Navigation Links
Genes Tied to Hair Loss Disorder
Date:6/30/2010

dded.

The researchers discovered that the number of alopecia-associated genes a person had correlated with the severity of the condition. Those who carried 16 or more genes (the genes are in pairs) were more likely to progress to alopecia universalis, or total hair loss.

Researchers had expected that alopecia genes would be the same as those associated with other autoimmune diseases of the skin, such as psoriasis (in which the immune system signals the overproduction of skin cells, resulting in dry, scaly lesions) or vitiligo (loss of pigment to the skin when cells called melanocytes no longer function).

Yet alopecia and psoriasis had only one of the eight genes in common, Christiano said.

"We undertook this genome-wide association study to ask in an unbiased way, and to let the genes tell us, what are the likely associations with alopecia areata," Christiano said. "We were very surprised to find the genes that came up have a mechanism shared by type I diabetes and rheumatoid arthritis."

In people with alopecia, immune system T cells are present in large numbers in the hair follicle. Under a microscope, "it looks like the hair follicle is being swarmed or attacked by bees, which are the T cells," she explained.

What researchers didn't know was what attracted the "bees" in the first place, though the study hints at the answer.

Among the eight genes, one in particular -- ULBP3 -- has been shown to attract toxic cells that can invade and destroy an organ. In a person without alopecia, ULBP3 is turned off. But in people with alopecia, ULBP3 proteins are plentiful in the follicle.

"In people with alopecia areata, we see a huge expression of the ULBP3 gene in the outermost layer of the follicle," Christiano said. "ULBP3 is a danger signal that signals to T cells to come in and attack the follicle. It's like putting nectar on the hair follicle, then the 'bees' come in and do their damage."

When the follicle is attack
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. More Genes Implicated in Type 2 Diabetes
2. The language of RNA decoded: Study reveals new function for pseudogenes and noncoding RNAs
3. New world Helicobacter pylori genome sequenced, dynamics of inflammation-related genes revealed
4. Scientists Spot More Genes Related to Alzheimers
5. Least Healthy More Apt to Think Genes Explain Disease Risk
6. Researchers report new autism genes discovered
7. Genes Link to Certain Cancers Questioned
8. Single Lung Tumor Contains 50,000 Mutated Genes
9. A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging
10. Belly fat or hip fat -- it really is all in your genes, says UT Southwestern researcher
11. Tibetans Genes Help Them Thrive at High Altitudes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genes Tied to Hair Loss Disorder 
(Date:10/2/2014)... By Dennis Thompson ... -- A newborn,s risk of developing celiac disease isn,t reduced ... found in wheat called gluten to an infant,s diet help ... a pair of new studies in the Oct. 2 ... put to rest hopes that a child could avoid celiac ...
(Date:10/2/2014)... Dennis Thompson HealthDay Reporter ... and the District of Columbia now have a total of ... that has been infecting children since the summer, U.S. ... virus have died in recent weeks, but it,s not clear ... those deaths, officials said. Health officials are also trying ...
(Date:10/1/2014)... associated with Alzheimer,s disease; however, researchers are still looking ... agent of the onset and development of the disease. ... is not harmful when found in isolation but only ... form the so-called amyloid fibrils , "We are not ... multiple ones because each aggregate of peptide, which can ...
(Date:10/1/2014)... eye, the brain of a rat and a robot ... a QUT leading robotics researcher. , Dr Michael ... new study uses new computer algorithms to enable robots ... , "This is a very Frankenstein type of project," ... a thing together because we,re taking the eyes of ...
(Date:10/1/2014)... 2014) Despite a policy focus on expanding ... this vulnerable population continues to have significant dental ... Journal of the American Dental Association , researchers ... University School of Dental Medicine report on the ... oral care provided by caregivers to adults with ...
Breaking Medicine News(10 mins):Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 2Health News:Infant's Early Diet Doesn't Change Celiac Disease Risk, Study Finds 3Health News:42 States Reporting Respiratory Virus That Targets Kids 2Health News:42 States Reporting Respiratory Virus That Targets Kids 3Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:Robot researcher combines nature to nurture 'superhuman' navigation 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3
... among the scientific community about whether women who are ... to shed some light on this issue, scientists from ... methods used to detect substances in breast milk, their ... in this month,s issue of the journal Analytical ...
... Andrew Lees, Professor of Neurology at University College London, is ... Memorial Medal awarded for the scientific contributions he has ... He will receive the medal following his delivery of ... Stuff," at Barts and The London Medical School on June ...
... stromal tumors (GISTs) are the most common mesenchymal ... location is less common. Nowadays, surgery is ... procedures can be performed to remove duodenal GIST. ... difficult reconstruction (like pancreaticoduodenectomy; PD). One of the ...
... increase the risk of severe asthma attacks among people with ... Medical School, Harvard Pilgrim Health Care Institute and Brigham and ... the American Thoracic Society,s journal Web site ahead of the ... Critical Care Medicine . "We found that the interaction ...
... Council for Graduate Medical Education (ACGME) task force ... presented a comprehensive set of draft standards that ... better match residents, levels of experience and emerging ... patient care in the nation,s teaching hospitals. ...
... Texas (CPRIT) has granted $3.7 million to Rice University ... The funds will help the BioScience Research Collaborative ... Bioengineering and Chemistry, in its mission to make the ... into cancer and other diseases. The work ...
Cached Medicine News:Health News:Breast milk transmits drugs and medicines to the baby 2Health News:Breast milk transmits drugs and medicines to the baby 3Health News:Lord Brain Memorial Lecture is launched in recognizing outstanding contribution to neuroscience 2Health News:Moldy homes a serious risk for severe asthma attacks in some 2Health News:ACGME task force proposes graduated duty hour and supervision standards 2Health News:ACGME task force proposes graduated duty hour and supervision standards 3Health News:ACGME task force proposes graduated duty hour and supervision standards 4Health News:ACGME task force proposes graduated duty hour and supervision standards 5Health News:Rice wins $3.7 million for cancer research 2
(Date:10/2/2014)... 2014 The global high content screening market ... ,Threat of Obsolescence, wherein technologies as well as their ... biotechnology companies as well as academic and government institutes ... a powerful research tool in drug discovery. The high ... the high content screening market. In high content screening, ...
(Date:10/1/2014)... 2014  Abaxis, Inc. (NasdaqGS: ABAX ), ... for the medical, research, and veterinary markets worldwide and ... markets in the United States , ... agreement with Patterson Veterinary Supply. Patterson ... of Abaxis veterinary products throughout the United ...
(Date:10/1/2014)... BOSTON , Oct. 1, 2014   ... market-leading provider of Anesthesia Information Management Systems (AIMS), ... Systems, LLC , a wholly owned subsidiary of ... healthcare information systems and connectivity solutions.  ... http://photos.prnewswire.com/prnh/20140930/149407 This partnership ...
Breaking Medicine Technology:High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 2High Content Screening Market by Instruments (Cell Imaging and Analysis System), by Applications (Primary and Secondary Screening, Target Identification and Validation, Toxicity Studies, Compound Profiling), Software & Services - Global Forecasts to 3Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 2Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 3Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 4Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 2Plexus IS' Anesthesia Documentation Solution Strengthens NextGen Healthcare Product Offering 3
... , , , LIBERTYVILLE, Ill., ... today that the Office of Orphan Products Development of the Food ... for the treatment of Spinal Muscular Atrophy. , , ... for Spinal Muscular Atrophy has ever reached the important stage of ...
... , , , ... Forest Laboratories today announced that results of four phase III ... The Lancet showing that roflumilast, a phosphodiesterase 4 ... to severe COPD. , , COPD is ...
Cached Medicine Technology:Families of Spinal Muscular Atrophy Receives FDA Orphan Drug Designation For Quinazoline495 For The Treatment of Spinal Muscular Atrophy 2Families of Spinal Muscular Atrophy Receives FDA Orphan Drug Designation For Quinazoline495 For The Treatment of Spinal Muscular Atrophy 3Families of Spinal Muscular Atrophy Receives FDA Orphan Drug Designation For Quinazoline495 For The Treatment of Spinal Muscular Atrophy 4Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 2Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 3Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 4Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 5Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 6Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 7Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 8Four Studies Published in The Lancet Show roflumilast (Daxas(R)), a New Oral Approach to COPD, Improves Lung Function and Reduces Exacerbations 9
... PalmScan P2000 Pachymeter [i.e., PalmScan P2000] ... operated biometer, which incorporates A-mode pulsed-echo ... to accurately measure the corneal thickness ... eyes. PalmScan P2000 includes two software ...
The Cordis ANGIOGUARD® Capture Guidewire is the first embolic protection device shown in clinical testing to achieve a relative stroke reduction of 70% during carotid stenting procedures....
... hand-held, point-of-care device for the qualitative detection of ... The TOX/See device can detect up to nine ... to 8 minutes and requires only a few ... packaged to maximize convenience and ease of use. ...
... TOX/See™ is a 1-step, hand-held, point-of-care device for ... in human urine. The TOX/See device can ... abused drugs in 3 to 8 minutes and ... TOX/See cassette is individually packaged to maximize convenience ...
Medicine Products: