Navigation Links
Genetics May Help Fine-Tune Warfarin Dosage
Date:2/18/2009

would predict the ideal dose of warfarin in a study of more than 4,000 people.

The researchers found that the algorithm predicted the ideal dose of warfarin better than other approaches.

Specifically, the algorithm's predictions were, on average, within about 8.5 milligrams of a person's ideal weekly dose. Demographic and clinical data alone predicted doses of about 10 milligrams off the ideal weekly dose, and a method that used a fixed daily dose, or about 35 milligrams a week, was off by an average of 13 milligrams, the researchers found.

"Warfarin has a very narrow therapeutic range," said co-author Teri Klein, a senior research scientist in genetics at Stanford. "Overdosing and underdosing of warfarin results in patients either being at much greater risk for excessive bleeding (overdosing) or clotting (underdosing)," she said.

"We found, based on this population, that 46 percent of the population would benefit by including their genotypes for these two genes," Klein said. "By including the genotypes along with clinical and demographic information, initial dosing is much closer to the ideal dose, thus limiting potential adverse events."

Altman said a trial now is needed to see if people who are prescribed warfarin based on genetic testing actually do better than those whose dosage is not determined with the aid of genetics.

"More broadly," he said, the study's finding "tells us that the day when we routinely use genetic information to personalize the use of drugs is coming and may be almost here for warfarin."

Dr. Richard C. Becker, professor of medicine in the divisions of cardiology and hematology at Duke University School of Medicine, said that the researchers appear to be on the right track but that more testing is needed before the approach becomes standard practice.

"The safe and effective use of medications based on patient-specific needs is an achievable goal in the early 2
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Help Fine-Tune Warfarin Dosage
(Date:4/26/2015)... April 26, 2015 Forbes Living ... city is one which is synonymous with clean beaches, sparkling ... and education are major economic influencers in the city on ... dynamic talk show are pleased to announce the show will ... 26 at 3:00 PM PDT. Tune in to find out ...
(Date:4/26/2015)... Memphis, TN (PRWEB) April 26, 2015 ... plans to grow throughout the Southeast. MidSouth Pain Treatment ... clinic locations in Cordova, Southaven, Oxford and Jackson, two ... CLIA-certified laboratory in the Southaven and Cordova locations. , ... said ”I went into medicine to help people, ...
(Date:4/25/2015)... Portland, ME (PRWEB) April 26, 2015 ... a Canadian based integrative healthcare event. The Integrative ... taking place October 23-24, 2015 at the Sheraton ... Healthcare Symposium Canada is one of the most ... a clinically relevant, evidenced-based CME program. The event ...
(Date:4/25/2015)... In observance of World Malaria Day, today thousands ... a two-year pledge by the United Nations Foundation’s Nothing ... million bednets by 2016. This ambitious $10 million pledge ... protect children, refugees, and families displaced by conflict in ... a large surge in refugee families displaced by conflict ...
(Date:4/25/2015)... 2015 In the United States alone, ... needed treatment for an illicit drug or ... and Mental Health Services Administration’s Survey on Drug Use ... numbers are harrowing stories of men and women whose ... David H. Kerr , founder and retired president ...
Breaking Medicine News(10 mins):Health News:Forbes Living TV Will Air in San Diego, California 2Health News:Growing Pains for MidSouth Pain Treatment Center 2Health News:Integrative Healthcare Event launching in Canada 2Health News:Supporters Worldwide Join The Million Nets Pledge on World Malaria Day 2Health News:Supporters Worldwide Join The Million Nets Pledge on World Malaria Day 3Health News:Supporters Worldwide Join The Million Nets Pledge on World Malaria Day 4Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3
... guard this hospital, but I can,t afford to see ... at Kaiser Sunset Medical Center in Los Angeles OAKLAND, ... against unfair labor practices and slashed health benefits by ... Oakland and Los Angeles today. Workers chanted, marched, and ...
... Issued in Massachusetts General Hospital LawsuitVANCOUVER, May 21 /PRNewswire-FirstCall/ ... QLT) announced that on May 21, 2009, the District ... on QLT,s Motion to Dismiss all the claims filed ... General Hospital ("MGH") in its lawsuit against QLT. In ...
... Action to Improve Delivery of PMTCTGENEVA, May 21 ... in Geneva, members of the International Treatment Preparedness Coalition ... approximately 100 staff members of UNAIDS and WHO to ... Failing Women, Failing Children: HIV, Vertical Transmission and ...
... 21 As a health care practitioner, Trina Hammack ... with ovarian cancer, she knew her prognosis was bleak. ... Mexico offering effective new treatments for ovarian cancer. ... thousands of Americans diagnosed with cancer will travel to ...
... YORK, May 21 Immtech Pharmaceuticals, Inc. (OTC: IMMP) ... its common stock on the Pink OTC Markets quotation ... the ticker symbol "IMMP".As announced previously, on March 27, ... (the "Exchange") of its intention to initiate proceedings to ...
... MarketBERKELEY, Calif., May 21 In spite of fewer openings ... economic recession -- there is still a nursing shortage, according ... Institute for Nursing & Health Care (CINHC)."About half of all ... is just one factor in the job market for registered ...
Cached Medicine News:Health News:Security Officers Who Protect Kaiser Hospitals Rally With Community Supporters for Access to Affordable Healthcare 2Health News:QLT Announces Court Response to Motion to Dismiss and Removal of Case to Federal Court 2Health News:QLT Announces Court Response to Motion to Dismiss and Removal of Case to Federal Court 3Health News:AIDS Treatment Activists Push UNAIDS and WHO to Meet Commitments to Reduce HIV in Women and Newborns 2Health News:AIDS Treatment Activists Push UNAIDS and WHO to Meet Commitments to Reduce HIV in Women and Newborns 3Health News:The Diagnosis Every Woman Dreads - Ovarian Cancer 2Health News:The Diagnosis Every Woman Dreads - Ovarian Cancer 3Health News:Immtech to be Listed on OTC Market 2Health News:Hard Times for Nursing Hires Doesn't Signal End to Shortage According to California Institute for Nursing & Health Care 2
(Date:4/24/2015)... N.C. , April 24, 2015 ... are establishing employee groups around the world to ... round-the-clock business hours. While there are many areas ... leaders must examine which best practices are necessary ... excellence. According to research by ...
(Date:4/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/pmbmv2/global_biobanking ... Biobanking Market 2015-2019" report to their offering. ... grow at a CAGR of 7.07% over the period ... divided into two segments: Equipment and Consumables. This report ... the Global Biobanking market for the period 2015-2019. ...
(Date:4/24/2015)... YORK , April 24, 2015 ... (NIAID) (part of the National Institutes of Health ... to nine research projects for the development of ... of  recent HAI outbreaks at U.S. health facilities ... supporting research into rapid, multiplexed and effective tests ...
Breaking Medicine Technology:Work Around the Clock: Building Effective Global Capabilities 2Global Biobanking Market Report 2015-2019 - Increase in Strategic Collaborations with Beckman Coulter, Tecan & Thermo Fischer Scientific Dominating 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4
... Limited (ASX:CIR, OTCQX:CKDXY) announced today that it has commenced ... human monoclonal antibody against VEGF-C, VGX-100, at a leading ... study will examine the safety and tolerability of escalating ... who have no other standard treatment options both as ...
... LOUIS, Jan. 6, 2012  Pepex Biomedical, Inc., a privately held ... known as " CCM™ ", announced today it has reached ... division of West Pharmaceuticals Services, Inc. , to be ... systems and sensor modules.  The seven year contract also includes ...
Cached Medicine Technology:Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients 2Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients 3Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients 4Circadian Commences First Phase 1 Clinical Trial of VEGF-C Antibody VGX-100 in Cancer Patients 5Pepex Biomedical Signs Seven Year Deal to Manufacture "Trio™" 2Pepex Biomedical Signs Seven Year Deal to Manufacture "Trio™" 3
... Unparalleled Comfort Pick one of our pipettors ... the trigger and ejector positionsright where they should ... are ergonomically designed to help avoid repetitive stress ... Productivity In The Palm Of Your Hand ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
... Ergonomic Design for Unparalleled Comfort Pick ... Notice the balance. Notice the trigger and ejector ... Thats because our pipettors are ergonomically designed to ... hours of pipetting. Productivity In The Palm ...
... The total ergonomic solution and best value ... feather touch action and ultra lightweight design ... tip ejection with long, lever tip ejector ... , Accepts universal tips or for greater ...
Medicine Products: