Navigation Links
Genetics May Help Fine-Tune Warfarin Dosage
Date:2/18/2009

would predict the ideal dose of warfarin in a study of more than 4,000 people.

The researchers found that the algorithm predicted the ideal dose of warfarin better than other approaches.

Specifically, the algorithm's predictions were, on average, within about 8.5 milligrams of a person's ideal weekly dose. Demographic and clinical data alone predicted doses of about 10 milligrams off the ideal weekly dose, and a method that used a fixed daily dose, or about 35 milligrams a week, was off by an average of 13 milligrams, the researchers found.

"Warfarin has a very narrow therapeutic range," said co-author Teri Klein, a senior research scientist in genetics at Stanford. "Overdosing and underdosing of warfarin results in patients either being at much greater risk for excessive bleeding (overdosing) or clotting (underdosing)," she said.

"We found, based on this population, that 46 percent of the population would benefit by including their genotypes for these two genes," Klein said. "By including the genotypes along with clinical and demographic information, initial dosing is much closer to the ideal dose, thus limiting potential adverse events."

Altman said a trial now is needed to see if people who are prescribed warfarin based on genetic testing actually do better than those whose dosage is not determined with the aid of genetics.

"More broadly," he said, the study's finding "tells us that the day when we routinely use genetic information to personalize the use of drugs is coming and may be almost here for warfarin."

Dr. Richard C. Becker, professor of medicine in the divisions of cardiology and hematology at Duke University School of Medicine, said that the researchers appear to be on the right track but that more testing is needed before the approach becomes standard practice.

"The safe and effective use of medications based on patient-specific needs is an achievable goal in the early 2
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Help Fine-Tune Warfarin Dosage
(Date:7/4/2015)... ... July 05, 2015 , ... Dating a real millionaire online ... best online millionaire dating service and strives to remove the worries from meeting partners. ... millionaire dating app of 2015 and readers have responded with excitement. ...
(Date:7/4/2015)... ... July 04, 2015 , ... Tyler Boden, Project Developer ... sales expertise from the North American Board of Certified Energy Practitioners (NABCEP®), and ... highly respected and well established national certification organization for renewable energy professionals. Designation ...
(Date:7/3/2015)... ... July 03, 2015 , ... ... its 2015 Annual Conference , the premiere continuing education and networking ... Orlando at SeaWorld in Orlando, Florida. Speakers include the leading rheumatology experts ...
(Date:7/3/2015)... , ... July 03, 2015 , ... ... to healthcare providers, has been retained to lead a national chief nursing ... the top-ranked executive search firms in the healthcare industry, B. E. Smith has ...
(Date:7/3/2015)... ... July 03, 2015 , ... Jennifer Renee Hanes, DO is the new ... the largest network of independent freestanding emergency rooms in the United States. , “We ... Sienna Plantation facility,” said Executive Medical Director of First Choice Emergency Room, Dr. James ...
Breaking Medicine News(10 mins):Health News:MillionaireMatchapp.com Publishes the Best Millionaire Dating App and Official Dating Site Reviews 2015 2Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 2Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 3Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 2Health News:Jane Phillips Medical Center Retains B. E. Smith to Recruit New Chief Nursing Officer 3Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3
... (August 15, 2011) Autism Speaks, the world,s largest autism ... the largest known study of younger siblings of children who ... study, based on data from the Autism Speaks High Risk ... the UC Davis MIND Institute, was published online today in ...
... are at an increased risk of dying due to ... BioMed Central,s open access journal Arthritis Research & ... for people with RA is due to disease-related inflammation ... general population. Treatment of arthritis with disease modifying antirheumatic ...
... Aug. 13 (HealthDay News) -- Although many children anxiously anticipate ... about the transition than others. Children who are excessively ... larger problem, an expert says. "Even though most children ... quite happy and adjust to the new school within two ...
... Standing water is a breeding ground for mosquitoes that can ... many urban families don,t take simple steps such as dumping ... Last summer, researchers polled 242 urban residents to find out ... risks posed by standing water, a mosquito breeding ground. Researchers ...
... disease who go to a neurologist for their care are more ... nursing home and less likely to break a hip than people ... published in the August 10, 2011, online issue of Neurology, ... The study also found that women and minorities were ...
... News) -- More doctors are performing weight-loss surgery today, ... study finds. Researchers analyzing trends in bariatric surgery ... as adjustable gastric banding, has led to a greater ... , "We,ve identified a national trend ...
Cached Medicine News:Health News:Risk of autism among younger siblings of a child with autism much greater than previously reported 2Health News:Planning Ahead Can Reduce Back-to-School Stress 2Health News:Get Rid of Standing Water to Protect From Mosquitoes 2Health News:Study suggests seeing a neurologist helps people with Parkinson's live longer 2Health News:Weight-Loss Surgery Gains More Practitioners 2
(Date:7/3/2015)... A global continuing medical education ... thyroid disorders in Central and South-East Asia ... major conference dedicated to these diseases.      ... , Manage Hypertension Online and Manage ... EXCEMED - combine the world,s top expertise ...
(Date:7/3/2015)... A global continuing medical education ... thyroid disorders in Latin America ... dedicated to these diseases.      (Logo: http://photos.prnewswire.com/prnh/20150630/227033) ... Manage Hypertension Online and Manage Thyroid Online ... - combine the world,s top expertise with dynamic ...
(Date:7/3/2015)... STOCKHOLM , July 3, 2015 ... agreement with Broda Technologies Co., Ltd., operating in both ... use the company,s proprietary IntelliGel ® supramolecular hydrogel ... under development and other ophthalmic therapies. The Broda technology ... polymer solution is a free-forming liquid and with low ...
Breaking Medicine Technology:Combating Three Major Chronic Diseases in Central and South-East Asia With Medical Education 2Combating Three Major Chronic Diseases in Latin America With Medical Education 2Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2
... , , , , FRAZER, Pa., Jan. ... that effective February 5, 2010, Robert P. Roche, Jr., Executive ... with the company to pursue other longstanding interests. During ... and marketing organization into a global business that exceeded $2 ...
... , SOUTH SAN FRANCISCO, Dec. 31 ... was unable to satisfy the closing conditions set forth in ... among Anesiva, Arca Acquisition Corporation, a wholly-owned subsidiary of Anesiva, ... and IX only of the agreement, each of the Arcion ...
Cached Medicine Technology:Cephalon Executive Vice President of Worldwide Pharmaceutical Operations Robert Roche to Resign Position 2Cephalon Executive Vice President of Worldwide Pharmaceutical Operations Robert Roche to Resign Position 3Cephalon Executive Vice President of Worldwide Pharmaceutical Operations Robert Roche to Resign Position 4Anesiva Announces Merger With Arcion Therapeutics Will Not be Completed 2
A distal femoral nail providing high purchase in osteoporotic metaphyseal bone and two distal locking options: one spiral blade plus one locking screw or two locking screws....
... neurodiagnostic for basic and advanced ... a large 12.1" XGA (1024 ... and the latest in technology ... speed, advanced NCS capabilities, advanced ...
... potential vision tester measures retinal acuity in ... Potential vision testing requires two related tools, ... (formerly known as the Illuminated Near Card) ... a pinhole disc and hinged lens). ...
The ACCU-Beam® line of Surgical Microscope Accessories includes digital camera adaptors, beam splitters, objective lenses, fiber optic cables, and fiberoptic retrofits....
Medicine Products: