Navigation Links
Genetic regulator opens new avenues to AIDS, immune system research
Date:7/1/2010

CORVALLIS, Ore. Researchers at Oregon State University and the California Institute of Technology have discovered that a genetic regulator which is critical to many life functions also plays a key role in the formation of "T cells," a type of white blood cell that's important in immune function.

The discovery, to be announced Friday in the journal Science, suggests that some types of immune function might be influenced by manipulation of this genetic regulator. This could be a target for drug development, and could open the door to new immune system-based therapies for everything from diseases of T cells, such as HIV/AIDS, to autoimmune disorders and allergies.

Other aspects of the research could be of interest to scientists trying to re-program cells to perform different functions, which is the basis of stem cell research.

The genetic regulator, or transcription factor, is called Ctip2, and it's also known as Bcl11b. It's a protein that controls gene "expression," or what aspects of a cell's genetic code will be turned on and which will be left silent. Discovered at OSU in 2000, Ctip2 has in recent years been found to be a master regulator of gene expression, controlling tissue formation in organs as diverse as tooth enamel, brain cells, skin, and T cells.

"Ctip2 is so important to various life functions that laboratory mice lacking this gene die within a few hours after birth," said Mark Leid, a professor and assistant dean in the OSU College of Pharmacy. "Ctip2 is not expressed in every cell, but plays essential roles in several different organs. The new finding about its relationship to early events in T cell formation may be of substantial interest to immunologists and clinicians alike."

T cells are important players in what's called the "adaptive" immune system, or the ability of an organism to mount an attack against a new invader, fight it off and then provide full or partial immunity to it in the future.

Ctip2 helps regulate the complicated process that ends up creating T cells. Depending on the stage of development when it's knocked out, this can result either in T cells not being formed, or different kinds of cells being formed something that would be of significant interest to researchers who are trying to re-program cells to perform different functions.

Part of what's remarkable about Ctip2, researchers say, is the range of seemingly separate yet critical functions it performs. Ctip2 is essential in the creation of teeth, the formation of skin, and T cells. In all of these cells and tissues, Ctip2 is involved in differentiation of one cell type into another, more mature cell. OSU researchers have also found that the amount of Ctip2 expressed by certain cancer cells is correlated with the aggressiveness of tumors, which may be helpful for diagnostic purposes.

Every cell in the human body, and that of plants and other animals, contains the entire "genome," or genetic blueprint of life of the particular organism. Research on genetic regulators has been of increasing interest in recent years because these proteins hold the key to which genes are expressed, instructing one cell to become a brain cell while another is directed to become a blood cell.

"I've always been in awe of how transcription factors direct complicated events, such as development, in which mammals progress from a single, fertilized cell into a complex, three-dimensional organism in a relatively short period of time," Leid said. "It's just a beautifully choreographed dance, and timing is everything."

Ctip2 seems to be a very top-level regulator of development and differentiation in many different cell types, Leid said. It should be possible to develop drugs that decrease, increase or otherwise modify Ctip2 activity, and such drugs may be useful in the treatment of certain malignancies, such as leukemia, and skin cancers, he said.


'/>"/>

Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Related medicine news :

1. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
2. Genetic Variants in Depressed People Raise Suicide Risk
3. St. Jude and Washington University team to unravel genetic basis of childhood cancers
4. Discovery of epigenetic memory during breast cancer
5. Genetic Test May Someday Help Spot Breast Cancer
6. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
7. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
8. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
9. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
10. Chicago Cancer Genome Project studies genetics of 1,000 tumors
11. Adding a genetic supertool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/27/2016)... ... 27, 2016 , ... Each year Standard Process Inc. ... is this year’s Life University winner of a $2,500 scholarship from ... Leadership Awards ceremony. , Outerbridge is approaching her last quarter at Life University ...
(Date:5/26/2016)... ... 2016 , ... There are many ways to cook a hot dog, but ... Americans prefer their dogs straight off the grill. Of the 90 percent of Americans ... to cook a hot dog, far outpacing other cooking methods such as steaming (12 ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... aplicación médica para ayudar a los médicos a compartir ... los pacientes a escala mundial. Profesionales médicos de Europa, ... ya se han apuntado a la aplicación, que combina ... en un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... CHRISTCHURCH, New Zealand , May 24, 2016 ... scanning and informatics solutions for the healthcare sector, has been ... the New Zealand Hi-Tech Awards 2016. Dr ... a fantastic acknowledgement for our team.  It,s really good to ... the burden healthcare internationally. Our products are used in 35 ...
(Date:5/24/2016)... KONG , May 24, 2016 ... , the world , s first ... AV fistula intervention   OrbusNeich, a global ... has expanded its portfolio to include products to treat ... are the company,s first entry devices for lower limb ...
Breaking Medicine Technology: