Navigation Links
Genomic detectives crack the case of the missing heritability
Date:2/22/2013

riations that, when added together, accounted for almost all of the offsprings' inherited characteristics, indicating that there was very little missing heritability in yeast.

Although the search for heritability was successful in yeast, finding missing heritability in humans is far more complicated, Kruglyak said. For example, interactions between genes can contribute to heritable traits, but such interactions are difficult to detect with genome-wide association studies (GWAS), which are the primary means by which geneticists look for DNA variations associated with diseases or traits. In addition, environmental factors such as nutrition also can influence gene activity, and these influences can be elusive to the genome-wide study. GWAS also may be inadequate at detecting common DNA spelling errors that have only small effects, or it may fail to find DNA variations that have a large effect but are rare.

The study sheds light on the role of nature (genetic factors) versus nurture (environmental factors) in determining traits and disease risk, according to Bert Vogelstein, director of the Ludwig Center at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute Investigator.

"The nature versus nurture argument has been brewing for decades, both among scientists and the lay public, and 'missing heritability' has been problematic for the 'nature' component," said Vogelstein, who was not involved in the Princeton study.

"This beautiful study demonstrates that the genetic basis for heritability (nature) can be precisely defined if extensive, well-controlled experiments can be performed," Vogelstein said. "Though the results were obtained in a model organism, I would be surprised if they didn't apply, at least in part, to higher organisms, including humans."

Kruglyak said that one approach to finding the missing heritability in humans might be to apply genome-wide scans to large families, rather
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Following the genomic pathways to stop the spread of cancer
2. Genomic study of rare childrens cancer yields possible prognostic tool
3. Mayo, UCSF team discovers genomic variant that increases risk of brain tumors
4. Study identifies genes associated with genomic expansions that cause disease
5. $8.9 million NIH grant to study genomic link to premature heart disease
6. Edith Sanford Breast Cancer Foundation and TSRI partner in genomic breast cancer research
7. Molecular Genetics & Genomic Medicine: New open access journal launched by Wiley
8. Ontario Genomics Institute invests in stem cell technology at Tissue Regenerative Therapeutics
9. Study shows large-scale genomic testing feasible, impacts therapy
10. Stanford/Yale study gives insight into subtle genomic differences among our own cells
11. NIH grant moves pathologists to the forefront of genomic medicine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genomic detectives crack the case of the missing heritability
(Date:7/29/2014)... 2014 Nuanced Media, a leading digital ... HIPAA (Health Insurance Portability and Accountability Act) certified firm. ... storage and transfer of Personal Health Information (PHI). ... Nuanced Media can effectively serve their medical industry clients. ... to offer medical industry specific products such as ...
(Date:7/29/2014)... Ticketability.com has reduced the cost of Phantom of the Opera ... on the secure website. Customers are invited to use savings ... are priced lower every day. , Click Here ... Theatergoers know that attending an entertaining show can be costly, ... tickets for sale that are priced to fit their budgets. ...
(Date:7/29/2014)... 2014 All brides want their bridal ... memorable. LunaDress’ extensive collection is sure to provide designs ... available from local stores. It has recently announced its ... information, all the new products come with big savings, ... LunaDress have been working in the garment ...
(Date:7/28/2014)... of a gene controlling red blood cell development have ... the globe, according to a new study led by ... of world populations to look for the origin of ... haemoglobin production into adulthood. Fetal haemoglobin is normally found ... blood disorders who are able to keep making it ...
(Date:7/28/2014)... NAPW honors Pamela ... Center, as a 2014 Professional Woman of the Year. ... leadership in community health. As the largest, most-recognized networking ... industry and profession, the National Association of Professional Women ... 600,000 members and nearly 300 Local Chapters. , In ...
Breaking Medicine News(10 mins):Health News:Nuanced Media Web Design Agency Now Hipaa Certified 2Health News:Phantom of the Opera Tickets for Sale: Ticketability.com Delights Customers with Phantom of the Opera Theatre Tickets While Seats Last 2Health News:LunaDress’ Summer Sale Has Arrived: All Its Gorgeous Lace Wedding Dresses are Affordable Now 2Health News:Study tracks worldwide spread of beneficial blood cell gene variant 2Health News:Study tracks worldwide spread of beneficial blood cell gene variant 3Health News:National Association of Professional Women Announces Pamela A. Schulters, Head Nurse at Kings County Hospital Center, a 2014 Professional Woman of the Year 2
... SALT LAKE CITY Researchers have found that a synthetic ... wort, may be a promising treatment for patients with recurrent ... 31, 2011 in the journal Cancer . ... are largely incurable cancers with a poor prognosis. An estimated ...
... In a first-of-its-kind study with nuts, randomized controlled-feeding ... the United States Department of Agriculture (USDA) found that ... the body. The findings indicate that pistachios may ... further validating pistachios as one of the lowest ...
... new analysis has found that childhood cancer survivors often ... their attention and memory. Published early online in ... Society, the study indicates that addressing sleep hygiene among ... cognitive health. Cognitive problems, such as trouble ...
... C.S. Lewis, the famous author and Oxford academic, once proclaimed ... a book long enough to suit me." We sip it ... biscuits in the afternoon, and relax with it at the ... integral infusion worldwide, carrying both epicurean and economic significance. But, ...
... than a "fat" tax for deterring overweight people from making ... A survey of 364 shoppers in random Alberta grocery stores ... for junk food, shoppersincluding those with the heaviest body mass ... and included a note that the item was being taxed ...
... It is important that the United States begin to live within ... that as a nation we need to be smart about how ... understanding of what it means for America,s future jeopardizes the very ... than half a century, science and technology have been the primary ...
Cached Medicine News:Health News:Scientists find potential benefit of hypericin for recurrent brain tumors 2Health News:Pistachios deliver weight management support, heart health benefits 2Health News:Sleep issues contribute to cognitive problems in childhood cancer survivors 2Health News:Green tea and tai chi enhance bone health and reduce inflammation in postmenopausal women 2Health News:Green tea and tai chi enhance bone health and reduce inflammation in postmenopausal women 3Health News:Warning labels better than a fat tax, University of Alberta study shows 2Health News:US House budget plans would jeopardize scientific research facilities 2
(Date:7/28/2014)... , July 28, 2014  Air Products (NYSE: ... supply of medical oxygen is vital to any healthcare ... innovations that not only improve the efficiency of its ... Products will highlight these systems—including systems for emergency ... oxygen loss—from August 4-5 at the 51 st ...
(Date:7/28/2014)... 2014 Southern Research Institute today announced ... and CEO of Southern Research Institute, has been ... for the 2014-2015 term.  The inauguration took place ... in Chicago with attendees ... The Controlled Release Society is an international, interdisciplinary, ...
(Date:7/28/2014)... July 28, 2014  A prospective study conducted ... has validated the performance of VolparaDensity ... has associated volumetrically assessed breast density measurements to ... Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the article, ... for widespread breast cancer risk assessment," was authored ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... , MADISON, N.J., Nov. ... the world,s leading provider of diagnostic testing, information and services, ... Annual Piper Jaffray Healthcare Conference in New York City. ... 9:30 a.m. Eastern Time. , During the conference, the company ...
... , POTOMAC, Md., Nov. 24 ... Diane Wisneski has added Philadelphia jurors to her Thanksgiving gratitude ... just choice. I am so thankful to them," she said ... Pharmaceuticals. , Wisneski is among 12,000 women nationwide who ...
Cached Medicine Technology:Quest Diagnostics To Speak At The 21st Annual Piper Jaffray Healthcare Conference 2Maryland Woman Thankful for Wyeth Verdicts 2
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Accumedics Electronic Medical ... real-time HL7 EDI Interface ... demographics, and provides custom ... Record Software Interface is ...
... RecordsTFC System supports approaches to ... patient/resident record keeping functions using ... multiple facilities and cut across ... clinics, community clinics, physician, agency, ...
... was developed expressly to help you ... applying the right combination of EMR ... you can be confident your practice ... What's more, athenaClinicals seamlessly integrates ...
Medicine Products: