Navigation Links
Genomic detectives crack the case of the missing heritability
Date:2/22/2013

riations that, when added together, accounted for almost all of the offsprings' inherited characteristics, indicating that there was very little missing heritability in yeast.

Although the search for heritability was successful in yeast, finding missing heritability in humans is far more complicated, Kruglyak said. For example, interactions between genes can contribute to heritable traits, but such interactions are difficult to detect with genome-wide association studies (GWAS), which are the primary means by which geneticists look for DNA variations associated with diseases or traits. In addition, environmental factors such as nutrition also can influence gene activity, and these influences can be elusive to the genome-wide study. GWAS also may be inadequate at detecting common DNA spelling errors that have only small effects, or it may fail to find DNA variations that have a large effect but are rare.

The study sheds light on the role of nature (genetic factors) versus nurture (environmental factors) in determining traits and disease risk, according to Bert Vogelstein, director of the Ludwig Center at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute Investigator.

"The nature versus nurture argument has been brewing for decades, both among scientists and the lay public, and 'missing heritability' has been problematic for the 'nature' component," said Vogelstein, who was not involved in the Princeton study.

"This beautiful study demonstrates that the genetic basis for heritability (nature) can be precisely defined if extensive, well-controlled experiments can be performed," Vogelstein said. "Though the results were obtained in a model organism, I would be surprised if they didn't apply, at least in part, to higher organisms, including humans."

Kruglyak said that one approach to finding the missing heritability in humans might be to apply genome-wide scans to large families, rather
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Following the genomic pathways to stop the spread of cancer
2. Genomic study of rare childrens cancer yields possible prognostic tool
3. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
4. Study identifies genes associated with genomic expansions that cause disease
5. $8.9 million NIH grant to study genomic link to premature heart disease
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Study shows large-scale genomic testing feasible, impacts therapy
10. Stanford/Yale study gives insight into subtle genomic differences among our own cells
11. NIH grant moves pathologists to the forefront of genomic medicine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genomic detectives crack the case of the missing heritability
(Date:7/6/2015)... ... July 06, 2015 , ... Acara Partners, a leading business ... of its complimentary educational webinar series for the summer of 2015. ... for their clients through targeted marketing, sales, digital communications, branding and business development ...
(Date:7/6/2015)... ... July 06, 2015 , ... Olive Fertility Centre is proud to announce that ... Award on behalf of the department of Family Practice. , “This award is a ... practicing in. The technology is changing so rapidly and we are also developing new ...
(Date:7/6/2015)... ... July 06, 2015 , ... Cancer Hope Network ... caregivers and medical professionals to chat with the CHN patient services team and ... a cancer diagnosis is often the most traumatic experience of a person’s life,” ...
(Date:7/6/2015)... , ... July 06, 2015 , ... MD Now, the ... July 6. The newly constructed urgent care center will serve residents and visitors in ... addition to being MD Now’s 22nd South Florida location, the new facility will be ...
(Date:7/6/2015)... ... ... World renowned Los Angeles facial plastic surgeon , Dr. Paul Nassif, ... solutions. Individuals that want to make multiple changes to their facial appearance are able ... of their needs. , "Anytime I see an opportunity to change the life ...
Breaking Medicine News(10 mins):Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 2Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 3Health News:Olive Fertility Centre Physician Honoured for Teaching 2Health News:Cancer Hope Network Launches Upgraded Website to Support Cancer Patients, Caregivers 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 2Health News:MD Now Urgent Care Opens its Fourth Miami-Dade County Facility in Cutler Bay 3Health News:Los Angeles Plastic Surgeon, Dr. Paul Nassif, is Now Offering Comprehensive Facial Plastic Surgery Procedures 2
... significant bone mass in the first year after the transplant, ... bodies from rejecting the new organ. The bone loss greatly ... fractures among this group ranges from 22 percent to 44 ... but which drugs work best in this situation is unclear. ...
... suggest that kids who struggle to breathe during sleep ... out. ,Adenotonsillectomy is a common surgical procedure in ... performed to treat recurring bouts of tonsillitis. During the ... to treat obstructive sleep apnea (OSA), a condition in ...
... 34 years old. Advances in chemotherapy and radiotherapy have ... cancer, but since men who get the disease are ... and its treatment on fertility remains. ,While ... found fertility rates unchanged. These conflicting results suggested the ...
... has shown that a chemotherapy regimen combining vinorelbine (Navelbine) ... in the treatment of hormone-refractory prostate cancer . Specialists ... earlier in their disease. , However researchers ... treatment regimen is planned. From a group of 66 ...
... failure is a chronic but deadly condition caused by the ... weaker and weaker. An estimated 5 million Americans ... five years. It can be caused by high blood pressure, ... In a recent study it was seen that heart failure ...
... Previous studies show conflicting results over whether hormone replacement ... A recent study examines the pros and cons of ... combined HRT therapy for five years. All the women ... had menopausal symptoms, while others did not.Results show women ...
Cached Medicine News:Health News:A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer 2
(Date:7/6/2015)... , July 6, 2015 Hologic, Inc. (NASDAQ: ... to release its financial results for the third quarter ... the market closes.  In conjunction with the release, management ... p.m. Eastern Time. Interested participants may listen ... the United States ) or 719-325-4804 (for international ...
(Date:7/6/2015)... 2015 E-QURE Corp (OTCQB: EQUR), today announced that ... VirtualInvestorConferences.com on July 9, 2015. DATE: Thursday, July ... This will be a live, interactive ... company questions in real-time - both in the presentation ... If attendees are not able to join the event ...
(Date:7/6/2015)... and FARMINGTON, Conn. ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of Series E warrants to purchase ... F warrants to purchase 2,191,781 shares of its ...
Breaking Medicine Technology:Hologic to Announce Financial Results for the Third Quarter of Fiscal 2015 on Wednesday, July 29, 2015 2E-QURE Corp to Webcast, Live, at VirtualInvestorConferences.com July 9 2Palatin Technologies Completes $30 Million Financing 2Palatin Technologies Completes $30 Million Financing 3Palatin Technologies Completes $30 Million Financing 4Palatin Technologies Completes $30 Million Financing 5
... Weiss, Director of Maryland Laser, Skin and Vein,Institute, ... BALTIMORE, Oct. 2 Robert Weiss, M.D., board ... U.S. to offer his,patients DOT Therapy (Dermal Optical ... Dr. Weiss is an,internationally renowned dermatologist, who is ...
... Biotechnologies AB and Dyax,Corp. (NASDAQ: DYAX ) ... a,collaboration to discover and to develop therapeutic ... inflammatory diseases., The collaboration follows the ... Professors Frostegard and de Faire of the ...
Cached Medicine Technology:DOT Therapy: Newest Breakthrough Technology in Laser Skin Resurfacing 2Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation 2Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation 3Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation 4
... BX620S. Digital stability control, analog display ... counting and percent measure functions, auto ... and time data from built-in clock. ... (selectable from 200g to 600g). Built-in ...
The EK-H Series offer 10 selectable units of measure...
60 month warranty, constructed entirely of aluminum alloy, allows the selection of 11 units of measure....
The EK-H Series offer 10 selectable units of measure...
Medicine Products: