Navigation Links
Genetic regulator opens new avenues to AIDS, immune system research
Date:7/1/2010

ure.

Ctip2 helps regulate the complicated process that ends up creating T cells. Depending on the stage of development when it's knocked out, this can result either in T cells not being formed, or different kinds of cells being formed something that would be of significant interest to researchers who are trying to re-program cells to perform different functions.

Part of what's remarkable about Ctip2, researchers say, is the range of seemingly separate yet critical functions it performs. Ctip2 is essential in the creation of teeth, the formation of skin, and T cells. In all of these cells and tissues, Ctip2 is involved in differentiation of one cell type into another, more mature cell. OSU researchers have also found that the amount of Ctip2 expressed by certain cancer cells is correlated with the aggressiveness of tumors, which may be helpful for diagnostic purposes.

Every cell in the human body, and that of plants and other animals, contains the entire "genome," or genetic blueprint of life of the particular organism. Research on genetic regulators has been of increasing interest in recent years because these proteins hold the key to which genes are expressed, instructing one cell to become a brain cell while another is directed to become a blood cell.

"I've always been in awe of how transcription factors direct complicated events, such as development, in which mammals progress from a single, fertilized cell into a complex, three-dimensional organism in a relatively short period of time," Leid said. "It's just a beautifully choreographed dance, and timing is everything."

Ctip2 seems to be a very top-level regulator of development and differentiation in many different cell types, Leid said. It should be possible to develop drugs that decrease, increase or otherwise modify Ctip2 activity, and such drugs may be useful in the treatment of certain malignancies, such as leukemia, and skin cancers, he said.


'/>"/>

Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
2. Genetic Variants in Depressed People Raise Suicide Risk
3. St. Jude and Washington University team to unravel genetic basis of childhood cancers
4. Discovery of epigenetic memory during breast cancer
5. Genetic Test May Someday Help Spot Breast Cancer
6. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
7. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
8. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
9. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
10. Chicago Cancer Genome Project studies genetics of 1,000 tumors
11. Adding a genetic supertool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... 2015 , ... Lecrae is quickly developing into one of the biggest music ... New York Times to Billboard Magazine and Variety, among others. His transparency and ... why so many people are taking notice. , “We are very excited about this ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... be held October 28-31, 2015 at Disney’s Coronado Springs Resort in Lake Buena ... and networking. Each year, this premiere event for psychiatric-mental health nursing draws more ...
(Date:6/30/2015)... ... 2015 , ... Izenda is proud to acknowledge the hard ... an accredited American educational institution through its scholarship program. , In today's Age ... environment, political campaigns, and a variety of other worldwide trends. Modern day technology ...
(Date:6/30/2015)... ... June 30, 2015 , ... Americans report feeling more ... buzzer on Monday mornings, which puts stressed out people right over the edge. ... 22% suffering from sleep deprivation every night. Sleeping pills now lead the list of ...
(Date:6/30/2015)... ... June 30, 2015 , ... Scott Purdy, the spokesperson for ... Provider XO. Scott Purdy stated that the XO stands for eXtra Operability (XO) which ... the workflow processes of the Revenue Cycle. , Provider XO, based in Cleveland ...
Breaking Medicine News(10 mins):Health News:Hands of Hope to Present Grammy Award-Winner Lecrae in Concert this August 2Health News:Hands of Hope to Present Grammy Award-Winner Lecrae in Concert this August 3Health News:American Psychiatric Nurses Association 29th Annual Conference: Continuing Education and Collaboration in Psychiatric-Mental Health and Nursing 2Health News:American Psychiatric Nurses Association 29th Annual Conference: Continuing Education and Collaboration in Psychiatric-Mental Health and Nursing 3Health News:Izenda Offers Embedded BI and Analytics Scholarship 2Health News:Izenda Offers Embedded BI and Analytics Scholarship 3Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 2Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 3Health News:Dephinitive Systems Is Getting a New Name 2
... a third of American,adults take some type of multivitamin ... is better health, even though there is no firm ... one thing, but the presence of,harm is another: A ... concluded that there was an increased prostate cancer risk ...
... to Stethoscope, the distinguished public lecture series organized by ... (MUHC), is embarking on a second season. "Again this ... on a journey into a possible future, when current ... declared Dr. Arthur T. Porter, Director General of the ...
... The Russell,Investment Group has advised Protalix Biotherapeutics ... float weight adjustment effective after the close of,trading ... Russell 2000,Russell 2000 Growth, Russell 2500, Russell 2500 ... Growth, Russell Small Cap,Completeness and the Russell Small ...
... Sept. 28 Transcept,Pharmaceuticals, Inc., a specialty pharmaceutical ... drugs, today announced,that Glenn A. Oclassen, President and ... 2007 BIO Investor Forum at the Palace Hotel ... 3:00 PM Pacific Time. About Transcept Pharmaceuticals ...
... Doctors need to be more proactive in diagnosing the condition, ... in seven women suffers from depression before, during or after ... can be devastating to the mother, her baby and her ... of The American Journal of Psychiatry . , ...
... M. Williams Speak Out on Mental Health Crisis,Facing ... Experts in mental,health, Members of Congress and other ... Caucus Foundation,s 2007 Annual,Legislative Conference to shed light ... Needs." Rep. Julia Carson (D - IN) together,with ...
Cached Medicine News:Health News:Excessive Multivitamin Use May Raise Risk for Prostate Cancer, from Harvard Men's Health Watch 2Health News:Russell Investment Group Advises Protalix Biotherapeutics of Index Adjustment 2Health News:15% of Women Struggle With Pregnancy-Related Depression 2Health News:15% of Women Struggle With Pregnancy-Related Depression 3Health News:Black America Urged to Confront Its Secret Pain: Depression 2Health News:Black America Urged to Confront Its Secret Pain: Depression 3Health News:Black America Urged to Confront Its Secret Pain: Depression 4Health News:Black America Urged to Confront Its Secret Pain: Depression 5
(Date:6/30/2015)... June 30, 2015  Today, the National Mobility Equipment ... 2015 National Mobility Awareness Month Local Heroes Contest on ... online entries that received 1.3 million votes. The sponsors ... Toyota Mobility , and Valley Honda Dealers ... and Vantage Mobility International (VMI) and ...
(Date:6/30/2015)... Calif. , June 30, 2015  Avanir ... PRISM II study showing that treatment with NUEDEXTA ... reduction in symptoms of pseudobulbar affect (PBA) in ... PBA is a distressing condition characterized by sudden ... from certain neurologic diseases or brain injury. PRISM ...
(Date:6/30/2015)... Minn. , June 30, 2015  EnteroMedics Inc. ... devices that use neuroblocking technology to treat obesity, metabolic ... its previously announced public offering  of 40,229,886 units. Each ... of a Series A warrant to purchase one share ... warrant to purchase one share of common stock, at ...
Breaking Medicine Technology:NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 2Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 3Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 4Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 5Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 6Avanir Pharmaceuticals Announces Positive Top-line Results from Stroke and TBI Cohorts of PRISM II Study 7EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Pricing of $35.0 Million Public Offering of Common Stock and Warrants 3