Navigation Links
Greater representation of elderly patients in Phase III trials are needed
Date:2/22/2013

DENVER The median age of patients diagnosed with advanced nonsmall-cell lung cancer (NSCLC) has steadily increased over the recent years and is presently 70 years. Despite this, the elderly are significantly underrepresented in clinical trials. A recent study published in the March 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, investigated the degree to which exclusion or underrepresentation of elderly occurs in practice-changing clinical trials in advanced NSCLC. Researchers conclude that greater representation of elderly patients in phase III trials is required to better define evidence-based paradigms in the increasingly elderly NSCLC population.

Researchers did an extensive literature search, included articles for review if they were phase III, involved systemic therapy alone, studied advanced NSCLC and were conducted between 1980 and 2010. A total of 248 studies were identified and their full text reviewed by the authors.

Among the 100 most cited trials, 33 percent excluded elderly patients in their trial design. The average reported median patient age in those trials was 60.9 years.

The authors "have clearly demonstrated that a significant proportion of highly cited phase III clinical trials in advanced NSCLC overtly exclude elderly patients." They recommend that a greater emphasis be placed on recruiting clinical trial patients with age demographics that better represent the median age of the advanced NSCLC population.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Bullied Children at Greater Risk for Self-Harm, Study Finds
2. Greater numbers of highly educated women are having children, bucking recent history
3. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
4. Hepatitis C Causing Liver Damage in Greater Numbers: Study
5. Unemployed Americans face greater risk of mortality: UBC study
6. Greater L.A. Heating Up, Climate Experts Predict
7. Greater availability of neurosurgeons could reduce risk of death from motor vehicle accidents
8. Early treatment could mean greater earning potential for people with HIV
9. Men Have a Greater Lifetime Risk for Kidney Failure: Study
10. More Friends, Greater Well-Being at Midlife?
11. Ancestral link places Mexican-Americans at greater risk for metabolic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... The digital health ... organization with pending recognition status from the Centers for Disease Control and Prevention ... classes and live video conferencing. , The DPP resulted from clinical work ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician ... its Orlando location as an interventional pain management physician. He brings a wealth ... treatment of migraine headaches, and significant experience in spinal cord stimulation for chronic ...
(Date:8/18/2017)... New York, New York (PRWEB) , ... ... ... Q International Courier, LLC, d/b/a Quick International, LLC (“Quick”), a highly specialized ... today announced it has entered into a definitive agreement to purchase Unitrans ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm ... for efforts to educate the local population on cancer realities while attracting donations to ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed and ...
(Date:8/18/2017)... ... , ... The Brian Gifford Agency, an Indiana-based firm providing asset protection and ... Academy in a charity drive to provide for at-risk children and teens in the ... is a nonprofit organization that has offered critical programs to at-risk and foster children ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
(Date:7/31/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), has been named one ... by Crain,s Detroit Business . The annual ... three-year revenue growth. This year,s edition measures growth from 2013 ... the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... said Phil Hagerman , CEO and chairman of Diplomat. ...
(Date:7/28/2017)... July 28, 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") ... third quarter ended June 30, 2017, and updated its ... For the fiscal third quarter, Hill-Rom ... $0.68 per diluted share in the prior-year period. These ... $0.39 per diluted share primarily related to the non-cash ...
Breaking Medicine Technology: