Navigation Links
From genomic data to new cancer drug
Date:10/27/2011

New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell, a Cell Press publication, demonstrates how genetic insights can be translated directly into therapies.

The findings are but one example of what has now become possible given the avalanche of data on cancer genomes.

"With access to tumor genomic data, suddenly we can do this; we know what has changed, and the question now is to define which changes are really important," says Hans-Guido Wendel of Memorial Sloan-Kettering Cancer Center, and senior author of this study. "With that information, we can start to develop new therapies."

Wendel's group has developed a way to target and shrinks tumors when delivered to mice with an incurable form of lymphoma. Loss of the anti-cancer protein known as EPHA7 (ephrin receptor A7) is an important driver of the disease, the new evidence shows.

"We went all the way from genomic data to a potential new drug," said Wendel. "EPHA7 was not on anyone's radar screen for lymphoma. Now it is."

Wendel's team focused their attention on a portion of chromosome 6 that is commonly lost in human patients and is related to poor outcomes. But such large-scale changes can only tell you so much. "Tumors often acquire complex genomic aberrations including gains and losses of large sections or even entire chromosomes," the researchers said. "Identifying the target gene or genes from such complex genomic changes remains a significant challenge."

They used a method called RNA interference to silence genes in that stretch of the genome. That effort led them to EPHA7, a tumor suppressor protein that is shed from the surface of lymphocytes.

It is important that EPHA7 is a soluble factor, Wendel explained. "You can purify it, put it in a bottle, and see if it can be administered as a drug."
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dana-Farber, Brigham and Womens launch large-scale genomic database project
2. Structural Genomics Project creates blueprint for infectious disease and biodefense research
3. Lung tumors in never-smokers show greater genomic instability than those in smokers
4. Novel analysis method organizes genomic cancer data
5. Genomic test shows promise as chemotherapy response, survival predictor for women with breast cancer
6. Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
7. New genomics research investigates metastatic childhood cancers
8. Promise of genomics research needs a realistic view
9. NHGRI charts course for the next phase of genomics research
10. Tufts University calls for moderate approach to teaching personalized genomic testing
11. Genomic markers may head off thousands of thyroid surgeries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... A new ... for inmates who continued methadone maintenance treatment (MMT) during incarceration versus those subjected ... relapse to opiate use (1) and more likely to require hospitalization or emergency ...
(Date:7/28/2015)... ... July 28, 2015 , ... Morristown Medical Center, part of Atlantic Health System, ... first five hospitals in the nation, to implant the newly approved CoreValve® Evolut® R ... all are in good condition. , The CoreValve® Evolut® R System was approved by ...
(Date:7/28/2015)... ... 28, 2015 , ... Healthline , a provider of intelligent health information ... consumers’ perspectives on digital health . The survey, which was conducted among 3,679 ... digital health, level of trust in the security of digital health tools, impact of ...
(Date:7/28/2015)... ... ... Dr. Aziz Ahmad recently gave a talk on the current treatments of ... Tuesday, June 23, at the Gulf Coast Regional Medical Center Large HR Classroom, 449 ... surgery and has more than 35 years of experience in the surgical specialty. He ...
(Date:7/28/2015)... ... ... According to Kxan on June 24th a previously FDA approved blood ... study involving isradipine has garnered national attention and is making drug and alcohol rehabilitation ... alcohol addictions. The study was conducted by the University of Texas. Human trials may ...
Breaking Medicine News(10 mins):Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 2Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 3Health News:Novus Medical Detox Center Analyzes Methadone Study Findings and Implications for Opiate Abuse Treatment 4Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 2Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 3Health News:Consumers Concerned About Privacy of Personal Health Data on Wearables and Mobile Apps, According to New Healthline Survey 2Health News:Consumers Concerned About Privacy of Personal Health Data on Wearables and Mobile Apps, According to New Healthline Survey 3Health News:Consumers Concerned About Privacy of Personal Health Data on Wearables and Mobile Apps, According to New Healthline Survey 4Health News:Consumers Concerned About Privacy of Personal Health Data on Wearables and Mobile Apps, According to New Healthline Survey 5Health News:Dr. Aziz Ahmad Delivers Talk at Gulf Coast Medical Center 2Health News:Blood Pressure Medication May be the Key to Treating Addiction 2Health News:Blood Pressure Medication May be the Key to Treating Addiction 3
... Make Harmful Choices in Efforts to Contain Costs , ... San Mateo, ... make more difficult economic choices than ever before. A new survey ... nationwide are concerned patients are being forced to make cutbacks on medications ...
... in northern Illinois to use a new, cutting ... improve patient care and outcomes.WOBURN, Mass. and VEDBAEK, ... Anthony Medical Center in Rockford, Illinois has implemented ... 1 to 3 days earlier than conventional methods ...
... today,announced the initiation of a Phase IIa clinical trial ... being developed for,the treatment of type 2 diabetes. S-EH ... a key signaling molecule implicated in diabetes,hypertension and inflammatory ... II clinical trial program breaks new ground in two ...
... shows signs of stabilization; December 2008 to January 2009 ... CINCINNATI, Feb. 10 /PRNewswire-FirstCall/ -- LCA-Vision Inc. ... laser vision correction services under the Lasik Plus (R) ... three and 12 months ended December 31, 2008. Fourth ...
... end to insurer scheme that shifts medical ... Feb. 10 The American Medical Association ... the Medical Society of New Jersey, joined ... lawsuits against Aetna Health, Inc. and CIGNA ...
... Veterans Relief Fund ( http://www.disabledveteransrelieffund.org ) today announced its .99 CENT ... month to help disabled veterans and their families--and every person who ... raffle for a grand prize valued at $25,000. , ... ...
Cached Medicine News:Health News:Doctors Fear Patients Not Filling Prescriptions 2Health News:Doctors Fear Patients Not Filling Prescriptions 3Health News:OSF Saint Anthony Medical Center Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 2Health News:OSF Saint Anthony Medical Center Implements PNA FISH(R) Tests to Help Provide Best Care for Patients with Bloodstream Infections 3Health News:Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes 2Health News:Arete Therapeutics Initiates Phase IIa Clinical Trial for AR9281, a Novel s-EH Inhibitor to Treat Type 2 Diabetes 3Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 2Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 3Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 4Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 5Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 6Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 7Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 8Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 9Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 10Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 11Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 12Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 13Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 14Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 15Health News:LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results 16Health News:AMA Announces Physician Class-Actions Against Aetna and CIGNA 2Health News:With So Many Charities Struggling In This Economy, Disabled Veterans Relief Fund Is Thriving With a .99 Cent Fundraiser Program 2Health News:With So Many Charities Struggling In This Economy, Disabled Veterans Relief Fund Is Thriving With a .99 Cent Fundraiser Program 3
(Date:7/28/2015)... , July 28, 2015  Insulet Corporation (NASDAQ: ... with its OmniPod ® Insulin Management System, today ... appointed to Insulet,s Board of Directors. Dr. ... experience to the Insulet Board. She currently serves as ... Diabetes Center, the world,s largest diabetes research center, diabetes ...
(Date:7/28/2015)... 2015  Express Scripts Holding Company (Nasdaq: ESRX ... Express Scripts stockholders of $600.1 million, or $0.88 per ... in Table 4, were $1.44 for the second quarter. ... companies across healthcare are validating the need for size ... Officer. "But, what matters most is how that size ...
(Date:7/28/2015)... MENLO PARK, Calif. , July 28, 2015 ... global medical device company that is providing innovative ... today announced the publication of the SENZA-RCT results ... , the official Journal of the American Society of ... was a ground-breaking study that was the first ...
Breaking Medicine Technology:Insulet Appoints Jessica Hopfield, PhD, to Board of Directors 2Insulet Appoints Jessica Hopfield, PhD, to Board of Directors 3Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 2Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 3Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 4Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 5Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 6Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 7Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 8Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 9Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 10Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 11Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 12Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 13Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 14Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 15Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 16Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 17Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 18Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 19Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 20Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 21Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 22Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 23Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 24Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 25Nevro Announces Publication of SENZA-RCT Results in Anesthesiology 2
... program is critical, CHICAGO, March 29 ... successfully in medical centers without,on-site cardiac surgical back-up, ... quality. These are the findings of the,largest clinical ... on-site,cardiac surgery to PCI programs that transfer patients ...
... Are Overweight and Do ... Device Applies Electrical Stimulation to Stomach as Person ... Hospital/Weill,Cornell Medical Center is recruiting patients for a national ... help,those with type-2 diabetes who are overweight and do ...
Cached Medicine Technology:Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 2Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 3Study Finds PCI Safe, Effective Despite Off-Site Cardiac Surgery 4New York-Presbyterian/Weill Cornell is First New York Medical Center to Offer Tantalus Clinical Trial to Diabetes Patients 2
... Freedom leg bags are part ... a versatile line of leg bags, ... the varied needs of our customers. ... several sizes, and constructed of 100% ...
... bags are part of the Freedom ... of leg bags, kits, and accessories ... of our customers. These leg bags ... constructed of 100% latex-free soft, textured ...
The latex-free, PVC-free Antibacterial Hydro Personal catheter combines two remarkable innovations into one exclusive catheter that delivers an antibacterial agent while providing the virtually frict...
The Antibacterial Personal Catheter® features a unique silicone composition that provides an antibacterial coated soft outer layer of silicone combined with a firm inner layer....
Medicine Products: