Navigation Links
Genetic regulator opens new avenues to AIDS, immune system research
Date:7/1/2010

CORVALLIS, Ore. Researchers at Oregon State University and the California Institute of Technology have discovered that a genetic regulator which is critical to many life functions also plays a key role in the formation of "T cells," a type of white blood cell that's important in immune function.

The discovery, to be announced Friday in the journal Science, suggests that some types of immune function might be influenced by manipulation of this genetic regulator. This could be a target for drug development, and could open the door to new immune system-based therapies for everything from diseases of T cells, such as HIV/AIDS, to autoimmune disorders and allergies.

Other aspects of the research could be of interest to scientists trying to re-program cells to perform different functions, which is the basis of stem cell research.

The genetic regulator, or transcription factor, is called Ctip2, and it's also known as Bcl11b. It's a protein that controls gene "expression," or what aspects of a cell's genetic code will be turned on and which will be left silent. Discovered at OSU in 2000, Ctip2 has in recent years been found to be a master regulator of gene expression, controlling tissue formation in organs as diverse as tooth enamel, brain cells, skin, and T cells.

"Ctip2 is so important to various life functions that laboratory mice lacking this gene die within a few hours after birth," said Mark Leid, a professor and assistant dean in the OSU College of Pharmacy. "Ctip2 is not expressed in every cell, but plays essential roles in several different organs. The new finding about its relationship to early events in T cell formation may be of substantial interest to immunologists and clinicians alike."

T cells are important players in what's called the "adaptive" immune system, or the ability of an organism to mount an attack against a new invader, fight it off and then provide full or partial immunity to it in the fut
'/>"/>

Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medco Acquires Leading Genetics Healthcare Company, DNA Direct
2. Genetic Variants in Depressed People Raise Suicide Risk
3. St. Jude and Washington University team to unravel genetic basis of childhood cancers
4. Discovery of epigenetic memory during breast cancer
5. Genetic Test May Someday Help Spot Breast Cancer
6. Advances in Genetic Understanding and Treatment Protocols Lead to Significant Progress in Leukemia and Myeloproliferative Disorders
7. Wistar-led research team discovers genetic pattern that indicates early-stage lung cancer
8. New License Agreement with University of Colorado Gives Viral Genetics, Inc., Right to Develop Cancer Therapies
9. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
10. Chicago Cancer Genome Project studies genetics of 1,000 tumors
11. Adding a genetic supertool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... (HealthDay News) -- Seniors are more easily distracted during ... study finds. "Almost any type of memory test ... of 25 on," study co-author Randi Martin, professor of ... release. However, Martin said, this study shows that ... older adults compared with younger adults. The study ...
(Date:7/25/2014)... USA (PRWEB) July 25, 2014 As reported ... Use, OD Deaths Increase (7/20), Michigan has seen a nearly ... four years. While the count was 271 between 1999 and ... range. DEA Agents believe that, like other states, drug users ... the drug via prescription pills. He compared the price of ...
(Date:7/25/2014)... Florida Hospital and MOSI officially announced a transformational ... to come and make a difference in the Tampa Bay ... check to provide the support needed to keep the science ... transform the IMAX Dome Theatre from film to a state-of-the-art ... Dome Theatre in the state of Florida, and it is ...
(Date:7/25/2014)... Merrill Corporation ( http://www.merrillcorp.com ), ... the financial, legal, healthcare and other corporate markets, ... Merrill DataSite, has been recognized as the “Technology ... the M&A Awards 2014 event. , ... management teams, advisors and financiers as they demonstrate ...
(Date:7/25/2014)... York, ON (PRWEB) July 25, 2014 A ... Michael’s Hospital revealed that 39 percent of all children in ... a dentist. , The survey looked at 2,505 children during the ... all around four years of age. The final result was ... any dental care. Many of these children were from lower-income families ...
Breaking Medicine News(10 mins):Health News:Distractions Seem More Troublesome With Age 2Health News:Rise in Heroin Use, Overdose Deaths in Michigan 2Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 2Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 3Health News:Florida Hospital Donates a Two Million Dollar Transformational Gift to the Museum of Science and Industry (MOSI) 4Health News:Merrill DataSite Recognized as “Technology Provider of the Year” by GrowthBusiness at the M&A Awards 2014 Event 2Health News:North York Dental Provides Services to Toronto Children in Light of Growing Demand 2Health News:North York Dental Provides Services to Toronto Children in Light of Growing Demand 3
... January 4, 2012 The American Cancer Society,s annual cancer statistics ... declined by 0.6% per year in men and were stable in ... men and by 1.6% per year in women. The report, ... A Cancer Journal for Clinicians says over the past 10 ...
... be saved every year, thanks to a simple online calculator ... having ovarian cancer at a much earlier stage. Academics ... a new QCancer algorithm using the UK QResearch database. The ... factors to red flag those most likely to have ovarian ...
... New Rochelle, NY -- The current issue of ... Ann Liebert, Inc., explores how the U.S. military is ... of military personnel serving in the war zones and ... The issue is available online at http://www.liebertpub.com/acu . ...
... disease (IBD) are increasing with time and in different ... in Gastroenterology , the official journal of the ... epidemiology of inflammatory bowel disease is important for the ... G. Kaplan, MD, MPH, of the University of Calgary ...
... the New Year for a new start on old habits. ... plan it in advance, research funded by the Economic and ... with someone can really boost the likelihood of sticking to ... a big difference to people following dieting plans, health programmes ...
... , WEDNESDAY, Jan. 4 (HealthDay News) -- Arrogant people are ... who needs it, new research finds. Although personal factors ... distress) and outside influences (such as how many people are ... whether someone decides to lend a helping hand, according to ...
Cached Medicine News:Health News:American Cancer Society report finds continued progress in reducing cancer mortality 2Health News:American Cancer Society report finds continued progress in reducing cancer mortality 3Health News:American Cancer Society report finds continued progress in reducing cancer mortality 4Health News:Simple online tool to aid GPs in early ovarian cancer diagnosis 2Health News:Simple online tool to aid GPs in early ovarian cancer diagnosis 3Health News:IBD emerges as a global disease 2Health News:If you plan, then you'll do… but it helps to have a friend 2Health News:Need Help? Seek Out the Humble 2
(Date:7/25/2014)... MEXICO CITY , July 25, 2014 IBM ... Latin American healthcare sciences publisher, launched a library of ... conditions such as cancer and heart disease. Healthcare providers ... up-to-date information to deliver better patient care. ... with many relying on smartphones and tablets to access ...
(Date:7/25/2014)... 25, 2014  Semler Scientific, Inc. (Nasdaq: ... assessment company that develops patented products that assist ... diseases, today reported financial results for the second ... "The second quarter of 2014 ... Doug Murphy-Chutorian , M.D., chief executive officer of ...
(Date:7/25/2014)... -- Dr. Michael Gabriel of a prominent ... recent study, which shows how grief in pregnancy may cause ... According to US News , "Unborn ... than others to grow up overweight or obese, even if ... two specific types of stress that caused obesity: "Children whose ...
Breaking Medicine Technology:Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 2Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 3Healthcare Sciences Publisher PLM and IBM Speed Access to Medical Information to Deliver Better Patient Care with Mobile 4Semler Reports Second Quarter 2014 Financial Results 2Semler Reports Second Quarter 2014 Financial Results 3Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2
... NEW YORK, Nov. 16, 2010 See ... http://www.thenewsmarket.com/CustomLink/CustomLinks.aspx?GUID=72690337-6fc0-4bf1-8833-45ae38f30e57&alertid=b6f7ca94-a2d2-4716-93fd-60c34a56470e ... International Society of Clinical Densitometry (ISCD) convened ... regarding the use of FRAX® in clinical ...
... New results from an observational substudy from TRITON–TIMI ... (AHA) Scientific Sessions annual meeting showed that patients ... bypass graft surgery (CABG) had a reduced overall ... (clopidogrel) (2.3 percent versus 8.7 percent respectively, p=0.016).(1) ...
Cached Medicine Technology:VIDEO from International Osteoporosis Foundation available on thenewsmarket.com: IOF Focuses on WHO Fracture Risk Assessment Tool for International Discussions 2Mortality Data Presented for Patients Treated with Effient® Who Underwent Isolated Coronary Artery Bypass Surgery 2Mortality Data Presented for Patients Treated with Effient® Who Underwent Isolated Coronary Artery Bypass Surgery 3Mortality Data Presented for Patients Treated with Effient® Who Underwent Isolated Coronary Artery Bypass Surgery 4Mortality Data Presented for Patients Treated with Effient® Who Underwent Isolated Coronary Artery Bypass Surgery 5Mortality Data Presented for Patients Treated with Effient® Who Underwent Isolated Coronary Artery Bypass Surgery 6
... a Matching Card, three HRR symbol cards and ... child for subsequent HRR 4th Edition color testing. ... For the youngest patients, the parents can borrow ... concept of matching and become familiar with the ...
... Richmond Products includes the four demonstration plates, the ... for a total of 24 plates. Each of ... and clean page selection. The test also includes ... laminated copy of the score sheet. The score ...
10 plate suitable for children and the illiterate....
MVR Blades for water tight self sealing incision....
Medicine Products: