Navigation Links
Glazer receives grant to study light-activated cancer drugs
Date:1/31/2013

LEXINGTON, Ky. (Jan. 31, 2013) University of Kentucky assistant professor of chemistry Edith "Phoebe" Glazer has received an American Cancer Society Research Scholar Grant for $715,000 over four years to continue her research into ruthenium-based cancer drugs. These compounds are less toxic to healthy cells than a similar and widely used inorganic drug.

Cisplatin is a common platinum-based cancer drug used in a variety of cancer treatments. But while cisplatin kills cancer cells, it also attacks healthy cells, causing debilitating side effects. Ruthenium is another transition metal and belongs to the same group of the periodic table as iron.

Previously, the Glazer group developed two new ruthenium complexes designed to kill cancer cells while preserving healthy cells. These complexes are inert in the dark, but when activated with light, they become up to 200 times as toxic, and up to three times as potent as cisplatin against tumor cells.

Funded by the American Cancer Society, the new grant will allow Glazer's team to develop improved ruthenium-based compounds and to study their effectiveness. Using the strategy of combining organic ligands as building blocks that assemble around the ruthenium center "core," a large family of compounds with different structures and properties can be rapidly synthesized. This is in marked contrast to approaches using compounds discovered in nature, called natural products, as chemotherapeutics.

Many chemotherapeutics are natural products, but their synthesis is challenging and there are limited chemical modifications that can be made into the molecules. In the ruthenium compounds, the organic components can be easily changed to alter chemical properties and possibly even what types of cells the compounds will enter in the body. The different structures can also potentially prevent the development of drug resistance, as tumors that become resistant to one particular ruthenium drug structure co
'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Loyola Cancer Center receives Outstanding Achievement Award
2. MU receives national award for using mind-body approach to improve health
3. Neuropsychologist receives University of Houstons highest faculty honor
4. Boston researcher, surgical oncologist receives national award
5. LA BioMed receives Grand Challenges Explorations grant
6. Lawson researcher receives 1 of first-ever Pfizer Psychiatry Research Awards
7. Dr. Arthur Slutsky, vice-president of research at St. Michaels, receives lifetime award
8. UC San Diego Superfund Research Program receives $15 million grant renewal
9. Markey receives $6.25 million to study deadly blood and bone marrow disease
10. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
11. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... (PRWEB) March 27, 2015 While deep learning ... 2015 GPU technology conference (GTC) , the CEO of one ... and push the human lifespan well beyond the generally-agreed ceiling ... informatics company , is one of 12 companies recognized as ... other startups in the GTC Emerging Companies Summit ...
(Date:3/27/2015)... UK (PRWEB) March 27, 2015 DrugDev ... Melissa (Liss) Easy was named to the 2015 Philadelphia ... Under 40 list spotlights 40 dynamic, up-and-coming leaders less ... and community involvement. Winners are honored at an awards ... of the Philadelphia Business Journal. , Lyn Kremer, Publisher ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The report ... an essential source of information on and analysis of ... The population of the US in 2013 amounted to ... Rate (CAGR) of 0.8% from 2008. The country’s increasingly ... chronic diseases will help to boost the growth of ...
(Date:3/27/2015)... SMI (Silicon Microstructures, Inc.), a global ... the SM1120 MEMS based ultra-miniature pressure sensor designed especially ... at only 220um x 75um provides ample space for ... With industry leading in vivo drift performance of ... broad operating pressure range from 0 to 1,100 mmHg ...
(Date:3/27/2015)... When struck with the aftermath of a trucking ... begin. The latest eBook released by Dax Jones ... victims a clear and concise process for obtaining the ... injury claim is seen through to successful completion. , ... should be taken immediately following the trucking incident. From ...
Breaking Medicine News(10 mins):Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 2Health News:InSilico Medicine, Inc. Stands Out from High Tech Startups at 2015 GPU Conference 3Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 2Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 3Health News:US Pharmaceutical Market worth $548.4 billion by 2020 Says a New Report Available at RnRMarketResearch.com 4Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Dax Jones Updated eBook on Trucking Accidents Offers Helpful Information to Crash Victims 2
... new study shows that monitoring levels of exhaled nitric oxide ... improve the course of their disease. , The study ... is funded by the National Institute of Allergy and Infectious ... The Sept. 20 issue of The Lancet reports ...
... GetResearchSmart LLC serves as Guest Editor for a special issue of ... entitled Measuring Trust in Clinical Research. , ... St. ... of The Monitor, journal of the Association of Clinical Research Professionals ...
... ,do not board, list comes as a surprise to ... -- Thirty-three would-be air travelers with suspected or confirmed ... health "Do Not Board" list in the first year ... , Authorized under the Aviation and Transportation Security Act ...
... National Poll Shows Large Majority Supports Funding ... of the nation,s,largest veterans service organizations, representing ... Veterans, Affairs Committee Chairman Daniel,Akaka (D-Hawaii), House ... a group of bipartisan cosponsors for introducing,legislation ...
... a top concern for businesses of all sizes. Just when,employers ... these that complicate the enrollment:, -- Employees don,t ... of what their employer provides. -- Health ... -- A handful of employees who are located in remote ...
... WHITE PLAINS, N.Y., Sept. 18 Dee Snider,best known as ... Sister,is taking on a new lead role this year as ... is personal: two of his children were,born prematurely, and he,s ... Despite the wild-man image from his heavy metal days, Snider ...
Cached Medicine News:Health News:Monitoring exhaled nitric oxide does not help manage asthma 2Health News:Monitoring exhaled nitric oxide does not help manage asthma 3Health News:GetResearchSmart LLC Website Founder Honored as Guest Editor 2Health News:U.S. Barred 33 TB-Infected People From Flying Over Past Year 2Health News:U.S. Barred 33 TB-Infected People From Flying Over Past Year 3Health News:Historic Legislation to End Delays in Veterans Health Care Funding 2Health News:Historic Legislation to End Delays in Veterans Health Care Funding 3Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 2Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 3Health News:Dee Snider Joins March of Dimes Bikers for Babies(R) 2
(Date:3/27/2015)... , March 27, 2015 Dynatronics Corporation (NASDAQ: ... has been appointed to the Company,s Board of Directors ... the death in November 2014 of board member Joseph ... Linder to our Board of Directors represents an important ... , chairman and president of Dynatronics.  "Rich is a proven ...
(Date:3/27/2015)... 27, 2015 Biopharmaceutical Industry Leads Manufacturing ... comes out on top as the country,s manufacturing leader ... report  from ndp│analytics. According to the  analysis , the ... over the last decade, accounting for 27 percent of ... A Short Video on Medicare Part D ...
(Date:3/27/2015)... DIEGO , March 27, 2015   ... company, today announced new data showing that, compared ... TM technology provided highly equivalent interpretations of ... disease, and did so in a fraction of ... the way for more comprehensive genetic analysis in ...
Breaking Medicine Technology:Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2Week in Review: The Latest from PhRMA 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 2New Data at ACMG Shows Cypher's Software Can Automate Interpretation of Genetic Variants to Advance Non-invasive Prenatal Testing 3
... People recovering,from acute heart problems such as ... develop habits to control heart attack risk factors ... to researchers at,Mayo Clinic in Rochester. These managers ... programs that last,three years. With these risk factors ...
... 4 AstraZeneca (NYSE:,AZN) today announced that it ... U.S. Food and Drug Administration (FDA) for approval ... Aerosol for the long-term maintenance treatment of asthma ... SYMBICORT is currently approved,for the long-term maintenance treatment ...
Cached Medicine Technology:Heart Patients More Likely to Adopt Healthy Habits in 3-Year Program Led by Cardiac Rehabilitation Experts, Mayo Clinic Research Shows 2Heart Patients More Likely to Adopt Healthy Habits in 3-Year Program Led by Cardiac Rehabilitation Experts, Mayo Clinic Research Shows 3Heart Patients More Likely to Adopt Healthy Habits in 3-Year Program Led by Cardiac Rehabilitation Experts, Mayo Clinic Research Shows 4AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six 2AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six 3AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six 4AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six 5AstraZeneca Submits an sNDA for SYMBICORT(R) for the Treatment of Asthma in Children as Young as Age Six 6
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: