Navigation Links
Genes Tied to Hair Loss Disorder
Date:6/30/2010

dded.

The researchers discovered that the number of alopecia-associated genes a person had correlated with the severity of the condition. Those who carried 16 or more genes (the genes are in pairs) were more likely to progress to alopecia universalis, or total hair loss.

Researchers had expected that alopecia genes would be the same as those associated with other autoimmune diseases of the skin, such as psoriasis (in which the immune system signals the overproduction of skin cells, resulting in dry, scaly lesions) or vitiligo (loss of pigment to the skin when cells called melanocytes no longer function).

Yet alopecia and psoriasis had only one of the eight genes in common, Christiano said.

"We undertook this genome-wide association study to ask in an unbiased way, and to let the genes tell us, what are the likely associations with alopecia areata," Christiano said. "We were very surprised to find the genes that came up have a mechanism shared by type I diabetes and rheumatoid arthritis."

In people with alopecia, immune system T cells are present in large numbers in the hair follicle. Under a microscope, "it looks like the hair follicle is being swarmed or attacked by bees, which are the T cells," she explained.

What researchers didn't know was what attracted the "bees" in the first place, though the study hints at the answer.

Among the eight genes, one in particular -- ULBP3 -- has been shown to attract toxic cells that can invade and destroy an organ. In a person without alopecia, ULBP3 is turned off. But in people with alopecia, ULBP3 proteins are plentiful in the follicle.

"In people with alopecia areata, we see a huge expression of the ULBP3 gene in the outermost layer of the follicle," Christiano said. "ULBP3 is a danger signal that signals to T cells to come in and attack the follicle. It's like putting nectar on the hair follicle, then the 'bees' come in and do their damage."

When the follicle is attack
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. More Genes Implicated in Type 2 Diabetes
2. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
3. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
4. Scientists Spot More Genes Related to Alzheimers
5. Least Healthy More Apt to Think Genes Explain Disease Risk
6. Researchers report new autism genes discovered
7. Genes Link to Certain Cancers Questioned
8. Single Lung Tumor Contains 50,000 Mutated Genes
9. A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging
10. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
11. Tibetans Genes Help Them Thrive at High Altitudes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Tied to Hair Loss Disorder 
(Date:7/29/2014)... (PRWEB) July 29, 2014 The Eleventh ... Venture Summit concluded with the $10,000 prize being presented ... ( http://www.bikanta.com ) , The 11th Annual Summit was ... with entrepreneurs who can bring innovative products and services ... are pleased to have had such excellent array of ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 Lean and Lovely, ... choice for women who want to wear a bikini in ... Stan Stevenson, prompting an investigative review. , “Our Lean ... designed for women at all fitness levels. Neither your age ... how unfit your body is at the beginning, you will ...
(Date:7/29/2014)... July 29, 2014 Consilium Staffing, Your Partner ... at the halfway point of 2014, with strong indications the ... second half of this year. , “This is a great ... President of Consilium Staffing. , “We are proud of ... year, but we are even more excited about how things ...
(Date:7/29/2014)... 29, 2014 The Multiple System Atrophy ... announced the appointment of five new members to its ... announced the election of its executive directors. The ... members and 2 Physician Advisors. These 12 dedicated ... mission of education, support, advocacy and research funding for ...
(Date:7/29/2014)... 2014 Launched in 2012 by veteran ... 20,000 hangovers earlier this year at its Vegas location. ... and the publication of research data related to the ... , The only licensed medical practice dedicated to the ... in 2012 and treated thousands of patients within the ...
Breaking Medicine News(10 mins):Health News:Silicon Valley Boomer Venture Summit Names Bikanta Competition Winner 2Health News:Lean and Lovely: Review Examining Neghar Fonooni’s Program Released 2Health News:Consilium Staffing Experiences Significant Revenue Growth 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 2Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 3Health News:The Multiple System Atrophy Coalition Appoints Five New Members to Board of Directors 4Health News:Hangover Heaven Surpasses 20,000 Hangovers 2Health News:Hangover Heaven Surpasses 20,000 Hangovers 3
... another look at that attractive magazine their daughter is ... who read articles on weight loss and dieting in ... weight reducing techniques such as vomiting, laxatives or smoking ... published in Pediatrics' January edition, was conducted by studying ...
... the US the present guidelines should be modified affirms ... Respiratory and// Critical Care Medicine. This will need all ... have originally come from high risk areas around the ... ,Data on all 2004 TB cases listed ...
... or methicillin-resistant Staphylococcus aureus, or CA-MRSA was thought to ... are anything to go by, the bug appears to ... has resulted in an upsurge of infection in the ... ,Lately infections have been on the ...
... British doctor of Indian origin and his colleague are set ... challenge to the monopoly of multinational drug companies. ,Sunil ... Steve Brocchini from the London School of Pharmacy are leading ... ,The two academics have devised a way to ...
... post-traumatic stress disorder show reduced pain sensitivity, a pattern ... the brain, according to a report. ,Post-traumatic stress ... in individuals exposed to a traumatic event. It is ... avoidance of stimuli related to the event, according to ...
... levels of symptoms of Post-Traumatic Stress Disorder (PSTD) may ... same age without the disorder, a new study says. ... potentially debilitating condition that can occur in people who ... a natural disaster or a serious accident. ...
Cached Medicine News:Health News:Drop That Glossy, Girl! 2Health News:TB can Be Eradicated in the U.S With Modified Guidelines: Study 2Health News:NRI Doctor's R&D Model in India to Slash Cost of Drugs 2Health News:Patients With PTSD Experience Less Pain Sensitivity 2
(Date:7/28/2014)... , July 28, 2014  Air Products (NYSE: ... supply of medical oxygen is vital to any healthcare ... innovations that not only improve the efficiency of its ... Products will highlight these systems—including systems for emergency ... oxygen loss—from August 4-5 at the 51 st ...
(Date:7/28/2014)... 2014 Southern Research Institute today announced ... and CEO of Southern Research Institute, has been ... for the 2014-2015 term.  The inauguration took place ... in Chicago with attendees ... The Controlled Release Society is an international, interdisciplinary, ...
(Date:7/28/2014)... July 28, 2014  A prospective study conducted ... has validated the performance of VolparaDensity ... has associated volumetrically assessed breast density measurements to ... Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the article, ... for widespread breast cancer risk assessment," was authored ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... , MADISON, N.J., Nov. ... the world,s leading provider of diagnostic testing, information and services, ... Annual Piper Jaffray Healthcare Conference in New York City. ... 9:30 a.m. Eastern Time. , During the conference, the company ...
... , POTOMAC, Md., Nov. 24 ... Diane Wisneski has added Philadelphia jurors to her Thanksgiving gratitude ... just choice. I am so thankful to them," she said ... Pharmaceuticals. , Wisneski is among 12,000 women nationwide who ...
Cached Medicine Technology:Quest Diagnostics To Speak At The 21st Annual Piper Jaffray Healthcare Conference 2Maryland Woman Thankful for Wyeth Verdicts 2
... Knee System is designed to provide the ... of clinical indications. Based on the clinically ... 1984, P.F.C. SIGMA continues a history of ... designed to address implant longevity by maximizing ...
The Biopro Modular TKO implant is among the thinnest bone conserving Posterior Cruciate Ligament sparing knees available. It provides all the benefits of the Biopro TKO implant and gives the option o...
... allows for full interchangeability between femoral ... offers a one-piece molded tibial component ... component as well as modular capability.,The ... in total knee replacement when primary ...
Tibial distractor...
Medicine Products: