Navigation Links
Gender influences symptoms of genetic disorder
Date:2/7/2014

A genetic disorder that affects about 1 in every 2,500 births can cause a bewildering array of clinical problems, including brain tumors, impaired vision, learning disabilities, behavioral problems, heart defects and bone deformities. The symptoms and their severity vary among patients affected by this condition, known as neurofibromatosis type 1 (NF1).

Now, researchers at Washington University School of Medicine in St. Louis have identified a patient's gender as a clear and simple guidepost to help health-care providers anticipate some of the effects of NF1. The scientists report that girls with NF1 are at greater risk of vision loss from brain tumors. They also identified gender-linked differences in male mice that may help explain why boys with NF1 are more vulnerable to learning disabilities.

"This information will help us adjust our strategies for predicting the potential outcomes in patients with NF1 and recommending appropriate treatments," said David H. Gutmann, MD, PhD, the Donald O. Schnuck Family Professor of Neurology, who treats NF1 patients at St. Louis Children's Hospital.

The findings appear online in the Annals of Neurology.

Kelly Diggs-Andrews, PhD, a postdoctoral research associate in Gutmann's laboratory, reviewed NF1 patient data collected at the Washington University Neurofibromatosis (NF) Center. In her initial assessment, Diggs-Andrews found that the number of boys and girls was almost equal in a group of nearly 100 NF1 patients who had developed brain tumors known as optic gliomas. But vision loss occurred three times more often in girls with these tumors.

With help from David Wozniak, PhD, research professor of psychiatry, the scientists looked for an explanation in Nf1 mice (which, like NF1 patients, have a mutation in their Nf1 gene). They found that more nerve cells died in the eyes of female mice, and they linked the increased cell death to low levels of cyclic AMP, a chemical me
'/>"/>

Contact: Michael C. Purdy
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UK review examines gender differences in COPD patients
2. Fenway Health Releases Transgender Awareness Week 2013 Infographic
3. Transgender patients have special needs in the ER
4. Considerable gender, racial and sexuality differences in attitudes toward bisexuality
5. GVSU study on gender: Who counts as a man and who counts as a woman
6. Discover How to Determine Baby Gender With the “Prince Or Princess” Book – Vkoolelite
7. Three Physicians Join Texas Children’s Urology Division and Bring Robotics, Gender Medicine and Research Expertise
8. New University of Michigan Study Discovers Obesity Causes Vary By Gender
9. Researcher awarded $1.8 million grant to study gender differences in antidepressant effects
10. A Gender Specific Hair Re-Growth Product "Provillus" Finally Released
11. Men, women lie about sex to match gender expectations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... article published online in The Gerontologist ... music is associated with a decrease in anxiety about ... of control over their lives. In particular, listening to ... about death and an increase in sense of control. ... women and men, and individuals of both low- and ...
(Date:4/18/2014)... of Medicine researchers have been awarded two-year grants for ... announced this month. Of the 110 initial submissions to ... Forum Program, only four projects were funded, three of ... Jonathan Powell, M.D., Ph.D.; G. William Wong, Ph.D.; and ... professor of oncology, will use his $500,000 proof of ...
(Date:4/18/2014)... 18, 2014) Benaroya Research Institute at Virginia Mason ... a particular molecule in metastatic breast cancer reduces both ... lung metastases. BRI scientists have found in models of ... by 60 - 80 percent and can keep the ... $1.8 million five-year grant comes from the National Cancer ...
(Date:4/18/2014)... A new study in the American Journal of ... searches reveals a recurring pattern that could be leveraged ... from San Diego State University, the Santa Fe Institute, ... Google searches (searches that included the term healthy and ... U.S. from 2005 to 2012. They found that on ...
(Date:4/18/2014)... to potential new treatments for breaking the cycle of ... or scarring, is a hallmark of the disease, and ... to serious organ damage and, in some cases, death. ... findings made by Swati Bhattacharyya, PhD, research assistant professor ... protein plays in promoting fibrosis. , "Our results ...
Breaking Medicine News(10 mins):Health News:Religious music brings benefit to seniors' mental health 2Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:New research shows people are thinking about their health early in the week 2Health News:New clues on tissue scarring in scleroderma 2
... foot and mouth disease is playing havoc with the ... adopting a more conservative,approach of vaccinating the animals for ... against FMD on a regular basis is the best,means ... S M Lal, the joint,director of the Bangalore-based Indian ...
... the first signs of a reverse brain drain in ... time. The emergence of modern,corporate and investorowned hospitals in ... back to home turf. ,And unlike other sectors, where ... draw, doctors are actually taking pay cuts to work ...
... The world health organization says, water related illnesses claim up ... to coincide with World Water Day on 22nd of March. ... and much of the suffering is needless. People in the ... 2.2 million people die of diarrhea caused by drinking contaminated ...
... always raises many uncomfortable questions and more troubling answers is ... ethical issue and has kindled a lot of heated arguments ... victims suffer the most when it comes to drug testing ... on unsuspecting victims in the name of conducting a study.,A ...
... from Edmonton, Alberta, wandered into a neighbor’s backyard and was ... She was frozen stiff and her heart had stopped beating. ... her clinically dead, but lo and behold, she was awake ... to know more. , The temperature outside was –24 degree ...
... by Dr. Michael Brent, an associate professor of computer ... us an insight into the way children understand and ... presented at the annual meeting of the American association ... the ability of children to pick up language and ...
Cached Medicine News:Health News:India takes on foot-and-mouth disease by vaccinating animals 2Health News:Lure of the home turf brings back NRI doctors 2
(Date:1/15/2014)... 2014 The Cadence Fitness & Health Center has ... Medical Fitness Association, a non-profit organization assisting medically integrated ... The Cadence Fitness & Health Center is the only ... in the Chicagoland area. "The certification means ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are ...
(Date:1/15/2014)... LAVAL, Quebec , Jan. 15, 2014  Valeant Pharmaceuticals ... VRX) announced that the applicable waiting period under the ... to the previously announced tender offer by its indirect ... the outstanding shares of common stock of Solta Medical, ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... SpineSmith, a Texas-based medical device company, today announces the ... the VisuALIF, following a successful Alpha launch.   ... indicated for intervertebral body fusion of the lumbar spine ... United States in October 2010.   VisuALIF is the first ...
... 2011 Samplify Systems, Inc., a leading provider ... equipment market, announced today that Chris Daft, Ph.D. ... he will apply his expertise to extend the ... beamforming technology and products. (Logo: http://photos.prnewswire.com/prnh/20080411/AQF028LOGO) ...
Cached Medicine Technology:SpineSmith Successful in VisuALIF Alpha Launch 2Ultrasound Industry Expert, Chris Daft, Joins Samplify Systems 2
This orthopaedics refresher and study tool for the recertification exam is perfect for residents and practitioners....
A quick reference for the diagnosis and treatment of many orthopedic conditions....
The Urinary System Flash Cards product uses the time tested content and images from BryanEdwards.com and displays the necessary images to demonstrate the urinary system....
... all-original guide prepared specifically for ... from "PocketMedicine/Internal Medicine", it will ... those training in the field, ... are frequently the first to ...
Medicine Products: