Navigation Links
Genetic regulator opens new avenues to AIDS, immune system research
Date:7/1/2010

CORVALLIS, Ore. Researchers at Oregon State University and the California Institute of Technology have discovered that a genetic regulator which is critical to many life functions also plays a key role in the formation of "T cells," a type of white blood cell that's important in immune function.

The discovery, to be announced Friday in the journal Science, suggests that some types of immune function might be influenced by manipulation of this genetic regulator. This could be a target for drug development, and could open the door to new immune system-based therapies for everything from diseases of T cells, such as HIV/AIDS, to autoimmune disorders and allergies.

Other aspects of the research could be of interest to scientists trying to re-program cells to perform different functions, which is the basis of stem cell research.

The genetic regulator, or transcription factor, is called Ctip2, and it's also known as Bcl11b. It's a protein that controls gene "expression," or what aspects of a cell's genetic code will be turned on and which will be left silent. Discovered at OSU in 2000, Ctip2 has in recent years been found to be a master regulator of gene expression, controlling tissue formation in organs as diverse as tooth enamel, brain cells, skin, and T cells.

"Ctip2 is so important to various life functions that laboratory mice lacking this gene die within a few hours after birth," said Mark Leid, a professor and assistant dean in the OSU College of Pharmacy. "Ctip2 is not expressed in every cell, but plays essential roles in several different organs. The new finding about its relationship to early events in T cell formation may be of substantial interest to immunologists and clinicians alike."

T cells are important players in what's called the "adaptive" immune system, or the ability of an organism to mount an attack against a new invader, fight it off and then provide full or partial immunity to it in the fut
'/>"/>

Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
2. Genetic Variants in Depressed People Raise Suicide Risk
3. St. Jude and Washington University team to unravel genetic basis of childhood cancers
4. Discovery of epigenetic memory during breast cancer
5. Genetic Test May Someday Help Spot Breast Cancer
6. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
7. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
8. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
9. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
10. Chicago Cancer Genome Project studies genetics of 1,000 tumors
11. Adding a genetic supertool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Hay House is pleased to announce the official release ... (Paperback; $10.82) written by the highly esteemed Tommy Rosen, leader ... is meant to help readers of all kinds end their ... Recovery 2.0 is not the average self-help book, or a ... for what comes next. For many, Alcoholics Anonymous ...
(Date:10/22/2014)... October 22, 2014 Best Cheap Hosting ... the world. The site has recently announced that iPower ... supplier for people from around the world. , “iPower ... operation today and is providing various kinds of useful ... company insists on offering excellent customer service and a ...
(Date:10/22/2014)... 22, 2014 Although there are only 24 hours ... many people who have trouble finding time within their busy schedules ... for long periods of time to get in shape. Here are ... on the go. , Change Up Your Commute , Consider ... to add some exercise into your daily routine. If you must ...
(Date:10/22/2014)... 22, 2014 Akeso Biomedical, Inc. ... the treatment of bacterial infections, microbial biofilms, and chronic ... its board of directors. , Dr. Sinskey ... at The Massachusetts Institute of Technology, or MIT. He ... 1968. Dr. Sinskey also holds positions as Co-Director of ...
(Date:10/22/2014)... sisters in high school have developed ways to measure ... use electronic stethoscopes, which electronically amplify body sounds, to ... heartbeats. Ilina, a senior at Port Huron Northern ... to detect early lung damage in people exposed to ... one breath cycle each from 16 smokers, 25 nonsmokers ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2
... ARLINGTON HEIGHTS, Ill. Using gene therapy, plastic surgeons ... on cancerous tumors on rats with a 79 percent ... the May issue of Plastic and Reconstructive Surgery, the ... Surgeons (ASPS). This new delivery technique, which has ...
... to Cover MLS Events;, Launches User-Generated Video Contest, Winning Entries to ... ... NEW YORK and LOS ANGELES, May 8 Juniper,Content Corporation,s (OTC Bulletin ... their,"Juega Como un MLS Pro" (translated "Play Like an MLS Pro") seven-month,joint ...
... may help to prevent osteoporosis later in life, research ... your teenage daughter to have strong bones? Steer her ... you may help her prevent low bone density later ... the combination of weight-bearing exercise and repetitive, "impact-loading" from ...
... Inc.,("GNC" or the "Company"), the largest global specialty ... for the first,quarter ended March 31, 2008., ... of GNC Parent LLC,which was acquired on March ... and Ontario Teachers, Pension Plan Board ("Teachers"). As ...
... Inc. (Nasdaq:,COWN) today announced its operating results for the quarter ... March 31, 2008 was $55.0 million,representing a decrease of 25% ... ended March 31, 2008, the Company reported net income of,$0.7 ... income of,$2.5 million in the prior year period, or $0.18 ...
... Regular daily activities can,expose us to hundreds of toxins ... the,common body care and household products we use. Toxicologists ... combined in the body and,have named this synergy the ... organ damage, can result., The May issue of ...
Cached Medicine News:Health News:Skin flaps deliver cancer-fighting therapy, ASPS study reveals 2Health News:Sorpresa! and Major League Soccer Kick Off Partnership With Interactive Online Contests for Young Soccer Fans 2Health News:Sorpresa! and Major League Soccer Kick Off Partnership With Interactive Online Contests for Young Soccer Fans 3Health News:Sorpresa! and Major League Soccer Kick Off Partnership With Interactive Online Contests for Young Soccer Fans 4Health News:Soccer's a Winner for Building Bone Health in Girls 2Health News:Soccer's a Winner for Building Bone Health in Girls 3Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 2Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 3Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 4Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 5Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 6Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 7Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 8Health News:General Nutrition Centers, Inc. Reports First Quarter 2008 Financial Results 9Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 2Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 3Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 4Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 5Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 6Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 7Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 8Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 9Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 10Health News:Cowen Group, Inc. Announces 2008 First Quarter Results 11Health News:Natural Solutions May Issue Illustrates 'Cocktail Effect' of Everyday Toxins; Offers Tips to Reduce Toxic Load 2
(Date:10/22/2014)... N.J. , Oct. 22, 2014  Quest Diagnostics ... of diagnostic information services, today announced that its Board ... serve as a director, effective December 1, 2014. Including ... Dr. Leiden is the Chairman, President and CEO of ... years of scientific and commercial experience in the pharmaceutical ...
(Date:10/22/2014)... RIDGE, N.J. , Oct. 22, 2014 /PRNewswire/ ... (RMANJ), a world-renowned leader in the field of ... rapid approach to embryonic screening. The research abstract, ... Society for Reproductive Medicine (ASRM) meeting in ... screening (CCS) and single gene defect (SGD) pre-implantation ...
(Date:10/22/2014)... October 22, 2014 A new ... Market (Product type, Form, End user, Application and Geography) ... Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 - ... market. Based on key trends tracked, it is anticipated ... $7.9 billion by 2020, registering a CAGR of 6.2% ...
Breaking Medicine Technology:Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
... CIVCO Medical Solutions is showcasing its RFSuite RFID ... is also hosting an RFSuite Symposium Monday, August 1st, ... at the Fairmont Waterfront, Vancouver. The event will include ... Click here to view the invitation and register ...
... 20, 2011 CryoLife, Inc. (NYSE: CRY ), ... cardiac and vascular surgery, announced today that 2011 ... 28, 2011.  On that day, the Company will hold a ... to discuss the results, followed by a question and answer ...
Cached Medicine Technology:CIVCO Showcases RFSuite RFID Tracking and Verification System at AAPM 2011 Booth #817 2CIVCO Showcases RFSuite RFID Tracking and Verification System at AAPM 2011 Booth #817 3CryoLife Announces Release Date and Teleconference Call Details for 2011 Second Quarter Financial Results 2
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
... These 3mL PYREX volumetric pipets ... tolerances in accordance with ASTM ... pipet is individually serialized and ... Identification and Capacity, traceable to ...
... action skin stapler with a ... designed to provide a clear ... your normal vantage point. Vista ... four configurations: 35 regular or ...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
Medicine Products: