Navigation Links
Gene variant identified as a heart disease risk factor for women
Date:7/22/2014

When it comes to heart disease, Dr. Ross Feldman says women are often in the dark. Historically, it was thought that heart disease was a men's-only disease, however, data has shown that post-menopausal women are just as likely as men to get heart disease and are less likely to be adequately diagnosed and treated. New research from Western University published online this week in the British Journal of Clinical Pharmacology brings to light a genetic basis for heart disease in women and helps to identify which women are more prone to heart disease.

The study, led by Dr. Feldman, a clinical pharmacologist at London Health Sciences Centre and a researcher at the Schulich School of Medicine & Dentistry's Robarts Research Institute, identifies a common gene variant in women for the G-protein coupled estrogen receptor 30 (GPER) that makes them significantly more likely to have high blood pressure, the single biggest risk factor for heart attack and stroke.

GPER, when functioning normally, is activated in part by the hormone estrogen and has been previously shown to relax the blood vessels, and in turn, lower blood pressure. This new study demonstrates that many women have a less functional form of GPER, increasing their risk of developing high blood pressure.

The research looked at the effect of expression of the GPER gene variant versus the normal GPER gene in the vascular smooth muscle cells as well as its association with blood pressure in humans. It also looked at the frequency of the gene variant in a group of women referred a tertiary care clinic at London Health Sciences Centre. The study found that women, but not men, carrying the GPER gene variant had higher blood pressure, and almost half of women who attended a hard-to-treat blood pressure clinic, where Dr. Feldman is a physician, expressed the variant. Twice as many women than men with hard to treat hypertension carried the gene.

"This is one step in understanding the effects of estrogen on heart disease, and understanding why some women are more prone to heart attack and stroke than others," Dr. Feldman said. "Our work is a step forward in developing approaches to treating heart disease in this under-appreciated group of patients." Video of Dr. Feldman discussing the research can be found at http://youtu.be/uK2-t7D1JMc


'/>"/>

Contact: Crystal Mackay
crystal.mackay@schulich.uwo.ca
519-661-2111 x80387
University of Western Ontario
Source:Eurekalert

Related medicine news :

1. Common gene variants account for most of the genetic risk for autism
2. Splice variants reveal connections among autism genes
3. Certain genetic variants may identify patients at higher risk of bladder cancer recurrence
4. Gene variants protect against relapse after treatment for hepatitis C
5. Researchers identify genomic variant associated with sun sensitivity, freckles
6. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
7. Noodles Box launches variants in serving size
8. Gene variant ID could lead to better fatty liver disease diagnosis
9. Common gene variants explain 42 percent of antidepressant response
10. An international study identifies new DNA variants that increase the risk for cancer
11. eVariant Welcomes Advocate Health Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... ... Guide to FDA and EU Medical Device Regulations: 2017 Edition, **An FDAnews ... Atlantic devicemakers do business, this fully updated and expanded guide keeps them in touch ... full text of the FDA’s regulations in 21 CFR Parts 800 to 898, the ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... a one-day corporate governance program for mid-market executives as a kick-off to the ... held Sunday, Sept. 24, 2017 on the University of Pennsylvania campus, followed by ...
(Date:6/28/2017)... ... June 28, 2017 , ... Doner Financial, a ... access to insurance assistance and financial planning services, is announcing the commencement of ... in the region facing financial crisis. , Matthew 25: Ministries (M25M) is an ...
(Date:6/27/2017)... ... June 27, 2017 , ... DrugDev understands that ... they can trust the sponsor to pay them correctly and on time. As the ... establish payment strategies that encourage sites to work on their studies. , At a ...
(Date:6/27/2017)... ... 2017 , ... From June 20-22, EarQ and Widex held an ... York, where EarQ is headquartered. , Together, the organizations educate hearing care professionals ... consumer, and the latest in hearing technology. At the event, EarQ members got ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... Cincinnati location of Diplomat Specialty Infusion ... been awarded a Top Workplaces 2017 honor by ... on an employee survey administered by WorkplaceDynamics, LLC, a research ... measures several aspects of workplace culture, including alignment, execution, and ... ...
(Date:5/30/2017)... -- DarioHealth Corp. (NASDAQ: DRIO), a leading global digital health company ... will be presenting at the 7th annual LD Micro Invitational on ... , CEO, of DarioHealth will be giving the presentation and meeting ... 6th & 7th, 2017 at the Luxe Sunset Bel Air Hotel ... About LD Micro LD Micro ...
(Date:5/26/2017)... SANTA BARBARA, Calif. , May 25, 2017 /PRNewswire-USNewswire/ ... the United States , Direct Relief is working ... of overdose-reversing Naloxone available at no cost to community ... and other nonprofit providers nationwide. "Pfizer ... expanding access to medicines and ensuring patient safety through ...
Breaking Medicine Technology: