Navigation Links
Genetics May Help Fine-Tune Warfarin Dosage
Date:2/18/2009

Formula that includes DNA data proves faster, more accurate in early tests

WEDNESDAY, Feb. 18 (HealthDay News) -- A DNA test could make prescribing the widely used anticoagulant warfarin safer by predicting the lowest effective dose, a new study finds.

The U.S. Food and Drug Administration estimates that 2 million Americans take warfarin to prevent potentially dangerous blood clots that can cause strokes. Reasons range from implantation of an artificial heart valve to the abnormal heartbeat called atrial fibrillation. But establishing and maintaining the ideal dose is done by trial and error, with weekly and monthly monitoring.

"In a very large group of patients, we showed that the use of genetics helps predict the right dose, and this may take the dangerous guesswork out of prescribing warfarin," said Dr. Russ Altman, a professor of bioengineering, genetics and medicine at Stanford University School of Medicine and a co-author of the study. This "may be one of the first widely-used examples of pharmacogenetics -- the use of genetic information to make better prescribing decisions," he said.

Because an effective dose of warfarin can vary as much as 10-fold from one person to the next, doctors start most people on a low dose and increase it until blood tests indicate the dose is correct. That process can take months.

For the study, which is published in the Feb. 19 issue of the New England Journal of Medicine, researchers collected demographic and genetic data on people at risk for stroke, heart disease and other problems related to blood clotting. The ideal doses of warfarin for these individuals had already been established by trial and error.

In addition, they looked at variants of two genes: CYP2C9, which affects how the liver activates and excretes warfarin, and VKORC1, which activates vitamin K, essential for blood clotting.

They used the data to create an algorithm that
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Genetics Hold Promise, Challenges for Cancer Care
2. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
3. Salugen to Present Research on Generational Associations of Reward Deficiency Syndrome at XVth World Congress on Psychiatric Genetics
4. Obesity genetics
5. The genetics of MLL leukemogenesis
6. Vanda Pharmaceuticals to Present New Data on Iloperidone at the 2007 American Society of Human Genetics Annual Meeting
7. Clarient Names Michele Hibbard, Ph.D. Director of Genetics
8. Response Genetics Announces Presentation/Webcast at BIOCOM Investor Conference
9. Interleukin Genetics to Host Third Quarter 2007 Financial Results Conference Call November 7
10. Response Genetics to Announce Third Quarter 2007 Financial Results on Wednesday, November 14, 2007
11. Response Genetics Reports Third Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetics May Help Fine-Tune Warfarin Dosage
(Date:11/24/2014)... 2014 The typical American diet includes ... ingredients. Consistently consuming a diet high in calories and ... excess fat that typically accumulate around the internal organs ... ugly head in the form of love handles, beer ... the decision to rid themselves of the burden of ...
(Date:11/24/2014)... Pittsburgh, PA (PRWEB) November 24, 2014 ... as he was trying to cross the street in ... "The driver never saw him. I came up with ... easily visible at night." , He developed the Safety ... night or in low-lighting conditions. The device ensures that ...
(Date:11/23/2014)... has recently announced that its Special Friday Shoes sales, ... offer will provide ladies many gorgeous shoes at greatly discounted ... women’s dresses retailers, and its shoes include many models in ... that day: Everything at Tbdress.com is up to 90% off. ... People can use the following coupon codes as well: , ...
(Date:11/23/2014)... 23, 2014 Locks-Magnetic.com, a notable magnetic ... Moreover, all the new products are available at low ... manager is proud of the new emergency doors. The ... And customers can choose from several colors. All of ... quality emergency door release is not as easy as ...
(Date:11/23/2014)... November 23, 2014 AngelWeddingDress.com ... a new selection of beach wedding dresses. “If you ... prices, visit AngelWeddingDress.com as soon as possible. Here you ... The sales manager says. , Holding a big marriage ... And choosing a beautiful beach wedding dress is uppermost ...
Breaking Medicine News(10 mins):Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4Health News:Tbdress.com Special Friday Shoes Sales Online Now 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2
... The annual meeting of the American Association for Cancer Research ... and smearing skin with broccoli and garlic after several studies ... same.// ,After being [resented with irrefutable news, experts ... prolonging your life may be to change the way you ...
... is currently free of cases ... of importing vaccines to ... a government official.// ... up special central cell of ...
... government of India has today assured that there was no ... // ,The government has set up a ... on the domestic poultry population and migratory birds and to ... action as and when required. ,"We are keeping ...
... Aizawl: Mizoram the border state of the country has ... from its neighboring country Myanmar to combat the ongoing ... has a long (404-kms) international border with Myanmar and ... border. Mr. C Sangnghina, The Director of State Animal ...
... cancers occurring in humans. A clinical study involving patients ... drug for treatment of bowel // cancer has found ... study which is called as NICE study has proved ... than control group which received only cancer chemotherapeutic drug ...
... the Stony Brook University's School of Dental Medicine have ... candy and confections and will not promote cavity formation ... new technology, which has been named CaviStat(R), is more ... and tooth decay. This conclusion was arrived at after ...
Cached Medicine News:
(Date:11/24/2014)... 2014 The Female Health Company (NASDAQ-CM: FHCO), ... call to discuss its operating results for the fourth ... Tuesday, December 2, 2014 at 11:00 a.m. Eastern Standard ... results earlier the same day. Shareholders and ... by dialing 1-877-374-8416 (international participants dial 1-412-317-6716) and asking ...
(Date:11/24/2014)... , 24 novembre 2014  Surgical Theater ... tecnologia sarà esposta durante l,apertura in data ... d,Europa, ossia la Fondazione IRCCS Istituto Neurologico ... Planner (SRP) (strumento di pianificazione chirurgica) e ... navigazione chirurgica avanzata) saranno presentati in occasione ...
(Date:11/22/2014)... 2014  Sprout Pharmaceuticals today announced positive preliminary results from ... with flibanserin up to 200 mg at bedtime had no ... the 20 th Annual Fall Scientific Meeting of the ... in Miami . The Phase ... Response Letter and the Formal Dispute Resolution that was filed ...
Breaking Medicine Technology:The Female Health Company To Report FY2014 Operating Results on Tuesday, December 2, 2014 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 2La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 3La tecnologia di Surgical Theater in mostra in Italia all'apertura del centro Besta NeuroSim di Milano 4Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 2Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 3
... export sectors -- HONG KONG, Oct. 26 /PRNewswire-Asia/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so ...
... (Nasdaq: ROCM ) will announce quarterly results after ... will then hold a quarterly conference call to discuss its ... time (4:30 p.m. eastern time). This call is ... Medical,s website at www.rocm.com .  To listen live to ...
Cached Medicine Technology:Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 2Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 3Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 4Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 5Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 6Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 7Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 8Global Sources launches integrated, multi-channel offerings for three fast-growing export sectors 9Rochester Medical Announces Fourth Quarter 2010 Earnings Conference Call Thursday, November 4, 2010 2
... and helix provide distal shaft column ... Construction eliminates springback and provides for ... to provide a better fit for ... ,Trimmable ends provide a custom ...
... Alpha I continues to be a proven, ... Alpha I to have mechanical reliability rates ... first-time implants. ioflex material contributes to excellent ... Thats because Bioflex: ,Provides maximum, controlled girth ...
... The AMS 700 Series is an advanced ... in the abdomen, a pump placed in the ... the corpora cavernosa. It closely simulates the look ... standard for innovative penile implant technology, the AMS ...
Only Mentors reusable Alpine Leg Bag has patented Kraylex odor barrier, offset port options, and integrated loops providing total confidence and comfort....
Medicine Products: