Navigation Links
Gene variant identified as a heart disease risk factor for women
Date:7/22/2014

When it comes to heart disease, Dr. Ross Feldman says women are often in the dark. Historically, it was thought that heart disease was a men's-only disease, however, data has shown that post-menopausal women are just as likely as men to get heart disease and are less likely to be adequately diagnosed and treated. New research from Western University published online this week in the British Journal of Clinical Pharmacology brings to light a genetic basis for heart disease in women and helps to identify which women are more prone to heart disease.

The study, led by Dr. Feldman, a clinical pharmacologist at London Health Sciences Centre and a researcher at the Schulich School of Medicine & Dentistry's Robarts Research Institute, identifies a common gene variant in women for the G-protein coupled estrogen receptor 30 (GPER) that makes them significantly more likely to have high blood pressure, the single biggest risk factor for heart attack and stroke.

GPER, when functioning normally, is activated in part by the hormone estrogen and has been previously shown to relax the blood vessels, and in turn, lower blood pressure. This new study demonstrates that many women have a less functional form of GPER, increasing their risk of developing high blood pressure.

The research looked at the effect of expression of the GPER gene variant versus the normal GPER gene in the vascular smooth muscle cells as well as its association with blood pressure in humans. It also looked at the frequency of the gene variant in a group of women referred a tertiary care clinic at London Health Sciences Centre. The study found that women, but not men, carrying the GPER gene variant had higher blood pressure, and almost half of women who attended a hard-to-treat blood pressure clinic, where Dr. Feldman is a physician, expressed the variant. Twice as many women than men with hard to treat hypertension carried the gene.

"This is one step in understanding
'/>"/>

Contact: Crystal Mackay
crystal.mackay@schulich.uwo.ca
519-661-2111 x80387
University of Western Ontario
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Common gene variants account for most of the genetic risk for autism
2. Splice variants reveal connections among autism genes
3. Certain genetic variants may identify patients at higher risk of bladder cancer recurrence
4. Gene variants protect against relapse after treatment for hepatitis C
5. Researchers identify genomic variant associated with sun sensitivity, freckles
6. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
7. Noodles Box launches variants in serving size
8. Gene variant ID could lead to better fatty liver disease diagnosis
9. Common gene variants explain 42 percent of antidepressant response
10. An international study identifies new DNA variants that increase the risk for cancer
11. eVariant Welcomes Advocate Health Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... WASHINGTON, DC September 14, 2014 A ... provisional side branch (SB) stenting of true coronary ... standard of care. The DKCRUSH-VI clinical trial is ... stenting. , Findings were reported today at ... symposium. Sponsored by the Cardiovascular Research Foundation (CRF), ...
(Date:9/16/2014)... therapy and radiation therapy as part of breast ... women with hormone-receptor positive (HR+) invasive breast cancer. ... Cancer Center, however, shows that combination may not ... disease. , The results, which Fox Chase ... Oncology,s 56th Annual Meeting on Sunday, September 14, ...
(Date:9/16/2014)... that corn absorbs the right balance of nitrogen, phosphorus ... Purdue and Kansas State University study finds. , A ... the U.S. and other regions showed that high yields ... took up key nutrients at specific ratios - nitrogen ... and potassium at a ratio of 1-to-1. These nutrient ...
(Date:9/16/2014)... Seven heroes who have dramatically improved the ... in New York City on November 6 by World ... recognition and funding program that honors individuals serving vulnerable ... the “Nobel Prize for Child Advocates,” this year’s selection ... benefit children in countries around the world dealing with ...
(Date:9/16/2014)... Who:, The Pulmonary Hypertension Association (PHA), ... Children’s Hospital Colorado are hosting Colorado PH in the ... association that works to find ways to prevent and cure ... affects the functioning of the heart and can lead to ... years. , What:, Colorado PH in the Park 2014 ...
Breaking Medicine News(10 mins):Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2Health News:Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer? 2Health News:Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer? 3Health News:Boosting global corn yields depends on improving nutrient balance 2Health News:Boosting global corn yields depends on improving nutrient balance 3Health News:World of Children® Award Announces 2014 Honorees 2Health News:World of Children® Award Announces 2014 Honorees 3Health News:World of Children® Award Announces 2014 Honorees 4Health News:World of Children® Award Announces 2014 Honorees 5Health News:World of Children® Award Announces 2014 Honorees 6Health News:World of Children® Award Announces 2014 Honorees 7Health News:World of Children® Award Announces 2014 Honorees 8Health News:Help Fight Pulmonary Hypertension at the Colorado PH in the Park 2014 2
... A new study shows that estrogen therapy does not ... postmenopausal women, say researchers //.Previous studies have reported an ... dementia. ,A placebo-controlled trial of estrogen or estrogen ... looked at associated risk for dementia. In the estrogen-only ...
... in your 20s could reduce the risk of developing high ... psychological stress with spikes in blood pressure are more likely ... 40s. ,Specialists say assessing blood pressure changes in response ... person’s future risk of high blood pressure. In a large ...
... shows dogs may be able to anticipate seizures in ... dogs in this study was // licking, often ... and “protective" behavior without aggression. In previous studies, owners ... even prevent their seizures. Some breeds of seizure-alerting ...
... patients consume about 40 milligrams of vitamin C daily ... vitamin C may protect against rheumatoid arthritis. ,Researchers ... 45 and 74. Participants' diets were assessed by using ... in two or more joints for at least one ...
... with a number of other side effects. For some people ... through with it may not even get rid of their ... to delivering chemotherapy. ,Perfusion therapy is the most aggressive ... avoid the toxicity to the rest of the body .Blood ...
... might help protect the eyes against a leading cause of ... // men and women it was found that those ... had a 36-percent lower risk of developing age-related maculopathy than ... have linked consumption of antioxidant vitamins and minerals to lower ...
Cached Medicine News:
(Date:9/16/2014)... 16, 2014 The Pulmonary Fibrosis Foundation (PFF) ... more than 1,100 patients and families suffering from pulmonary ... (FDA) for the Patient-Focused Drug Development Meeting for Idiopathic ... FDA initiative to seek patient input in order to ... "We applaud the FDA for focusing its ...
(Date:9/16/2014)... 2014 Chindex International, Inc. ("Chindex" or the ... a special meeting of stockholders held today, the Company,s ... Agreement") by and among the Company, Healthy Harmony Holdings, ... Parent is an affiliate of TPG, Shanghai Fosun Pharmaceutical ... , the CEO of the Company. The ...
(Date:9/16/2014)... /PRNewswire-iReach/ -- Dan York has been named ... the RTD ® Advanced Wound Care Dressing, as ... presence in the U.S. Under York,s leadership, GWM Products, ... sales representatives in new sales territories that will complement ... up to 20 sales representatives in major metropolitan areas ...
Breaking Medicine Technology:PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 2PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 3PFF Submits Survey Data From More Than 1,100 Pulmonary Fibrosis Patients And Families To U.S. Food And Drug Administration For Upcoming Drug Development Meeting 4Chindex Stockholders Approve Merger 2Chindex Stockholders Approve Merger 3GWM Products, LLC, announces U.S. market expansion. Dan York added as Director of Sales as part of nationwide growth initiative. 2
... studies including a pivotal Phase III trial in patients,with ... tablets will be presented at the Annual,Meeting of the ... June 1 - 5, 2007. , On this occasion ... on June 4, 2007. Starting at around 2:00 p.m. ...
... of Eisai's,Commitment to Oncology, WOODCLIFF LAKE, N.J., May ... abstracts covering clinical data about,their oncology pipeline compounds ... of Clinical Oncology (ASCO),annual meeting. ASCO takes place ... reveal a growing and diverse oncology clinical,development program ...
Cached Medicine Technology:Clinical Data on Eisai's Oncology Pipeline to be Presented at ASCO,Annual Meeting 2Clinical Data on Eisai's Oncology Pipeline to be Presented at ASCO,Annual Meeting 3Clinical Data on Eisai's Oncology Pipeline to be Presented at ASCO,Annual Meeting 4
Scoville cervical disc retractor, self-retaining with ratchet action....
... Image-Line offers superior retractor blade stability ... all cervical spine retraction objectives. The ... rapid and accurate blade size determination. ... accommodates a variety of patients and ...
Small, removable blades, length 178 mm, (7"). Function: tissue retracting....
The High Sensitivity C-Reactive Protein (RCRP) Flex reagent cartridge is an in vitro diagnostic test intended for the quantitative determination of CRP in serum and plasma. This assay is not availabl...
Medicine Products: