartburn a Growing Problem in U.S.
6. Worlds Tiniest Preemies Growing Up Healthy: Report
7. Growing US violent extremism by the numbers: UMD database
8. Worlds tiniest preemies are growing up and doing fine
9. CU-Boulder led study of smoking twins points to growing influence of genetic factors
10. What can we learn from Americas fastest growing and least understood age group?
11. Sport tourism development book reveals new insights on growing leisure activity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 2015 Ticket Down is a reputable source of ... Blackhawks are currently in the middle of their series against the ... series. If the Blackhawks can win tonight at home, this ... Saturday, May 30th at the Honda Center in Anaheim. , ... in the Western Conference as they won the Pacific Division by ...
(Date:5/27/2015)... 27, 2015 Ticket Down is a reputable source ... Cavs have been super hot during the 2014-15 NBA season and ... points with a final score of 118-88. , For ... Finals since 2006-2007 when they lost to the San Antonio Spurs. ... chances of the Cavaliers making it to the NBA finals increased ...
(Date:5/27/2015)... 2015 “We are honored to receive ... vice president and vice president of clinical affairs for ... allows us to provide comprehensive care to more individuals ... SSCHC provides clinical care and behavioral health services for ... 2014, many of whom took advantage of the clinic’s ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 Continuing its ... of healthier patients in the community, SmartPractice® ... (formerly John C. Lincoln). SmartPractice Vice President of Human ... Shaw presented a $25,000 check to Paulla Miller, Sherry ... Breast Health & Research Center on April 30. The ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 In today's ... getting tighter, it can be challenging for doctors and ... cutting edge treatments. , Austin-based HealthTronics, Inc. ... minimally invasive, mobile medical therapies for clinically sophisticated applications. ... with the acquisition of Laser Ventures, Inc ., ...
Breaking Medicine News(10 mins):Health News:Blackhawks vs. Ducks NHL Western Conference Finals Tickets: Ticket Down Slashes Ticket Prices on Chicago Blackhawks vs. Anaheim Ducks 2015 NHL Western Conference Finals 2Health News:Cavs NBA Finals Tickets: Ticket Down Slashes Ticket Prices on Cleveland Cavaliers 2015 NBA Finals Tickets at Quicken Loans Arena and Offers Valuable Promo Code 2Health News:Sixteenth Street Community Health Centers To Expand Primary Care and Behavioral Health Services Through $1 Million Grant From Aurora's Better Together Fund 2Health News:SmartPractice Donates $25,000 to HonorHealth Breast Health and Research Center 2Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 2Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 3
... Reinberg HealthDay Reporter , WEDNESDAY, May 25 ... a "polypill," appears to cut users, odds for heart ... study finds. The pill combines two blood pressure-lowering ... designed to make all these heart-protecting drugs easy to ...
... 25, 2011) The cost of cancer care is threatening ... but at staggering costs. This coupled with aging baby boomers ... billion annually on cancer care by the year 2020. This ... maintain or improve the quality of care while saving money ...
... CA (May 26, 2011) Precision tinted lenses have ... poor readers, and are increasingly used for migraine sufferers, ... been unclear. Now research published in the journal ... imaging (fMRI) for the first time to suggest a ...
... NY, May 26, 2011Young adults ages 19-29 are struggling to ... other age group, demonstrating the need for Affordable Care Act ... and make it more affordable, according to a new Commonwealth ... of young adults couldn,t afford the care they needed, meaning ...
... 2011 UT Southwestern Medical Center researchers are engaging the ... component in red wine and grapes could help reduce the ... recruit about two dozen professional boxers to take the neuroprotective ... damage to the brain after impact and helps restore subtle ...
... bats and dolphins echolocate, emitting bursts of sounds and then ... What is less well-known is that people can echolocate too. ... make clicks with their mouths and to use the returning ... these individuals are so adept at echolocation that they can ...
Cached Medicine News:Health News:Daily Four-Drug Combo Pill Halves Heart Disease Risk: Study 2Health News:Daily Four-Drug Combo Pill Halves Heart Disease Risk: Study 3Health News:Oncologists hold key to curbing cancer costs 2Health News:Oncologists hold key to curbing cancer costs 3Health News:Tinted specs offer real migraine relief, says fMRI study 2Health News:Tinted specs offer real migraine relief, says fMRI study 3Health News:Health reform essential to young adults: Nearly half can't afford needed health care 2Health News:Health reform essential to young adults: Nearly half can't afford needed health care 3Health News:Health reform essential to young adults: Nearly half can't afford needed health care 4Health News:Researchers evaluate red wine compound for treating concussions in pro boxers 2Health News:'I can hear a building over there' 2
(Date:5/27/2015)... Research and Markets ( http://www.researchandmarkets.com/research/f6rkcf/north_america ... America Portable X Ray Devices Market - Growth, ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... market for Portable X-Ray Devices is expected to ... 2020 X-Ray is a form of ...
(Date:5/27/2015)... , May 26, 2015 Research and Markets( ... Pacific Portable X Ray Devices Market - Growth, Trends And ... The Asia Pacific market ... healthy CAGR from 2014 to 2020 X-Ray is ... the abnormalities in the body, especially bones. The need of ...
(Date:5/27/2015)... 2015 Tout ... horaire. Il nuit sérieusement à la productivité. ... les réunions de mi-journée et vous empêche ... moment dans votre chambre d,hôtel. Même une ... risque de vous empêcher de tenir compagnie ...
Breaking Medicine Technology:North America Portable X Ray Devices Market Report 2015 - Growth, Trends And Forecasts 2014-2019 2Asia Pacific Portable X Ray Devices Market 2015 - Trends And Forecasts to 2019 2HumanCharger, l'allié des sportifs d'élite, vous aide à vaincre le décalage horaire deux fois plus vite 2HumanCharger, l'allié des sportifs d'élite, vous aide à vaincre le décalage horaire deux fois plus vite 3HumanCharger, l'allié des sportifs d'élite, vous aide à vaincre le décalage horaire deux fois plus vite 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: