Navigation Links
From genomic data to new cancer drug
Date:10/27/2011

New discoveries about follicular lymphoma, a currently intractable form of cancer, highlight the power of functional genomics in cancer gene discovery. A report in the Oct 28th issue of Cell, a Cell Press publication, demonstrates how genetic insights can be translated directly into therapies.

The findings are but one example of what has now become possible given the avalanche of data on cancer genomes.

"With access to tumor genomic data, suddenly we can do this; we know what has changed, and the question now is to define which changes are really important," says Hans-Guido Wendel of Memorial Sloan-Kettering Cancer Center, and senior author of this study. "With that information, we can start to develop new therapies."

Wendel's group has developed a way to target and shrinks tumors when delivered to mice with an incurable form of lymphoma. Loss of the anti-cancer protein known as EPHA7 (ephrin receptor A7) is an important driver of the disease, the new evidence shows.

"We went all the way from genomic data to a potential new drug," said Wendel. "EPHA7 was not on anyone's radar screen for lymphoma. Now it is."

Wendel's team focused their attention on a portion of chromosome 6 that is commonly lost in human patients and is related to poor outcomes. But such large-scale changes can only tell you so much. "Tumors often acquire complex genomic aberrations including gains and losses of large sections or even entire chromosomes," the researchers said. "Identifying the target gene or genes from such complex genomic changes remains a significant challenge."

They used a method called RNA interference to silence genes in that stretch of the genome. That effort led them to EPHA7, a tumor suppressor protein that is shed from the surface of lymphocytes.

It is important that EPHA7 is a soluble factor, Wendel explained. "You can purify it, put it in a bottle, and see if it can be administered as a drug."
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dana-Farber, Brigham and Womens launch large-scale genomic database project
2. Structural Genomics Project creates blueprint for infectious disease and biodefense research
3. Lung tumors in never-smokers show greater genomic instability than those in smokers
4. Novel analysis method organizes genomic cancer data
5. Genomic test shows promise as chemotherapy response, survival predictor for women with breast cancer
6. Genomic signature in post-menopausal women may explain why pregnancy reduces breast cancer risk
7. New genomics research investigates metastatic childhood cancers
8. Promise of genomics research needs a realistic view
9. NHGRI charts course for the next phase of genomics research
10. Tufts University calls for moderate approach to teaching personalized genomic testing
11. Genomic markers may head off thousands of thyroid surgeries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Dr. Paul Vitenas, one of the most awarded ... Holiday Event for those in the area that would like to ... & Glow will take place on December 11, 2014, from 6:00 ... heart of Houston at 4208 Richmond Ave. , “We want ... will come and celebrate the season with us on December 11, ...
(Date:11/28/2014)... Minnesota (PRWEB) November 28, 2014 ... of the few insurance marketing organizations in the ... income and asset protection marketplace. Secura Consultants is ... partnership with Principal Financial Group, a leading global ... multiple ownership interests. With the ownership interest comes ...
(Date:11/28/2014)... 2014 (HealthDay News) -- Celebration can quickly turn ... Thanksgiving Day, experts say. Over the last decade, ... occurred while people were using turkey fryers, according to ... actually cared for a patient who tried to deep ... done in any circumstances," Dr. Arthur Sanford, a burn ...
(Date:11/28/2014)... Alex Kramer HealthDay Reporter , ... in the kitchen, through cooking classes or at home, may ... a recent review. Cooking programs and classes for children ... to the new research. And, although the review didn,t look ... such programs might help children develop long-lasting healthy habits. ...
(Date:11/28/2014)... PreDiabetes Centers , a national ... learn their risk for type 2 diabetes by ... local school in partnership with the American Diabetes ... As the Presenting Sponsor for the Stop ... co-hosting diabetes-prevention presentations at Austin-area companies with the ...
Breaking Medicine News(10 mins):Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 2Health News:Cosmetic Surgeon Dr. Paul Vitenas to Host Glitter & Glow Holiday Event 3Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2Health News:Turkey Fryer Mishaps Can Cause Serious Burns 2Health News:Want Kids to Eat Better? Get Them Cooking 2Health News:Want Kids to Eat Better? Get Them Cooking 3Health News:PreDiabetes Centers Offers Workplace Diabetes Screening at Local School 2
... To Do the Right Thing and Override the ... Keehan, DC,president and chief executive officer of the ... the following statement:, By vetoing legislation to ... President has just played partisan politics,with the lives ...
... Oct. 3 The Missouri House of Representatives,recognized ... serving the state,s National Guard Service members and ... TriWest beneficiary service and,education representative serving Missouri, in ... time and energy to assisting soldiers,and airmen of ...
... Curative ... Therapy Driving Growth, ARCADIA, Calif., Oct. 3 ... Program for Los Angeles, a,ranking of the 50 fastest growing technology, ... Touche USA LLP, one,of the nation,s leading professional services organizations. Rankings ...
... tags will be on display,throughout Ralphs stores again ... and suppliers to support National Breast Cancer Awareness,month ... can be found on shelves in Ralphs,stores across ... to support breast cancer awareness in their,community. Several ...
... 3 Nowhere are the,consequences of premature birth more ... Wisconsin. In the next week, 151 babies,will be born ... by and watch their babies be admitted into a ... one of the most frightening and overwhelming,experiences a parent ...
... New York Citys infant mortality rate widely regarded as ... in 2006, the Health Department reported today. The rate in ... from 6.0 the previous year. The City has made major ... the rate was double what it is today, but the ...
Cached Medicine News:Health News:Missouri House Recognizes 'Extraordinary' Efforts Supporting National Guard Families 2Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 2Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 3Health News:StemCyte, Inc. Ranked Number Six in Deloitte's Technology Fast 50 Program for Los Angeles 4Health News:Ralphs 'Pink Tag' Campaign to Raise $170,000 for Breast Cancer Awareness in October 2Health News:March of Dimes NICU Family Support(R) Programs Give Wisconsin Families Comfort and Information during a Crisis 2Health News:New York City's infant mortality rate declined in 2006 2Health News:New York City's infant mortality rate declined in 2006 3Health News:New York City's infant mortality rate declined in 2006 4
(Date:11/26/2014)...  Cohen, Placitella & Roth, PC is investigating ... Nymox Pharmaceutical Corporation ("Nymox" or "Company") (NASDAQ: ... 31, 2011 through November 2, 2014 ("Class Period").  ... its officers and directors publically disseminated materially false ... and 20(a) of the Securities Exchange Act of ...
(Date:11/26/2014)... Nov. 26, 2014  Avanir Pharmaceuticals, Inc. (NASDAQ: ... Food and Drug Administration (FDA) has issued a ... (NDA) for AVP-825. AVP-825 is an investigational drug-device ... intranasally utilizing a novel Breath Powered delivery technology. ... and consistent with the preliminary feedback announced on ...
(Date:11/26/2014)... -- BioScrip ® , Inc. (NASDAQ: BIOS ) announced today ... will present at the Bank of America Merrill Lynch 2014 Leveraged ... , , , Wednesday, December 3, 2014 , , , ... , , Location: , , , Boca Raton Resort and Club, ... BioScrip, Inc. is a leading national provider of ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 2Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 3Avanir Pharmaceuticals Receives Complete Response Letter (CRL) from FDA on AVP-825 NDA 4
... , Jan. 19 Recognized as one of ... St. Louis Children,s Hospital in St. Louis is further ... a SOMATOM® Definition AS computed tomography (CT) scanner from Siemens Healthcare. ... intelligently adapts, on the fly, to the patient, for aiding in ...
... LOS ANGELES , Jan. 19 With ... money yet they cannot afford to cut live receptionist service. ... center and live answering service that provides customized solutions for ... Los Angeles , Global Messaging Network caters to all ...
Cached Medicine Technology:Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 2Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 3Siemens Delivers Complete Dose Protection to St. Louis Children's Hospital 4Global Messaging Network Saves Companies Overhead Costs by Outsourcing Call Processing 2
... Centuries of German ... finest surgical instrumentation in ... makes them available to ... the coveted Meisterbrief certificate, ...
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
Protects the eye from symptoms caused by "dry eye, medical conditions, drug reactions and environmental factors. Forms a moisture chamber over the eye area during rest....
Medicine Products: