Navigation Links
From genomic data to new cancer drug
Date:10/27/2011

New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell, a Cell Press publication, demonstrates how genetic insights can be translated directly into therapies.

The findings are but one example of what has now become possible given the avalanche of data on cancer genomes.

"With access to tumor genomic data, suddenly we can do this; we know what has changed, and the question now is to define which changes are really important," says Hans-Guido Wendel of Memorial Sloan-Kettering Cancer Center, and senior author of this study. "With that information, we can start to develop new therapies."

Wendel's group has developed a way to target and shrinks tumors when delivered to mice with an incurable form of lymphoma. Loss of the anti-cancer protein known as EPHA7 (ephrin receptor A7) is an important driver of the disease, the new evidence shows.

"We went all the way from genomic data to a potential new drug," said Wendel. "EPHA7 was not on anyone's radar screen for lymphoma. Now it is."

Wendel's team focused their attention on a portion of chromosome 6 that is commonly lost in human patients and is related to poor outcomes. But such large-scale changes can only tell you so much. "Tumors often acquire complex genomic aberrations including gains and losses of large sections or even entire chromosomes," the researchers said. "Identifying the target gene or genes from such complex genomic changes remains a significant challenge."

They used a method called RNA interference to silence genes in that stretch of the genome. That effort led them to EPHA7, a tumor suppressor protein that is shed from the surface of lymphocytes.

It is important that EPHA7 is a soluble factor, Wendel explained. "You can purify it, put it in a bottle, and see if it can be administered as a drug."

When the researchers injected EPHA7 into mice with human tumors, those tumors shrunk. They found that a particularly effective way to deliver EPHA7 to cancer cells is to fuse it with an antibody that specifically targets lymphomas.

The researchers say EPHA7 has immediate therapeutic potential, although they intend to pursue smaller versions of the protein that might be easier to make. There is also reason to think EPHA7 may ultimately have promise for the treatment of other forms of cancer as it binds a protein with links to breast and ovarian cancer.


'/>"/>
Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Dana-Farber, Brigham and Womens launch large-scale genomic database project
2. Structural Genomics Project creates blueprint for infectious disease and biodefense research
3. Lung tumors in never-smokers show greater genomic instability than those in smokers
4. Novel analysis method organizes genomic cancer data
5. Genomic test shows promise as chemotherapy response, survival predictor for women with breast cancer
6. Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
7. New genomics research investigates metastatic childhood cancers
8. Promise of genomics research needs a realistic view
9. NHGRI charts course for the next phase of genomics research
10. Tufts University calls for moderate approach to teaching personalized genomic testing
11. Genomic markers may head off thousands of thyroid surgeries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... Dothan, AL (PRWEB) , ... December 02, 2016 ... ... leaders from across the Dothan-Wiregrass Area in Alabama are expected to attend the ... Mike Schmitz, will help provide scholarship funds for area students and operating support ...
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare health ... is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their ... D) need to make changes during this period order for their new policy to ...
(Date:12/2/2016)... , ... December 02, 2016 , ... ... Beverly Hills, California, will be included in the 2016 “Guide to America’s Top ... professionals based on the amalgamation of their education, experience, and professional associations. ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional ... Resort and Spa in Honolulu, offering local frontline clinicians the opportunity to extend ... , The demand for supplemental training related to pain management has surged dramatically ...
(Date:12/2/2016)... ... 2016 , ... Yisrayl Hawkins, at The House of Yahweh in Abilene, Texas, ... Bible Prophecy. Yisrayl says this generation, known as the Last Generation, started in 1934 ... details line up exactly with Bible Prophecy – a protected way for those who ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- Maxor National Pharmacy Services, LLC ("Maxor"), today announced that it ... combination of Texas -based Maxor Specialty / ... together both company,s clinical expertise and high-touch patient service models ... pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... WOONSOCKET, R.I. , Dec. 2, 2016 ... hold its annual Analyst Day in New York City on Thursday, December ... the CVS Health leadership team will provide an in-depth ... and enhance shareholder value. The company will also discuss ... audio and video webcast of the event will be ...
(Date:12/2/2016)... 2, 2016 Orthopedic Implants (Including Spinal ... Expected to Gain a Significant Market Share Owing to a ... ... According to a new report by ... Sterile Packaging: Clamshell Product Type Segment Projected to Witness a ...
Breaking Medicine Technology: